EGFR 돌연변이와 ROS1 전위를 동시에 가진 폐선암 환자의 Erlotinib 치료 1예

김민환,박예현,박혜정,지아영,송창호,진무년,김영주,김선욱,이중희,김인수,김혜련,김주항,조병철 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1

The rearrangement of c-ros oncogene 1 (ROS1) has been recently identified as an important molecular target in non small cell lung cancer (NSCLC). ROS1 rearrangement and epidermal growth factor receptor (EGFR) mutation were mutually exclusive each other in previous studies, and the clinical implication of co-existence of the two genetic alterations has not been determined. We report a case of 46-year-old female never-smoker NSCLC patient whose tumor harbored ROS1 rearrangement and EGFR mutation concomitantly. She had undergone curative surgery for stage IIIA NSCLC, and the recurrence in left pleura and brain occurred at 2 years after the surgery. She received several lines of chemotherapy including docetaxel plus carboplatin, erlotinib, pemetrexed, and gemcitabine. Erlotinib therapy showed a favorable treatment response with progression-free survival of 9.5 months and partial response of tumor on radiologic evaluations. This case represents a successful erlotinib treatment in a NSCLC patient with concurrent ROS1 rearrangement and EGFR mutation.

Development of a Novel Endoscopic Scoring System to Predict Relapse after Surgery in Intestinal Behcet’s Disease

( Jung Won Park ),( Yehyun Park ),( Soo Jung Park ),( Tae Il Kim ),( Won Ho Kim ),( Jae Hee Cheon ) 대한소화기학회 2018 Gut and Liver Vol.12 No.6

Background/Aims: The cumulative surgery rate and postoperative relapse of intestinal Behcet’s disease (BD) have been reported to be high. This study aimed to establish a scoring system based on follow-up endoscopic findings that can predict intestinal BD recurrence after surgery. Methods: Fifty-four patients with intestinal BD who underwent surgery due to bowel complications and underwent follow-up colonoscopy were retrospectively investigated. Their clinical data, including colonoscopic findings, were retrieved. Classification and regression tree analysis was used to develop an appropriate endoscopic classification model that can explain the postsurgical recurrence of intestinal BD most accurately based on the following classification: e0, no lesions; e1, solitary ulcer <20 mm in size; e2, solitary ulcer ≥20 mm in size; and e3, multiple ulcers regardless of size. Results: Clinical relapse occurred in 37 patients (68.5%). Among 38 patients with colonoscopic recurrence, only 29 patients had clinically relapsed. Multivariate analysis identified higher disease activity index for intestinal BD at colonoscopy (hazard ratio [HR], 1.013; 95% confidence interval [CI], 1.005 to 1.021; p=0.002) and colonoscopic recurrence (HR, 2.829; 95% CI, 1.223 to 6.545; p=0.015) as independent risk factors for clinical relapse of intestinal BD. Endoscopic findings were classified into four groups, and multivariate analysis showed that the endoscopic score was an independent risk factor of clinical relapse (p=0.012). The risk of clinical relapse was higher in the e3 group compared to the e0 group (HR, 6.284; 95% CI, 2.036 to 19.391; p=0.001). Conclusions: This new endoscopic scoring system could predict clinical relapse in patients after surgical resection of intestinal BD. (Gut Liver 2018;12:674-681)

Pushing Coated Conductor Critical Currents Beyond 1 kA per cm Width: Stacks of YBCO Layers

Yehyun Jung,Sheehan, C J,Coulter, J Y,Matias, V,Dojun Youm IEEE 2011 IEEE transactions on applied superconductivity Vol.21 No.3

<P>For a number of superconducting power applications, a high value of the engineering critical current density (<I>Je</I>) for the wire is crucial. The superconducting layer in the coated conductor is typically a small portion of the overall cross-section, so increasing the superconductor fraction will directly result in an increase of <I>Je</I> . However, as the thickness of the superconductor is increased, <I>Jc</I> eventually drops. We describe a way to increase <I>Je</I> by making a stack of superconducting layers using sequential Ion-Beam Assisted Deposition (IBAD)/Superconductor deposition. Reactive Co-Evaporation by Cyclic Deposition and Reaction (RCE-CDR) is used for superconductor. An IBAD-textured layer resets the crystalline structure after each superconducting layer and we use IBAD-MgO for this purpose. However, IBAD-MgO texturing requires an extremely smooth starting surface (about 1 nm root mean square roughness), whereas the YBCO layer is typically 10-100 times rougher. We employ the Solution Deposition Planarization (SDP) process to planarize the rough surface of YBCO. The SDP layer is insulating and it provides for an easy way to separate the superconducting layers electrically. We discuss unique features of the stacking structure that allow for high <I>I</I><SUB>c</SUB>, low ac-losses in applied fields, as well as high <I>Je</I> .</P>

Primary surgery versus pharmacotherapy for newly diagnosed ileocecal Crohn’s disease: a hospital-based cohort study

Yehyun Park,Soo Jung Park,Tae Il Kim,Won Ho Kim,Jae Hee Cheon 대한내과학회 2024 The Korean Journal of Internal Medicine Vol.39 No.5

