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Fu You Fu,Lie Zhao Liu,You Rong Chai,Li Chen,Tao Yang,Ai Fen Ma,Cun Ming Qu,Lin Jiang,Zheng Sheng Zhang,Jia Na Li 한국유전학회 2007 Genes & Genomics Vol.29 No.3
Husk proportion (HP) and lignin content (LC) are two important traits of seed quality of B. napus. Efficient selection of these two traits is an important way to improve the seed quality in meal improvement. A set of recombinant inbred lines (RILs) of B. napus (GH06 × Zhongyou 821) was used for mapping QTLs of HP and LC in a two-year study in different environments. 509 markers (78 SSR markers, 66 RAPD markers and 365 SRAP markers) were mapped on 26 linkage groups with an average length of 73.96 cM. The map covered a total of 1923 cM, and the average distance between two adjacent markers was 3.78 cM. Analysis of variance of LC and HP indicated that. LC might not be significantly affected by environment (F = 2.96 < 3.02) and HP might be affected by genotype × environment interactions. A total of 15 significant QTLs were detected in eight linkage groups with a LOD threshold value of 2.5 (LR ≥ 11.5) by CIM, explaining 4.99-16.14% of phenotype variation. Some QTLs of LC and HP were detected in near regions of the same linkage groups, such as qLCBB05-6-1 and qLCWZ06-6-1, qLCBB05-10-2 and qLCBB06-10-1 and qLCWZ06-10-2, qHPBB05-9-3 and qHPBB06-9-1, qHPBB05-10-4 and qHPBB06-10-2 and qHPBB06-10-3 and qHPWZ06-10-1. This study indicates that the repeatedly detected QTLs of LC and HP might be major-effect QTLs of LC and HP.
You-Fu Yang,Lin-Hai Han 국제구조공학회 2006 Steel and Composite Structures, An International J Vol.6 No.3
The behaviour of hollow structural steel (HSS) stub columns and beams filled with normal concrete and recycled aggregate concrete (RAC) under instantaneous loading was investigated experimentally. A total of 40 specimens, including 30 stub columns and 10 beams, were tested. The main parameters varied in the tests were: (1) recycled coarse aggregate (RCA) replacement ratio, from 0 to 50%, (2) sectional type, circular and square. The main objectives of these tests were threefold: first, to describe a series of tests on new composite columns; second, to analyze the influence of RCA replacement ratio on the compressive and flexural behaviour of recycled aggregate concrete filled steel tubes (RACFST), and finally, to compare the accuracy of the predicted ultimate strength, bending moment capacity and flexural stiffness of the composite specimens by using the recommendations of ACI318-99 (1999), AIJ (1997), AISC-LRFD (1999), BS5400 (1979), DBJ13-51-2003 (2003) and EC4 (1994).
You-Fu Yang 국제구조공학회 2015 Steel and Composite Structures, An International J Vol.18 No.1
A nonlinear finite element analysis (FEA) model is presented for simulating the behaviour of recycled aggregate concrete-filled steel tube (RACFST) beam-columns subjected to constant axial compressive load and cyclically increasing flexural loading. The FEA model was developed based on ABAQUS software package and a displacement-based approach was used. The proposed engineering stress versus engineering strain relationship of core concrete with the effect of recycled coarse aggregate (RCA) replacement ratio was adopted in the FEA model. The predicted results of the FEA model were compared with the experimental results of several RACFST as well as the corresponding concrete-filled steel tube (CFST) beam-columns under cyclic loading reported in the literature. The comparison results indicated that the proposed FEA model was capable of predicting the load versus deformation relationship, lateral bearing capacity and failure pattern of RACFST beam-columns with an acceptable accuracy. A parametric study was further carried out to investigate the effect of typical parameters on the mechanism of RACFST beam-columns subjected to cyclic loading.
Recycled aggregate concrete filled steel SHS beam-columns subjected to cyclic loading
You-Fu Yang,Lin-Tao Zhu 국제구조공학회 2009 Steel and Composite Structures, An International J Vol.9 No.1
The present paper provides test data to evaluate the seismic performance of recycled aggregate concrete (RAC) filled steel square hollow section (SHS) beam-columns. Fifteen specimens, including 12 RAC filled steel tubular (RACFST) columns and 3 reference conventional concrete filled steel tubular (CFST) columns, were tested under reversed cyclic flexural loading while subjected to constant axially compressive load. The test parameters include: (1) axial load level (n), from 0.05 to 0.47; and (2) recycled coarse aggregate replacement ratio (r), from 0 to 50%. It was found that, generally, the seismic performance of RACFST columns was similar to that of the reference conventional CFST columns, and RACFST columns exhibited high levels of bearing capacity and ductility. Comparisons are made with predicted RACFST beam-column bearing capacities and flexural stiffness using current design codes. A theoretical model for conventional CFST beam-columns is employed in this paper for square RACFST beam-columns. The predicted load versus deformation hysteretic curves are found to exhibit satisfactory agreement with test results.
