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Yoon, Pyoung Oh,Park, Jin Wook,Lee, Chang-Min,Kim, Sung Hwan,Kim, Han-Na,Ko, Youngho,Bae, Seon Joo,Yun, Sungil,Park, Jun Hong,Kwon, Taewoo,Kim, Woo Seok,Lee, Jiyoung,Lu, Qing,Kang, Hye-Ryun,Cho, Won-K American Society for Biochemistry and Molecular Bi 2016 The Journal of biological chemistry Vol.291 No.12
<P>The siRNA silencing approach has long been used as a method to regulate the expression of specific target genes in vitro and in vivo. However, the effectiveness of delivery and the nonspecific immune-stimulatory function of siRNA are the limiting factors for therapeutic applications of siRNAs. To overcome these limitations, we developed self-assembled micelle inhibitory RNA (SAMiRNA) nanoparticles made of individually biconjugated siRNAs with a hydrophilic polymer and lipid on their ends and characterized their stability, immune-stimulatory function, and in vivo silencing efficacy. SAMiRNAs form very stable nanoparticles with no significant degradation in size distribution and polydispersity index over 1 year. Overnight incubation of SAMiRNAs (3 m) on murine peripheral blood mononuclear cells did not cause any significant elaboration of innate immune cytokines such as TNF-, IL-12, or IL-6, whereas unmodified siRNAs or liposomes or liposome complexes significantly stimulated the expression of these cytokines. Last, the in vivo silencing efficacy of SAMiRNAs was evaluated by targeting amphiregulin and connective tissue growth factor in bleomycin or TGF- transgenic animal models of pulmonary fibrosis. Intratracheal or intravenous delivery two or three times of amphiregulin or connective tissue growth factor SAMiRNAs significantly reduced the bleomycin- or TGF--stimulated collagen accumulation in the lung and substantially restored the lung function of TGF- transgenic mice. This study demonstrates that SAMiRNA nanoparticle is a less toxic, stable siRNA silencing platform for efficient in vivo targeting of genes implicated in the pathogenesis of pulmonary fibrosis.</P>
Sintering and Consolidation of Silver Nanoparticles Printed on Polyimide Substrate Films
Yoon, Sang-Hwa,Lee, Jun-Ho,Lee, Pyoung-Chan,Nam, Jae-Do,Jung, Hyun-Chul,Oh, Yong-Soo,Kim, Tae-Sung,Lee, Young-Kwan The Polymer Society of Korea 2009 Macromolecular Research Vol.17 No.8
We investigated the sintering and consolidation phenomena of silver nanoparticles under various thermal treatment conditions when they were patterned by a contact printing technique on polyimide substrate films. The sintering of metastable silver nanoparticles commenced at 180 $^{\circ}C$, where the point necks were formed at the contact points of the nanoparticles to reduce the overall surface area and the overall surface energy. As the temperature was increased up to 250 $^{\circ}C$, silver atoms diffused from the grain boundaries at the intersections and continued to deposit on the interior surface of the pores, thereby filling up the remaining space. When the consolidation temperature exceeded 270 $^{\circ}C$, the capillary force between the spherical silver particles and polyimide flat surface induced the permanent deformation of the polyimide films, leaving crater-shaped indentation marks. The bonding force between the patterned silver metal and polyimide substrate was greatly increased by the heat treatment temperature and the mechanical interlocking by the metal particle indentation.
윤평원(Pyoung-Won Yoon),김동진(Dong-Jin Kim),한승오(Seung-Oh Han) 대한전자공학회 2017 대한전자공학회 학술대회 Vol.2017 No.6
In this study, we developed a game simulator that makes us enjoy snowboarding whenever and everwhere. Four springs were installed to the snowboard to rotate about roll and pitch areas. The motor, aligned to yaw axis, was used to realize the yaw rotation due to the estimated friction, which makes the gamer feel a sense of spinning. The tite was measured with a 3-axis accelerometer. Finally, virtual reality was added by adopting HMD.
PCB와 ACF를 이용한 77 GHz 슬롯 배열 안테나
윤평화(Pyoung-Hwa Yoon),권오윤(Oh-Yun Kwon),송림(Reem Song),김병성(Byung-Sung Kim) 한국전자파학회 2018 한국전자파학회논문지 Vol.29 No.10
본 논문은 인쇄기판을 금속 구조물에 접착하여 제작한 77 GHz 도파관 슬롯 배열 안테나의 성능 평가 결과를 제시한다. 77 GHz 도파관을 상판과 하부 구조체로 나누어 상판은 저가로 미세 슬롯 구현에 유리한 인쇄기판을 이용하여 제작하고, 하부 구조체는 금속 가공하여 제작한 후, ACF(Anisotropic Conductive Film)을 이용하여 접합하였다. 안테나 성능평가를 위해 1×16 슬롯 배열 안테나를 제안 방식으로 제작하고, 이득과 패턴을 측정하여 시뮬레이션 값과 비교하였다. 측정 결과, 이상적 접합 조건으로 시뮬레이션한 결과 대비 2.3~3.5 dB의 이득 저하가 나타났지만 패턴은 변화가 거의 없으며, 제안 방식을 이용하면 77 GHz에서 약 17 dBi의 이득의 슬롯 안테나를 저가로 간단히 제작할 수 있음을 확인하였다. This study presents the performance evaluation results of a 77-GHz waveguide slot array antenna that was fabricated by attaching a patterned printed circuit board(PCB) on a metal block. The 77-GHz waveguide was divided into a top plate and a bottom structure. The top plate was fabricated using a patterned PCB that can implement a fine slot at low cost. The top cover was then bonded to the bottom metal structure with a waveguide trough using anisotropic conductive film. For evaluating the antenna performance, a 1× 16 slot array antenna was fabricated using our proposed method and the gain and pattern were measured and compared with the simulation results. Though the measurement results demonstrate a reduction in gain of around 2.3~3.5 dB compared to the simulation results assuming ideal bonding conditions, the pattern hardly changed and the slot antenna with a gain of approximately 17 dBi at 77 GHz can be easily manufactured at a low cost using the proposed method.
Ho-Young Kim,임태연,Mi-Hyun Ahn,Pyoung-Oh Yoon,Soo-Ho Kim,이상한,Choon-Sik Park 한국분자세포생물학회 2008 Molecules and cells Vol.25 No.1
In a search for new molecular pathways associated with asthma, we performed an mRNA differential display analysis using total RNA extracted from the tracheal tissues of ovalbumin (OVA)-challenged mice and sham controls. cDNAs corresponding to mRNAs for which expression levels were altered by OVA-challenge were isolate and sequenced. Twenty-eight genes differentially expressed in sham and OVA challenged mice were identified. A GenBank BLAST homology search revealed that they were related to cytoskeleton remodeling, transcription, protein synthesis and modification, energy production, and cell growth and differentiation. Two were selected for further characterization. Up-regulation of both the perinatal skeletal myosin heavy chain (skMHC) and fast skeletal muscle myosin light chain (skMLC) genes was confirmed by RT-PCR of trachea tissue from OVA challenged mice. Overexpression of skMLC protein was observed in the smooth muscle layers of OVA-challenged mice by immunohistochemistry, and the surface areas stained with skMLC antibody increased in the OVA-challenged mice. The overexpression of skMLC in murine asthma may be associated with the changes of bronchial smooth muscle.