Fault Analysis and Tolerant Control for High Speed PEMS Maglev Train End Joint Structure with Disturbance Rejection

Zhi-Qiang Wang,Zhi-Qiang Long,Xiao-Long Li 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.3

It is observed in test operation that for permanent magnet electro-magnetic suspension (PEMS) type high speed maglev train, when a single levitation unit in an end joint structure fails to work, the performance of the entire joint structure deteriorates rapidly, whereas in electro-magnetic suspension (EMS) type maglev system, there is no such phenomenon under the same failure. To solve this problem and to enhance system performance under faulty condition, fi rstly a comparative modeling of EMS and PEMS maglev end joint structure system was made to analyze the underlying reasons. Then a dynamic compensation method and a disturbance rejection method based on disturbance estimation and feedback linearization were proposed respectively. The performances of the proposed measures are verifi ed and compared in simulations.

Down-regulation of Phosphoglucose Isomerase/Autocrine Motility Factor Enhances Gensenoside Rh2 Pharmacological Action on Leukemia KG1α Cells

You, Zhi-Mei,Zhao, Liang,Xia, Jing,Wei, Qiang,Liu, Yu-Min,Liu, Xiao-Yan,Chen, Di-Long,Li, Jing Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3

Aims and Background: Ginsenoside Rh2, which exerts the potent anticancer action both in vitro and in vivo, is one of the most well characterized ginsenosides extracted from ginseng. Although its effects on cancer are significant, the underlying mechanisms remain unknown. In this study, we sought to elucidate possible links between ginsenoside Rh2 and phosphoglucose isomerase/autocrine motility factor (PGI/AMF). Methods: $KG1{\alpha}$, a leukemia cell line highly expressing PGI/AMF was assessed by western blot analysis and reverse transcription- PCR (RT-PCR) assay after transfection of a small interfering (si)-RNA to silence PGI/AMF. The effect of PGI/AMF on proliferation was measured by typan blue assay and antibody array. A cell counting kit (CCK)-8 and flow cytometry (FCM) were adopted to investigate the effects of Rh2 on PGI/AMF. The relationships between PGI/AMF and Rh2 associated with Akt, mTOR, Raptor, Rag were detected by western blot analysis. Results: KG1${\alpha}$ cells expressed PGI/AMF and its down-regulation significantly inhibited proliferation. The antibody array indicated that the probable mechanism was reduced expression of PARP, State1, SAPK/JNK and Erk1/2, while those of PRAS40 and p38 were up-regulated. Silencing of PGI/AMF enhanced the sensibility of $KG1{\alpha}$ to Rh2 by suppressing the expression of mTOR, Raptor and Akt. Conclusion: These results suggested that ginsenoside Rh2 suppressed the proliferation of $KG1{\alpha}$, the same as down-regulation of PGI/AMF. Down-regulation of PGI/AMF enhanced the pharmacological effects of ginsenoside Rh2 on KG1${\alpha}$ by reducing Akt/mTOR signaling.

Good performance of Sc (0001) surface adsorbing CO molecule

Hao Zhi-Qiang,Yang Jian-Long,Li Hui,Yao Jian-Gang 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.80 No.9

There is a big discrepancy in terms of calculating the surface energy of the HCP Sc (0001) surface for previous theoretical results. Herein, we used a relatively reasonable method to predict the calculated value (1.263 J/m2), which agrees well with the experimental outcome (1.275 J/m2). Based on this, the adsorption behaviors of CO at different sites, i.e., hollow (H1, H2, and H3), bridge (B1), and top sites (T1), were explored theoretically. The results suggest that hollow sites, particularly the H1 site exhibits a good performance in adsorbing CO molecule, and that the adsorption energy reaches nearly 3.5 eV, which corresponds to a significant elongation of the C–O distance (more than 24%). In addition, the CO adsorbed at the H1 site is seen to be located parallelly at the surface. An obvious substantive variation of the CO molecular orbit of H1 adsorption site is observed.

