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RISS 인기검색어
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- 저자 : Zhan-Feng Ying (검색결과 9 건)
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New DTR Estimation Method Without Measured Solar and Wind Data
Ying, Zhan-Feng,Chen, Yuan-Sheng,Feng, Kai The Korean Institute of Electrical Engineers 2017 Journal of Electrical Engineering & Technology Vol.12 No.2
Dynamic thermal rating (DTR) of overhead transmission lines can provide a significant increase in transmission capacity compared to the static thermal rating. However, the DTR are usually estimated by the traditional thermal model of overhead conductor that is highly dependent on the solar, wind speed and wind direction data. Consequently, the estimated DTR would be unreliable and the safety of transmission lines would be reduced when the solar and wind sensors are out of function. To address this issue, this study proposed a novel thermal model of overhead conductor based on the thermal-electric analogy theory and Markov chain. Using this thermal model, the random variation of conductor temperature can be simulated with any specific current level and ambient temperature, even if the solar and wind sensors are out of function or uninstalled. On this basis, an estimation method was proposed to determine the DTR in the form of probability. The laboratory experiments prove that the proposed method can estimate the DTR reliably without measured solar and wind data.
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New DTR Estimation Method Without Measured Solar and Wind Data
Zhan-Feng Ying,Yuan-Sheng Chen,Kai Feng 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.2
Dynamic thermal rating (DTR) of overhead transmission lines can provide a significant increase in transmission capacity compared to the static thermal rating. However, the DTR are usually estimated by the traditional thermal model of overhead conductor that is highly dependent on the solar, wind speed and wind direction data. Consequently, the estimated DTR would be unreliable and the safety of transmission lines would be reduced when the solar and wind sensors are out of function. To address this issue, this study proposed a novel thermal model of overhead conductor based on the thermal-electric analogy theory and Markov chain. Using this thermal model, the random variation of conductor temperature can be simulated with any specific current level and ambient temperature, even if the solar and wind sensors are out of function or uninstalled. On this basis, an estimation method was proposed to determine the DTR in the form of probability. The laboratory experiments prove that the proposed method can estimate the DTR reliably without measured solar and wind data.
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Feng, Sen-Ling,Luo, Hai-Bin,Cai, Liang,Zhang, Jie,Wang, Dan,Chen, Ying-Jiang,Zhan, Huan-Xing,Jiang, Zhi-Hong,Xie, Ying The Korean Society of Ginseng 2020 Journal of Ginseng Research Vol.44 No.2
Background: Multidrug resistance (MDR) to chemotherapy drugs remains a major challenge in clinical cancer treatment. Here we investigated whether and how ginsenoside Rg5 overcomes the MDR mediated by ABCB1 transporter in vitro and in vivo. Methods: Cytotoxicity and colon formation as well as the intracellular accumulation of ABCB1 substrates were carried out in MDR cancer cells A2780/T and A549/T for evaluating the reversal effects of Rg5. The expressions of ABCB1 and Nrf2/AKT pathway were determined by Western blotting. An A549/T cell xenograft model was established to investigate the MDR reversal activity of Rg5 in vivo. Results: Rg5 significantly reversed ABCB1-mediated MDR by increasing the intracellular accumulation of ABCB1 substrates without altering protein expression of ABCB1. Moreover, Rg5 activated ABCB1 ATPase and reduced verapamil-stimulated ATPase activity, suggesting a high affinity of Rg5 to ABCB1 binding site which was further demonstrated by molecular docking analysis. In addition, co-treatment of Rg5 and docetaxel (TXT) suppressed the expression of Nrf2 and phosphorylation of AKT, indicating that sensitizing effect of Rg5 associated with AKT/Nrf2 pathway. In nude mice bearing A549/T tumor, Rg5 and TXT treatment significantly suppressed the growth of drug-resistant tumors without increase in toxicity when compared to TXT given alone at same dose. Conclusion: Therefore, combination therapy of Rg5 and chemotherapy drugs is a strategy for the adjuvant chemotherapy, which encourages further pharmacokinetic and clinical studies.
