KMT-2017-BLG-0165Lb: A Super-Neptune-mass Planet Orbiting a Sun-like Host Star

Kil Jung, Youn,Gould, Andrew,Zang, Weicheng,Hwang, Kyu-Ha,Ryu, Yoon-Hyun,Han, Cheongho,Yee, Jennifer C.,Albrow, Michael D.,Chung, Sun-Ju,Shin, In-Gu,Shvartzvald, Yossi,Zhu, Wei,Cha, Sang-Mok,Kim, Dong American Astronomical Society 2019 The Astronomical journal Vol.157 No.2

Application Research on Mechanical Strength and Durability of Porous Basalt Concrete

Zhu, Yuelei,Li, Jingchun,Zhu, He,Jin, Long,Ren, Qifang,Ding, Yi,Li, Jinpeng,Sun, Qiqi,Wu, Zilong,Ma, Rui,Oh, Won-Chun Materials Research Society of Korea 2022 한국재료학회지 Vol.32 No.3

Porous basalt aggregate is commonly used in roadbed engineering, but its application in concrete has rarely been studied. This paper studies the application of porous basalt in concrete. Porous basalt aggregate is assessed for its effects on mechanical strength and durability of prepared C50 concrete; because it has a hole structure, porous basalt aggregate is known for its porosity, and porous basalt aggregates can be made full of water through changing the content of saturated basalt; after full-water condition is achieved in porous basalt aggregate mixture of C50 concrete, we discuss its mechanical properties and durability. The effects of C50 concrete prepared with basalt aggregate on the compressive strength, water absorption, and electric flux of concrete specimens of different ages were studied through experiments, and the effects of different replacement rates of saturated porous basalt aggregate on the properties of concrete were also studied. The results show that porous basalt aggregate can be prepared as C50 concrete. For early saturated porous basalt aggregate concrete, its compressive strength decreases with the increase of the replacement rate of saturated aggregate; this occurs up to concrete curing at 28 d, when the replacement rate of saturated basalt aggregate is greater than or equal to 40 %. The compressive strength of concrete increases with the increase of the replacement rate of saturated aggregate. The 28 d electric flux decreases with the increase of the replacement rate of saturated aggregate, indicating that saturated porous basalt aggregate can improve the chloride ion permeability resistance of concrete in later stages.

White-light crosslinkable milk protein bioadhesive with ultrafast gelation for first-aid wound treatment

Zhu Qinchao,Zhou Xuhao,Zhang Yanan,Ye Di,Yu Kang,Cao Wangbei,Zhang Liwen,Zheng Houwei,Sun Ziyang,Guo Chengchen,Hong Xiaoqian,Zhu Yang,Zhang Yajun,Xiao Ying,Valencak Teresa G.,Ren Tanchen,Ren Daxi 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00

Background : Post-traumatic massive hemorrhage demands immediately available first-aid supplies with reduced operation time and good surgical compliance. In-situ crosslinking gels that are flexibly adapting to the wound shape have a promising potential, but it is still hard to achieve fast gelation, on-demand adhesion, and wide feasibility at the same time. Methods : A white-light crosslinkable natural milk-derived casein hydrogel bioadhesive is presented for the first time. Benefiting from abundant tyrosine residues, casein hydrogel bioadhesive was synthesized by forming di-tyrosine bonds under white light with a ruthenium-based catalyst. We firstly optimized the concentration of proteins and initiators to achieve faster gelation and higher mechanical strength. Then, we examined the degradation, cytotoxicity, tissue adhesion, hemostasis, and wound healing ability of the casein hydrogels to study their potential to be used as bioadhesives. Result : Rapid gelation of casein hydrogel is initiated with an outdoor flashlight, a cellphone flashlight, or an endoscopy lamp, which facilitates its usage during first-aid and minimally invasive operations. The rapid gelation enables 3D printing of the casein hydrogel and excellent hemostasis even during liver hemorrhage due to section injury. The covalent binding between casein and tissue enables robust adhesion which can withstand more than 180 mmHg blood pressure. Moreover, the casein-based hydrogel can facilitate post-traumatic wound healing caused by trauma due to its biocompatibility. Conclusion : Casein-based bioadhesives developed in this study pave a way for broad and practical application in emergency wound management.

Structural and component characterization of the B4C neutron conversion layer deposited by magnetron sputtering

Zhu Jingtao,Liu Yang,Zhou Jianrong,Yang Zehua,Zhu Hangyu,Zhou Xiaojuan,Tan Jinhao,Cui Mingqi,Sun Zhijia 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.9

Neutron conversion detectors that use 10B-enriched boron carbide are feasible alternatives to 3 He-based detectors. We prepared boron carbide films at micron-scale thickness using direct-current magnetron sputtering. The structural characteristics of natural B4C films, including density, roughness, crystallization, and purity, were analyzed using grazing incidence X-ray reflectivity, X-ray diffraction, X-ray photoelectron spectroscopy, time-of-flight secondary ion mass spectrometry, and scanning electron microscopy. A beam profile test was conducted to verify the practicality of the 10B-enriched B4C neutron conversion layer. A clear profile indicated the high quality of the neutron conversion of the boron carbide layer.

