Impact of Metabolic Syndrome on Response to Medical Treatment of Benign Prostatic Hyperplasia

Ali Cyrus,Ali Kabir,Davood Goodarzi,Afsaneh Talaei,Ali Moradi,Mohammad Rafiee,Mehrdad Moghimi,Elham Shahbazi,Elaheh Farmani 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.12

Purpose: To investigate the effect of metabolic syndrome (MetS) on the response to medicaltherapy of benign prostatic hyperplasia (BPH) after a 3-month period of treatment. Materials and Methods: This was a cohort study of 100 patients, 47 with MetS and 53without MetS, referred to either the primary care unit or referral hospital with BPHwho had moderate lower urinary tract symptoms of prostate involvement and were candidatesfor medical treatment. Our main outcome was response to medical treatmentwith prazosin 1 mg twice a day and finasteride 5 mg daily in patients with BPH on thebasis of International Prostate Symptom Score (IPSS). Multivariate analysis of covariancewas used to compare BPH treatment response in patients with and withoutMetS before and after receiving treatment. Results: The mean volume of the prostate was significantly higher in MetS patientsthan in patients without MetS (57±32.65 mL compared with 46.00±20.19 mL, p=0.036). The control group demonstrated an 11-unit reduction in IPSS, whereas those with MetSshowed a reduction in the symptom score of only 6 units (p<0.001). Regarding the componentsof MetS separately, triglyceride (p<0.001), fasting blood sugar (p=0.001), andwaist circumference (p=0.028) significantly affected the clinical progression of BPH. The observational nature of this study may be a limitation in comparison with an interventionalstudy. Conclusions: The results of the present study showed that MetS can negatively affectthe response to medical treatment of BPH. Therefore, it is necessary to consider MetSin selecting patients with BPH for drug therapy.

Effects of High White and Brown Sugar Consumption on Serum Level of Brain-Derived Neurotrophic Factor, Insulin Resistance, and Body Weight in Albino Rats

Ali Shamsi-Goushki,Zinat Mortazavi,Mohammad Ali Mirshekar,Fatemeh Behrasi,Nasroallah Moradi-Kor,Rasul Taghvaeefar 대한비만학회 2020 The Korean journal of obesity Vol.29 No.4

Background: In recent decades, consumption of simple sugars has increased dramatically, which contributes to health problems including insulin resistance and obesity. In this study, we investigated the effects of high concentrations of white sugar (WS) and brown sugar (BS) on serum concentration of brain-derived neurotrophic factor (BDNF), insulin resistance, and body weight in albino rats. Methods: Twenty-four male Wistar rats were randomly divided into three groups: control, a group treated with 15% WS, and a group treated with 15% BS. Rats were given WS and BS by gavage (daily) for 42 days. At the end of the intervention period, serum level of BDNF, insulin resistance, and body weight were measured. Results: Body weight and insulin resistance were significantly increased and serum BDNF level was decreased in both WS and BS groups compared to the control group (P<0.05). In the WS-treated rats, the amount of changes in the insulin resistance, body weight, and serum BDNF level was greater compared to that in BS-treated (P< 0.05). Conclusion: Due to the adverse effects of consuming high levels of WS and BS on serum level of BDNF, insulin resistance, and body weight, high intakes of these sweeteners are not recommended.

Model Determination of Delayed Causes of Analgesics Prescription in the Emergency Ward in Arak, Iran

( Ali Cyrus ),( Mehrdad Moghimi ),( Abolfazle Jokar ),( Mohammad Rafeie ),( Ali Moradi ),( Parisa Ghasemi ),( Hanieh Shahamat ),( Ali Kabir ) 대한통증학회 2014 The Korean Journal of Pain Vol.27 No.2