Prevalence and Genotype Distribution of Human Papillomavirus Infections in Women Attending Hospitals in Chaozhou of Guangdong Province

Chen, Qiang,Luo, Zhao-Yun,Lin, Min,Lin, Qi-Li,Chen, Chan-Yu,Yang, Chun,Xie, Long-Xu,Li, Hui,Zheng, Jia-Kun,Yang, Li-Ye,Ju, Gui-Zhi Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Background: Human papillomavirus (HPV) infection is the main cause of cervical cancer. Limited epidemiologic data of HPV prevalence are available for women attending hospitals in southern China. This study aimed to evaluate the profiles of HPV infection and cytology status in gynecological outpatients in Chaozhou City. Methods: A total of 2833 eligible women were enrolled. The HPV GenoArray test was used for HPV detection and genotyping. Nearly one half of the HPV positive women received liquid-based cytology test. Logistic regression analysis was performed to assess the predictable effects of age and genotype for categories of abnormal cytology. Results: The prevalence of overall, high-risk, and low-risk HPV infection were 24.5%, 19.5% and 8.4%, respectively. A U-shaped age-specific prevalence curve was observed in overall HPV and high-risk HPV, but not in low-risk HPV, which declined with age increasing. The 6 most common high-risk HPV type in descending order, were types 52, 16, 58, 18, 68, and 33. Age and HPV genotype were both important determinants of abnormal cytology incidence, the older women (>45 years) and those infected with HPV type 16 and/or 18 having the highest risk for abnormal cytology. Conclusion: Our findings support the hypothesis that second-generation HPV prophylactic vaccines including HPV-52 and -58 may offer higher protection for women residing in Chaozhou and neighboring cities in Guangdong.

Effect of Trichostatin A on Anti HepG2 Liver Carcinoma Cells: Inhibition of HDAC Activity and Activation of Wnt/β-Catenin Signaling

Shi, Qing-Qiang,Zuo, Guo-Wei,Feng, Zi-Qiang,Zhao, Lv-Cui,Luo, Lian,You, Zhi-Mei,Li, Dang-Yang,Xia, Jing,Li, Jing,Chen, Di-Long Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

Purpose: To investigate the effect of deacetylase inhibitory trichostatin A (TSA) on anti HepG2 liver carcinoma cells and explore the underlying mechanisms. Materials and Methods: HepG2 cells exposed to different concentrations of TSA for 24, 48, or 72h were examined for cell growth inhibition using CCK8, changes in cell cycle distribution with flow cytometry, cell apoptosis with annexin V-FTIC/PI double staining, and cell morphology changes under an inverted microscope. Expression of ${\beta}$-catenin, HDAC1, HDAC3, H3K9, CyclinD1 and Bax proteins was tested by Western blotting. Gene expression for ${\beta}$-catenin, HDAC1and HDAC3 was tested by q-PCR. ${\beta}$-catenin and H3K9 proteins were also tested by immunofluorescence. Activity of Renilla luciferase (pTCF/LEF-luc) was assessed using the Luciferase Reporter Assay system reagent. The activity of total HDACs was detected with a HDACs colorimetric kit. Results: Exposure to TSA caused significant dose-and time-dependent inhibition of HepG2 cell proliferation (p<0.05) and resulted in increased cell percentages in G0/G1 and G2/M phases and decrease in the S phase. The apoptotic index in the control group was $6.22{\pm}0.25%$, which increased to $7.17{\pm}0.20%$ and $18.1{\pm}0.42%$ in the treatment group. Exposure to 250 and 500nmol/L TSA also caused cell morphology changes with numerous floating cells. Expression of ${\beta}$-catenin, H3K9and Bax proteins was significantly increased, expression levels of CyclinD1, HDAC1, HDAC3 were decreased. Expression of ${\beta}$-catenin at the genetic level was significantly increased, with no significant difference in HDAC1and HDAC3 genes. In the cytoplasm, expression of ${\beta}$-catenin fluorescence protein was not obvious changed and in the nucleus, small amounts of green fluorescence were observed. H3K9 fluorescence protein were increased. Expression levels of the transcription factor TCF werealso increased in HepG2 cells following induction by TSA, whikle the activity of total HDACs was decreased. Conclusions: TSA inhibits HDAC activity, promotes histone acetylation, and activates Wnt/${\beta}$-catenin signaling to inhibit proliferation of HepG2 cell, arrest cell cycling and induce apoptosis.

Cyclic Loading Tests on Composite Joints with Flush End Plate Connections

SHI Wen-long,LI Guo-qiang,YE Zhi-ming,R. Y. Xiao 한국강구조학회 2007 International Journal of Steel Structures Vol.7 No.2

The tests on composite joint specimens with flush end plate connections subjected to cyclic loads have been conducted inTongji University. One bare steel joint specimen has also been tested for comparison. Various instrumentations have been usedto measure: beam strains, column strains, rebar strains, connection deformations and deflections of specimens. The testobservations are reported in detail in this paper. The main results are as folows: (1) the moment-rotation relationships of thenability; (2) the composite joint specimens show large strength resistance and god ductility, and all the rotations of conectionare greater than 0.03rad as required by the FEMA-97; (3) similar failure modes have been identified from the observation ofthe composite specimens, which are found to be concentrated around the joint zone; and (4) the slipage between the concreteslab and steel beam is very small, which shows that betwen the concrete slab and steel beam the ful composition can be

