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이상현(Sang-Hyun Lee),박진민(Jin-Min Park),문상필(Sang-Pil Mun),서기영(Ki-Young Suh) 한국조명·전기설비학회 2003 한국조명·전기설비학회 학술대회논문집 Vol.2003 No.-
For small capacity rectifier circuits such as these for consumer electronics and appliances, capacitor input type rectifier circuits are generally used. Consequently, various harmonics generated within the power system become a serious problem. Various studies of this effect have been presented previously. However, most of these employ switching devices, such as FETs and the like. The absence of switching devices makes systems more tolerant to over-load, and brings low radio noise benefits. We propose a power factor correction scheme using a LC resonant in commercial frequency without switching devices. In this method, it makes a sinusoidal wave by widening conduction period using the current resonance in commercial frequency, Hence the harmonic characteristics can be significantly improved, where the lower order harmonics, such as the fifth and seventh order are much reduced. The result are confirmed by the theoretical and experiment implementations.
( Nae Yun Heo ),( Young Suk Lim ),( Woochang Lee ),( Minkyung Oh ),( Jiyun An ),( Dan Bi Lee ),( Ju Hyun Shim ),( Kang Mo Kim ),( Han Chu Lee ),( Yung Sang Lee ),( Dong Jin Suh2 ) 대한간학회 2014 Clinical and Molecular Hepatology(대한간학회지) Vol.20 No.2
Background/Aims: There are few available data regarding the association between the single nucleotide polymorphisms (SNPs) of the gene encoding interleukin 28B (IL28B) and a sustained virologic response (SVR) to peginterferon (PEG-IFN) plus ribavirin (RBV) therapy in Korean chronic hepatitis C patients. Methods: This was a retrospective cohort study of 156 patients with chronic hepatitis C virus (HCV) infection who received combination treatment of PEG-IFN plus RBV. Blood samples from these patients were analyzed to identify the IL28B SNPs at rs12979860, rs12980275, rs8099917, and rs8103142. Association analyses were performed to evaluate the relationships between each IL28B SNP and SVRs. Results: Seventy six patients with HCV genotype 1 and 80 with genotype non-1 were enrolled. The frequencies of rs12979860 CC and CT genotypes were 90.4% and 9.6%, respectively; those of rs12980275 AA and AG genotypes were 87.2% and 12.8%, respectively; those of rs8099917 TT and TG genotypes were 92.3% and 7.7%, respectively; and those of rs8103142 TT and CT genotypes were 90.4% and 9.6%, respectively. Among the patients with HCV genotype 1, the SVR rates were 69.7% and 80.0% for rs12979860 CC and CT, respectively (P=0.71). Among the HCV genotype non-1 patients, SVR rates were 88.0% and 100% for rs12979860 CC and CT (P=1.00), respectively. Conclusions: Genotypes of the IL28B SNP that are known to be favorable were present in most of the Korean patients with chronic hepatitis C in this study. Moreover, the IL28B SNP did not influence the SVR rate in either the HCV genotype 1 or non-1 patients. Therefore, IL28B SNP analysis might be not useful for the initial assessment, prediction of treatment outcomes, or treatment decision-making of Korean chronic hepatitis C patients. (Clin Mol Hepatol 2014;20:177-184)
( Young-sun Lee ),( Ji Hoon Kim ),( Yang Jae Yoo ),( Jihye Je ),( Sang Jun Suh ),( Young Kul Jung ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Jong Eun Yeon ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: The role of systemic cytotoxic chemotherapy has not to be elucidated in patients with advanced hepatocellular carcinoma (HCC) after sorafenib failure. We analyzed clinical outcomes of patients who received systemic cytotoxic chemotherapy after sorafenib failure. Methods: Between 2007 and 2015, there were 47 advanced HCC patients treated with systemic chemotherapy after sorafenib at Korea University Guro hospital. The most common regimen was doxorubicin, cisplatin and capecitabine containing regimen (87.2%). Data for each patient was collected retrospectively including demographic, laboratory, clinical, treatment and survival data. Tumor response was assessed by RECIST version 1.1. Overall survival and progression free survival were analyzed through Kaplan-Meier curve. Results: In baseline characteristics, chronic hepatitis B (76.6%) was main etiologic factor in development of HCC. ECOG performance status 0 and 1 were 29.8% and 68.1%. 85.4% of patients were Child-Pugh class A. 40 patients (85.4%) had distant metastasis and lung was the most frequent metastatic organ (26 patients). Patients with portal vein invasion were 20 (42.5%). During follow up, 33 patients were died and overall median survival was 9.8 months (95% CI, 6.0-13.6). The median progression-free survival was 6.0 months (95% CI, 4.6-7.4). In analysis of best response rate, no patient had CR, 10 patients had PR (21.3%), 14 patients had SD (29.8%), and 16 patients had PD (34.0%). The overall objective response rate was 21.3% and the disease control rate was 51.1%. Conclusions: In this study, systemic cytotoxic chemotherapy showed favorable response. Therefore, systemic cytotoxic chemotherapy could be considered in patients with hepatocellular carcinoma after sorafenib failure in present situation that there is no option for second- line therapy.
