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Effect of Cold Water Intake During Exercise in Heat on Cognitive Function
( Yunbin Lee ),( Somi Yun ),( Jaegu Hwang ),( Heejin Lee ),( Ah Reum Jung ),( Dae Taek Lee ) 한국운동생리학회(구 한국운동과학회) 2021 운동과학 Vol.30 No.1
PURPOSE: The purpose of this study was to examine the effect of cooling treatment by cold water intake before and during exercise in a hot environment on cognitive function. METHODS: Twelve healthy adult men (26.3±4.4 years, 176.2±5.8 cm, 77.2±14.6 kg, 24.8±3.7 kg/m<sup>2</sup>) completed 3 exercise tests; with drinking warm water (36.5℃), with drinking cold water (4℃), or without drinking water. Each test was separated at least 3 days. During each test, they ran on a treadmill for 20 minutes at 75% of their maximal heart rate in 40℃ with 40% of humidity. For the drinking conditions, the total volume of drinking was set to 1% of the participant’s weight. Before the test in each drinking condition, they consume 1/3 of the total volume at once. The remaining 2/3 was consumed separately 3 times at six-min interval during exercise. A neuropsychological test using the Stroop Color and Word Test (SCWT) was conducted before and after the exercise to examine the changes of cognitive abilities. Data were analyzed using a two way repeated measures ANOVA. RESULTS: Comparing pre- and post-exercise SCWT, the main effects in words, colors, and words and colors were noticed (p=.000, p=.003, and p=.008, respectively). No differences were found between water drinking conditions. CONCLUSIONS: Overall, a short bout of high-intensity exercise in the hot environment improved cognitive functions, but it was not possible to determine how water temperature and water intake affected cognitive ability. Further research is needed considering the ages and fitness levels of participants.
EEG and EMG recording system for sleep study with a freely moving rat
Youjin Lee,Yena Lee,Seoyoung Hwang,Hee Soo Jeong,Yunjin Kim,Yunbin Lee,Jihoo Lee,Seoyeon Park,Sang Beom Jun 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7
Sleep is known to play an important role in cognitive functions as well as in physical recovery. Especially, high-quality sleep is closely associated with smooth sleep cycles between NREM (non-rapid eye movement) and REM (rapid eye movement) sleep. It is well known that both sleep stages show clear distinction in electroencephalogram (EEG) and electromyogram (EMG) signals. Therefore, as a first step for sleep study with rodents, a sleep monitoring system must be established for stable measurement of EEG and EMG. There are two challenges for the setup. First, animals should be able to freely move without interruption of EEG or EMG recording cable, so that their natural behavior and sleep can occur. Second, long-term EEG and EMG should be recorded stably. Also, the movements of animals can cause a cable tension and moving artifacts. The movement-related artifacts can interfere with judgment of sleep stages. Also, rodent gnawing of the recording cable frequently leads to early termination of sleep study. In this study, in order to overcome these problems, acrylic cages were developed for sleep monitoring which can minimize the interruption of cables and the artifacts. Principle of lever mechanics is applied to rotational cover of the cage, and it rotates vertically in synchronization with rat’s movement. When the rat stand up, the cage cover opens up to prevent the cable from loosening. Therefore, cable tension can be stably maintained, allowing the rat to move freely without causing artifact. As a result, long-term EEG and EMG recordings are successful performed, and specific characteristics of each sleep stages can be extracted due to the high-quality recorded signals. We expected that the developed sleep monitoring setup can be applied to various long-term in vivo experiments with rats.
