스마트폰 사용여부에 따른 온도와 상대습도 변화가 건성안 유발에 미치는 영향

김대종,차정원,박문찬,이화자 대한시과학회 2014 대한시과학회지 Vol.16 No.3

Purpose: This study was to measure and asses for confirming whether the use of smart phone was related to dry eye or not under various temperature and humidity. Methods: Undergraduate applicants 30 subjects were studied under constant temperature and constant humidity for 2hr. who were divided into two groups: smart phone user group and non-user group. They were checked at 9 times in a person, whether they have dry eye or not, by using 4 kinds of dry eye examination which were questionnaire, Non invasive break up time, tear film Break-Up Time and Schirmer test. Results: In McMonnies dry eye symptom questionnaire, we analyzed that low humidity and smart phone user group had 1.27 times (95% CI : 1.201-1.348) and 0.43 times (95% CI : 0.211-0.886) higher risk of dry eye than non-user group. And, in Schirmer test, low humidity and smart phone user group had 1.36 times(95% CI : 1.264-1.478) and 0.19 times (95% CI : 0.080-0.465) higher risk of dry eye than non-user group, which showed significant result. In tear film Break-Up Time examination, low humidity and smart phone user group had 1.23 times(95% CI : 1.176-1.303) and 0.15 times(95% CI : CI : 0.075-0.330) higher risk of dry eye than high humidity and non-user group. In non-invasive break up time examination, also it was investigated that low humidity and smart phone user group had 1.20 times(95% CI : 1.149-1.258) and 0.27 times(95% CI : 0.141-0.528) higher risk of dry eye. Conclusions: We knew that low humidity and smart phone users were related in dry eye, but temperature was not related in dry eye. 목 적: 본 연구의 목적은 스마트폰의 사용여부에 따른 온도와 상대습도의 변화가 건성안에 영향을 미치는지 파악하기 위하여 측정 평가하였다. 방 법: 실험은 온도와 습도의 조건을 설정하여 총 9회 측정을 실시하였다. 대상자는 건성안과 관련이 없는 지원자 30명을 스마트폰 사용 군과 사용하지 않는 군으로 분류하였으며, 1회 측정 시 같은 실험공간과 환경조건에서 동일하게 2시간동안 지내게 한 후 설문과 Non invasive break up time, tear film Break-Up Time, Schirmer test의 4가지 건성안검사를 실시해 건성안의 유무를 파악하였다. 결 과: McMonnies dry eye symptom questionnaire에서는 상대습도가 낮을 때와 스마트폰을 사용하는 군에서 안구 건조의 발생 가능성이 각각 1.27배(95% CI: 1.201-1.348) 및 0.43배(95% CI: 0.211-0.886) 높은 것으로 분석되었으며, Schirmer test에서도 상대습도가 낮을 때와 스마트폰을 사용하는 군에서 각각 건성안의 발생 가능성이 1.36배(95% CI: 1.264-1.478) 및 0.19배(95% CI: 0.080-0.465)로 유의한 결과를 나타내었다. tear film Break-Up Time의 검사에서의 건성안에 대한 발생 가능성은 상대습도가 낮을 때 1.23배(95% CI: 1.176-1.303), 스마트폰을 사용하는 군에서 0.15배(95% CI: 0.075-0.330)로 높아졌으며, Non invasive break up time검사에서도 건성안의 발생 가능성이 상대습도가 낮을 때 1.20배(95% CI: 1.149-1.258), 스마트폰을 사용할 때 0.27배(95% CI: 0.141-0.528)로 높아지는 것으로 측정 분석되었다. 결 론: 상대습도가 낮을 때와 스마트폰 사용자에서 건성안의 영향이 있는 것을 알 수 있었으며, 온도의 변화는 건성안에 영향을 미치지 않았다.

