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Kim, Sang-Tae,Lee, Seung-Yeon,Kim, Seung-Chul,Byun, Hye-Won,Lee, Sang-Tae,Kim, Mu-Yeal,Hong, Seok-Pyo,Chung, Young-Jae,Park, Ki-Ryong,Lee, Chung-Hee,Lee, Joong-Ku,Heo, Kyeong-In,Lee, Ji-Ye,Lee, Eun-Je National Science Museum of Korea 2011 Journal of Korean nature Vol.4 No.3
We developed the educational purpose mobile application, named "Wild Flowers of Bukhansan National Park (version 1.0)", aiming for easy identification of wild flowers for students and visitors in the park. When visitors find a flower or part of plant in the park, visitors can search for its name utilizing the pictures and characters provided in their own smartphone mobile devices or tablet PCs. The application provides pictures of wild flowers in the park and character-based searching system based on 12 diagnostic features (e.g., growth form, leaf arrangement, flower symmetry, petal color, petal number, sepal number, etc). We adopted the complete floristic survey of Chung and Lee (1962) and added species that we confirmed their distribution in the park during the development of this application. In summary, number of vascular plants in this park was estimated to be 428 taxa including 100 families, 280 genera, 327 species, 1 subspecies, 50 varieties, and 5 formas. We provided a total of 588 pictures representing 358 taxa and each taxon includes multiple pictures in many cases. Included identification quizzes can be an efficient educational tool as well as fun activity for students and visitors who are learning plant species in Korea. Our next step will include GPS function in the application for indicating visitor's location and for providing previously reported sites of the species that we interested in the map of the park. The future application which includes GPS function will be a valuable tool for the monitoring of rare plants, plant researches related to the climate changes, etc. We currently provide Korean iPhone version only, and English version and both of android versions will be serviced soon.
Mon1 Is Essential for Fungal Virulence and Stress Survival in Cryptococcus neoformans
( Ye-eun Son ),( Won-hee Jung ),( Sang-hun Oh ),( Jin-hwan Kwak ),( Maria E. Cardenas ),( Hee-soo Park ) 한국균학회 2018 Mycobiology Vol.46 No.2
Mon1 is a guanine nucleotide exchange factor subunit that activates the Ypt7 Rab GTPase and is essential for vacuole trafficking and autophagy in eukaryotic organisms. Here, we identified and characterized the function of Mon1, an ortholog of Saccharomyces cerevisiae Mon1, in a human fungal pathogen, Cryptococcus neoformans. Mutation in mon1 resulted in hypersensitivity to thermal stress. The mon1 deletion mutant exhibited increased sensitivity to cell wall and endoplasmic reticulum stress. However, the mon1 deletion mutant showed more resistance to the antifungal agent fluconazole. In vivo studies demonstrated that compared to the wild-type strain, the mon1 deletion mutant attenuated virulence in the Galleria mellonella insect model. Moreover, the mon1 deletion mutant was avirulent in the murine inhalation model. These results demonstrate that Mon1 plays a crucial role in stress survival and pathogenicity in C. neoformans.
Non-clinical pharmacokinetic behavior of ginsenosides
Won, Hyo-Joong,Kim, Hyun Il,Park, Taejun,Kim, Hyeongmin,Jo, Kanghee,Jeon, Hyojin,Ha, Seo Jun,Hyun, Jung Min,Jeong, Aeri,Kim, Jung Sik,Park, Ye Jin,Eo, Yun Ho,Lee, Jaehwi The Korean Society of Ginseng 2019 Journal of Ginseng Research Vol.43 No.3
Ginsenosides, the major active ingredients of ginseng and other plants of the genus Panax, have been used as natural medicines in the East for a long time; in addition, their popularity in the West has increased owing to their various beneficial pharmacological effects. There is therefore a wealth of literature regarding the pharmacological effects of ginsenosides. In contrast, there are few comprehensive studies that investigate their pharmacokinetic behaviors. This is because ginseng contains the complicated mixture of herbal materials as well as thousands of constituents with complex chemical properties, and ginsenosides undergo multiple biotransformation processes after administration. This is a significant issue as pharmacokinetic studies provide crucial data regarding the efficacy and safety of compounds. Moreover, there have been many difficulties in the development of the optimal dosage regimens of ginsenosides and the evaluation of their interactions with other drugs. Therefore, this review details the pharmacokinetic properties and profiles of ginsenosides determined in various animal models administered through different routes of administration. Such information is valuable for designing specialized delivery systems and determining optimal dosing strategies for ginsenosides.
