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Non-Hydrostatic Model of Near Shore Flow Calculation
Yoon, Bum-Sang,Park, Chul-Woo The Korean Association of Ocean Science and Techno 2006 Journal of Ocean Science and Technology Vol.3 No.1
In this paper, the fractional step approach is applied to calculation of flow in near shore area with complicated boundary shape in order to consider non-hydrostatic pressure induced by geometrical irregularities at the boundaries. At a time instant, intermediate solutions for flow velocities and free surface are obtained through the hydrostatic multi-layer calculation in the first step, and non-hydrostatic pressure field is predicted using the intermediate solutions in the second step. In the third step, final solutions are calculated considering not only hydrostatic pressure but also non-hydrostatic pressure. Present calculation algorithm with fully explicit finite difference scheme in ${\sigma}$a-coordinate is successfully applied to the near shore flow calculation. Hydrostatic model is thought practically good tool enough to predict general ocean circulation problems. However, effects of non-hydrostatic pressure on flow field and free surface movements are to be emphasized, not negligible, in the vicinity of irregularities both of continental and bottom boundaries. Present method can be applied to the mesoscale free surface flows with complex bottom topography where MAC-like 3-d hydrodynamic calculations are quite ineffective and uneconomic.
Bioactive Non-Woven Silica Fabric Made Through Electro-Spinning Method
Yoon, Hanna,Lee, Yong Keun,Lim, Bum Soon,Rhee, Sang Hoon Trans Tech Publications, Ltd. 2006 Key Engineering Materials Vol.309 No.-
<P>Non-woven silica fabric was made by electro-spinning method for the application as a bone grafting material. The silica gel, the source material for electro-spinning, was prepared by the hydrolysis of tetraethyl orthosilicate in the presence of water, hydrochloric acid and ethanol. It was transferred to a syringe (spinneret), which was connected to the high voltage supply generating a high electric field between the spinneret and the ground collecting drum. The silica fibers were spun under the electric field of 2 KV/cm. Their diameters were in the range from about 100 nm to 5 µm. After soaking in the SBF for 4 week, low crystalline apatite crystals were observed to occur partly on their surfaces. From the results, it can be concluded that the non-woven silica fabric made by electro-spinning method has the apatite forming ability in the SBF and it means it has a potential to be used as a bone grafting material because of its apatite-forming ability, high surface area to volume ratio and high porosity. </P>
Yoon, Hye Eun,Hyoung, Bok Jin,Hwang, Hyeon Seok,Lee, So Young,Jeon, Youn Joo,Song, Joon Chang,Oh, Eun-Jee,Park, Sun Cheol,Choi, Bum Soon,Moon, In Sung,Kim, Yong Soo,Yang, Chul Woo The Korean Academy of Medical Sciences 2009 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.24 No.suppl
<P>Intravenous immunoglobulin (IVIG) and/or plasmapheresis (PP) are effective in preventing antibody-mediated rejection (AMR) of kidney allografts, but AMR is still a problem. This study reports our experience in living donor renal transplantation in highly sensitized patients. Ten patients with positive crossmatch tests or high levels of panel-reactive antibody (PRA) were included. Eight patients were desensitized with pretransplant PP and low dose IVIG, and two were additionally treated with rituximab. Allograft function, number of acute rejection (AR) episodes, protocol biopsy findings, and the presence of donor-specific antibody (DSA) were evaluated. With PP/IVIG, six out of eight patients showed good graft function without AR episodes. Protocol biopsies revealed no evidence of tissue injury or C4d deposits. Of two patients with AR, one was successfully treated with PP/IVIG, but the other lost graft function due to de novo production of DSA. Thereafter, rituximab was added to PP/IVIG in two cases. Rituximab gradually decreased PRA levels and the percentage of peripheral CD20+ cells. DSA was undetectable and protocol biopsy showed no C4d deposits. The graft function was stable and there were no AR episodes. Conclusively, desensitization using PP/IVIG with or without rituximab increases the likelihood of successful living donor renal transplantation in sensitized recipients.</P>
Comparison of Two pMDIs in Adult Asthmatics: A Randomized Double-Blind Double-Dummy Clinical Trial
Sang Min Lee,Tae-Hyun Nam,Sung-Yoon Kang,Tae- Bum Kim,Sang Pyo Lee 대한결핵및호흡기학회 2022 Tuberculosis and Respiratory Diseases Vol.85 No.1
Background: Only a few studies directly compared the therapeutic efficacy and safety of two pressurized metereddoseinhalers (pMDIs) in asthma. We analyzed the asthma treatment outcomes, safety, and patient preferences usingformoterol/beclomethasone (FORM/BDP), a pMDI with extra-fine particles, compared with formoterol/budesonide(FORM/BUD), another pMDI with non-extra-fine particles. Methods: In this randomized, double-blind, double-dummy parallel group study, 40 adult asthmatics were randomized toFORM/BDP group (n=18; active FORM/BDP and placebo FORM/BUD) or FORM/BUD group (n=22; active FORM/BUDand placebo FORM/BDP). During the two visits (baseline and end of 8-week treatment), subjects were asked to answerquestionnaires including asthma control test (ACT), asthma control questionnaires (ACQ), and Quality of Life Questionnaire forAdult Korean Asthmatics (QLQAKA). Lung function, compliance with inhaler, and inhaler-handling skills were also assessed. Results: Ten subjects in the FORM/BDP group and 14 in the FORM/BUD group completed follow-up visits. ACT, ACQ,QLQAKA (a primary outcome), and adverse events did not differ between two groups. We found that the increase inforced expiratory volume in 1 second/forced vital capacity and forced expiratory flow at 25% to 75% of the pulmonaryvolume in the FORM/BDP group was higher than in the FORM/BUD group. Regarding preference, subjects respondedthat the flume velocity of FORM/BDP was higher, but more adequate than that of FORM/BUD. They also answered thatFORM/BDP reached the trachea and bronchus and irritated them significantly more than FORM/BUD. Conclusion: The use of pMDI with extra-fine particles may relieve small airway obstruction more than the one withnon-extra-fine particles despite no significant differences in overall treatment outcomes. Some asthmatics have amisconception about the adequacy of high flume velocity of pMDIs.