According to the reports of the World Health Organization 20% of world population suffer from pain and 33% of them suffer to some extent that they cannot live independently. Methods: This is a cross-sectional study which was conducted in the emergency department (ED) of Valiasr Hospital of Arak, Iran, in order to determine the causes of delay in prescription of analgesics and to construct a model for prediction of circumstances that aggravate oligoanalgesia. Data were collected during a period of 7 days. Results: Totally, 952 patients participated in this study. In order to reduce their pain intensity, 392 patients (42%) were treated. Physicians and nurses recorded the intensity of pain for 66.3% and 41.37% of patients, respectively. The mean (SD) of pain intensity according to visual analogue scale (VAS) was 8.7 (1.5) which reached to 4.4 (2.3) thirty minutes after analgesics prescription. Median and mean (SD) of delay time in injection of analgesics after the physician``s order were 60.0 and 45.6 (63.35) minutes, respectively. The linear regression model suggested that when the attending physician was male or intern and patient was from rural areas the delay was longer. Conclusions: We propose further studies about analgesics administration based on medical guidelines in the shortest possible time and also to train physicians and nurses about pain assessment methods and analgesic prescription. (Korean J Pain 2014; 27: 152-161)

Theoretical Study of Thiazole Adsorption on the (6,0) zigzag Single-Walled Boron Nitride Nanotube

Moradi, Ali Varasteh,Peyghan, Ali Ahmadi,Hashemian, Saeede,Baei, Mohammad T. Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.10

The interaction of thiazole drug with (6,0) zigzag single-walled boron nitride nanotube of finite length in gas and solvent phases was studied by means of density functional theory (DFT) calculations. In both phases, the binding energy is negative and presenting characterizes an exothermic process. Also, the binding energy in solvent phase is more than that the gas phase. Binding energy corresponding to adsorption of thiazole on the BNNT model in the gas and solvent phases was calculated to be -0.34 and -0.56 eV, and about 0.04 and 0.06 electrons is transferred from the thiazole to the nanotube in the phases. The significantly changes in binding energies and energy gap values by the thiazole adsorption, shows the high sensitivity of the electronic properties of BNNT towards the adsorption of the thiazole molecule. Frontier molecular orbital theory (FMO) and structural analyses show that the low energy level of LUMO, electron density, and length of the surrounding bonds of adsorbing atoms help to the thiazole adsorption on the nanotube. Decrease in global hardness, energy gap and ionization potential is due to the adsorption of the thiazole, and consequently, in the both phases, stability of the thiazole-attached (6,0) BNNT model is decreased and its reactivity increased. Presence of polar solvent increases the electron donor of the thiazole and the electrophilicity of the complex. This study may provide new insight to the development of functionalized boron nitride nanotubes as drug delivery systems for virtual applications.

Theoretical Study of Thiazole Adsorption on the (6,0) zigzag Single-Walled Boron Nitride Nanotube

Ali Varasteh Moradi,Ali Ahmadi Peyghan,Saeede Hashemian,Mohammad T. Baei 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.10

The interaction of thiazole drug with (6,0) zigzag single-walled boron nitride nanotube of finite length in gas and solvent phases was studied by means of density functional theory (DFT) calculations. In both phases, the binding energy is negative and presenting characterizes an exothermic process. Also, the binding energy in solvent phase is more than that the gas phase. Binding energy corresponding to adsorption of thiazole on the BNNT model in the gas and solvent phases was calculated to be −0.34 and −0.56 eV, and about 0.04 and 0.06 electrons is transferred from the thiazole to the nanotube in the phases. The significantly changes in binding energies and energy gap values by the thiazole adsorption, shows the high sensitivity of the electronic properties of BNNT towards the adsorption of the thiazole molecule. Frontier molecular orbital theory (FMO) and structural analyses show that the low energy level of LUMO, electron density, and length of the surrounding bonds of adsorbing atoms help to the thiazole adsorption on the nanotube. Decrease in global hardness, energy gap and ionization potential is due to the adsorption of the thiazole, and consequently, in the both phases, stability of the thiazole-attached (6,0) BNNT model is decreased and its reactivity increased. Presence of polar solvent increases the electron donor of the thiazole and the electrophilicity of the complex. This study may provide new insight to the development of functionalized boron nitride nanotubes as drug delivery systems for virtual applications.

