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증례 : 감염 ; Haemophilus aphrophilus에 의한 감염성 심내막염 1예
장윤미 ( Yun Mi Jang ),기세윤 ( Sae Yoon Kee ),김범성 ( Bum Sung Kim ),김영백 ( Young Baek Kim ),안수영 ( Su Young Ahn ),최용훈 ( Yong Hoon Choi ),기현균 ( Hyun Kyun Ki ) 대한내과학회 2010 대한내과학회지 Vol.78 No.2
Haemophilus aphrophilus에 의한 심내막염은 매우 드물게 발생하며, 다른 병원체에 비해 합병증이 흔하고 사망률 또한 높다. 현재까지 국내에서 Haemophilus aphrophilus에 의한 감염심내막염은 3예밖에 보고된 바가 없으며 모두 수술적 치료를 병행하였다. 저자들은 61세 여자 환자에서 6주간의 항생제 치료만으로 뇌색전증을 동반한 Haemophilus aphrophilus에 의한 감염심내막염을 성공적으로 치료하였기에 문헌고찰과 함 Haemophilus aphrophilus, a fastidious, gram-negative oropharyngeal species grouped as a HACEK organism, is a rare cause of infective endocarditis. Three cases of endocarditis with Haemophilus aphrophilus were reported in Korea, and all of them required val
인공판막 심내막염 환자의 혈액에서 Haemophilus aphrophilus와 Coagulase-Negative Staphylococci 동시 분리 1예
김창기,조인주,박윤희,노경호,용동은,이경원,김준명,정윤섭 대한임상미생물학회 2006 Annals of clinical microbiology Vol.9 No.1
Haemophilus aphrophilus is a facultative anaerobic, gram-negative coccobacillus or bacillus and its growth is stimulated by 5 to 10% CO2. Most Haemophilus species require either exogenous X or V factor or both to grow, but H. aphrophilus can grow without these factors. H. aphrophilus rarely causes invasive infections such as endocarditis, septicemia, pneumonia and peritonitis in human. Two cases of infective endocarditis by H. aphrophilus have been reported in Korea. However, there has been no report of polymicrobial endocarditis by H. aphrophilus and other bacteria. We isolated H. aphrophilus and coagulase-negative staphylococci (CNS) from the blood of a 38-year-old woman with prosthetic valve endocarditis. She underwent an emergent operation and a culture of the prosthetic valve grew H. aphrophilus. Brain abscess was developed at hospital day 11. H. aphrophilus was susceptible to all antibiotics tested such as ampicillin and cefotaxime, and CNS was susceptible to oxacillin and vancomycin. The patient responded well to therapy with ceftriaxone, teicoplanin, and gentamicin.