Yoon, Hoon-Seok,Hyun, Chang-Gu,Lee, Nam-Ho,Park, Sung-Soo,Shin, Dong-Bum The Korean Society of Food Science and Nutrition 2016 Preventive Nutrition and Food Science Vol.21 No.2
Previous research showed that resveratrol (trans-3,4',5-trihydroxystilbene) and pinostilbene (trans-3-methoxy-4',5-dihydroxystilbene) were able to inhibit tyrosinase directly; however, anti-melanogenic effects of pterostilbene (trans-3,5-dimethoxy-4'-hydroxystilbene) and resveratrol trimethyl ether (RTE) have not been compared. To investigate the hypopigmentation effects of pterostilbene and RTE, melanin contents and intracellular tyrosinase activity were determined by western blot analysis. Firstly, pterostilbene showed the inhibitory effects on ${\alpha}$-melanocyte stimulating hormone (MSH)-induced melanin synthesis stronger than RTE, resveratrol, and arbutin. Pterostilbene inhibited melanin biosynthesis in a dose-dependent manner in ${\alpha}$-MSH-stimulated B16/F10 murine melanoma cells. Specifically, melanin content and intracellular tyrosinase activity were inhibited by 63% and 58%, respectively, in response to treatment with $10{\mu}m$ of pterostilbene. The results of western blot analysis indicated that pterostilbene induced downregulation of tyrosinase protein expression and suppression of ${\alpha}$-MSH-stimulated melan-A protein expression stronger than RTE or resveratrol. Based on these results, our study suggests that pterostilbene can induce hypopigmentation effects more effectively than resveratrol and RTE, and it functions via downregulation of protein expression associated with hyperpigmentation in ${\alpha}$-MSH-triggered B16/F10 murine melanoma cells.
Endoscopic management of occluded metal biliary stents: metal versus 10F plastic stents.
Yoon, Won Jae,Ryu, Ji Kon,Lee, Jung Won,Ahn, Dong-Won,Kim, Yong-Tae,Yoon, Yong Bum,Woo, Sang Myung,Lee, Woo Jin WJG Press 2010 WORLD JOURNAL OF GASTROENTEROLOGY Vol.16 No.42
<P>To compare the efficacy of self-expandable metal stents (SEMSs) with 10F plastic stents (PSs) in the endoscopic management of occluded SEMSs.</P>
( Yoon-kyoung Sung ),( Soo-kyung Cho ),( Dam Kim ),( Soyoung Won ),( Chan-bum Choi ),( Tae-hwan Kim ),( Jae-bum Jun ),( Dae-hyun Yoo ),( Sang-cheol Bae ) 대한내과학회 2018 The Korean Journal of Internal Medicine Vol.33 No.5
Background/Aims: To evaluate the impact of isoniazid (INH) treatment for latent tuberculosis infection (LTBI) on the development of liver function test (LFT) abnormality and the persistence of tumor necrosis factor (TNF) inhibitors in rheumatoid arthritis (RA) patients. Methods: We retrospectively enrolled patients with RA who were treated with TNF inhibitors at a university hospital between December 2000 and November 2011. After dividing the patients into two groups based on the occurrence of LFT abnormality during follow-up, we compared demographic and clinical features between the two groups. A multivariable logistic regression analysis was performed to identify the impact of INH treatment on LFT abnormality. The impact of INH treatment on the persistence of TNF inhibitors was also evaluated with the log-rank test and the Cox-proportional hazards model. Results: A total of 312 RA patients including 96 patients (30.9%) who took INH for LTBI were included in this analysis. Thirty-nine patients (12.5%) experienced LFT abnormalities while using TNF inhibitors. The use of INH was associated with LFT abnormalities (odds ratio, 3.01; 95% confidence interval [CI], 1.39 to 6.48) after adjusting for covariates, including methotrexate use. However, the persistence of TNF inhibitors over 5 years did not differ between patients receiving or not receiving INH treatment (49.4 vs. 54.6%, p = 0.79). INH treatment was not a risk factor for discontinuation of TNF inhibitors (hazard ratio, 1.01; 95% CI, 0.66 to 1.57). Conclusion: INH treatment for LTBI in RA patients who started TNF inhibitors is associated with the occurrence of LFT abnormality; however, it does not lead to discontinuation of TNF inhibitors.
Multicentric Biatrial Myxoma in a Young Female Patient : Case Report
Sang Jeong Yoon,Soon Chang Park,Yun Pyo You,Bum Yong Kim,Myong Kon Kim,Kyung Tae Jeong,Jae Won Lee 대한내과학회 2000 The Korean Journal of Internal Medicine Vol.15 No.3
We report a case of multicentric, biatrial cardiac myxoma in a 29-year-old female who complained of exertional dyspnea, abdominal distension and peripheral edema. Any other associated skin lesions, breast mass or endocrine disorder presenting complex form