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Combination of honokiol and magnolol inhibits hepatic steatosis through AMPK-SREBP-1 c pathway
Lee, Ju-Hee,Jung, Ji Yun,Jang, Eun Jeong,Jegal, Kyung Hwan,Moon, Soo Young,Ku, Sae Kwang,Kang, Seung Ho,Cho, Il Je,Park, Sook Jahr,Lee, Jong Rok,Zhao, Rong Jie,Kim, Sang Chan,Kim, Young Woo SAGE Publications 2015 Experimental biology and medicine Vol.240 No.4
Radiotherapy diagnostic biomarkers in radioresistant human H460 lung cancer stem-like cells
Yun, Hong Shik,Baek, Jeong-Hwa,Yim, Ji-Hye,Um, Hong-Duck,Park, Jong Kuk,Song, Jie-Young,Park, In-Chul,Kim, Jae-Sung,Lee, Su-Jae,Lee, Chang-Woo,Hwang, Sang-Gu TaylorFrancis 2016 Cancer Biology & Therapy Vol.17 No.2
<P><B>ABSTRACT</B></P><P>Tumor cell radioresistance is a major contributor to radiotherapy failure, highlighting the importance of identifying predictive biomarkers for radioresistance. In this work, we established a radioresistant H460 (RR-H460) cell line from parental radiosensitive H460 lung cancer cells by exposure to fractionated radiation. The radiation-resistant, anti-apoptotic phenotype of RR-H460 cell lines was confirmed by their enhanced clonogenic survival and increased expression of the radioresistance genes Hsp90 and Her-3. RR-H460 cells displayed characteristics of cancer stem-like cells (CSCs), including induction of the surface marker CD44 and stem cell markers Nanog, Oct4, and Sox2. RR-H460 cells also exhibited sphere formation and malignant behavior, further supporting a CSC phenotype. Using proteomic analyses, we identified 8 proteins that were up-regulated in RR-H460 CSC lines and therefore potentially involved in radioresistance and CSC-related biological processes. Notably, 4 of these—PAI-2, NOMO2, KLC4, and PLOD3—have not been previously linked to radioresistance. Depletion of these individual genes sensitized RR-H460 cells to radiotoxicity and additively enhancing radiation-induced apoptosis. Our findings suggest the possibility of integrating molecular targeted therapy with radiotherapy as a strategy for resolving the radioresistance of lung tumors.</P>
Lee, Yong-Soon,Park, Jin-Sung,Che, Jeong-Hwan,Li, Guang-Xun,Kim, Tea-Won,Kim, Hyung-Sub,Park, Jie-Eun,Yun, Jun-Won,Kang, Kyung-Sun Korean Society of ToxicologyKorea Environmental Mu 2000 Toxicological Research Vol.16 No.1
Acute oral, intramuscluar, and intravenous toxicity studies of recombinant human interferon $\alpha$2$\alpha$(rhIFN $\alpha$2$\alpha$) were performed in Sprague-Dawley (SD) rats. SD rats were administered with doses of 31.25, 62.5, 125, 250 and 500 MIU/kg, respectively, and clinical signs, mortality and body weight changes were observed for 2 weeks. In all animals administered with rhIFN $\alpha$2$\alpha$, there was neither dead animals nor significant changes of body weights. In addition, no differences were found between control and treated groups in clinical signs and autopsy findings. Therefore, $LD_{50}$ of rhIFN $\alpha$2$\alpha$ was considered to be higher than 500 MIU/kg in SD rats.
Chao-Jie Wang,Yun-Suhk Suh,Hyuk-Joon Lee,Ji-Hyeon Park,Shin-Hoo Park,Jong-Ho Choi,Fadhel Alzahrani,Khalid Alzahrani,Seong-Ho Kong,Do-Joong Park,Hui Cao,Han-Kwang Yang 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.103 No.1
Purpose: The European Organization for Research and Treatment of Cancer quality of life (QOL) questionnaires (QLQ-C30, QLQ-OG25, and QLQ-STO22) are widely used for the assessment of gastric cancer patients. This study aimed to use these questionnaires to evaluate QOL in postgastrectomy patients. Methods: We prospectively evaluated 106 patients with distal gastrectomy (DG), 57 with pylorus-preserving gastrectomy (PPG), and 117 with total gastrectomy (TG). Body weight and QOL questionnaires were evaluated preoperatively and postoperatively (at 3 weeks, and 3, 6, and 12 months). Results: TG patients had significantly more weight loss than DG/PPG patients. Compared with DG, patients after PPG had less dyspnea (P = 0.008) and trouble with coughing (P = 0.049), but more severe symptoms of insomnia (P = 0.037) and reflux (P = 0.030) at postoperative 12 months. Compared with DG/PPG, TG was associated with worse body image, dysphagia, eating, and taste in both OG25 and STO22. Moreover, OG25 revealed worse QOL in the TG group with respect to odynophagia, eating with others, choked when swallowing, trouble talking, and weight loss. The QOL of patients who received chemotherapy was worse than those in the chemo-free group in both physical functioning and symptoms such as nausea/vomiting, appetite loss, and trouble with taste; however, these side effects would soon disappear after finishing chemotherapy. Conclusion: PPG was similar to DG in terms of postoperative QOL and maintaining body weight, while TG was always inferior to both DG and PPG. Adjuvant chemotherapy can affect both body weight and QOL despite being reversible.
이지영(Jie Young Lee),안영화(Young Hwa An),윤석창(Suck Chang Yun),원동호(Dong Ho Won),김병찬(Byung Chan Kim) 한국정보과학회 1988 정보과학회논문지 Vol.15 No.1
본 논문에서는 유리수 상에서의 RSA공개Key 암호방식을 2차체 상에서의 RSA공개Key 암호방식으로 확장한 새로운 공개Key 암호방식을 제안하여 구체적인 예를 들어 확인하고, 그 타당성을 증명하였다. 이 암호방식은 2차체 상에서 서로 상이한 소(prime) ideal [p, q]을 선택하여 암호화 Key와 복호화Key를 구하고, 이것을 사용하여 암호화 및 복호화를 수행하므로써, 공개Key 암호계구성의 근본이 되는 파라메터 p, q의 선택폭을 넓혔다. In this paper, we propose a new method for constructing the Public-key Cryptosystem which is extended the RSA cryptosystem over quadratic field, and verify the new Public-key Cryptosystem with some examples. For our method, we select each different prime ideals [p, q] over quadratic field, and using this result, the encryption key and the decryption key are made. So a number of pameters p.q which we can select is increased.
김지관 ( Jie-kwan Kim ),이윤홍 ( Yun-hong Lee ),이상용 ( Sang-yong Rhee ) 대한설비관리학회 2017 대한설비관리학회지 Vol.22 No.1
In software, the function and usability of the product are the top priority but the quality of the software including all of these factors is the most important factor in the life cycle of the software. Especially, the software market has grown explosively since 2002 when system intelligence has been launched in earnest, and will become a bigger market after 2020 when the fourth industrial revolution is expected to start. The use of such software will be even higher in the Fourth Industrial Revolution and it will surely be the determining factor for the completion of the Fourth Industrial Revolution. Therefore, increasing the quality capability of software has become a pending issue in industry not just software. Unlike the emphasis on the importance of software, building a systematic software quality management system and a quantitative software development management system is delayed due to cost problems. Also, the perception of system users` quality of software is not analyzed accurately. In this paper, we analyze the quality characteristics of software and propose improvement of quality capability of software by comparing and analyzing cases of improving quality competitiveness of domestic and foreign companies.