Dry Eye After Cataract Surgeryand Associated Intraoperative Risk Factors

조양경,김만수 대한안과학회 2009 Korean Journal of Ophthalmology Vol.23 No.2

Purpose: To investigate changes in dry eye symptoms and diagnostic test values after cataract surgery and to address factors that might influence those symptoms and test results. Methods: Twenty-eight eyes from 14 patients with preoperative dry eye (dry eye group) and 70 eyes from 35 patients without preoperative dry eye (non-dry eye group) were studied prospectively. In each group, we measured values such as tear break-up time (tBUT), Schirmer I test (ST-Ⅰ), tear meniscus height (TMH), and subjective dry eye symptoms (Sx), and evaluated the postoperative changes in these values. We also evaluated the influence of corneal incision location and shape on these values. The correlations between these values and microscopic light exposure time and phacoemulsification energy were investigated. Results: In the dry eye group, there were significant aggravations in Sx at 2 months postoperatively and in TMH at 3 days, 10 days, 1 month, and 2 months postoperatively, compared with preoperative values. All dry eye test values were significantly worse after cataract surgery in the non-dry eye group. With regard to incision location, there was no difference in tBUT, Sx, ST-Ⅰ, or TMH in either the dry eye group or the non-dry eye group at any postoperative time point. Regarding incision shape, there was no difference in tBUT, Sx, ST-Ⅰor TMH at any postoperative time point in the dry eye group. In the superior incision sub-group of the non-dry eye group, tBUT and Sx were worse in the grooved incision group at day 1. In the temporal incision sub-group of the non-dry eye group, Sx were worse in the grooved incision group at 1 day, 3 days, and 10 days postoperatively. In both groups, significant correlations were noted between microscopic light exposure time and dry eye test values, but no correlation was noted between phacoemulsification energy and dry eye test values. Conclusions: Cataract surgery may lead to dry eye. A grooved incision can aggravate the symptoms during the early postoperative period in patients without dry eye preoperatively. Long microscopic light exposure times can have an adverse effect on dry eye test values.

The Association between Sleep Duration and Dry Eyes by General Characteristics: The 7th Korea National Health and Nutrition Examination Survey

Hye-Won Park,Tae-Hun Kim 대한시과학회 2021 대한시과학회지 Vol.23 No.4

목적 : 본 연구는 40세 이상 한국 성인의 수면시간과 안구건조의 관련성을 알아보기 위해 시행하였다. 방법 : 국민건강영양조사 제7기에 참가한 성인 16,119명 중 성인 2,506명을 대상으로 하였다. 수집된 자료는 복합표본설계방법으로 평균, 표준 편차, t-검정을 분석하였다. 수면시간과 안구건조의 연관성은 카이제곱으로 분석하였다. 일반적 특성이 안구건조에 영향을 분석하기 위해 로지스틱 회귀 분석하였다. 성별, 연령, 학력, 가구소득, 직업, 근무시간대, 체질량지수, 흡연, 음주 등의 변수를 통제하였다. 결과 : 분석 결과 전체 수면시간은 7시간이었다. 수면시간과 안구건조는 관련이 있는 것으로 나타났다. 안구건조에 영향을 미치는 요인을 로지스틱 회귀분석 한 결과 안구건조는 7시간보다 5시간 이하에서 증가하였다(OR 1.93[95% CI: 1.38-2.71]). 안구건조는 남성보다 여성에서 증가하였다. 저체중보다 비만에서 증가하였으며(OR 1.89[95% CI: 1.11-3.19]), 음주에서 주 4회 이상이면 안구건조가 증가하였다(OR 2.43[95% CI: 1.42-4.16]). 결론 : 안구건조와 수면시간과의 연관성을 확인하였다. 그러므로 적절한 수면시간으로 안구건조를 예방해야 할 것이다. Purpose : This study was performed to evaluate the correlation between sleep duration and the prevalence of dry eyes in Korean adults over the age of 40. Methods : Among the 16,119 adults who participated in the 7th Korean National Health and Nutrition Examination Survey, and 2,506 adults were enrolled in our study. The collected data were analyzed composite samples, with the calculations for mean, standard deviation, t-test, ANOVA. The correlation between sleep duration and dry eyes was analyzed by chi-square test. Logistic regression analysis was performed to analyze the effect of general characteristics on dry eyes. We controlled for Variables including gender, age, education, household income, job, work time zone, BMI, smoking, and drinking. Results : As a result of the analysis, the overall sleep duration was 7 hours. Sleep duration and dry eyes have been found to be related. As a result of logistic regression analysis of factors affecting dry eyes, dry eyes increased more in shorter than 5 hours than in 7 hours of sleep duration (OR 1.93 [95% CI: 1.38-2.71]). Dry eye increased in women than men (OR 0.40 [95% CI: 0.32-0.49]). The odds ratio increased obesity compared to low weight (OR 1.89 [95% CI: 1.11-3.19]), and dry eyes increased in more than 4 times a week on drinking (OR 2.43 [95% CI: 1.42-4.16]). Conclusion : The association between dry eyes and sleep duration was confirmed. Therefore, it is necessary to prevent dry eyes through proper sleep duration.