Production of isophthalic acid from m-xylene oxidation under the catalysis of the H3PW12O40/carbon and cobalt catalytic system

Xiang-li Long,Zhi-hao Wang,San-qiang Wu,Shi-ming Wu,Hai-feng Lv,Wei-kang Yuan 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.1

Isophthalic acid (IPA) is commercially produced from m-xylene oxidation with the catalysis of thehomogeneous Co–Mn–Br catalyst system. In this study, a catalytic system consisting of HPW/C and Co(II)has been put forward to oxidize m-xylene (MX) to IPA. The experimental results prove that the HPW/Cand Co catalytic system is capable of catalyzing the oxidation of MX to IPA, which can obtain a higher MXconversion and IPA concentration than the homogeneous H3PW12O40/Co(OAc)2/Mn(OAc)2 catalyticsystem. The heterogeneous catalytic system is also advantageous over the homogeneous catalyticsystem in the inhibition of the oxidation of acetic acid and IPA. The optimal amount of phosphotungsticacid supported on carbon is 7.5% (wt). The best dosage of HPW/C is 15 g l-1. The optimum Co(II)concentration in the catalytic system for IPA production is 0.064% (wt). The best HPW/C activationtemperature is 220℃ .

Ginsenoside Rg1 Induces Apoptosis through Inhibition of the EpoR-Mediated JAK2/STAT5 Signalling Pathway in the TF-1/Epo Human Leukemia Cell Line

Li, Jing,Wei, Qiang,Zuo, Guo-Wei,Xia, Jing,You, Zhi-Mei,Li, Chun-Li,Chen, Di-Long Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

Ginsenoside Rg1 is one effective anticancer and antioxidant constituent of total saponins of Panax ginseng (TSPG), which has been shown to have various pharmacological effects. Our previous study demonstrated that Rg1 had anti-tumor activity in K562 leukemia cells. The aim of this study was designed to investigate whether Rg1 could induce apoptosis in TF-1/Epo cells and further to explore the underlying molecular mechanisms. Here we found that Rg1 could inhibit TF-1/Epo cell proliferation and induce cell apoptosis in vitro in a concentration and time dependent manner. It also suppressed the expression of EpoR on the surface membrane and inhibited JAK2/STAT5 pathway activity. Rg1 induced up-regulation of Bax, cleaved caspase-3 and C-PAPR protein and down-regulation of Bcl-2 and AG490, a JAK2 specific inhibitor, could enhance the effects of Rg1. Our studies showed that EpoR-mediated JAK2/STAT5 signaling played a key role in Rg1-induced apoptosis in TF-1/Epo cells. These results may provide new insights of Rg1 protective roles in the prevention a nd treatment of leukemia.

The Design of Control System for the Magnetic Bearing

Yong De Jin,Yan Zhou,Zhi Qiang Long 대한전자공학회 1991 International Conference on Electronics, Informati Vol.1 No.1

Behaviour of micropiles in collapsible loess under tension or compression load

Qian, Zeng-Zhen,Lu, Xian-Long,Yang, Wen-Zhi,Cui, Qiang Techno-Press 2014 Geomechanics & engineering Vol.7 No.5

This study examines the behaviour of single micropiles subjected to axial tension or compression load in collapsible loess under in-situ moisture content and saturated condition. Five tension loading tests and five compression loading tests on single micropiles were carried out at a typical loess site of the Loess Plateau in Northwest China. A series of laboratory tests, including grain size distribution, specific gravity, moisture content, Atterberg limits, density, granular components, shear strength, and collapse index, were carried out during the micropile loading tests to determine the values of soil parameters. The loess at the test site poses a severe collapse risk upon wetting. The tension or compression load-displacement curves of the micropiles in loess, under in-situ moisture content or saturated condition, can generally be simplified into three distinct regions: an initial linear, a curvilinear transition, and a final linear region, and the bearing capacity or failure load can be interpreted by the L1-L2 method as done in other studies. Micropiles in loess should be considered as frictional pile foundations though the tip resistances are about 10%-15% of the applied loads. Both the tension and compression capacities increase linearly with the ratio of the pile length to the shaft diameter, L/d. For micropiles in loess under in-situ moisture content, the interpreted failure loads or capacities under tension are 66%-87% of those under compression. However, the prewetting of the loess can lead to the reductions of 50% in the tensile bearing capacity and 70% in the compressive bearing capacity.