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Persistence of Genetically Modified Potatoes in the Field
Kim, Chang-Gi,Kim, Do-Young,Moon, Ye-Seul,Kim, Hyo-Jeong,Kim, Dae-In,Chun, Young-Jin,Park, Kee-Woong,Jeong, Soon-Chun,Kim, Soo-Young,Kim, Hwan-Mook 한국식물학회 2010 Journal of Plant Biology Vol.53 No.6
Volunteers from genetically modified (GM) potatoes may pose an environmental problemif allowed to grow in the field after the annual crop is harvested. We tested whether they are more likely to produce volunteers than non-GM potatoes. Specifically, we compared the number of volunteers, number of tubers per plant, tuber size, and their vertical distribution in the soil. More volunteer plants came from non-GM potatoes than from GM potatoes, but the number and size of tubers were similar between the two. Vertical distribution of the tubers differed significantly, with most non-GM tubers being found in shallower soil (<2 cm deep). Our results suggest that spontaneous GM volunteers may emerge and produce tubers to a degree similar to that of the non-GM plants. No viable volunteers emerged from GM tubers in the next growing season, probably deterred by winter frost and a period of low soil temperatures (below $-2^{\circ}C$) at our study site. However, in regions with warmer climates, such GM volunteers may survive Winter and produce more plants the following year.
Cost-Effectiveness Analysis of Home-Based Hospice-Palliative Care for Terminal Cancer Patients
Ye-seul Kim,한은아,이재우,강희택 한국호스피스완화의료학회 2022 한국호스피스.완화의료학회지 Vol.25 No.2
Purpose: We compared cost-effectiveness parameters between inpatient and homebased hospice-palliative care services for terminal cancer patients in Korea. Methods: A decision-analytic Markov model was used to compare the cost-effectiveness of hospicepalliative care in an inpatient unit (inpatient-start group) and at home (home-start group). The model adopted a healthcare system perspective, with a 9-week horizon and a 1-week cycle length. The transition probabilities were calculated based on the reports from the Korean National Cancer Center in 2017 and Health Insurance Review & Assessment Service in 2020. Quality of life (QOL) was converted to the quality-adjusted life week (QALW). Modeling and cost-effectiveness analysis were performed with TreeAge software. The weekly medical cost was estimated to be 2,481,479 Korean won (KRW) for inpatient hospice- palliative care and 225,688 KRW for home-based hospice-palliative care. One-way sensitivity analysis was used to assess the impact of different scenarios and assumptions on the model results. Results: Compared with the inpatient-start group, the incremental cost of the home-start group was 697,657 KRW, and the incremental effectiveness based on QOL was 0.88 QALW. The incremental cost-effectiveness ratio (ICER) of the home-start group was 796,476 KRW/QALW. Based on one-way sensitivity analyses, the ICER was predicted to increase to 1,626,988 KRW/QALW if the weekly cost of home-based hospice doubled, but it was estimated to decrease to -2,898,361 KRW/QALW if death rates at home doubled. Conclusion: Home-based hospice-palliative care may be more cost-effective than inpatient hospice-palliative care. Home-based hospice appears to be affordable even if the associated medical expenditures double.
Kim Ye-Seul,Choi Jae-Woong,Song Sang Hoon,Hwang Ho Young,Sohn Suk Ho,Kim Ji Seong,Kang Yoonjin,Gu Ja-Yoon,Kim Kyung-Hwan,Kim Hyun Kyung 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.4
Background: Point-of-care testing (POCT) coagulometers are increasingly used for monitoring warfarin therapy. However, in high international normalized ratio (INR) ranges, significant discrepancy in the INR between POCT and conventional laboratory tests occurs. We compared the INR of POCT (CoaguChek XS Plus; Roche Diagnostics, Mannheim, Germany) with that of a conventional laboratory test (ACL TOP 750; Instrumentation Laboratory SpA, Milan, Italy) and explored possible reasons for discrepancy. Methods: Paired POCT and conventional laboratory test INRs were analyzed in 400 samples from 126 patients undergoing warfarin therapy after cardiac surgery. Coagulation factor and thrombin generation tests were compared using the Mann–Whitney U test. Correlations between coagulation factors and INRs were determined using Pearson correlation coefficients. Results: The mean difference in the INR between the tests increased at high INR ranges. Endogenous thrombin potential levels were decreased at INR <2.0 for CoaguChek XS Plus and 2.0< INR <3.0 for ACL TOP 750 compared with those at INR <2.0 for both tests, indicating a better performance of ACL TOP 750 in assessing thrombin changes. The correlation coefficients of coagulation factors were stronger for ACL TOP 750 INR than for CoaguChek XS Plus INR. Vitamin K-dependent coagulation factors were found to contribute to the INR discrepancy. Conclusions: Decreases in vitamin K-dependent coagulation and anticoagulation factors can explain the significant discrepancy between the two tests in high INR ranges. Since conventional laboratory test INR values are more reliable than POCT INR values, a confirmatory conventional laboratory test is required for high INR ranges.