Yang-soo Yoon,Aiguo Liu,You-Ree Shin,Jae-sook Gho,Candace Hicks,Qian-Jie Fu,Allison Coltisor 한국언어재활사협회 2016 Clinical Archives of Communication Disorders Vol.1 No.1
Purpose: The present study used the acoustic simulation of bilateral cochlear implants to investigate the effect of presentation level (EXP 1) and channel interaction (EXP 2) on binaural summation benefit in speech recognition. Methods: The acoustic 6-channel processors were constructed, and the envelope of each band was used to modulate a sinusoid (EXP 1) or band-pass filtered white noise (EXP 2) with a frequency matching the center frequency of the carrier band. Presentation level was fixed for one ear and varied for the other. Channel interaction was simulated by altering filter slopes while keeping interaural spectral peaks matched in the carrier bands. Two separate groups of ten adult subjects with normal hearing participated in EXP 1 and EXP 2. Sentence recognition was measured with left ear alone, right ear alone, and both ears in quiet and in noise at +5 dB signal-to-noise ratio. Results: A significant binaural summation benefit occurs only in noise, regardless of interaural mismatch in channel interactions and presentation levels. Conclusions: Results suggest that factors other than channel interaction are important and that matching interaural loudness is an unimportant factor in binaural summation benefit in noise. For both EXP 1 and EXP 2, the data trend is indicative of speech information perceived in quiet being fully coded by the better performing ear alone, which leads to no binaural summation benefit. The results of current and future studies could have implications in programming of bilateral cochlear implant users.
You-en Zhang,Jia-ning Wang,Jun-ming Tang,Ling-yun Guo,Jian-ye Yang,Yong-zhang Huang,Yan Tan,Shou-zhi Fu,Xia Kong,Fei Zheng 한국분자세포생물학회 2009 Molecules and cells Vol.27 No.2
Myocardial ischemia-reperfusion injury is a medical problem occurring as damage to the myocardium following blood flow restoration after a critical period of coronary occlusion. Oxygen free radicals (OFR) are implicated in reperfusion injury after myocardial ischemia. The antioxidant enzyme, Cu, Zn-superoxide dismutase (Cu, Zn-SOD, also called SOD1) is one of the major means by which cells counteract the deleterious effects of OFR after ischemia. Recently, we reported that a PEP-1-SOD1 fusion protein was efficiently delivered into cultured cells and isolated rat hearts with ischemia-reperfusion injury. In the present study, we investigated the protective effects of the PEP-1-SOD1 fusion protein after ischemic insult. Immunofluorescecnce analysis revealed that the expressed and purified PEP-1-SOD1 fusion protein injected into rat tail veins was efficiently transduced into the myocardium with its native protein structure intact. When injected into Sprague-Dawley rat tail veins, the PEP-1-SOD1 fusion protein significantly attenuated myocardial ischemia-reperfusion damage; characterized by improving cardiac function of the left ventricle, decreasing infarct size, reducing the level of malondialdehyde (MDA), decreasing the release of creatine kinase (CK) and lactate dehydrogenase (LDH), and relieving cardiomyocyte apoptosis. These results suggest that the biologically active intact forms of PEP-1-SOD1 fusion protein will provide an efficient strategy for therapeutic delivery in various diseases related to SOD1 or to OFR.
Two Androstane Derivatives from the Cultures of Fungus Marasmiellus ramealis (Bull.) Singer
Yang, Ning-Ning,Ma, Qing-Yun,Huang, Sheng-Zhuo,Dai, Hao-Fu,Guo, Zhi-Kai,Yu, Zhi-Fang,Zhao, You-Xing Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.11
A new androstane derivative, $4{\beta}$-methyl-15-oxa-$14{\beta}$-androstane-7-ene-$4{\alpha}$-carboxylic acid (1) and a known one $4{\beta}$-methyl-15-oxa-$14{\beta}$-androstane-7-ene-$4{\alpha}$-hydroxyl (2) were isolated from the EtOAc extract of the cultures of the fungus Marasmiellus ramealis (Bull.) Singer. Their structures were elucidated on the basis of 1D and 2D NMR as well as MS spectroscopic data analysis. The inhibitory activity of two isolates against acetylcholinesterase (AChE) revealed that compound 1 exhibited definitely inhibitory activity.
Luo, You,She, Dong-Li,Xiong, Hu,Fu, Sheng-Jun,Yang, Li Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14
Purpose: To evaluate and update evidence for prognostic effects of kidney-sparing (KS) management and nephroureterectomy (NU) for upper tract urothelial carcinomas. Materials and Methods: Pubmed, Embase and the Cochrane Library were retrieved for the identification of comparative studies of kidney-sparing procedure and nephroureterectomy for upper tract urothelial carcinoma prior to December 2014. The data were extracted independently by 2 reviewers and the quality of the included studies was assessed. Review Manager 5.3 and STATA 13 were used to perform the meta-analysis. Results: Twenty-three observational studies including 1,587 KS and 3,996 NU were evaluated. The results of the meta-analysis showed that nephroureterectomy had no significant benefit with regard to intravesical recurrence (IRFS), metastasis (MFS), cancer specific survival (CSS) and overall survival (OS) except the total tumor recurrence (RFS) when compared with kidney sparing management. The respectively pooled outcomes were HR 1.36 (0.69-2.68, P=0.38) for IRFS, 1.09 (0.59-2.01, P=0.78) for MFS, 1.17 (0.77-1.79, P=0.47) for CSS, 1.50 (0.90-2.48, P=0.12) for OS and 1.61 (1.03-2.51, P=0.04) for RFS. Conclusions: On the whole, kidney-sparing management had equivalent prognostic effect on upper tract urothelial carcinoma as the standard nephroureterectomy except in tumor recurrence. However, the results should be interpreted with caution for lack of stage and grade stratification and multi-center randomized controlled trials are still needed to verify our results.