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Zhenzhen Hu,Eun-Hye Oh,Yeon Bok Chung,Jin Tae Hong,Ki-Wan Oh 대한생리학회-대한약리학회 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.2
The aim of this study was to investigate the involvement of dopaminergic receptors (DR) in behavioral sensitization, as measured by locomotor activity, and the over-expression of cocaine- and amphetamine-regulated transcript (CART) peptides after repeated administration of cocaine in mice. Repeated administrations of cocaine induced behavioral sensitization and CART over-expression in mice. The levels of striatal CART mRNA were significantly increased on the 3<sup>rd</sup> day. CART peptides were over-expressed on the 5<sup>th</sup> day in the striata of behaviorally sensitized mice. A higher proportion of CART<sup>+</sup> cells in the cocaine-treated mice were present in the nucleus accumbens (NAc) shell than in the dorsolateral (DL) part of caudate putamen (CP). The concomitant administration of both D<sub>1</sub>R and D<sub>2</sub>R antagonists, SCH 23390 (D<sub>1</sub>R selective) and raclopride (D<sub>2</sub>R selective), blocked cocaine induced- behavioral sensitization, CART over-expression, and cyclic adenosine 5’-monophosphate (cAMP)/ protein kinase A (PKA)/phospho-cAMP response element-binding protein (<i>p</i>CREB) signal pathways. SCH 23390 more predominantly inhibited the locomotor activity, CART over-expression, <i>p</i>CREB and PKA activity than raclopride. Cocaine induced-behavioral sensitization was also attenuated in the both D<sub>1</sub>R and D<sub>2</sub>R knockout (KO) mice, respectively. CART over-expression and activated cAMP/PKA/<i>p</i>CREB signal pathways were inhibited in the D<sub>1</sub>R-KO mice, but not in the D<sub>2</sub>R-KO mice. It is suggested that behavioral sensitization, CART over-expression and activated cAMP/PKA/<i>p</i>CREB signal pathways induced by repeated administration of cocaine could be more predominantly mediated by D<sub>1</sub>R.
Sleep-Aids Derived from Natural Products
Hu, Zhenzhen,Oh, Seikwan,Ha, Tae-Woo,Hong, Jin-Tae,Oh, Ki-Wan The Korean Society of Applied Pharmacology 2018 Biomolecules & Therapeutics(구 응용약물학회지) Vol.26 No.4
Although drugs such as barbiturates and benzodiazepines are often used for the treatment of insomnia, they are associated with various side effects such as habituations, tolerance and addiction. Alternatively, natural products with minimal unwanted effects have been preferred for the treatment of acute and/or mild insomnia, with additional benefits of overall health-promotion. Basic and clinical researches on the mechanisms of action of natural products have been carried out so far in insomnia treatments. Recent studies have been focusing on diverse chemical components available in natural products, with an interest of developing drugs that can improve sleep duration and quality. In the last 15 years, our co-workers have been actively looking for candidate substances from natural products that can relieve insomnia. This review is, therefore, intended to bring pharmacological data regarding to the effects of natural products on sleep duration and quality, mainly through the activation of $GABA_A$ receptors. It is imperative that phytochemicals will provide useful information during electroencephalography (EEG) analysis and serve as an alternative medications for insomnia patients who are reluctant to use conventional drugs.
Hu, Zhenzhen,Oh, Eun-Hye,Chung, Yeon Bok,Hong, Jin Tae,Oh, Ki-Wan The Korean Society of Pharmacology 2015 The Korean Journal of Physiology & Pharmacology Vol.19 No.2
The aim of this study was to investigate the involvement of dopaminergic receptors (DR) in behavioral sensitization, as measured by locomotor activity, and the over-expression of cocaine- and amphetamine-regulated transcript (CART) peptides after repeated administration of cocaine in mice. Repeated administrations of cocaine induced behavioral sensitization and CART over-expression in mice. The levels of striatal CART mRNA were significantly increased on the $3^{rd}$ day. CART peptides were over-expressed on the $5^{th}$ day in the striata of behaviorally sensitized mice. A higher proportion of $CART^+$ cells in the cocaine-treated mice were present in the nucleus accumbens (NAc) shell than in the dorsolateral (DL) part of caudate putamen (CP). The concomitant administration of both $D_1R$ and $D_2R$ antagonists, SCH 23390 ($D_1R$ selective) and raclopride ($D_2R$ selective), blocked cocaine induced-behavioral sensitization, CART over-expression, and cyclic adenosine 5'-monophosphate (cAMP)/ protein kinase A (PKA)/phospho-cAMP response element-binding protein (pCREB) signal pathways. SCH 23390 more predominantly inhibited the locomotor activity, CART over-expression, pCREB and PKA activity than raclopride. Cocaine induced-behavioral sensitization was also attenuated in the both $D_1R$ and $D_2R$ knockout (KO) mice, respectively. CART over-expression and activated cAMP/PKA/pCREB signal pathways were inhibited in the $D_1R$-KO mice, but not in the $D_2R$-KO mice. It is suggested that behavioral sensitization, CART over-expression and activated cAMP/PKA/pCREB signal pathways induced by repeated administration of cocaine could be more predominantly mediated by $D_1R$.