Dry Eye Assessment of Patients Undergoing Endoscopic Dacryocystorhinostomy for Nasolacrimal Duct Obstruction Combined with Dry Eye Syndrome

Min Han Kim,Kangmin Lee,Minwook Chang 대한안과학회 2023 Korean Journal of Ophthalmology Vol.37 No.5

Purpose: To evaluate the prevalence of dry eye symptoms after endoscopic dacryocystorhinostomy (EDCR) for patients with primary acquired nasolacrimal duct obstruction (PANDO) combined with dry eye syndrome. Methods: The patients diagnosed with PANDO combined with dry eye syndrome who underwent EDCR were divided into two groups according to the questionnaire about dry eye symptoms after surgery. The medical records were retrospectively analyzed. Before and after surgery, we compared the tear meniscus height, tear breakup time, and the presence of corneal punctuate epithelial erosion. The level of dry eyes of patients after surgery was assessed by using the Korean guidelines for the diagnosis of dry eye. Results: At 6 months after EDCR, the proportion of patients with dry eye symptoms was 30% in a total of 80 patients. The duration of epiphora and tear breakup time after EDCR were higher in the group without dry eye symptoms and the proportion of eyes with corneal punctuate epithelial erosion after EDCR was higher in the group with dry eye symptoms. About 15% of total patients started treatment with a dry eye of level 2 or higher. Conclusions: About 15% of patients who underwent EDCR for PANDO combined with dry eye syndrome developed significant dry eye syndrome after surgery. The short onset of epiphora was associated with the development of the dry eye symptoms. Therefore, it is necessary to evaluate dry eye syndrome before surgery, and surgeons should be careful about this.