Model Determination of Delayed Causes of Analgesics Prescription in the Emergency Ward in Arak, Iran

Cyrus, Ali,Moghimi, Mehrdad,Jokar, Abolfazle,Rafeie, Mohammad,Moradi, Ali,Ghasemi, Parisa,Shahamat, Hanieh,Kabir, Ali The Korean Pain Society 2014 The Korean Journal of Pain Vol.27 No.2

Background: According to the reports of the World Health Organization 20% of world population suffer from pain and 33% of them suffer to some extent that they cannot live independently. Methods: This is a cross-sectional study which was conducted in the emergency department (ED) of Valiasr Hospital of Arak, Iran, in order to determine the causes of delay in prescription of analgesics and to construct a model for prediction of circumstances that aggravate oligoanalgesia. Data were collected during a period of 7 days. Results: Totally, 952 patients participated in this study. In order to reduce their pain intensity, 392 patients (42%) were treated. Physicians and nurses recorded the intensity of pain for 66.3% and 41.37% of patients, respectively. The mean (SD) of pain intensity according to visual analogue scale (VAS) was 8.7 (1.5) which reached to 4.4 (2.3) thirty minutes after analgesics prescription. Median and mean (SD) of delay time in injection of analgesics after the physician's order were 60.0 and 45.6 (63.35) minutes, respectively. The linear regression model suggested that when the attending physician was male or intern and patient was from rural areas the delay was longer. Conclusions: We propose further studies about analgesics administration based on medical guidelines in the shortest possible time and also to train physicians and nurses about pain assessment methods and analgesic prescription.

Introducing new rigid I-beam to box column connections by using a stiffened channel link

Allah Reza Moradi Garoosi,Mehrzad Tahamouli Roudsari,Morteza Torkaman,Shahab Bonyadirad,Ali Saeedmanesh,Khalil soleimani,Hosein Reza Lotfi,Roya Jowkar,Ali Alipour 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.41 No.4

The aim of this study is to present a new and suitable connection for I-shaped beams and box columns that is both constructionally convenient to implement and reliable in terms of its performance. Six full-scale experimental samples were constructed and subjected to cyclic Quasi-static loading. The first sample included an I-shaped beam which was directly connected to a box column, the second sample incorporated a channel link, and stiffened channel links were used in the remaining four samples. The results show that compared to the direct connection, using the stiffened channel link significantly improves the performance of the connection and increases its ultimate strength and ductility by 58% and 70%, respectively. Also, these connections satisfy the code-specified criteria for special moment resisting frames. They are therefore a suitable detail for rigid I-shaped-beam-to-box-column connections in seismically active regions.

Application of the World Health Organization Quality of Life Instrument, Short Form (WHOQOL-BREF) to patients with cataract

Ali Gholami,Mahmood Tavakoli Araghi,Fatemeh Shamsabadi,Mahdiye Bayat,Fatemeh Dabirkhani,Farhad Moradpour,Kamyar Mansori,Yousef Moradi,Abdolhalim Rajabi 한국역학회 2016 Epidemiology and Health Vol.38 No.-

