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Zhang, Lu,Feng, Qiang,Wang, Jiuling,Zhang, Shuai,Ding, Baoquan,Wei, Yujie,Dong, Mingdong,Ryu, Ji-Young,Yoon, Tae-Young,Shi, Xinghua,Sun, Jiashu,Jiang, Xingyu American Chemical Society 2015 ACS NANO Vol.9 No.10
<P>The functionalized lipid shell of hybrid nanoparticles plays an important role for improving their biocompatibility and <I>in vivo</I> stability. Yet few efforts have been made to critically examine the shell structure of nanoparticles and its effect on cell–particle interaction. Here we develop a microfluidic chip allowing for the synthesis of structurally well-defined lipid-polymer nanoparticles of the same sizes, but covered with either lipid-monolayer-shell (MPs, monolayer nanoparticles) or lipid-bilayer-shell (BPs, bilayer nanoparticles). Atomic force microscope and atomistic simulations reveal that MPs have a lower flexibility than BPs, resulting in a more efficient cellular uptake and thus anticancer effect than BPs do. This flexibility-regulated cell–particle interaction may have important implications for designing drug nanocarriers.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2015/ancac3.2015.9.issue-10/acsnano.5b05792/production/images/medium/nn-2015-05792e_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn5b05792'>ACS Electronic Supporting Info</A></P>
Zhang Zhaoqi,Guo Peiwen,Liang Liang,Jila Shiju,Ru Xufang,Zhang Qiang,Chen Jingyu,Chen Zhi,Feng Hua,Chen Yujie 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Hydrocephalus is a severe complication that can result from intracerebral hemorrhage, especially if this hemorrhage extends into the ventricles. Our previous study indicated that the NLRP3 inflammasome mediates cerebrospinal fluid hypersecretion in the choroid plexus epithelium. However, the pathogenesis of posthemorrhagic hydrocephalus remains unclear, and therapeutic strategies for prevention and treatment are lacking. In this study, an Nlrp3−/− rat model of intracerebral hemorrhage with ventricular extension and primary choroid plexus epithelial cell culture were used to investigate the potential effects of NLRP3-dependent lipid droplet formation and its role in the pathogenesis of posthemorrhagic hydrocephalus. The data indicated that NLRP3-mediated dysfunction of the blood–cerebrospinal fluid barrier (B-CSFB) accelerated neurological deficits and hydrocephalus, at least in part, through the formation of lipid droplets in the choroid plexus; these lipid droplets interacted with mitochondria and increased the release of mitochondrial reactive oxygen species that destroyed tight junctions in the choroid plexus after intracerebral hemorrhage with ventricular extension. This study broadens the current understanding of the relationship among NLRP3, lipid droplets and the B-CSFB and provides a new therapeutic target for the treatment of posthemorrhagic hydrocephalus. Strategies to protect the B-CSFB may be effective therapeutic approaches for posthemorrhagic hydrocephalus.
Yujie Zhang,Xu Zhang,Nini Cheng,Yanping Li,Jinyi Xing 한국유전학회 2015 Genes & Genomics Vol.37 No.7
Identification of essential fragments in the promoter region of genes to drive tissue-specific expression of exogenous genes in the skeletal muscle is obligatory for animal transgenic study. The skeletal a-actin is a major protein of the thin filaments of skeletal muscle fiber. In this study, the specificity and activity of porcine skeletal aactin gene promoter were investigated by approaches of cell transfection and assayed with green fluorescent protein (GFP) and dual luciferase reporter activity, respectively. The results revealed that the obtained 3717 bp fragment of porcine skeletal a-actin gene promoter drives GFP to be expressed uniquely in murine C2C12 cells, and two segments of 2.0–2.3 and 0.06–0.37 kb in the promoter region were essential for porcine skeletal a-actin gene expression. The regulatory elements in the 0.06–0.37 kb fragment were further investigated, and when it is deleted or the CArG box within this fragment was mutated, the promoter activity was reduced to 20 or 43 % (P\0.01), respectively, compared to the 3.04 kb segment, suggesting an important role of CArG box in regulating porcine skeletal a-actin gene transcription. The results may provide reference for creating transgenic pigs to express exogenous genes uniquely in pork.
