다환방향족탄화수소류의 음식물을 통한 섭취량과 혈중농도

문찬석,Moon, Chan-Seok 한국환경보건학회 2012 한국환경보건학회지 Vol.38 No.5

Objectives: This study aims to evaluate the blood concentrations and dietary intake for 24-hour food duplicate of low level polycyclic aromatic hydrocarbons (PAHs). Design: The geometric means of the blood concentrations and dietary intake of 16 PAHs in college student candidates were simply compared with instrumental detection. Methods: The concentrations of 16 PAHs in venous blood and 24-hour food duplicates were analyzed with head-space solid phase microextraction (HS-SPME) of gas chromatography-mass spectrometry. Results: Naphthalene, acenaphthylene, pyrene, benz(a)anthracene, chrysene, and acenaphthene among the 16 analyzed PAHs were simultaneously detected both in venous blood and 24-hour food duplicate samples. Conclusion: The main exposure source of the six PAHs is thought to be oral intake from food through low level non-occupational exposure.

The associations between blood mercury levels and shark meat intake among workers in Gyeongsangbuk-do

Gun Il Park,Young Seok Byun,Man Joong Jeon,Joon Sakong 대한직업환경의학회 2017 대한직업환경의학회지 Vol.29 No.-

Background: Shark meat is used as sacrificial food in Gyeongsangbuk-do, and is a major source of dietary mercury. This study aimed to evaluate the effects of shark meat intake or the ritual of Jesa on blood mercury levels within workers living in Gyeongsangbuk-do. Methods: This study was conducted from September 2016 to October 2016 in two cities of Gyeongsangbuk-do. To compare the differences between urban and rural areas, two workplaces each in Daegu as the urban area and Yeongcheon as the rural area were selected. General characteristics and characteristics related to shark meat consumption of the workers were acquired by personal interviews during their health examination. Blood mercury concentrations were analyzed by the gold amalgamation method using a direct mercury analyzer (DMA-80; Milestone Inc., Shelton, CT, USA). Results: The shark consumption group had a higher blood mercury concentration than the non-consumption group. The levels of blood mercury increased with the frequency, annual intake, as well as most recent date of shark meat consumption. Moreover, the levels of mercury in blood increased according to the annual frequency of participation in Jesa (times per year) and the annual frequency of shark meat consumption during Jesa (times per year). Conclusions: Shark meat intake and the ritual of Jesa contributed to an increase in the blood mercury levels of workers in Gyeongsangbuk-do. Therefore, it is necessary to evaluate dietary exposure, occupational as well as other factors that may influence blood mercury concentrations in workers during their health examination, particularly in regions with high mercury exposures.

Dietary intake estimation of PCDD/Fs via milk and meat consumption in Korean population using the probabilistic model

Sung-Won Park,Hwan-Goo Kang 한국예방수의학회 2022 예방수의학회지 Vol.46 No.4

The objective of this study is to estimate the dietary exposure of polychlorinated dibenzo-p-dioxins and dibezofurans (PCDD/Fs) of Korean population via milk and meat using a probabilistic exposure assessment model. Total 319 raw milk and meat samples collected in the period 2006-2008 from nationwide Korea were measured the concentrations of 17 PCDD/Fs. Distributions of dietary exposure of 7 age subgroups to PCDD/Fs from the commodities were estimated probabilistically using Monte Carlo simulations. Dietary exposure groups were divided as lower, medium and high consumer subgroups according to the consumption of each commodity. The amounts of dietary exposures of Korean population subgroups were compared to the provisional maximum tolerable monthly intake (PTMI) recommended by the Joint FAO/WHO Expert Committee on Food Additives and Contaminants (JECFA). The mean PCDD/Fs concentrations in raw milk and meat of beef, prok and chicken were measured as 0.501, and 0.022~0.150pg WHO-TEQ/g, respectively. Dietary exposure of children was significantly higher than that of adults due to their high milk consumption per body weight (BW). Dietary intake of PCDD/Fs of the Korean populations estimated ranged from 0.154 to 1.248 pg WHO- TEQ/kg BW/day for high consumers (the 97.5th percentile) at the upper bound. Dietary intakes of average population of various subgroups were below the half of PTMI, but those of higher consumers were found exceeding or comparable to PTMI at the upper bound level. This study also suggests that the estimated PCDD/Fs concentrations in milk and meat are comparable to those reported in previous studies. Probabilistic assessment model for PCDD/Fs exposure in meat and milk commodities could be used to estimate the exposure of PCDD/Fs in Korean population for the development of risk mangement mesaures for PCDD/Fs in meat and milk.