Background/Aims: Limited knowledge exists regarding the optimal timing and relative advantages of primary surgery compared to medical treatment in ileocecal Crohn’s disease (CD). This study aimed to compare long-term outcomes between medication-based treatment versus surgery in newly diagnosed ileocecal CD patients in an Asian population. Methods: Among the 885 patients diagnosed with CD and enrolled in the study site hospital cohort between 1980 and 2013, 93 (10.5%) had ileocecal CD. Patients were categorized into either the surgical or medical remission group based on their initial management strategy that led to remission. The rates of relapse, hospitalization, and surgery after achieving remission were compared using Kaplan-Meier curves. Results: The numbers of patients assigned to surgical and medical remission groups were 15 (17.0%) and 73 (83.0%), respectively. The surgical remission group exhibited a lower relapse rate and longer maintenance of remission (10.7 vs. 3.7 yr; p = 0.017) during a median follow-up of 6.6 years. Hospitalization after the first remission tended to be lower in the surgical remission group (p = 0.054). No cases required repeated intestinal resection after the initial surgical remission, whereas a 23% surgery rate was reported at 5 years after initial medical treatment (p = 0.037). In the multivariable analysis, the initial medication-based treatment was significantly associated with relapse (hazard ratio = 3.23, p = 0.039). Conclusions: In selected cases of localized ileocecal CD, ileocolic resection might be a favorable alternative to medication- based treatment, as it demonstrates a lower relapse rate and longer maintenance of remission.

달 궤도선의 고이득 안테나 자세명령에 관한 효율적인 근사화 기법 비교분석

김예현(Yehyun Kim),정유연(Youeyun Jung),방효충(Hyochoong Bang),이동헌(Donghun Lee) 한국항공우주학회 2017 한국항공우주학회 학술발표회 논문집 Vol.2017 No.4

달 탐사선 안테나의 기준지향벡터 생성 및 지향각도 분석

김예현(Yehyun Kim),정유연(Youeyun Jung),방효충(Hyochoong Bang) 한국항공우주학회 2016 한국항공우주학회 학술발표회 논문집 Vol.2016 No.11

Scanning Hall probe measurements of field distributions of a coated conductor under applied fields

Yoo, Jaeun,Jung, Yonghwan,Lee, Jaeyoung,Lim, Sunme,Lee, SangMoo,Jung, YeHyun,Youm, Dojun,Kim, Hosup,Ha, HongSoo,Oh, Sangsoo IOP Publishing Ltd 2006 Superconductor science & technology Vol.19 No.12

<P>We measured the field profiles near the surface of a coated conductor (CC) under various applied fields by using the scanning Hall probe method. The field, applied in the normal direction, was increased from zero to 171.5 Oe and then decreased to −58.8 Oe. We could not analyse our data completely by the direct use of Brandt’s calculation but by a modification with unusual field dependences of the introduced parameters. Since Brandt’s original calculation was based on homogeneous films, it was not suitable for CCs with coarse granular structures. The modified calculations with appropriate parameters are related to the coarse granular structures. Those parameters, <I>D</I>, <I>J</I><SUB>c</SUB>, and <I>R</I>, represent the three characteristics of the flux penetration network: the average distance of flux penetrations, the density of critical sheet currents, and the range of meandering of the flux penetration front, respectively. The external field dependences of these parameters were different from those of the classical critical state model. </P>

A simple model for the estimation of hysteresis energy loss in a coated conductor under the simultaneous application of a magnetic field and current

Lee, SangMoo,Jung, YeHyun,Kwak, Kisung,Rhee, Joonkyu,Yoo, Jaeun,Youm, Dojun,Kim, Hosup,Ha, Hongsoo,Oh, SangSoo IOP Publishing Ltd 2010 Superconductor science & technology Vol.23 No.4

<P>A simple model for estimating the hysteresis energy loss of coated conductors under a general load line was studied. We took advantage of the characteristic line <I>I</I><SUB>b</SUB>(<I>H</I><SUB>a</SUB>) to determine the major parameters used in this model. The value of <I>I</I><SUB>b</SUB>(<I>H</I><SUB>a</SUB>) was based on the scanning Hall probe measurements (SHP) on a Sm<SUB>1</SUB>Ba<SUB>2</SUB>Cu<SUB>3</SUB>O<SUB>7 − δ</SUB> coated conductor. During SHP measurement, a magnetic field (<I>H</I><SUB>a</SUB>) and current (<I>I</I><SUB>a</SUB>) were applied simultaneously and were varied along 11 different load lines. From the values of SHP measurements, the current density profiles, <I>J</I>(<I>x</I>, <I>H</I><SUB>a</SUB>, <I>I</I><SUB>a</SUB>), were calculated using a numerical inversion method. We define the quantity <I>I</I><SUB>b</SUB> = ∫ <SUB> − <I>w</I></SUB><SUP><I>w</I></SUP>|<I>J</I>(<I>x</I>, <I>H</I><SUB>a</SUB>, <I>I</I><SUB>a</SUB>)| d<I>x</I> and we calculated <I>I</I><SUB>b</SUB> at many points (<I>H</I><SUB>a</SUB>, <I>I</I><SUB>a</SUB>) in every load line. We found that when <I>I</I><SUB>a</SUB> is less than <I>I</I><SUB>b</SUB> and the flux trap regions are absent, the values of <I>I</I><SUB>b</SUB> for all points (<I>H</I><SUB>a</SUB>, <I>I</I><SUB>a</SUB>) constitute a single line <I>I</I><SUB>b</SUB>(<I>H</I><SUB>a</SUB>), which can be easily extrapolated to a high field. This line provided a major parameter for our model. </P>