Risk Factors for Inflammatory Dry Eye in Young Adults in Twenties

Jung-Eun Park,Min-Hye Park,Koon-Ja Lee 대한시과학회 2020 대한시과학회지 Vol.22 No.1

목적 : 건성안의 핵심적인 원인으로 염증이 제시됨에 따라 본 연구에서는 한국 20대 성인을 대상으로 콘택트렌즈 착용 및 각막굴절교정술이 염증성 건성안(inflammatory dry eye syndrome)에 미치는 영향을 알아보고자 하였다. 방법 : 안질환이 없는 20대 성인 81명(162안)을 대상으로 염증 생체지표인 ‘기질금속단백분해효소’(MMP-9: Matrix Metalloproteinase-9)의 활성도와 염증성 건성안 감별진단법으로 제시된 ‘안구표면질환지수(OSDI, Ocular Surface Disease Index)/결막충혈’ 검사법으로 염증성 건성안을 감별진단하였다. 각막굴절교정술 및 콘택트렌즈 착용 여부에 따른 유병률과 위험요인은 χ2-test 검정과 하였고, 위험비(odds ratio, OR)는 로지스틱 회귀분석으 로 검정하였으며 유의수준은 0.050 이하로 하였다. 결과 : 전체 대상자의 염증성 건성안 유병률은 MMP-9 검사, ’OSDI, 결막충혈’ 검사 기준 각각 77.15%, 64.31% 로 나타났다. 콘택트렌즈 착용군의 염증성 건성안 비율은 검사법 기준으로 각각 85.23%, 75.00%로 미착용군의 67.57%, 52.70% 보다 높았고, 염증성 건성안 발생 가능성이 2.77배(OR 2.77, 95% CI 1.29~5.99), 2.69배 (OR 2.69, 95% CI 1.39~5.23)로 높게 나타났다. 각막굴절교정술을 받은 군의 염증성 건성안 비율은 검사법 기준 각각 81.25%, 75.00%로 수술을 받지 않은 군의 76.71%, 63.69%보다 높았으나 통계적으로 유의한 차이는 아니 었다(p=0.682), (p=0.370). 결론 : 20대 한국 성인의 염증성 건성안 비율은 매우 높고, 콘택트렌즈를 착용한 경우에 염증성 건성안의 발병 확률은 미착용안에 비해 2배 이상 높은 것으로 나타나 콘택트렌즈 착용자의 경우 이를 예방하기 위한 콘택트렌즈 관리교육이 중요할 것으로 생각된다. Purpose : As inflammation is suggested as a core drive factor for dry eye, in this study the effects of contact lens wear and corneal refractive surgery on inflammatory dry eye were investigated in Korean twenties. Methods : Eighty-one adults (162 eyes) in their twenties who had no ocular disease were evaluated by 'Matrix Metalloproteinase-9 (MMP-9)' test as known biomarker for inflammatory dry eye and 'OSDI/conjunctival hyperemia' test for screening of inflammatory dry eye. We analyzed prevalence and risk factors of inflammatory dry eye based on two inflammatory dry eye tests, and analyzed them using Chi-square test and logistic regression. The statistical significance level was p<0.050. Results : The prevalence of inflammatory dry eye evaluated by MMP-9 and OSDI/conjunctival hyperemia tests in all subjects was shown 77.15% and 64.31%, respectively. The prevalence of inflammatory dry eye in contact lens wearer group with two tests was 85.23% and 75.00%, respectively, and that in the non-wearer group was 67.57% and 52.70%, respectively. The risk of inflammatory dry eye in contact lens wears was 2.77 times (OR 2.77, 95% CI 1.29~5.99), and 2.69 times (OR 2.69, 95% CI 1.39~5.23) higher than non contact lens wearers, respectively. The prevalence of inflammatory dry eye in corneal refractive surgery group compared with non operative group was not significantly different (p=0.682 and p=0.370, respectively). Conclusion : It was confirmed that the prevalence of inflammatory dry eye in Korean twenties was very high, and the odds ratio of inflammatory dry eye was 2 times higher than contact lens wearers. Therefore, the contact lens care education for contact lens weareres would be necessary to prevent inflammatory dry eye.

Analysis of Prevalence and Risk Factors for Dry Eye Syndrome in Korean Adults; Based on the 5th National Health and Nutrition Examination Survey (2012)

Young-Woo Jeon,Jung-Hyun Kim,Seung-Sun Baek,Kang-Oh Rhee,Tae-Yong Lee,Hyun Lee 대한시과학회 2017 대한시과학회지 Vol.19 No.1