Measures for a closer-to-real estimate of dietary exposure to total mercury and lead in total diet study for Koreans

Eunmi Koh,Hyehyung Shin,Miyong Yon,Ji Woon Nam,Yoonna Lee,Dohee Kim,Jeeyeon Lee,Meehye Kim,Sung-Kug Park,Hoon Choi,Cho-il Kim 한국영양학회 2012 Nutrition Research and Practice Vol.6 No.5

Previous Korean total diet studies (KTDSs) have estimated dietary exposure to toxic chemicals based on 110-120 representative foods selected from over 500 foods appeared in the Korea National Health & Nutrition Examination Surveys (KNHANES), which would result in a possible underestimation. In order to find measures for a closer-to-real estimate of dietary exposure to heavy metals, this study examined the feasibility of mapping foods to the representative foods in the KTDS by comparing estimates. In mapping, those foods not analyzed in the 2009 KTDS (443 out of 559 foods appeared in the 2007 KNHANES) were mapped to the 114 representative foods used in the 2009 KTDS based on the closeness in regards to biological systematics and morphological similarity. Dietary exposures to total mercury and lead were re-estimated using the content of total mercury and lead in 114 foods analyzed in the 2009 KTDS, food intake, and individual’s own body weight for respondents in the 2007 KNHANES instead of mean body weight of Koreans used in the 2009 KTDS. The re-estimates of exposure with mapping were approximately 50% higher than the original estimates reported in the 2009 KTDS. In addition, mapping enabled the comparison of percentile distribution of the exposure among populations of different age groups. In conclusion, estimates via mapping resulted in a more comprehensive estimation of dietary exposure to heavy metals present in foods that Koreans consume.

수산생물 중 유해물질의 인체 노출 및 위해평가 시스템 개발

이재원(Jaewon Lee),이승우(Seungwoo Lee),최민규(Minkyu Choi),이헌주(Hunjoo Lee) 한국환경보건학회 2021 한국환경보건학회지 Vol.47 No.5

Background: Fish and fishery products (FFPs) unintentionally contaminated with various environmental pollutants are major exposure pathways for humans. To protect human health from the consumption of contaminated FFPs, it is essential to develop a systematic tool for evaluating exposure and risks. Objectives: To regularly, accurately, and quickly evaluate adverse health outcomes due to FFPs contamination, we developed an automated dietary exposure and risk assessment system called HERA (the Human Exposure and Risk Assessment system for chemicals in FFPs). The aim of this study was to develop an overall architecture design and demonstrate the major features of the HERA system. Methods: For the HERA system, the architecture framework consisted of multi-layer stacks from infrastructure to fish exposure and risk assessment layers. To compile different contamination levels and types of seafood consumption datasets, the data models were designed for the classification codes of FFP items, contaminants, and health-based guidance values (HBGVs). A systematic data pipeline for summarizing exposure factors was constructed through down-scaling and preprocessing the 24-hour dietary recalls raw dataset from the Korea National Health and Nutrition Examination Survey (KNAHES). Results: According to the designed data models for the classification codes, we standardized 167 seafood items and 2,741 contaminants. Subsequently, we implemented two major functional workflows: 1) preparation and 2) main process. The HERA system was developed to enable risk assessors to accumulate the concentration databases sustainably and estimate exposure levels for several populations linked to seafood consumption data in KNAHES in a user-friendly manner and in a local PC environment. Conclusions: The HERA system will support policy-makers in making risk management decisions based on a nation-wide risk assessment for FFPs.

어린이용품 함유 유해인자의 위해성평가를 위한 노출계수 조사

김정곤,서정관,김탁수,박건호,Kim, Jungkon,Seo, Jung-Kwan,Kim, Taksoo,Park, Gun-Ho 한국환경보건학회 2014 한국환경보건학회지 Vol.40 No.1

Background: Despite children's unique characteristics that distinguish them from adults, relatively few attempts have been made to measure exposure factors for characterization of children's exposure to hazardous chemicals in child-specific products (CSP). This study was conducted to establish the child-specific exposure factors for exposure and risk assessment of hazardous substances in CSP. Methods: We investigated the exposure factors (e.g., time use of child-products, time and frequency of object-to-body contact, time and frequency of object-to-mouth contact) influencing children's exposure to CSP (e.g., toys, playmats, oil pastels, etc.) in 650 children through a parent-completed questionnaire using a web-based survey. Participants were recruited in five age groups, <1, 1-2, 2-3, 3-6, and 6-12 years of age. Results: The child-specific exposure factors were presented as the mean, median, $95^{th}$ percentile, minimum, and maximum values. Time activity for play mats was the longest among CSP and infants spent more time on them than did elder age groups (189.3-224.7 min/day for <1-2 years vs. 91.2 min/day for 6-12 years). It is apparent that time and frequency of toy block- and plastic toy-to-mouth contact significantly decreased as a function of age. When the variation of CSP use patterns was compared by gender, the only variable that was statistically different between genders was time activity in child-products exposure space. Conclusion: We believe the five child-specific exposure factors suggested in the present study will be valuable for reducing uncertainty in the estimation of chemical exposure during risk assessment of CSP and furthermore, in the appropriate regulations to protect children's health.

