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      • KCI등재

        Discrimination of Out-of-Control Condition Using AIC in (x, s) Control Chart

        Yasuhiko Takemoto,Ikuo Arizono,Takanori Satoh 대한산업공학회 2013 Industrial Engineeering & Management Systems Vol.12 No.2

        The x control chart for the process mean and either the R or s control chart for the process dispersion have been used together to monitor the manufacturing processes. However, it has been pointed out that this procedure is flawed by a fault that makes it difficult to capture the behavior of process condition visually by considering the relationship between the shift in the process mean and the change in the process dispersion because the respective characteristics are monitored by an individual control chart in parallel. Then, the (x, s) control chart has been proposed to enable the process managers to monitor the changes in the process mean, process dispersion, or both. On the one hand, identifying which process parameters are responsible for out-of-control condition of process is one of the important issues in the process management. It is especially important in the (x, s) control chart where some parameters are monitored at a single plane. The previous literature has proposed the multiple decision method based on the statistical hypothesis tests to identify the parameters responsible for out-of-control condition. In this paper, we propose how to identify parameters responsible for out-of-control condition using the information criterion. Then, the effectiveness of proposed method is shown through some numerical experiments.

      • A Study on Open Space Design in Terms of the Relation between Parks and Their Bordering Facilities in Urban Areas

        Yasuhiko Shimomura,Oshie Kotake,Hiroyuki Kaga,Noboru Masuda Korean Institute of Landscape Architecture 2004 Journal of the Korean institute of landscape archi Vol.2 No.-

        This study aimed at providing suggestions in designing open space so that parks and bordering facilities are well related to each other in terms of the visual access and human activities. The design survey was conducted in the center of Osaka City, using parks there as the study material. The relation between parks and their bordering facilities was evaluated in terms of the visual access and human activities. Through the results of this study, as the design methods for improving relations between parks and their bordering facilities, unified design and creation of square in the boundary area between them, placing access paths to facilities in parks, and planting trees to create Vista, Screen, and Framework landscapes are of great importance.

      • Prospect of plant molecular cytogenetics in the 21st century

        Yasuhiko Mukai 한국생명과학회 2003 한국생명과학회 심포지움 Vol.40 No.-

        The genomes of Arabidopsis and rice have been fully sequenced. Genomic sequencing provides global information about genome structure and organization. A comprehensive research account of our recent studies conducted on genome painting, comparative genomics and genome fusion is provided in order to project the prospects of plant cytogenetic research in post-genomics era. Genome analysis by GISH using genome painting is demonstrated as an excellent means suitable for visualization of a whole genome, since total genomic DNA representing the overall molecular composition of the genome is used as a probe. FISH on extended DNA fibers has been developed for high-resolution FISH and has contributed to determining the copy number and order of genes. We have also mapped a number of genes involving starch synthesis on wheat chromosomes by FISH and compared the position of these genes on linkage map of rice. Macro synteny between wheat and rice can be observed by comparing the location of these genes in spite of the fact that the size of DNA per chromosome differs by 20 fold in two. Moreover, to approach our goal towards making bread and udon noodles from rice flour in future by incorporating bread making and the noodle qualities in rice, we have been successful in introducing large genomic DNA fragments containing agronomically important genes of wheat into a rice by successive introduction of large insert BAC clones, there by expanding genetic variability in rice. We call this method genome fusion.

      • SCOPUSKCI등재

        Hepatitis C and Liver Transplantation

        ( Yasuhiko Sugawara ) 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.5(S)

        OBJECTIVES: Hepatitis C virus (HCV) is the most common indication for living donor liver transplantation in Japan. A recent paper in the Western world reported that HCV infection was associated with a 23% increase in mortality and a 30% increase in the rate of liver graft failure. The poor results might be due to recurrence of HCV disease in the graft. If HCV recurs earlier and more severely after transplantation, a specific strategy for preventing the detrimental effects of HCV on the grafts must be developed. METHODS: One strategy might be aggressive treatment for HCV. Treatment of recurrent HCV disease with interferon and ribavirin after liver transplantation is used. One standard regimen includes interferon-alpha2b (3 MU x 3 per week) or PEG interferon (1.5 microg/kg) and ribavirin (600-800 mg/day) for 48 weeks. RESULTS: We have adopted the preemptive therapy in the 92 living donor liver transplant recipients until the end of 2006 and obtained a sustained viral response rate 35%. The 5-year survival rate was 82% which was not significantly different from that of the non hepatitis patients. CONCLUSIONS: Living donor liver transplantation is an effective life saving option with excellent outcome for patients suffering from end-stage liver disease including those due to HCV in regions where deceased donor liver transplantation remains an unrealistic option.