OBJECTIVES: Cataract is a prevalent disease in the elderly, and negatively influences patients’ quality of life. This study was conducted to study the application of the World Health Organization Quality of Life Instrument, Short Form (WHOQOL-BREF) to patients with cataract. METHODS: In this cross-sectional study, 300 patients with cataract were studied in Neyshabur, Iran from July to October 2014. The Iranian version of the WHOQOL-BREF questionnaire was used to measure their quality of life. Cronbach’s alpha coefficient, Pearson’s correlation coefficient, the paired t-test, the independent t-test, and a linear regression model were used to analyze the data in SPSS version 16.0 (SPSS Inc., Chicago, IL, USA). RESULTS: The mean age of the participants was 68.11±11.98 years, and most were female (53%). The overall observed Cronbach’s alpha coefficient for the WHOQOL-BREF was 0.889, ranging from 0.714 to 0.810 in its four domains. The total mean score of the respondents on the WHOQOL-BREF was 13.19. The highest and lowest mean scores were observed in the social relationship domain (14.11) and the physical health domain (12.29), respectively. A backward multiple linear regression model found that duration of disease and marital status were associated with total WHOQOL scores, while age, duration of disease, marital status, and income level were associated with domains one through four, respectively (p<0.05). CONCLUSIONS: The reliability analysis conducted in this study indicated that the WHOQOL-BREF scale exhibited an acceptable degree of internal consistency in the measurement of the quality of life of patients with cataract. It was also found that the patients with cataract who were surveyed reported a relatively moderate quality of life.

Cutaneous Leishmaniasis Situation and Predicting the Distribution of Phlebotomus papatasi and P. sergenti as Vectors of Leishmaniasis in Ardabil Province, Iran

Ali Khamesipour,Soheila Molaei,Navid Babaei-Pouya,Eslam Moradi-Asl 대한기생충학ㆍ열대의학회 2020 The Korean Journal of Parasitology Vol.58 No.3

Cutaneous leishmaniosis (CL) is the most common form of leishmaniasis.CL caused by L. major and L. tropica is endemic in 17 provinces of Iran. This study was carried out to elucidate situation of CL in Ardabil province and to pre- dict distribution of Phlebotomus papatasi and Phlebotomus sergenti (Diptera: Psychodidae) as vectors of CL in the re- gion. In this cross-sectional study, data on CL patients were collected from local health centers of Ardabil province, Iran during 2006-2018 to establish a geodatabase using ArcGIS10.3. A total of 20 CL cases were selected randomly and skin samples were collected and analyzed by PCR method. MaxEnt 3.3.3 model was used to determine ecologically suitable niches for the main vectors. A total, 309 CL human cases were reported and the highest incidence rate of disease was occurred in Bilasavar (37/100,000) and Germi (35/100,000). A total of 2,794 sand flies were collected during May to Octo- ber 2018. The environmentally suitable habitats for P. papatasi and P. sergenti were predicted to be present in northern and central areas of Ardabil province. The most variable that contributed ratio in the modeling were Isothermality and slope factors. Ardabil province is possibly an endemic are for CL. The presence of P. papatasi and P. sergenti justifies lo- cal transmission while the vectors of CL are existing in the northern and central areas of the province.

Eco-friendly inorganic-organic bionanocomposite (Copper oxide - Carboxyl methyl cellulose - Guar gum): Preparation and effective removal of dye from aqueous solution

Ali Hosseinian Naeini,Mohammadreza Kalaee,Omid Moradi,Ramin Khajavi,Majid Abdouss 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.8

Biopolymers, such as Carboxyl methylcellulose (CMC) and Guar gum (GG), have attracted much attention. Herein, binary organic composite (Carboxyl methyl cellulose - Guar gum) and ternary inorganic-organic ecofriendlybionanocomposite (Copper oxide - Carboxyl methyl cellulose - Guar gum) with different wt% of CuO (1%,3%, and 5% denoted as CMC/GG/CuO-1, CMC/GG/CuO-3, and CMC/GG/CuO-5) were prepared. The CMC, GG,CuO, CMC/GG, CMC/GG/CuO-1, CMC/GG/CuO-3, and CMC/GG/CuO-5 were characterized by XRD, FTIR, SEM,and EDX and used to remove malachite green (MG) dye from water. The effect of operational parameters on theadsorption process was investigated in detail. The maximum dye capacity was 18.5mg/g. The isotherm data showedthe Freundlich isotherm, which indicated the non-uniformity of adsorption on the adsorbent surface. Pollutant removalfollowed the pseudo-second-order kinetics. Also, the thermodynamic study presented that adsorption was spontaneousand endothermic.