Ye An Kim,Ji Won Yoon,Young Lee,최혁진,Jae Won Yun,Eunsin Bae,Seung-Hyun Kwon,So Eun Ahn,Ah-Ra Do,Heejin Jin,Sungho Won,Do Joon Park,Chan Soo Shin,서제현 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.6
Background: Epidemiological data have shown that vitamin D deficiency is highly prevalent in Korea. Genetic factors influencing vitamin D deficiency in humans have been studied in Europe but are less known in East Asian countries, including Korea. We aimed to investigate the genetic factors related to vitamin D levels in Korean people using a genome-wide association study (GWAS). Methods: We included 12,642 subjects from three different genetic cohorts consisting of Korean participants. The GWAS was performed on 7,590 individuals using linear or logistic regression meta- and mega-analyses. After identifying significant single nucleotide polymorphisms (SNPs), we calculated heritability and performed replication and rare variant analyses. In addition, expression quantitative trait locus (eQTL) analysis for significant SNPs was performed. Results: rs12803256, in the actin epsilon 1, pseudogene (ACTE1P) gene, was identified as a novel polymorphism associated with vitamin D deficiency. SNPs, such as rs11723621 and rs7041, in the group-specific component gene (GC) and rs11023332 in the phosphodiesterase 3B (PDE3B) gene were significantly associated with vitamin D deficiency in both meta- and mega-analyses. The SNP heritability of the vitamin D concentration was estimated to be 7.23%. eQTL analysis for rs12803256 for the genes related to vitamin D metabolism, including glutamine-dependent NAD(+) synthetase (NADSYN1) and 7-dehydrocholesterol reductase (DHCR7), showed significantly different expression according to alleles. Conclusion: The genetic factors underlying vitamin D deficiency in Korea included polymorphisms in the GC, PDE3B, NADSYN1, and ACTE1P genes. The biological mechanism of a non-coding SNP (rs12803256) for DHCR7/NADSYN1 on vitamin D concentrations is unclear, warranting further investigations.
Park, Do Young,Ji, Hyung-Min,Kwak, Kyu-Sung,Nair, Surej Gopinathan,Won, Ye-Yeon 대한정형외과학회 2012 Clinics in Orthopedic Surgery Vol.4 No.3
<P><B>Background</B></P><P>Due to its small size, variable shape, and lack of distinct anatomical landmarks, osteoarthritic knees make a precise patellar resection extremely difficult.</P><P><B>Methods</B></P><P>We performed virtual patellar resection with digital software using three dimensional computed tomography scans of knees from 49 patients who underwent primary total knee replacement at our hospital. We compared 2 commonly used resection methods, the tendon method (TM) and the subchondral method, to determine an ideal resection plane with respect to the symmetry and thickness of the patellar remnant.</P><P><B>Results</B></P><P>The TM gave a thicker resected patella, and a less oval cut surface shape, which gives better coverage for a domed prosthesis. Both methods, however, gave a symmetric resection both superior-inferiorly, as well as mediolaterally.</P><P><B>Conclusions</B></P><P>Although TM appears statistically better with respect to the thickness and cut surface shape, only further intraoperative studies with long-term clinical follow-up may provide us with the most appropriate patellar resection method.</P>
Park Ye-In,Kang Sang-Won,Kim Kyeong-Hyeon,Suh Tae Suk,Chung Jin Beom 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.77 No.11
The aim of this study is to evaluate the feasibility of a deep learning tumor segmentation network trained by merged tumor dataset. PET-CT datasets for head-and-neck (H&N) and limb tumors were used to train three different networks: H\&N, Limb, and merged (H&N + Limb). Dice similarity coefficient (DSC) of the merged network (0.89) in limb tumors was the same as that of the Limb network. In H&N tumor, DSC of the merged network (0.72) was higher than that of the H&N network (0.69). We found that the merged network could be applied simultaneously in H&N and limb tumor segmentation.
Street Tree Management Strategies for Different Special-Purpose Areas: Using Citizen Science Data
Ye Inn Kim,Ji Yeon Park,Won Seok Jang,Woo Hyeon Park,최윤의 인간식물환경학회 2023 인간식물환경학회지 Vol.26 No.6
Background and objective: This study investigated the occurrence characteristics of street tree management factors basedon different special-purpose areas with emphasis on citizen participation in data collection. Methods: We collected growth and management data of street tree sections and individual trees within sections using amonitoring form developed for street trees in four special-purpose areas in the urban area of Chuncheon. We used a binarylogistic regression model to analyze the probability of occurrence for each management factor (pruning traces, signblocking, disease and pest, felled trees, piled objects, and broken branches). Results: The probability of occurrence of management factors varied by special-purpose area, which was related to thecharacteristics of each area. Conclusion: This study suggests the need to develop efficient street tree management strategies by prioritizingmanagement factors in consideration of differences in special-purpose areas
( Ye Eun Kim ),( Jung-won Shin ),( Chang-hun Huh ),( Min-woo Kim ),( Ji-su Lee ),( Ohsang Kwon ),( Soyun Cho ),( Hyun-sun Park ) 대한피부과학회 2018 대한피부과학회 학술발표대회집 Vol.70 No.2
Background: Treatment of alopecia totalis and alopecia universalis is often challenging and unsatisfactory. Recently, Janus kinase inhibitor has shown promising results. Objectives: The aim of this study is to compare the efficacy and tolerability between oral tofacitinib and conventional modalities for treating refractory alopecia totalis/universalis. Methods: A total 74 patients (18, treated with tofacitinib; 26, treated with conventional oral treatment (steroid ± cyclosporine); 30, treated with diphenylcyclopropenone) were included and their medical records were reviewed retrospectively. Results: After 6 months, 44.4% of patients in the tofacitinib group, 37.5% in the conventional oral treatment group, and 11.1% in the diphenylcyclopropenone group achieved 50% SALT change. During the treatment, 10% of patients in the tofacitinib group, 73.1% in the conventional oral treatment group, and 10% in diphenylcyclopropenone group experienced adverse drug reactions. Conclusion: In conclusion, oral tofacitinib was more effective than diphenylcyclopropenone immunotherapy and more tolerable than conventional oral treatment after 6 months of treatment.