Korean research project on the integrated exposure assessment of hazardous substances for food safety

Lim, Ji-Ae,Kwon, Ho-Jang,Ha, Mina,Kim, Ho,Oh, Se Young,Kim, Jeong Seon,Lee, Sang-Ah,Park, Jung-Duck,Hong, Young-Seoub,Sohn, Seok-Joon,Pyo, Heesoo,Park, Kyung Su,Lee, Kwang-Geun,Kim, Yong Dae,Jun, Sang The Korean Society of Environmental Toxicology 2015 환경독성보건학회지 Vol.30 No.-

Objectives: This survey was designed to conduct the first nationwide dietary exposure assessment on hazardous substances including the intakes of functional food and herbal medicine. In this paper, we introduced the survey design and the results of the dietary exposure status and internal exposure levels of lead (Pb), cadmium (Cd), and mercury (Hg). Methods: We selected 4867 subjects of all ages throughout Korea. We conducted a food survey, dietary survey, biomonitoring, and health survey. Results: Pb and Cd were the highest (median value) in the seaweed ($94.2{\mu}g/kg$ for Pb; $594{\mu}g/kg$ for Cd), and Hg was the highest in the fish ($46.4{\mu}g/kg$). The dietary exposure level (median value) of Pb was $0.14{\mu}g/kg$ body weight (bw)/d, $0.18{\mu}g/kg$ bw/d for Cd, and $0.07{\mu}g/kg$ bw/d for Hg. Those with a blood Pb level of less than $5.00{\mu}g/dL$ (US Centers for Disease Control and Prevention, reference value for those 1 to 5 years of age) were 99.0% of all the subjects. Those with a blood Cd level with less than $0.30{\mu}g/L$ (German Federal Environmental Agency, reference value for non-smoking children) were 24.5%. For those with a blood Hg level with less than $5.00{\mu}g/L$ (human biomonitoring I, references value for children and adults, German Federal Environmental Agency) was 81.0 % of all the subjects. Conclusions: The main dietary exposure of heavy metals occurs through food consumed in a large quantity and high frequency. The blood Hg level and dietary exposure level of Hg were both higher than those in the European Union.

Korean research project on the integrated exposure assessment of hazardous substances for food safety

임지애,권호장,하미나,김호,오세영,김정선,Sang-Ah Lee,박정덕,홍영습,손석준,표희수,Kyung-SuPark,이광근,김용대,Sangil Jun,Myungsil Hwang 환경독성보건학회 2015 환경독성보건학회지 Vol.30 No.-

Objectives: This survey was designed to conduct the first nationwide dietary exposure assessment on hazardous substances including the intakes of functional food and herbal medicine. In this paper, we introduced the survey design and the results of the dietary exposure status and internal exposure levels of lead (Pb), cadmium (Cd), and mercury (Hg). Methods: We selected 4867 subjects of all ages throughout Korea. We conducted a food survey, dietary survey, biomonitoring, and health survey. Results: Pb and Cd were the highest (median value) in the seaweed (94.2 μg/kg for Pb; 594 μg/kg for Cd), and Hg was the highest in the fish (46.4 μg/kg). The dietary exposure level (median value) of Pb was 0.14 μg/kg body weight (bw)/d, 0.18 μg/kg bw/d for Cd, and 0.07 μg/kg bw/d for Hg. Those with a blood Pb level of less than 5.00 μg/dL (US Centers for Disease Control and Prevention, reference value for those 1 to 5 years of age) were 99.0% of all the subjects. Those with a blood Cd level with less than 0.30 μg/L (German Federal Environmental Agency, reference value for non-smoking children) were 24.5%. For those with a blood Hg level with less than 5.00 μg/L (human biomonitoring I, references value for children and adults, German Federal Environmental Agency) was 81.0 % of all the subjects. Conclusions: The main dietary exposure of heavy metals occurs through food consumed in a large quantity and high frequency. The blood Hg level and dietary exposure level of Hg were both higher than those in the European Union.