Ustekinumab, an effective therapeutic option for erythrodermic psoriasis
( Ye Seul Kim ),( Ga Hee Jung ),( Je Min An ),( Kyu Uang Whang ),( Jong Suk Lee ),( Young Lip Park ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.1
Erythrodermic psoriasis is a severe form of psoriasis, presenting as prominent erythema, affecting the whole body. Ustekinumab (Stelara®) is a human monoclonal antibody targeting the p40 subunit shared by interleukin IL-12 and IL-23. Erythrodermic psoriasis has been an exclusion criteria in studies looking at the efficacy of ustekinumab against psoriasis, but recently, a few reports have proven its efficacy on erythrodermic psoriasis. Herein, we report 2 cases of erythrodermic psoriasis that successfully improved with ustekinumab. A 42-year-old man presented with a 7-year history of erythrodermic psoriasis and psoriatic arthritis. The patient was treated with ustekinumab 45 mg subcutaneously at 0, week 4, and every 12 weeks thereafter. At week 28, his Psoriasis Areaand Severity Index (PASI) score decreased from 64.8 to 9.6. The second case is a 26-year-old man suffering from erythrodermic psoriasis for 10 years. Four months after the first administration of ustekinumab, the patient achieved 75% improvement of the PASI score and 90% improvement after 112 weeks. Although further studies are required, it is likely that ustekinumab can be an effective therapeutic option for patients affected by erythrodermic psoriasis.
Effect of Ovarian Extract on Oocyte Maturation and Early Embryonic Development in Pigs
Seul-Gi Yang(Seul-Gi Yang),Jae-Hun Choi(Jae-Hun Choi),Young-Seo Jo(Young-Seo Jo),Ye-Won Kim(Ye-Won Kim),Dong-Mok Lee(Dong-Mok Lee),Hyo-Jin Park(Hyo-Jin Park),Deog-Bon Koo(Deog-Bon Koo) 한국동물보건학회 2022 한국동물보건학회지 Vol.1 No.2
Various factors in the ovary are known to regulate oocyte maturation and hormone secretory functions; however, the effect of ovarian extract (OE) on oocyte maturation and embryonic development in pigs remains unknown. In this study, we first evaluated whether OE supplementation in the in vitro maturation (IVM) medium alters the oocyte maturation capacity by affecting glucose/amino acid metabolites, meiotic maturation, cumulus cell (CC) expansion, and antioxidants. Various OE concentrations (50, 100, 200, 500, and 5000 μg/mL) were included in the IVM medium. Only the oocytes treated with 100 μg/mL OE exhibited an improved meiotic maturation rate when compared with that of the other groups (non-treated group, 78.6 ± 3.0% vs. 100 μg/mL OE-treated group, 81.6 ± 4.3%); however, the difference was not significant. To observe the changes in glucose and amino acid metabolism in the OE-treated oocytes, we measured the amounts of diverse constituents (glucose, lactate, glutamine, and ammonia) in the IVM medium containing OE. Lactate and ammonia levels in the OE-treated group after 44 h of IVM were higher (p < 0.01) than those in the non-treated group. In addition, the expression of the CC expansion factors (Has2 and Tnfaip6) significantly increased (p < 0.05), whereas the mRNA expression levels of antioxidative enzymes (Sod1, Cat, and Gpx1) significantly diminished (p < 0.05) in the OE-treated group. Moreover, mature oocytes treated with 100 μg/mL OE demonstrated increased subsequent embryonic development rates after 144 h of IVM. Thus, the addition of OE in IVM mediums may improve oocyte maturation capacity which could enhance antioxidative enzyme activation, energy metabolism, and expression of the CC expansion factors in porcine oocytes.