      • KCI등재

        Diagnosis and treatment of patients with IgA nephropathy in Japan

        ( Yasuhiko Tomino ) 대한신장학회 2016 Kidney Research and Clinical Practice Vol.35 No.4

        Chronic kidney disease (CKD) is a worldwide public health problem that affects millions of people from all racial and ethnic groups. Although CKD is not one specific disease, it is a comprehensive syndrome that includes IgA nephropathy. As reported by the Japanese Society of Nephrology, 13.0 million people have CKD. In Japan, major causes of end-stage kidney disease are type 2 diabetic nephropathy, chronic glomerulonephritis, especially IgA nephropathy, hypertensive nephrosclerosis, and polycystic kidney disease. IgA nephropathy is characterized by polymeric IgA1 with aberrant galactosylation (galactose-deficient IgA1) increased in the blood and deposited in the glomerular mesangial areas, as well as partially in the capillary walls. The tonsils are important as one of the responsible regions in this disease. The clarification of the mechanism of galactose-deficient IgA1 production will pave the way for the development of novel therapies. The results of future research are eagerly awaited. At present, the most important therapeutic goals in patients with IgA nephropathy are the control of hypertension, the decrease of urinary protein excretion, and the inhibition of progression to end-stage kidney disease. Several investigators have reported that renin-eangiotensin-ealdosterone system inhibitors reduce levels of urinary protein excretion and preserve renal function in patients with IgA nephropathy. In Japan, tonsillectomy and steroid pulse therapy are more effective for patients with IgA nephropathy. Copyright ⓒ 2016. The Korean Society of Nephrology. Published by Elsevier. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

      • KCI등재후보

        Estimation of Change Point in Process State on CUSUM (x, s) Control Chart

        Yasuhiko Takemoto,Ikuo Arizono 대한산업공학회 2009 Industrial Engineeering & Management Systems Vol.8 No.3

        Control charts are used to distinguish between chance and assignable causes in the variability of quality characteristics. When a control chart signals that an assignable cause is present, process engineers must initiate a search for the assignable cause of the process disturbance. Identifying the time of a process change could lead to simplifying the search for the assignable cause and less process down time, as well as help to reduce the probability of incorrectly identifying the assignable cause. The change point estimation by likelihood theory and the built-in change point estimation in a control chart have been discussed until now. In this article, we discuss two kinds of process change point estimation when the CUSUM (x, s) control chart for monitoring process mean and variance simultaneously is operated. Throughout some numerical experiments about the performance of the change point estimation, the change point estimation techniques in the CUSUM (x, s) control chart are considered.

      • The C:N:P ratio of plankton and its significance for nutrient cycling in Lakes.

        Yasuhiko Tezuka 江原大學校 附設 環境硏究所 1992 環境硏究 Vol.9 No.-

        In the main (north) basin of Lake Biwa, an oli해-meso-trophic and phosphorus-limited lake in central Japan, and abundant accumulation of nitrate in the hypolimnion was observed during the stagnation period, in contrast with no such accumulation of phosphate. In order to clarify the mechanism of this phenomenon, seston was collected in summer from both epilimnion and hypolimnion of Lake Biwa and decomposed aerobically for three months in the laboratory. A large amount of nitrate but not phosphate was released from decomposing seston. The reason for this different release pattern of nitrate and phosphate was attributed to the high C:P and N:P ratios of the plankton grown in severely phosphorus-limited environment of Lake Biwa. Thus, it was concluded that the C:N:P ratio of plankton plays an important role in the recycling of nitrogen and phosphorus in lakes.

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