The dietary risk assessment of perfluorooctanoic acid (PFOA) and perfluorosulfonic acid (PFOS) in the root crops from the survey of the residue in agricultural soil and the crops

Choi Geun-Hyoung,Lee Deuk-Yeong,Song A-Reum,Moon Bo-Yeon,Kim Jin-Hyo 한국응용생명화학회 2022 Applied Biological Chemistry (Appl Biol Chem) Vol.65 No.4

Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) are persistent organic pollutants (POPs) that are prohibited from being produced and used. However, they remain in the agricultural environment and are transferred to crops. In addition, PFOA is classified as possibly carcinogenic to humans. To fully understand the exposure and risk of PFOA and PFOS for human in crops, a residue survey and estimation of dietary exposure assessment are needed. Therefore, we investigated the residues of PFOA and PFOS in upland soil and cultivated root crops. The average residues of PFOA and PFOS in the soil were < 0.054–0.541 μg kg– 1 and 0.024–0.111 μg kg– 1, and 0.067–0.193 μg kg– 1 and < 0.02 μg kg– 1 in the crops, respectively. The average PFOA residues were higher than PFOS in the soil and crops. The estimated daily intakes of PFOA and PFOS in the crops were 0.284 ng kgbw –1 day– 1 and 0.023 ng kgbw –1 day– 1, and the estimated hazard quotients were 0.355 and 0.013, respectively. In addition, the excess cancer risk of PFOA was calculated to be 1.99 × 10– 8. Thus, the non–carcinogenic and carcinogenic risks of PFOA and PFOS were not notable from the surveyed residues in the crops. However, the risks may be higher when the residues in other food crops are considered. Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) are persistent organic pollutants (POPs) that are prohibited from being produced and used. However, they remain in the agricultural environment and are transferred to crops. In addition, PFOA is classified as possibly carcinogenic to humans. To fully understand the exposure and risk of PFOA and PFOS for human in crops, a residue survey and estimation of dietary exposure assessment are needed. Therefore, we investigated the residues of PFOA and PFOS in upland soil and cultivated root crops. The average residues of PFOA and PFOS in the soil were < 0.054–0.541 μg kg –1 and 0.024–0.111 μg kg –1 , and 0.067–0.193 μg kg –1 and < 0.02 μg kg –1 in the crops, respectively. The average PFOA residues were higher than PFOS in the soil and crops. The estimated daily intakes of PFOA and PFOS in the crops were 0.284 ng kg bw –1  day –1 and 0.023 ng kg bw –1  day –1 , and the estimated hazard quotients were 0.355 and 0.013, respectively. In addition, the excess cancer risk of PFOA was calculated to be 1.99 × 10 –8 . Thus, the non–carcinogenic and carcinogenic risks of PFOA and PFOS were not notable from the surveyed residues in the crops. However, the risks may be higher when the residues in other food crops are considered.

식품으로 인한 유해물질 노출조사를 위한 식생활 설문지의 타당도 평가

김혜미(Kim,Hyemi),최슬기(Choi,Seul Ki),신상아(Shin,Sangah),이경윤(Lee,Kyung Youn),신상희 (Shin,Sanghee ),이정원 (Lee,Jung Won ),유수현 (Yu,Soo Hyun ),남혜선 (Nam,Hye-Soen ),김미경 (Kim,Mi-Gyeong ),정효지 (Joung,Hyojee ) 韓國營養學會 2011 Journal of Nutrition and Health Vol.44 No.2

Assessing human exposure to food-borne hazards requires standardized assessment tools. The objective of this study was to validate a newly developed dietary assessment questionnaire to assess human exposure to food-borne hazards, which include dietary behavior and food consumption patterns such as eating frequency, types of food containers and cooking methods. A total of 216 adults were recruited for two questionnaire surveys (questionnaire 1 and 2) about 1 week apart with a 3 day diet record. Reproducibility was evaluated by comparing responses from questionnaires 1 and 2, and validity was checked by comparing responses from questionnaire 2 and the 3 day diet record. Comparisons were based on the percent agreement and Spearman’s rank correlation coefficient. The mean exact agreement of food containers at purchase between questionnaires 1 and 2 was 73.5%, for storing containers it was 71.9%, and for cooking methods it was 83.0%. The mean correlation coefficient for food intake frequency between questionnaires 1 and 2 was 0.71 (range, 0.50-0.83). The mean correlation coefficient of the food intake frequency between questionnaire 2 and the 3 day diet record was 0.21 (range, 0.04-0.48). The exact and adjacent agreement of food intake frequency quartile assessed by questionnaire 2 and the 3 day diet record was 65.4% (range, 51.0-82.1%). Although the correlation coefficient for food intake frequency between questionnaire 2 and the 3 day diet record was low, the exact and adjacent food intake frequency agreement was higher than 50% and reproducibility of the dietary behaviors exceeded 70%. Therefore, the questionnaire developed in this study could be applied to assess diets for the human exposure to food-borne hazards as a qualitative assessment in a large population. (Korean J Nutr 2011 44(2): 171 ~ 180)