목 적: 본 연구는 제5기 국민건강영양조사(2012) 자료를 이용하여 한국 성인의 건성안 유병률과 위험요 인을 알아보고자 하였다. 방 법: 19세 이상 성인 중 안과의사에게 건성안 검진을 받은 5,698명(남자 2,368명, 여자 3,330명)을 대 상으로 인구사회학적 특성, 전신질환 특성, 건강관련행위 특성에 따른 건성안의 유병률과 위험요인을 분석 하였다. 결 과: 전체 연구대상자의 건성안 유병률은 13.5%이었다. 인구사회학적 특성별 건성안 유병률은 남성보 다 여성이, 50세 미만군보다 50세 이상군이, 농촌지역보다 도시지역에서 통계적으로 유의하게 높았으며, 전 신질환별 건성안 유병률은 고혈압, 이상지혈증, 골관절염, 류마티스 관절염, 우울증, 신부전증이 있는 경우 에 유의하게 높았다. 건강관련행위별 건성안 유병률은 비흡연자, 비음주자, 수면시간이 짧은 군이 높았다. 건성안 빈도는 여성에서(OR 2.29, CI 1.89-2.77)와 50세 이상군에서(OR 1.21, CI 1.01-1.46), 농촌지역에 서(OR 1.96, CI 1.56-2.47)에서 더 높았다. 유의한 모든 변수를 보정한 후에 건성안의 위험인자는 신부전 (OR 2.82, CI 1.48-5.69), 갑상선(OR 1.62, CI 1.16-2.26), 류마티스 관절염(OR 1.54, CI 1.01-2.33), 이상 지혈증(OR 1.42, CI 1.13-1.78), 우울증(OR 1.36, CI 1.11-1.66), 골관절염(OR 1.27, CI 1.02-1.57)이었다. 결 론: 우리나라 19세 이상 성인의 건성안 유병률은 13.5%으로 높은 수준이며, 50세 이상, 도시지역 거 주자, 여성과 신부전증, 갑상선, 류마티스 관절염, 이상지혈증, 우울증, 골관절염 환자에서 건성안의 위험이 높으므로 해당 위험요인을 가진 사람들을 대상으로 한 교육과 홍보를 통해 건성안증상을 조기 발견하여 적 절하게 대처하도록 할 필요가 있다 Purpose: The purpose of present study was to investigate the prevalence and risk factors for dry eye syndrome in Korean adults using data from the 5th National Health and Nutrition Examination Survey (2012). Methods: We analyzed the prevalence and risk factors for dry eye syndrome according to characteristics of sociodemographic, systemic diseases, and health related behaviors of 5,698 adults, men 2,368(41.6%) and women 3330(58.4%), aged 19 years and older, who were diagnosed with the dry eye syndrome by ophthalmologists. Results: The prevalence of dry eye syndrome was 13.5% in this population. The prevalence of dry eye syndrome in the sociodemographic characteristics was significantly higher in women than in men, in 50 years and older than under 50 years people, and in urban area than in rural area residents. The prevalence of dry eye syndrome by systemic diseases was significantly higher in subjects with hypertension, dyslipidemia, osteoarthritis, rheumatoid arthritis, depressive disorder, and renal failure. The prevalence of dry eye syndrome by health related behaviors was higher in non-smokers, non-drinkers, and short time sleepers. The dry eye syndrome was more frequent in women (OR 2.29, CI 1.89-2.77), in 50 years and older people (OR 1.21, CI 1.01-1.46), and rural area resident s (OR 1.96, CI 1.56-2.47). After adjusting for all significant variables, independent risk factors for dry eye syndrome were renal failure (multi-variable odds ratio (OR) 2.82, 95% confidence interval (CI) 1.48-5.69), thyroid disease (OR 1.62, CI 1.16-2.26), rheumatoid arthritis (OR 1.54, CI 1.01-2.33), dyslipidemia (OR 1.42, CI 1.13-1.78), depressive disorder (OR 1.36, CI 1.11-1.66), and osteoarthritis (OR 1.27, CI 1.02-1.57). Conclusion: The prevalence of dry eye syndrome in adults aged 19 and over was 13.5%. The dry eye syndrome was more frequent in women, 50 years and older people, and in urban residents, as a socio-demographic factor. Systemic disease factors related to dry eye were renal failure, thyroid disease, rheumatoid arthritis, dyslipidemia, depressive disorder, osteoarthritis. We suggest that people with dry eye syndrome risk factors should be provided about dry eye symptoms through the education, so that they can be found early and appropriately treated dry eye.