Diagnosis and Treatment of Lupus Nephritis: Survey Results on Four Important Issues
( Young Bin Joo ),( Yoon Kyoung Sung ),( Yong Beom Park ),( Chang Hee Suh ),( Seung Cheol Shim ),( Young Ho Lee ),( Ji Soo Lee ),( Hye Soon Lee ),( Hoon Suk Cha ),( Sang Cheol Bae ) 대한류마티스학회 2013 대한류마티스학회지 Vol.20 No.3
Objectives. To investigate the perception of and treatment pattern with regard to the four important issues in the management of lupus nephritis (LN), and to identify which parts of the LN treatment are difficult for physicians to carry out in clinical practice. Methods. Four steps were carried out: pre-survey, LN symposium, post-survey, and meeting after the symposium.The two surveys were conducted with the same contents regarding renal biopsy, induction and maintenance treatment for class III and IV LN, and treatment for class V LN. The results of the first survey and the changes in opinion reflected in the second survey were comparatively analyzed. Results. In the first survey, most of the respondent physicians replied that they would immediately conduct biopsy in the case of significant proteinuria. For the induction treatment of class III and IV LN, most of the respondent physicians selected high-dose cyclophosphamide. Mycophenolate mofetil and steroid combination therapy were selected for the maintenance treatment, and tacrolimus for the treatment of class V LN. There was a controversy in the drug selection, however, especially on the maintenance treatment of class III and IV LN and on the treatment of non-responsive class V LN. Conclusion. Some discrepancies were found in the treatment of LN in the real world. Although no recommendation was made for Korean LN patients in this study, the study results will help physicians select the most reasonable treatment for Korean LN patients based on experts` experiences and objective evidence.
( Sung Won Lee ),( Hae Lim Lee ),( Jung Hyun Kwon ),( Jun Suh Lee ),( Young Chul Yoon ),( Yu Ri Shin ),( Hye Ji Kim ),( Eun Chung ),( Young Woon Kim ),( Jeong Won Jang ),( Soon Woo Nam ),( Nam Ik Han 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Intraoperative radiofrequency ablation (RFA) is one of the treatment options for hepatocellular carcinoma (HCC) patients with relatively poor liver function to undergo surgical resection or when percutaneous approach for RFA is not feasible due to the difficult location of the tumor. The aim of this study is to investigate the clinical outcomes of intraoperative RFA compared to surgical resection. Methods: A total of 76 consecutive patients who received either intraoperative RFA (n=23) or surgical resection (n=53) with curative intent at the Incheon St Mary``s hospital from June 2012 to September 2015 were enrolled. Disease free survival and overall survival rates were analyzed. Results: The median follow-up period was 20.1 months (range, 0.9-41.5). The mean baseline Model for End-Stage Liver Disease (MELD) score was higher in the RFA group compared to the resection group (11.5±4.7 vs. 7.8±1.5, p=0.001). The resection group consisted of larger tumors with the median diameter of 2.7cm (range, 1-16) compared to 2cm (range, 1-5) of the RFA group (p=0.002). However, there was no difference in the number of tumors and the tumor stage between the two groups. The disease free survival rates at 6 and 12 months were 81.6%, 74.8% in the RFA group and 92.2%, 86.2% in the resection group, respectively (p=0.256). The overall survival rates at one year were 91.3% in the RFA group and 94.3% in the resection group, respectively (p=0.635). In the RFA group, 5 patients (21.7%) received liver transplantation (LT) after median interval of 10.9 months (range, 9.2~26.4) since the intraoperative RFA. Conclusions: The patients who received intraoperative RFA presented with relatively poor liver function but the disease free survival and overall survival rates were non-inferior compared to the patients who underwent resection. Therefore, intraoperative RFA may be considered as a useful option for patients ineligible to percutaneous RFA and surgical resection, or as a bridge therapy before liver transplantation.
Synthesis of cis-disubstitude cyclohexane synthesis of cis-1-ethenyl-2-hydroxymethyl-cyclohexane
Suh, Young-Ger,Kim, Soon-Ai,Cho, Youn-Sang The Pharmaceutical Society of Korea 1990 Archives of Pharmacal Research Vol.13 No.2
The efficient synthetic routes to cis-1-ethenyl-2-hydroxymethyl-cyclohexane, an useful synthetic intermediate, have been described. Access to the cis-disubstituted cyclo hexane is gained through the Clasen rearrangment and selective DHP protection of diol respectively.