Hepatotoxic mechanism of diclofenac sodium on broiler chicken revealed by iTRAQ-based proteomics analysis

Sun, Chuanxi,Zhu, Tianyi,Zhu, Yuwei,Li, Bing,Zhang, Jiaming,Liu, Yixin,Juan, Changning,Yang, Shifa,Zhao, Zengcheng,Wan, Renzhong,Lin, Shuqian,Yin, Bin 대한수의학회 2022 Journal of Veterinary Science Vol.23 No.3

Background: At the therapeutic doses, diclofenac sodium (DFS) has few toxic side effects on mammals. On the other hand, DFS exhibits potent toxicity against birds and the mechanisms remain ambiguous. Objectives: This paper was designed to probe the toxicity of DFS exposure on the hepatic proteome of broiler chickens. Methods: Twenty 30-day-old broiler chickens were randomized evenly into two groups (n = 10). DFS was administered orally at 10mg/kg body weight in group A, while the chickens in group B were perfused with saline as a control. Histopathological observations, serum biochemical examinations, and quantitative real-time polymerase chain reaction were performed to assess the liver injury induced by DFS. Proteomics analysis of the liver samples was conducted using isobaric tags for relative and absolute quantification (iTRAQ) technology. Results: Ultimately, 201 differentially expressed proteins (DEPs) were obtained, of which 47 were up regulated, and 154 were down regulated. The Gene Ontology classification and Kyoto Encyclopedia of Genes and Genomes pathway analysis were conducted to screen target DEPs associated with DFS hepatotoxicity. The regulatory relationships between DEPs and signaling pathways were embodied via a protein-protein interaction network. The results showed that the DEPs enriched in multiple pathways, which might be related to the hepatotoxicity of DFS, were "protein processing in endoplasmic reticulum," "retinol metabolism," and "glycine, serine, and threonine metabolism." Conclusions: The hepatotoxicity of DFS on broiler chickens might be achieved by inducing the apoptosis of hepatocytes and affecting the metabolism of retinol and purine. The present study could provide molecular insights into the hepatotoxicity of DFS on broiler chickens.

Parameter Sensitivity Study on Static and Dynamic Mechanical Properties of the Spatial Y-shaped Tied Arch Bridge

Jianpeng Sun,Zihan Tan,Jiaju Zhang,Wenwu Sun,Li Zhu 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.2

The spatial Y-shaped tied arch bridge is a rare form of innovative bridge on arch bridges around the world. It has important reference significance for the design and construction of bridge engineering worldwide. This arch bridge is novel in design and adopts single and double arch ribs combined structure. However, as a novel bridge type, its force situation is indetermination, so it is very important to study its mechanical properties and parameter sensitivity. In order to study the mechanical properties of the spatial Y-shaped tied arch bridge and the influence of structural parameters, this paper takes a spatial Y-shaped tied arch bridge under construction in China as the research object. The finite element software MIDAS Civil is used to establish the bridge model. The finite element model is used to analyze the static and dynamic performance of the spatial Y-shaped tied arch bridge under the use stage and the mechanical change trend under the influence of different rise-span ratios and double arch bifurcation angles. The results of single arch rib and double arch rib under constant load and live load are compared under different structural parameters in this paper, and the parameter sensitivity analysis of statics and dynamics is carried out. These analyses provide the adjustment basis and design reference for the design of the special-shaped arch bridge in the future.

Expression of the Arabidopsis vacuolar H+-pyrophosphatase gene AVP1 in peanut to improve drought and salt tolerance

Huaqin Sun,Qiang Gu,Sundaram Kuppu,Li Sun,Xunlu Zhu,Neelam Mishra,Rongbin Hu,Guoxin Shen,Junling Zhang,Yizheng Zhang,Longfu Zhu,Xianlong Zhang,Mark Burow,Paxton Payton,Hong Zhang 한국식물생명공학회 2013 Plant biotechnology reports Vol.7 No.3

The Arabidopsis gene AVP1 encodes an H?-pyrophosphatase that functions as a proton pump at thevacuolar membranes, generating a proton gradient acrossvacuolar membranes, which serves as the driving force formany secondary transporters on vacuolar membranes suchas Na?/H?-antiporters. Overexpression of AVP1 couldimprove drought tolerance and salt tolerance in transgenicplants, suggesting a possible way in improving drought andsalt tolerance in crops. The AVP1 was therefore introducedinto peanut by Agrobacterium-mediated transformation. Analysis of AVP1-expressing peanut indicated that AVP1-overexpression in peanut could improve both droughtand salt tolerance in greenhouse and growth chamberconditions, as AVP1-overexpressing peanuts producedmore biomass and maintained higher photosynthetic ratesunder both drought and salt conditions. In the field, AVP1-overexpressing peanuts also outperformed wild-type plantsby having higher photosynthetic rates and producing higheryields under low irrigation conditions.