정상안과 건성안에서 피팅상태에 따른 각막에서의소프트렌즈 움직임 비교

정다이,임신규,김소라,박미정 한국안광학회 2011 한국안광학회지 Vol.16 No.1

Purpose: The study was performed to compare the differences in lens rotation, lens movement by blinking and lens centration with alignment or steep fitting of soft contact lens in normal and dry eyes. Methods: Total 40 eyes (aged 20~30 years) were classified into the normal (n=20) or dry eye group (n=20) by the diagnosis methods for dry eyes and worn soft contact lens (polymacon material) with alignment fitting or steep fitting. Lens rotation, lens movement by blinking and lens centration were separately measured immediately after lens wearing and after stabilization of tear film and compared by fitting states of soft contact lenses. Results: With steep fitting of soft contact lens in dry eyes, averaged lens rotation immediately after lens wearing was not significantly different from that of the normal eye group with alignment fitting however, lens rotation after stabilization in dry eyes was significantly larger than that in normal eyes. Any significant difference in lens movement by blinking was not shown in normal eyes. However, lens movement by blinking in dry eyes was increased with steep fitting. The range of lens centration on cornea in normal eyes with alignment fitting was more vertically distributed. On the other hand, the range of lens centration on cornea in dry eyes with alignment fitting was more horizontally distributed. Lens centration was shown to be changed by stabilization of tear film. That is, lens centrations were somewhat vertically widespread immediately after lens wearing and restrictively distributed in horizontal direction, respectively, with steep fitting in dry eyes. Conclusions: These results suggested that lens movements and centration in dry eyes were different from those of normal eyes. Especially, those differences between normal and dry eyes were much bigger with steep fitting of soft contact lenses. Thus, those differences should be considered for the comfortable and safe fitting of soft contact lens in dry eyes. 목적: 소프트렌즈를 얼라인먼트(alignment) 피팅 또는 스팁(steep) 피팅하였을 때 각막에서의 렌즈의 회전 움직임, 순목에 의한 이동거리 및 중심위치가 정상안과 건성안에서 어떠한 차이를 보이는지 알아보고자 하였다. 방법: 20~30 대 남녀 40안을 정상안군과 건성안군으로 분류한 후 polymacon 재질의 소프트렌즈를 얼라인먼트 피팅 혹은 스팁 피팅상태로 착용시키고 렌즈 착용 직후 및 눈물층이 안정화 되었을 때의 회전 움직임, 순목에 의한 이동거리, 중심 위치를 비교하였다. 결과: 렌즈의 회전 움직임은 스팁하게 피팅하였을 경우 정상안 군은 얼라인먼트 피팅시와 큰 차 이를 보이지 않았으나, 건성안 군에서는 눈물층이 안정화되는 시점에서의 평균 회전 움직임이 정상안 군보다 통계 적으로 유의하게 컸다. 정상안 군에서는 피팅에 따른 렌즈 이동거리의 차이가 없었으나 건성안 군에서는 스팁하게 피팅된 경우 렌즈의 이동 거리가 증가하였다. 각막에서의 렌즈 중심 위치는 얼라인먼트 피팅된 렌즈를 착용한 정상 안 군의 경우 수직 방향으로의 분포가 더 컸으나 건성안의 경우는 수평 방향으로의 분포가 더 컸다. 또한 건성안에 렌즈를 스팁하게 피팅하였을 때에는 렌즈를 착용한 직후 렌즈의 중심 위치가 수직방향으로도 다소 넓게 분포하였 으며 눈물층이 안정화된 후에는 오히려 수평 방향의 분포가 좁아져 눈물층의 안정화에 따라 렌즈의 중심 위치가 변 함을 알 수 있었다. 결론: 본 연구를 통하여 건성안에서의 소프트렌즈의 움직임과 중심 위치가 정상안의 경우와 상 이하며 특히 스팁 피팅시에는 그 차이가 더 두드러짐을 알 수 있었다. 따라서 건성안에 소프트렌즈를 피팅할 시에 는 본 연구를 통하여 확인할 수 있었던 정상안과의 차이를 고려해야 할 것으로 생각된다.