( Sang Jung Park ),( Yeon Seok Seo ),( Seung Woon Park ),( Han Ah Lee ),( Tae Hyung Kim ),( Sang Jun Suh ),( Young Kul Jung ),( Ji Hoon Kim ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Kwan Soo Byun ),( S 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Practice guidelines recommend endoscopic band ligation (EBL) for the treatment of bleeding from cardiac varices on lesser curvature side of the stomach (CVs). However, endoscopic variceal obturation (EVO) using cyanoacrylate has been reported more effective than EBL for fundal variceal bleeding and considering that the mucosa covering cardiac varices is more thickened than esophageal varices and being exposed to gastric acids or food materials continuously, EVO could be more effective than EBL for the treatment of bleeding from CVs. This study was performed to compare the efficacy between EVO and EBL for the treatment of bleeding from CVs. Methods: All patients who were treated EBL or EVO for bleeding from CVs were enrolled. The patients diagnosed with hepatocellular carcinoma or treated with endoscopic injection therapy were excluded. Results: A total of 77 patients treated with bleeding from CVs were enrolled. Age was 56.4±10.6 years and 67 patients (87.0%) were men. Fifty-one and 26 patients were treated with EBL and EVO, respectively. Hemostasis were achieved in 73 patients (94.8%). Hemostasis rates did not differ between EBL (47 patients, 92.2%) and EVO (26 patients, 100%) groups. Varices rebled in 13 patients during follow-up. Rebleeding rate was significantly higher in EBL group compared to EVO group (P=0.044). During follow-up, 12 patients died (10 in EBL group, 2 in EVO group). Mean survival time was 310.4±13.5 days, which did not differ between two groups (P=0.142). Conclusions: Hemostasis success rate and survival did not differ between the EBL and EVO groups. However, rebleeding rate was significantly lower in EVO group compared to EBL group. EVO could be better option for the treatment of bleeding from CVs on lesser curvature side of the stomach.
Exosome Derived from Palmitic Acid-treated Hepatocytes Activates Hepatic Stellate Cells
( Young-sun Lee ),( Eunjung Ko ),( Yang Jae Yoo ),( Jihye Je ),( Sang Jun Suh ),( Young Kul Jung ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Jong Eun Yeon ),( Kwan Soo Byun ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Although nonalcoholic fatty liver disease (NAFLD) is becoming dominant cause of chronic liver disease, the exact mechanism of progression from simple steatosis to nonalcoholic steatohepatitis (NASH) have yet to be elucidated. We aimed to investigate the role of exosome from lipid laden hepatocyte in the context of NAFLD progression in vitro. Methods: We isolated exosome from human hepatoma cell lines (Huh7 or HepG2) treated with palmitic acid (PA). Concentration of exosome was determined with exosome quantitation assay kit. LX-2 cells, human hepatic stellate cell (HSC) line, were treated with isolated exosome from PA treated cells. Fibrosis marker including transforming growth factor beta1 (TGF-b1), alpha-smooth muscle actin (a-SMA) and collagen type 1 alpha 1 (Col1a1) expression were measured. Results: Compare with controls, PA-treated hepatocytes significantly increased CD36 and exosome production (8.6 vs. 5.5 X 10^7 /μL, p <0.01). When LX-2 cells were cultured with exosome from hepatocytes, TGF-β1, α-SMA, and Col1a1 expression in LX-2 cells were significantly increased compared to control. Moreover, exosome from PA-treated hepatocytes more increased the expression levels of fibrosis markers. High concentration of exosome (100 μg/mL) more increased the expression levels of fibrosis markers compared to low concentration of exosome (50 μg/mL). Conclusions: Palmitic acid treatment enhanced the production of exosome in hepatocytes. Exosomes derived from palmitic acid-treated hepatocytes increased expression levels of fibrotic genes in HSCs. Therefore, exosome might have important roles for crosstalk between hepatocytes and HSCs in the progression to NASH from simple steatosis.
A Literature Survey on Warranty Policies
Suh, Young-Sung,Park, Young-Taek,Son, Eun-Il The Korean Society for Quality Management 1996 품질경영학회지 Vol.24 No.2
Estimation of warranty costs is an important application area of reliability engineering. On the manufacturer's point of view, exact estimation of warranty costs helps decisions on budgeting, product pricing, and A/S capacity planning, etc. We reviewed the state-of-the-art of existing models on warranty policies and suggested some future research directions.