MiR-494-3p Upregulation Exacerbates Cerebral Ischemia Injury by Targeting Bhlhe40

Lingjiang Sun,Dandan Ji,Feng Zhi,Yu Fang,Zigang Zhu,Tong Ni,Qin Zhu,Jie Bao 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.4

Purpose: Cerebral ischemia is related to insufficient blood supply and is characterized by abnormal reactive oxygen species(ROS) production and cell apoptosis. Previous studies have revealed a key role for basic helix-loop-helix family member e40 (Bhlhe40)in oxidative stress and cell apoptosis. This study aimed to investigate the roles of miR-494-3p in cerebral ischemia/reperfusion(I/R) injury. Materials and Methods: A mouse middle cerebral artery occlusion (MCAO/R) model was established to mimic cerebral ischemiain vivo. Brain infarct area was assessed using triphenyl tetrazolium chloride staining. Oxygen-glucose deprivation/reoxygenation(OGD/R) operation was adopted to mimic neuronal injury in vitro. Cell apoptosis was analyzed by flow cytometry. Therelationship between miR-494-3p and Bhlhe40 was validated by luciferase reporter and RNA immunoprecipitation assays. Results: Bhlhe40 expression was downregulated both in MCAO/R animal models and OGD/R-induced SH-SY5Y cells. Bhlhe40overexpression inhibited cell apoptosis and reduced ROS production in SH-SY5Y cells after OGD/R treatment. MiR-494-3p wasverified to bind to Bhlhe40 and negatively regulate Bhlhe40 expression. Additionally, cell apoptosis and ROS production in OGD/R-treated SH-SY5Y cells were accelerated by miR-494-3p overexpression. Rescue experiments suggested that Bhlhe40 could reversethe effects of miR-494-3p overexpression on ROS production and cell apoptosis. Conclusion: MiR-494-3p exacerbates brain injury and neuronal injury by regulating Bhlhe40 after I/R.

Behavior of Circular RC Columns with Two Layers of Spirals

Lin-Zhu Sun,Dong-Yan Wu,Jun-Liang Zhao,Fang Yang,Wei Li 대한토목학회 2017 KSCE JOURNAL OF CIVIL ENGINEERING Vol.21 No.3

RC columns with two layers of hoops is a new kind of column recently proposed. The concrete of the column is under three different degrees of confinement, namely unconfined concrete cover, singly-confined concrete between the two layers of hoops and doubly-confined concrete inside the inner layer of hoops. The strength and ductility of the column can be greatly enhanced due to better confinement. In this study, the behaviour of circular RC columns confined using two layers of spirals were investigated through axial compression test on scaled-down column models. The responses and failure modes of the columns were examined. The average stress-strain curves of the singly-confined and doubly-confined concrete were derived, taking advantage of the concept of average effective confinement pressure. The performance of a stress-strain model previously proposed for square RC columns with two layers of hoops was also investigated.

Improved Mechanical Properties of Friction Stir Welded 1500 MPa Martensitic Steel Joints with Additional Water Cooling

Shuhao Zhu,Pengcheng Zhu,Binbin Wang,Liang Zhang,Yufeng Sun,Shaokang Guan 대한금속·재료학회 2024 METALS AND MATERIALS International Vol.30 No.1

This study proposes a method to improve the mechanical strength of martensitic welded joints by minimizing the effect ofmartensitic tempering. The high-strength martensitic steel plate exhibiting a tensile strength of 1500 MPa was successfullyjoined in this study utilizing additional water-cooling by friction stir welding (FSW) technique. Concurrently, conventionalair-cooled welded joints were produced utilizing identical welding parameters for comparison. Notwithstanding the macrostructureof both FSW joints was similar, the air-cooled joint contained a larger stir zone (SZ) and wider heat-affectedzone (HAZ). The air-cooled joint SZ exhibited a microstructure featuring coarse martensite, while the water-cooled jointSZ displayed a microstructure consisting of fine martensite. The degree of self-tempering of the martensite in the HAZ wassignificantly reduced, together with fewer and finer carbide particles than in the HAZ of air-cooled joints, by applying watercooling. The tensile test results indicated that the water-cooled FSW joint showed a significant improvement (23.6%) inultimate tensile strength compared to its air-cooled counterparts.