Study on the Causes of Dry Eye in Young Adults

Min-Ji Lee,Koon-Ja Lee 대한시과학회 2022 대한시과학회지 Vol.24 No.1

목적 : 청년층 건성안의 원인을 평가하고자, 정상안과 건성안의 눈물막을 비교분석하였다. 방법 : 청년 24명(48안, 남 11명, 여 13명, 평균연령 22.04±2.01세)을 대상으로 SPEED 건성안 설문지를 이 용하여 건성안을 판별하고, 눈물검사값을 정상안의 검사값과 비교하였다. 눈물의 양은 OCCUTUBE로, 눈물막 안 정성은 눈물막파괴시간검사(TBUT)로 평가하였다. 눈물지방층두께(LLT)와 눈깜박임 양상 및 마이봄샘 이상은 LIPIVIEW IIⓇ로 측정하고 Image JⓇ 프로그램을 이용하여 분석하였다. 결과: 건성안의 SPEED 설문값은 10.63±3.78점으로 높게 측정되었고, TBUT는 3.39±0.89초, OCCUTUBE 측정값은 2.67±0.92 mm로 정상안 (4.04±0.83초, 3.44±1.42 mm)보다 유의하게 짧았다(p=0.019, p=0.039). 불완전한 눈깜빡임 비율은 건성안의 경우 66.88±33.43%로 정상안의 23.63±25.66%보다 높았으나 LLT와 마이 봄샘 손상은 유의한 차이가 없었다. 결론 : SPEED 설문지로 건성안을 판별한 결과 청년층에서 건성안의 비율은 매우 높았으며, 건성안 증상은 눈 물의 양, TBUT 및 불완전한 눈깜빡임과 연관이 있었다. Purpose : To evaluate the cause of dry eye in youth, comparison between the tear film of normal eye and dry eye was performed. Methods : For 24 young adults (48 eyes, 11 males, 13 females, average age 22.04±2.01 years old), dry eyes were screened using the SPEED dry eye questionnaire, and compared tear test results of dry eyes with those of normal eyes. The amount of tear was evaluated by OCCUTUBE, and the stability of the tear film was evaluated by the tear film break-up time test (TBUT). Tear lipid layer thickness (LLT), blinking pattern, and meibomian gland damage were measured with LIPIVIEW II® and analyzed using Image J® program. Results : In the dry eyes, the SPEED questionnaire score was measured as high as 10.63±3.78 points, the TBUT was 3.39±0.89 s, and OCCUTUBE measurement was 2.67±0.92 mm, which was significantly shorter than those of the normal eye (4.04±0.83 s, 3.44±1.42 mm) (p=0.019, p=0.039, respectively). The rate of incomplete blinking in the dry eyes was 66.88±33.43%, which was higher than 23.63±25.66% in normal eyes, however, there was no significant difference between LLT and meibomian gland damage. Conclusion : As a result of screening dry eyes with the SPEED questionnaire, the percentage of dry eyes was very high in young people, and dry eye symptoms were associated with tear volume, TBUT, and incomplete blinking.

샤임플러그 전안부사진기를 이용한 눈물막의 두께 측정 및 건성안 지표와의 관계 분석

강나희(Na Hee Kang)박연꽃(Yeon Ggoch Park),전루민(Roo Min Jun) 대한안과학회 2015 대한안과학회지 Vol.56 No.11