( Young Chang ),( Hyoyoung Lee ),( Junsik Yoon ),( Sunwoong Lee ),( Sung-won Chung ),( Minsuk Lee ),( Yunbin Lee ),( Eun Ju Cho ),( Jeong-hoon Lee ),( Su Jong Yu ),( Yoon Jun Kim ),( Jung-hwan Yoon ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Sorafenib treatment is regarded as a first-line chemotherapy in patients with advanced hepatocellular carcinoma (HCC), although most patients are refractory to this drug. In this study, we aimed to establish Sorafenib-resistant HCC cell line and explore various signals involved in cell survival in order to investigate the mechanism of Sorafenib resistance in HCC. Methods: Huh7-Sorafenib resistant (SR) HCC cell line was established by culturing Huh7 HCC cells in increasing doses of Sorafenib. Gene expression, cell proliferation, and protein expression were determined by RT-PCR, MTS assay and Western blot. To identify the role of each signaling involved in Sorafenib resistance, cells were treated with LCL161 (a second mitochondria-derived activator of caspases (Smac) mimetic) and/or lysine demethylase 3A (KDM3A)-specific small interfering RNA (siRNA), or p21-specific siRNA. Results: Huh7-SR cells exhibited lower gene and protein expression of Smac than Huh7 cells. Sorafenib sensitivity of Huh7- SR cells as well as Huh7 cells was increased with LCL161, and the Sorafenib sensitizing effect of LCL161 was more potent in Huh7-SR cells than in Huh7 cells. KDM3A gene expression was higher in Huh7-SR cells than in Huh7 cells. Huh7-SR cells demonstrated improved sensitivity to Sorafenib following siRNA-mediated KDM3A knockdown. Moreover, Sorafenib sensitivity was further increased after KDM3A knockdown in combination with LCL161 treatment. Huh7-SR cells showed increased expression of p21 compared to Huh7 cells. Proliferation of Huh7-SR cells was markedly decreased with Sorafenib treatment after p21 knockdown, although there was no change in the antitumor effect of Sorafenib before and after p21 knockdown in Huh7 cells. Conclusions: Smac, KDM3A and p21 are involved in Sorafenib resistance mechanism in HCCs, which might be new therapeutic targets to overcome Sorafenib resistance.
이윤빈(Yunbin Lee),윤소미(Somi Yun),정민기(Min Gi Jung),임다혜(Dahye Lim),황은진(Eunjin Hwang),이대택(Dae Taek Lee),임승찬(Seung chan Lim) 인문사회과학기술융합학회 2019 예술인문사회융합멀티미디어논문지 Vol.9 No.6
본 연구는 가상현실(virtual reality: VR)을 접목한 학교체육수업을 기존의 학교체육수업(physical education class: Gym)과 비교하여 신체활동에 요구된 에너지소비량(energy expenditure: EE)을 분석하고, VR을 활용한 학교체육수업이 신체활동량을 높일 수 있는 수단으로써 활용가능성을 제시하고자 한다. VR과 Gym의 EE를 비교하기 위해, 초등학생 70명(남·여, 나이 11.8±0.8 세, 신장 146.4±7.2 cm, 체중 40.0±9.9 kg, BMI 18.6±3.6 kg/m2)을 대상으로 VR과 Gym의 활동을 촬영하였다. 활동적인 동작을 선별하고, 대사당량을 부여하여 EE를 산출하였다. 각 체육수업과 성별의 차이를 확인하기 위해 일원분산분석을 사용하였으며, VR과 Gym의 EE의 차이는 t검정을 이용하였다. EE의 차이는 VR의 3.5±0.9 kcal/min과 비교하여 Gym의 4.1±1.1 kcal/min에서 평균적으로 유의하게 높았다(p<.05). 성별의 경우 VR과 Gym모두 여아동과 비교하여, 남아동에서 EE가 높게 나타났으나(p<.01), Gym의 여아동과 VR의 남아동에서 Gym의 여아동의 EE가 높게 나타났다(p<.01). VR은 Gym 보다 평균적인 EE가 낮게 평가 되었으나, 걷기, 공부, 수면과 같은 일반적인 신체활동과 비교하여 높은 EE를 소비하는 것으로 신체활동을 높일 수 있는 체육수업으로 활용가능성을 보였다. This study compared the energy expenditure (EE) of physical education (PE) classes during application of virtual reality (VR) module to conventional PE classes occurred in Gymnasium (Gym). This study evaluated whether PE class with VR can be a potential substitute for the conventional PE class to promote physical activity. To compare EE between VR and Gym, 70 elementary school boys and girls (11.8±0.8 yrs old, height 146.4±7.2 cm, weight 40.0±9.9 kg, BMI 18.6±3.6 kg/m2) were video taped during their VR and Gym classes. From the tapes, their activity levels were categorized and metabolic equivalents were given for estimating EE. To compare sex differences during each class, one-way ANOVA with repeated measures were employed and, differences between VR and Gym were compared using independent t-test. The average EE in VR (3.5±0.9 kcal/min) was higher than that in Gym (4.1±1.1 kcal/min) (p<.05). The EE of boys were higher than that of girls in both VR and Gym (p<.01), but the EE of girls in Gym appeared to be higher than that of boys in VR (p<.01). Although EE in VR was less than EE in Gym, EE of VR showed a potential substitute of PE class promoting physical activity level since its EE was higher than daily prevalent physical activities such as walking, studying and sleeping.