Comparison of Long-term Outcomes of Infliximab versus Adalimumab Treatment in Biologic-Naïve Patients with Ulcerative Colitis

( Yong Il Lee ),( Yehyun Park ),( Soo Jung Park ),( Tae Il Kim ),( Won Ho Kim ),( Jae Hee Cheon ) 대한소화기학회 2021 Gut and Liver Vol.15 No.2

Background/Aims: The tumor necrosis factor-α inhibitors infliximab and adalimumab are standard treatments for moderate to severe ulcerative colitis (UC). However, there has been no head-to-head comparison of treatment efficacy and outcomes between the two agents. The aim of this study was to compare the efficacy and long-term outcomes of infliximab versus adalimumab treatment in biologic-naïve patients with UC. Methods: We retrospectively analyzed the records of 113 biologic-naïve patients with UC who were treated between September 2012 and December 2017 (the infliximab group [n=83] and the adalimumab group [n=30]). We compared remission and response rates between these groups at 8 and 52 weeks. We used Kaplan-Meier curves to compare long-term outcomes, and logistic regression analysis and Cox-proportional hazard regression models to assess factors affecting outcomes. Results: The median follow-up duration was 25.8 months. Baseline clinical characteristics were similar between groups. There were no significant differences between the two groups in the rate of clinical remission or clinical response at 8 or 52 weeks. Multivariate analyses also showed that long-term outcomes were not significantly different (adjusted hazard ratio [HR], 1.45; 95% confidence interval [CI], 0.81 to 2.56; p=0.208). An elevated C-reactive protein level (greater than 5 mg/L) was a significant predictive factor for poor outcomes (adjusted HR, 2.25; 95% CI, 1.37 to 3.70; p=0.001). During the follow-up period, the rates of adverse event were not significantly different between the two groups (p=0.441). Conclusions: In our study, infliximab and adalimumab had similar treatment efficacy and long-term outcomes in biologic-naïve patients with moderate to severe UC. (Gut Liver 2021;15:232- 242)

Estimation of hysteresis loss in Sm₁Ba₂Cu₃O_7−δ coated conductor via scanning Hall probe measurements with simultaneously applied field and current

Yoo, Jaeun,Lee, SangMoo,Jung, YeHyun,Kwak, Kisung,Rhee, Joonkyu,Youm, Dojun,Kim, Hosup,Ha, Hongsoo,Oh, SangSoo,Oh, Sangjun IOP Publishing Ltd 2009 Superconductor science & technology Vol.22 No.4

<P>The hysteresis loss in a Sm<SUB>1</SUB>Ba<SUB>2</SUB>Cu<SUB>3</SUB>O<SUB>7−δ</SUB> coated conductor was estimated from magnetic field profiles measured by the scanning Hall probe method. Current, <I>I</I><SUB>a</SUB>, and magnetic field, <I>B</I><SUB>a</SUB>, were applied simultaneously; <I>B</I><SUB>a</SUB> was applied in the normal direction with respect to the tape surface. <I>B</I><SUB>a</SUB> and <I>I</I><SUB>a</SUB> were varied from <I>B</I><SUB>peak</SUB> to −<I>B</I><SUB>peak</SUB> and from <I>I</I><SUB>peak</SUB> to −<I>I</I><SUB>peak</SUB>, respectively, with the ratio α = <I>I</I><SUB>a</SUB>/<I>B</I><SUB>a</SUB> fixed during the variation. Three values of α were taken for the three load lines. The values of <I>B</I><SUB>peak</SUB>/<I>I</I><SUB>peak</SUB> were varied from 0 mT/0 A to 10.7 mT/116 A, 99.1 mT/50 A, and 298.2 mT/46.1 A, respectively, for the three load lines. From the measured values of magnetic field profiles, the current profiles were calculated by the iterative inversion method. From the current profiles, the flux density profiles and the hysteresis loss, <I>Q</I>, were then calculated for various values of <I>I</I><SUB>peak</SUB>(= α<I>B</I><SUB>peak</SUB>) in each load line. The results were compared with theoretical calculations based on Brandt’s model. When <I>B</I><SUB>peak</SUB> was about 300 mT, the estimated values of <I>Q</I> were several times smaller than the theoretical values of <I>Q</I> with the self-field <I>I</I><SUB>c0</SUB>. The low value of <I>Q</I> in this case is due to the field dependent <I>I</I><SUB>c</SUB> and the saturation effect of the current profiles, which results in significant reduction of the induced magnetic moment, <I>M</I>. </P>