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Yingli Yu,MinWang,Rongchang Chen,Xiao Sun,Guibo Sun,Xiaobo Sun 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.6
Background: Effective strategies are dramatically needed to prevent and improve the recovery frommyocardialischemia and reperfusion (I/R) injury. Direct interactions between the mitochondria and endoplasmic reticulum(ER) during heart diseases have been recently investigated. This study was designed to explore the cardioprotectiveeffects of gypenoside XVII (GP-17) against I/R injury. The roles of ER stress, mitochondrial injury,and their crosstalk within I/R injury and in GP-17einduced cardioprotection are also explored. Methods: Cardiac contractility function was recorded in Langendorff-perfused rat hearts. The effects ofGP-17 on mitochondrial function including mitochondrial permeability transition pore opening, reactiveoxygen species production, and respiratory function were determined using fluorescence detection kitson mitochondria isolated from the rat hearts. H9c2 cardiomyocytes were used to explore the effects ofGP-17 on hypoxia/reoxygenation. Results: We found that GP-17 inhibits myocardial apoptosis, reduces cardiac dysfunction, and improvescontractile recovery in rat hearts. Our results also demonstrate that apoptosis induced by I/R is predominantlymediated by ER stress and associated with mitochondrial injury. Moreover, the cardioprotectiveeffects of GP-17 are controlled by the PI3K/AKT and P38 signaling pathways. Conclusion: GP-17 inhibits I/R-induced mitochondrial injury by delaying the onset of ER stress throughthe PI3K/AKT and P38 signaling pathways.
Han Ying-Hao,Chen Dong-Qin,Jin Mei-Hua,Jin Ying-Hua,Li Jing,Shen Gui-Nan,Li Wei-Long,Gong Yi-Xi,Mao Ying-Ying,Xie Dan-Ping,Lee Dong-Seok,Yu Li-Yun,Kim Sun-Uk,김지수,권태호,Cui Yu-Dong,Sun Hu-Nan 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.3
Severe inflammatory reactions caused by macrophage activation can trigger a systemic immune response. In the present study, we observed the anti-inflammatory properties of hispidin on LPS induced RAW264.7 macrophage cells. Our results showed that hispidin treatment significantly reduced the production of cellular NO, IL-6 and reactive oxygen species (ROS) while has not inhibitory effect on TNF-α productions. Excitingly, hispidin treatment retains the phagocytosis ability of macrophages which enabling them to perform the function of removing foreign invaders. Signaling studies showed, hispidin treatment dramatic suppressed the LPS induced mitogen activated protein kinases (MAPK) and JAK/STAT activations. In conclusion, our findings suggest that hispidin may be a new therapeutic target for clinical treatment of macrophages-mediated inflammatory responses.
<i>Acanthamoeba</i>: Keratopathogenicity of isolates from domestic tap water in Korea
Jeong, Hae Jin,Lee, Sun Joo,Kim, Jeong Hwan,Xuan, Ying Hua,Lee, Keun Hee,Park, Sang Kyun,Choi, Sun Hee,Chung, Dong Il,Kong, Hyun Hee,Ock, Mee Sun,Yu, Hak Sun Elsevier 2007 Experimental parasitology Vol.117 No.4
<P><B>Abstract</B></P><P>In a previous study, we reported on the contamination rate of free living amoeba, including <I>Acanthamoeba,</I> isolated from contact lens storage cases (CLSC) and domestic tap water in Korea. In an effort to evaluate the potential kerato-pathogenicity of 5 isolates from CLSC and 17 isolates from domestic tap water, we have conducted an investigation into the morphological features, mitochondrial DNA (mtDNA) restriction fragment length polymorphism (RFLP) phenotypes, 18S rDNA sequences, and drug sensitivities of these isolates, and have compared the results with those of 20 amoebic keratitis (AK) isolates from Korea, as well as 14 reference strains. Cysts from 22 isolates obtained from CLSC and domestic tap water showed typical characteristics of morphological group 2. A total of three and five mtDNA RFLP patterns generated by EcoRI were found in 5 of the isolates from CLSC and 17 of the isolates from domestic tap water, respectively. The mtDNA RFLP patterns of four of the five isolates from the CLSC were found to be identical to those of the isolates from domestic tap water of students who had contaminated CLSC. The majority had mtDNA RFLP patterns identical to those of AK isolates in Korea. The results of 18S rDNA sequencing analysis were also shown to coincide with the results of mtDNA RFLP analysis. KA/WP12 was determined to be profoundly sensitive to chlorhexidine (MCC; 6.25μg/ml), and KAWP2 was the most sensitive strain to polyhexamethylene biguanide (PHMB) (MCC; 4.69μg/ml). Some difference in the cytopathic effects of isolates against human corneal epithelial cells was observed according to their mtDNA genotypes. In conclusion, domestic tap water may constitute a source of <I>Acanthamoeba</I> contamination of CLSC, and most isolates from CLSC and domestic tap water appear to be potentially keratopathogenic.</P>
Interspecific Buckwheat Hybrid between Fagopyrum esculentum and F. cymosum through Embryo Rescue
Sun Hee Woo,Ying Jie Wang,Clayton G. Campbell,Tai Chi Adachi,Seung Keun Jong 한국육종학회 2002 한국육종학회지 Vol.34 No.4
In buckwheat, interspecific hybrids with perennial species could provide the opportunity to introgress new and useful characters into annual species. An in vitro embryo rescue procedure, previously developed to produce interspecific hybrids of selfpollina
MiR-186 Inhibited Migration of NSCLC via Targeting cdc42 and Effecting EMT Process
Ying Dong,Xintian Jin,Zhiqiang Sun,Yueming Zhao,Xianjing Song 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.3
In this study, qRT-PCR was employed to identify that miR-186 expression level in NSCLC tissues are highly associated with lymph node metastasis. In addition, through the application of western blotting, luciferase assay and qRT-PCR, it was found that miR-186 targeted 3UTR of cdc42 mRNA and down-regulated cdc42 protein level in a post-transcriptional manner. Transwell assay indicated that cdc42 partially reversed the effect of miR-186 mimics. Besides, miR-186 was proved to regulate EMT by influencing biomarkers of this process and cell adhesion ability. Thus, miR-186 is a potential target for NSCLC therapy. miR-186 is proposed to be one of tumor-suppressors and may serve as a therapeutic target in NSCLC treatment.