Xuzhong Zuo,Enjie He,Jin Bai,Shunjin Zhu,Xucai Kan,Zhenzhen Hui,Jie Yang,Xuebin Zhu,Jianming Dai 한국물리학회 2019 Current Applied Physics Vol.19 No.12
The structural, magnetic, dielectric and optical properties of Aurivillius Bi6Fe2Ti3O18-based ceramics were investigated in detail. The replacement of Co for Fe/Ti ions obviously varies the grain morphology. Compared with Bi6Fe2Ti3O18 (BFTO) with antiferromagnetic ordering, a spin glass state can be observed in Bi5.25La0.75Fe2Ti3O18 ceramic, while other samples exhibit the ferromagnetic behavior. The specimen Bi6Fe2Ti2(NbCo)0.5O18 (BFTNCO) represents the largest remanent magnetization Mr of 0.93emu/g among all the samples, which can be attributed to the combination of a short lattice parameter c and a large lattice distortion as well as more magnetic ions in a unit cell. The room-temperature dc conductivity of BFTNCO is one order magnitude lower than that of BFTO. In addition, the band gaps of Co-doped samples are about 0.2eV smaller than these of Co-free samples. This work provides a promising path forward to tailor the multiferroic and optical properties in five-layered Aurivillius compounds.
Enhancement of Pentobarbital-induced Sleep by Apigenin through Chloride Ion Channel Activation
Jae-Wook Kim,Ki-Wan Oh,Chung-Soo Kim,Zhenzhen Hu,Jin-Yi Han,김시관,Sung-Kwang Yoo,Yeong Man Yeo,정명수,Kinam Lee,홍진태 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.2
This experiment was performed to investigate whether apigenin has hypnotic effects and/or enhances pentobarbital-induced sleep behaviors through the GABAergic systems. Apigenin prolonged sleep time induced by pentobarbital similar to muscimol, a GABAA receptors agonist. Apigenin also increased sleep rate and sleep time in the combined administration with pentobarbital at the sub-hypnotic dosage, and showed synergic effects with muscimol in potentiating sleep onset and enhancing sleep time induced by pentobarbital. In addition, both of apigeinin and pentobarbital increased chloride influx in primary cultured cerebellar granule cells. Apigenin increased glutamate decarboxylase (GAD) and had no effect on the expression of GABAA receptor α-, β-, γ-subunits in n hippocampus of mouse brain, showing different expression of subunits from pentobarbital treatment group. In conclusion, it is suggested that apigenin augments pentobarbital-induced sleep behaviors through chloride ion channel activation.
Lotus-Like Nano-Architectures Constructed from Self-Assembled Micelles via Hierarchical Assembly
Rongli Zhang,Xiaoxia Fan,Xiaofang Xu,Jingjing Lv,Zhenzhen Jin,Hui Hao,Cuige Zhang 한국고분자학회 2018 Macromolecular Research Vol.26 No.1
Dopamine modified γ-polyglutamic acid (γ-PGA-DA) copolymer and melamine (Mel) can self-assemble into Mel/γ-PGA-DA micelles via weak intermolecular interactions in aqueous solution containing small amount of methanol. When Mel/γ-PGA-DA micellar solution was cast on the surface of formvar stabilized with carbon support films, the lotus-like nano-architectures were formed on the surface of substrate via hierarchical assembly of micelles. The size of lotus-like nanoarchitectures was approximately 200 nm×500 nm. The possible driving forces for hierarchical assembly of micelles were the solution fluid and interaction between micelles. The hierarchical assembly of micelles was similar to the fractal aggregation of inorganic particles and a possible reason was discussed.