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The EGF/hnRNP Q1 axis is involved in tumorigenesis via the regulation of cell cycle-related genes
Yu-Chu Wang,Kung-Chao Chang,Bo-Wen Lin,Jenq-Chang Lee,Chien-Hsien Lai,Li-Jyuan Lin,Yun Yen,Chang-Shen Lin,Shiang-Jie Yang,Peng-Chan Lin,Chung-Ta Lee,Liang-Yi Hung 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Heterogeneous nuclear ribonucleoprotein (hnRNP) Q1, an RNA-binding protein, has been implicated in many posttranscriptional processes, including RNA metabolism and mRNA splicing and translation. However, the role of hnRNP Q1 in tumorigenesis remains unclear. We previously performed RNA immunoprecipitation (RIP)-seq analysis to identify hnRNP Q1-interacting mRNAs and found that hnRNP Q1 targets a group of genes that are involved in mitotic regulation, including Aurora-A. Here, we demonstrate that altering the hnRNP Q1 level influences the expression of the Aurora-A protein, but not its mRNA. Stimulation with epidermal growth factor (EGF) enhances both binding between hnRNP Q1 and Aurora-A mRNA as well as the efficacy of the hnRNP Q1-induced translation of Aurora-A mRNA. The EGF/hnRNP Q1-induced translation of Aurora-A mRNA is mediated by the mTOR and ERK pathways. In addition, we show that hnRNP Q1 up-regulates the translation of a group of spindle assembly checkpoint (SAC) genes. hnRNP Q1 overexpression is positively correlated with the levels of Aurora-A and the SAC genes in human colorectal cancer tissues. In summary, our data suggest that hnRNP Q1 plays an important role in regulating the expression of a group of cell cycle-related genes. Therefore, it may contribute to tumorigenesis by up-regulating the translation of these genes in colorectal cancer.
陳亭伊(Ting-Yi Chen),謝杏慧(Hsing-Hui Hsieh),林漢明(Han-Ming Lin),陳怡昌(Yi-Chang Chen),黃招憲(Jau-Hsien Huang),郭殷豪(Yin-Hao Kuo),Hsin-Mien Wang 한국외국어대학교 대만연구센터 2016 대만연구 Vol.- No.9
For the promotion of community development, the first step is to investigate the specialty resources and human resources, to understand the process and the current appearance of community development, and to explore the future development vision or direction should be promoted. Secondly, the local smart people must have the abilities of cooperation, communication, cross-domain integration, and linking external support. It is one of the keypoints of adding-value workforce. Therefore, leaders of a community must find the local characteristics of the championship, and have the capacity to promote citizen participation and to integrate external support and cooperation, so that communities can acquire and integrate diverse and sufficient resources in order to succeed in community sustainability. Therefore, the main purpose of this paper is to establish a model of resource inventory and integration. Through the methods of literature analysis and focus group discussion, this paper explores the community cases of Guantu area in Taipei, Shennong Street and Jingliao community in Tainan how to inventory both natural and human resources, to seek community development and value-added directions, to promote civic participation, cooperation, and to link external groups, so as to achieve the success of internal and external resource integration.
The Determinants of South Korea’s Trade Balance: A Cointegrating Regression Approach
Ting-Huan Chang,Jun-De Lee,Yi-Hsien Wang 한국무역학회 2012 Journal of Korea trade Vol.16 No.3
This paper examines the key determinants of South Korea’s trade balance using three fully efficient cointegrating regression methods. We find that the trade balance, foreign income, money supply, real effective exchange rate, and domestic income are cointegrated. Consistent with the Marshall-Lerner condition, appreciation in the real effective exchange rate is negatively related to the trade balance. Our results have important implications for using exchange rate policy as a device to achieve trade balance.
Yu-Li Chen,Kung-Liahng Wang,Min-Yu Chen,Mu-Hsien Yu,Chen-Hsuan Wu,Yu-Min Ke,Yi-Jen Chen,Yin-Yi Chang,Keng-Fu Hsu,Ming-Shyen Yen 대한부인종양학회 2013 Journal of Gynecologic Oncology Vol.24 No.1
Objective: To evaluate the clinical outcome and parameters related to coexisting endometrial carcinoma in women with tissuediagnosed endometrial hyperplasia. Methods: Between January 1991 and December 2009, three hundred and eighty-six patients with the presumptive diagnosis of endometrial hyperplasia were retrieved. Among these, one hundred and twenty-five patients were identified as having coexisting endometrial carcinoma in hysterectomy specimens. The three hundred and eighty-six patients were divided into two groups: the hyperplasia-benign group (261 cases) and the hyperplasia-malignant group (125 cases). Several clinical parameters including age, menopausal status, history of abnormal uterine bleeding, obstetrical history, medical history of diabetes and hypertension, BMI, and preoperative pathologic results were investigated. Results: Age ≥53 (odds ratio [OR], 2.40; 95% confidence interval [CI], 1.26 to 4.57), menopausal status (OR, 2.07; 95% CI, 1.14to 3.76), diabetes history (OR, 7.33; 95% CI, 2.79 to 19.26), abnormal uterine bleeding (OR, 3.99; 95% CI, 1.22 to 13.02), atypical endometrial hyperplasia (OR, 7.38; 95% CI, 4.03 to 13.49), and body mass index ≥27 (OR, 3.24; 95% CI, 1.76 to 5.97) were independent risk factors for prediction of endometrial hyperplasia coexisting with endometrial carcinoma. The diagnostic efficacy of atypical endometrial hyperplasia to predict the endometrial hyperplasia coexisting with endometrial carcinoma was better than or similar to those of other independent factors and combinations of these factors. Conclusion: Coexisting malignancy should be considered when examining endometrial hyperplasia patients with the related risk factors, especially atypical endometrial hyperplasia.