Yujie Zhang,Yan Zhang,Maojun Liu,Xiaodong Shi,Zhiwei Zhao 한국미생물학회 2008 The journal of microbiology Vol.46 No.6
To understand the possible role of the plant root associated fungi on metal tolerance, their role in the uptake of heavy metals and the potential transfer of these metal ions to the plant, three strains of dark septate endophytic (DSE) fungi were isolated from a waste smelter site in southwest China, and one strain was isolated from a non-contaminated site. According to molecular phylogenetic analysis of the ITS 1-5.8S rDNA-ITS 2 gene regions and morphological characteristics, one is identified as Exophiala pisciphila, and the other three are non-sporulating fungi under the experiment condition with the nearest phylogenetic affinities to the Thysanorea papuana strain EU041814. Tolerance and accumulation abilities of the three DSE strains for metals were investigated in liquid culture. Minimum inhibitory concentrations (MIC) of Pb, Zn, and Cd were determined. It was demonstrated that the tolerance of the DSE strains varied between metal species and strains. The E. pisciphila strain is able to accumulate lead and cadmium over 20% and 5% of dry weight of biomass, respectively. Partial of the sequestrated metals can be washed with CaCl2. Morphological and enzyme activity changes taking place in the presence of excessive Pb, Cd, and/or Zn also indicate that the mechanism of heavy metal tolerance and accumulation of the DSE strains would be a complex process. The findings indicated promising tolerance and accumulation of the DSE strains with potential values in metal cycling and restoration of soil and water system.
Automatic Bunsetsu Segmentation of Japanese Sentences Using a Classification Tree
( Yujie Zhang ),( Kazuhiko Ozeki ) 한국언어정보학회 1998 국제 워크샵 Vol.1998 No.-
Bunsetsu, which is comprised of a content word followed by, possibly 0, function words, is a convenient unit for dependency structure analysis of Japanese. There are, however, no spaces indicating bunsetsu boundaries in the orthographic writing of Japanese. Thus a sentence must be segmented into bunsetsu``s by some means prior to dependency structure analysis. Conventionally, such segmentation has been performed by using some kind of hand-crafted rules. This paper describes a novel segmentation method using a classification tree, by which knowledge about bunsetsu boundaries is automatically acquired from a labeled corpus. The method enables quick and easy adaptation to a new task domain, and also to a new system of morpheme categorization without the need of changing the algorithm. Effectiveness of this method is shown through experiments on an ATR corpus and an EDR corpus.
Yujie Zhang,Zhihang Guo,Yimin Gong,Jianzhong Shi,Mohamed Hechmi El Ouni,Farhan Alhosny Techno-Press 2023 Advances in nano research Vol.15 No.2
The under-evaluation structure includes a functionally graded porous (FGP) core which is confined by two piezoelectric carbon nanotubes reinforced composite (CNTRC) layers. The whole structure rests on the Pasternak foundation. Using quasi-3D hyperbolic shear deformation theory, governing equations of a sandwich plate are driven. Moreover, face sheets are subjected to the electric field and the whole model is under thermal loading. The properties of all layers alter continuously along with thickness direction due to the CNTs and pores distributions. By conducting the current study, the results emerged in detail to assess the effects of different parameters on buckling of structure. As instance, it is revealed that highest and lowest critical buckling load and consequently stiffness, is due to the V-A and A-V CNTs dispersion type, respectively. Furthermore, it is revealed that by porosity coefficient enhancement, critical buckling load and consequently, stiffness reduces dramatically. Current paper results can be used in various high-tech industries as aerospace factories.