목적: 정상안과 건성안 두 군에서 Pentacam Ⓡ (Oculus, Wetzlar, Germany)을 이용하여 측정한 각막 앞 눈물막 두께(precorneal tear film thickness, PTFT)를 포함한 전안부 계측값을 비교해 보고, 건성안 군에서 PTFT와 건성안 지표들과의 관련성을 알아보고자 하였다. 대상과 방법: 정상안 31안(23명), 건성안 31안(25명)을 대상으로 Pentacam Ⓡ을 이용하여 측정한 PTFT, 각막두께 및 난시 값을 비교하 였다. 건성안 군에서 PTFT와 플루오레신 눈물막 파괴 시간(fluorescein tear break-up time, FBUT), 쉬르머 I 검사 및 안구표면질환지 수(ocular surface disease index, OSDI)와의 관련성을 알아보았다. 결과: 평균 PTFT는 정상안에서 37.6 ± 2.0 μm, 건성안에서 21.1 ± 2.0 μm로 건성안 군의 PTFT가 정상안에 비해 유의하게 얇았다 ( p <0.01). 건성안 군에서 각막두께는 더 두꺼웠으나 임상적으로 의미 있는 차이는 없었고, 각막난시의 빈도 및 정도가 높은 경향을 보였지만 통계적으로 유의하지 않았다. 건성안 군에서 OSDI는 FBUT 및 쉬르머 I 검사와 약한 음의 상관관계를 보였으나 유의하지 않았고, PTFT와는 통계적으로 유의한 음의 상관관계를 보였다(r=-0.46, p <0.01). PTFT는 FBUT와 쉬르머 I 검사와 약한 양의 상관관 계를 보였으나 통계적으로 유의하지 않았다. 결론: 건성안에서 Pentacam Ⓡ 으로 측정한 PTFT는 정상군에 비해 유의하게 얇았으며 주관적인 증상과 연관성을 보여 건성안 환자의 진단 및 치료에 유용하게 활용될 수 있을 것으로 생각된다. Purpose: To compare the anterior segment parameters including precorneal tear film thickness (PTFT) using Pentacam ??(Oculus, Wetzlar, Germany) between normal control and dry eye groups and to examine the relationships between the PTFT and other parameters for dry eye. Methods: The present study included 23 normal controls (31 eyes) and 25 patients with dry eyes (31 eyes). We compared meas-urements including PTFT, corneal thickness and astigmatism using Pentacam ?? and analyzed the correlations among the PTFT and fluorescein tear break-up time (FBUT), Schirmer I test (without anesthesia), and ocular surface disease index (OSDI). Results: The mean PTFT in dry eyes (21.1 ± 2.0 μm) was significantly thinner than in normal eyes (37.6 ± 2.0 μm; p < 0.01). In the dry eye group, the corneal thickness was thicker than in the normal eye group but there were no clinically significant differences. The dry eye group experienced more frequent and severe corneal astigmatism compared with the normal group. OSDI scores showed a weak negative correlation with objective clinical measures of dry eye (FBUT, Schirmer I test) but was not statistically significant. However, OSDI was statistically significantly negatively correlated with PTFT (r = -0.46, p < 0.01). The PTFT showed a weak positive correlation with FBUT and Schirmer I test without statistical significance. Conclusions: The mean PTFT using Pentacam ?? in the dry eye group was thinner than in the normal group. Additionally, the PTFT was correlated with subjective symptoms. Therefore, the PTFT measurement using Pentacam ?? could be considered a useful method for diagnosis and treatment of dry eye.

건성안 환자의 광학적 특성에 대한 객관적인 분석

전혜민,이동준,Hye Min Jeon,Dong Jun Lee 대한안과학회 2014 대한안과학회지 Vol.55 No.11

Purpose: To evaluate the efficacy of Optical Quality Analysis System (OQAS<SUP>Ⓡ) instrument for the assessment of dry eye syndrome. Methods: Dynamic recording of double-pass (DP) retinal images was performed in 1 eye dry eye patients (20 eyes) and in healthy controls (20 eyes) for 20 seconds after eye blinking. Results: The mean objective scatter Index (OSI) value was 4.53 in dry eyes, 0.67 in healthy eyes and the standard deviation of OSI was 1.20 in dry eyes and 1.18 in healthy eyes. The patients with dry eyes showed significantly higher mean OSI and standard deviation values. Ocular scatter increased over time and significant changes occurred 13.5 seconds after blinking. The difference in OSI value between 0 second and 20 seconds was significantly greater in dry eye patients (4.15) than in controls (0.32). Conclusions: Ocular scatter increased over time after blinking. The dry eye patients had larger and more variable ocular scatter index than the controls. OQAS<SUP>Ⓡ may be useful to detect and follow-up tear film-related patient complaints in dry eye syndrome. J Korean Ophthalmol Soc 2014;55(11):1600-1605