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( Feng Yun Gong ),( Ding Yu Zhang ),( Jiang Guo Zhang ),( Li Li Wang ),( Wei Li Zhan ),( Jun Ying Qi ),( Jian Xin Song ) 생화학분자생물학회(구 한국생화학분자생물학회) 2014 BMB Reports Vol.47 No.4
To gain insights into the effect of MexB gene under the short interfering RNA (siRNA), we synthesized 21 bp siRNA duplexes against the MexB gene. RT-PCR was performed to determine whether the siRNA inhibited the expression of MexB mRNA. Changes in antibiotic susceptibility in response to siRNA were measured by the E-test method. The efficacy of siRNAs was determined in a murine model of chronic P. aeruginosa lung infection. MexB-siRNAs inhibited both mRNA expression and the activity of P. aeruginosa in vitro. In vivo, siRNA was effective in reducing the bacterial load in the model of chronic lung infection and the P. aeruginosa-induced pathological changes. MexB-siRNA treatment enhanced the production of inflammatory cytokines in the early infection stage (P < 0.05). Our results suggest that targeting of MexB with siRNA appears to be a novel strategy for treating P. aeruginosa infections. [BMB Reports 2014; 47(4): 203-208]
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Sen-Ling Feng,Hai-Bin Luo,Liang Cai,Jie Zhang,Dan Wang,Ying-Jiang Chen,Huan-Xing Zhan,Zhi-Hong Jiang,Ying Xie 고려인삼학회 2020 Journal of Ginseng Research Vol.44 No.2
Background: Multidrug resistance (MDR) to chemotherapy drugs remains a major challenge in clinicalcancer treatment. Here we investigated whether and how ginsenoside Rg5 overcomes the MDR mediatedby ABCB1 transporter in vitro and in vivo. Methods: Cytotoxicity and colon formation as well as the intracellular accumulation of ABCB1 substrateswere carried out in MDR cancer cells A2780/T and A549/T for evaluating the reversal effects of Rg5. Theexpressions of ABCB1 and Nrf2/AKT pathway were determined by Western blotting. An A549/T cellxenograft model was established to investigate the MDR reversal activity of Rg5 in vivo. Results: Rg5 significantly reversed ABCB1-mediated MDR by increasing the intracellular accumulation ofABCB1 substrates without altering protein expression of ABCB1. Moreover, Rg5 activated ABCB1 ATPaseand reduced verapamil-stimulated ATPase activity, suggesting a high affinity of Rg5 to ABCB1 bindingsite which was further demonstrated by molecular docking analysis. In addition, co-treatment of Rg5 anddocetaxel (TXT) suppressed the expression of Nrf2 and phosphorylation of AKT, indicating that sensitizingeffect of Rg5 associated with AKT/Nrf2 pathway. In nude mice bearing A549/T tumor, Rg5 and TXTtreatment significantly suppressed the growth of drug-resistant tumors without increase in toxicitywhen compared to TXT given alone at same dose. Conclusion: Therefore, combination therapy of Rg5 and chemotherapy drugs is a strategy for the adjuvantchemotherapy, which encourages further pharmacokinetic and clinical studies.
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Pei-Rong Wu,Yu-Mei Feng,Ting Ge,Ying-Chao Kong,Zhan-Sheng Ma,Zan Liu,Zhi-Lin Cheng 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.63 No.-
The surface of self-made MoS2 nanosheets with five-layer structure was successively decorated by zinc borate (ZB) nanoparticles with coordination enhancement on the tribological performance and modified by three types of modifiers for improving dispersivity in oil. A series of characterizations determined the chemical modification and composite structure of the ZB/MoS2 nanocomposites. The tribological properties of the chemically capped ZB/MoS2 nanocomposites were extensively examined on a ball-on-ball wear tester. The average friction coefficient and average wear scar diameter of the OA-ZB/MoS2-based oil dropped by about 25.2% and 52.2%, and furthermore the extreme pressure performance increased by about 15.2% compared to oil.
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Modelling of the Hot Flow Behaviors for Ti-13Nb-13Zr Alloy by BP-ANN Model and Its Application
Guo-zheng Quan,Shi-ao Pu,Zong-yang Zhan,Zhen-yu Zou,Ying-ying Liu,Yu-feng Xia 한국정밀공학회 2015 International Journal of Precision Engineering and Vol. No.
The plastic deformation mechanisms and the constitutive model of flow behaviors at different deformation conditions in biomedical titanium alloy are an essential step to optimize the design of any forging process for implant productions. A series of isothermal compressions tests on Ti-13Nb-13Zr alloy in a wide range of true strain, temperature and strain rate were conducted on a thermomechanical simulator. The hot flow behaviors with different softening mechanisms, including dynamic recrystallization and dynamic recovery, were characterized based on true strain-stress curves. A back-propagational artificial neural network (BP-ANN) method was conducted to evaluate and predict this non-linear problem by self-training to be adaptable to the material characteristics. The flow stress of this material a wide deformation condition range can be predicted accurately by the BP-ANN model obtained in this study. The prediction ability of this BP-ANN Model was evaluated by three accuracy indexes, Absolute error, Relative error and Average absolute relative error. Sequently, the developed BP-ANN model was programed and implanted into the finite element (FE) analysis platform, Msc.Marc software. The results have sufficiently articulated that the well-trained ANN model has excellent capability to deal with the complex flow behaviors and has great application potentiality in hot deformation processes.
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Alu Tandem Sequences Inhibit GFP Gene Expression by Triggering Chromatin Wrapping
Xiu Fang Wang,Xiao Yan Wang,Jing Liu,Jing Jing Feng,Wen Li Mu,Xiao Juan Shi,Qin Qing Yang,Xiao Cui Duan,Ying Xie,Zhan Jun Lu 한국유전학회 2009 Genes & Genomics Vol.31 No.3
Alu elements belonging to the short interspersed nuclear elements (SINE) of repetitive elements are present in more than one million copies which altogether represent 10% of the whole human genome. In this study, the roles of Alu tandem sequences in the process of GFP gene (GFP) expression and packing into chromatin of its DNA were studied. To detect the effect of Alu repeats on gene expression, different copies of Alus were inserted GFP downstream respectively in pEGFP-C1 vector. We found that Alu sequences decreased the amount of GFP transcription, the percentage of GFP positive cells and the accessibility to DNase I in length-dependent manner. Inserting Alu caused the production of higher-molecular-mass RNA, indicating Alu sequence did not induce premature transcriptional termination. Tight packing chromatins keep silent and resist to DNase I digestion, which is a general phenomenon. We suggested that head and tail tandem Alu sequences suppressed GFP expression in length dependent manner by triggering chromatin packing.
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