The new focus of energy storage: flexible wearable supercapacitors

Yani Yan,Yi Zhou,Yongfeng Li,Yanzhen Liu 한국탄소학회 2023 Carbon Letters Vol.33 No.6

As the demand for flexible wearable electronic devices increases, the development of light, thin and flexible high-performance energy-storage devices to power them is a research priority. This review highlights the latest research advances in flexible wearable supercapacitors, covering functional classifications such as stretchability, permeability, self-healing and shapememory capabilities, as well as practical studies on energy harvesting capabilities.

Effect of bogie fairings on the snow reduction of a high-speed train bogie under crosswinds using a discrete phase method

Guangjun Gao,Yani Zhang,Jie Zhang,Fei Xie,Yan Zhang,Jiabin Wang 한국풍공학회 2018 Wind and Structures, An International Journal (WAS Vol.27 No.4

This paper investigated the wind-snow flow around the bogie region of a high-speed train under crosswinds using a coupled numerical method of the unsteady Realizable k-ε turbulence model and discrete phase model (DPM). The flow features around the bogie region were discussed and the influence of bogie fairing height on the snow accumulation on the bogie was also analyzed. Here the high-speed train was running at a speed of 200 km/h in a natural environment with the crosswind speed of 15 m/s. The mesh resolution and methodology for CFD analysis were validated against wind tunnel experiments. The results show that large negative pressure occurs locally on the bottom of wheels, electric motors, gear covers, while the positive pressure occurs locally on those windward surfaces. The airflow travels through the complex bogie and flows towards the rear bogie plate, causing a backflow in the upper space of the bogie region. The snow particles mainly accumulate on the wheels, electric motors, windward sides of gear covers, side fairings and back plate of the bogie. Longer side fairings increase the snow accumulation on the bogie, especially on the back plate, side fairings and brake clamps. However, the fairing height shows little impact on snow accumulation on the upper region of the bogie. Compared to short side fairings, a full length side fairing model contributes to more than two times of snow accumulation on the brake clamps, and more than 20% on the whole bogie.

Effect of bogie fairings on the snow reduction of a high-speed train bogie under crosswinds using a discrete phase method

Gao, Guangjun,Zhang, Yani,Zhang, Jie,Xie, Fei,Zhang, Yan,Wang, Jiabin Techno-Press 2018 Wind and Structures, An International Journal (WAS Vol.27 No.4

This paper investigated the wind-snow flow around the bogie region of a high-speed train under crosswinds using a coupled numerical method of the unsteady Realizable $k-{\varepsilon}$ turbulence model and discrete phase model (DPM). The flow features around the bogie region were discussed and the influence of bogie fairing height on the snow accumulation on the bogie was also analyzed. Here the high-speed train was running at a speed of 200 km/h in a natural environment with the crosswind speed of 15 m/s. The mesh resolution and methodology for CFD analysis were validated against wind tunnel experiments. The results show that large negative pressure occurs locally on the bottom of wheels, electric motors, gear covers, while the positive pressure occurs locally on those windward surfaces. The airflow travels through the complex bogie and flows towards the rear bogie plate, causing a backflow in the upper space of the bogie region. The snow particles mainly accumulate on the wheels, electric motors, windward sides of gear covers, side fairings and back plate of the bogie. Longer side fairings increase the snow accumulation on the bogie, especially on the back plate, side fairings and brake clamps. However, the fairing height shows little impact on snow accumulation on the upper region of the bogie. Compared to short side fairings, a full length side fairing model contributes to more than two times of snow accumulation on the brake clamps, and more than 20% on the whole bogie.

Nanoflower-like Ag/AAO SERS platform with quasi-photonic crystal nanostructure for efficient detection of goat serum

Guochao Shi,Mingli Wang,Yanying Zhu,Xiaoya Yan, Siye Pan,Siye Pan,Anqi Zhang 한국물리학회 2019 Current Applied Physics Vol.19 No.11

An effective SERS-based detection method has been developed to quantitatively diagnose the goat serum which overcomes the problem of diffusion limitation in traditional heterogeneous immunoassay. In this work, the ultrasensitive silver/anodic aluminum oxide (Ag/AAO) SERS platform was explored via magnetron sputtering which can precisely control the sample morphology and intergap distances. Results indicated that the localized surface plasmon resonance (LSPR) effect was sharply strengthened as the sub-10 nm nanogaps generated and the enhancement factor (EF) for crystal violet (CV) was calculated to be 3.677×107. This novel Ag/AAO substrate with substantial “hot spots” exhibited high SERS sensitivity which could obtain extremely low limits of detection (LOD) of 10−12M for CV. Importantly, this SERS platform was employed to detect goat serum and reached a LOD at 1 ng/μl. As a nondestructive detection technique, our SERS-based methodology required small sample quantity which expected to achieve more biomolecular detection.

Edaravone alleviates lung damage in mice with hypoxic pulmonary hypertension by increasing nitric oxide synthase 3 expression

Wan Zheng,Tianfa Li,Junping Wei,Yani Yan,Shanshan Yang 대한약리학회 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.3

This study is to determine the regulation of nitric oxide synthase 3 (NOS3) by edaravone in mice with hypoxic pulmonary hypertension (HPH). C57BL/6J mice were reared in a hypoxic chamber. HPH mice were treated with edaravone or edaravone + L-NMMA (a NOS inhibitor). Lung tissue was collected for histological assessment, apoptosis analysis, and detection of malondialdehyde, superoxide dismutase, tumor necrosis factor (TNF)-α, interleukin (IL)-6, and NOS3. The levels of serum TNF-α and IL-6 were also measured. Immunohistochemistry was used to visualize the expression of α-smooth muscle actin (SMA) in pulmonary arterioles. Edaravone treatment improved hemodynamics, inhibited right ventricular hypertrophy, increased NOS3 expression, and reduced pathological changes, pulmonary artery wall thickness, apoptotic pulmonary cells, oxidative stress, and the expression of TNF-α, IL-6, and α-SMA in HPH mice. L-NMMA treatment counteracted the lung protective effects of edaravone. In conclusion, edaravone might reduce lung damage in HPH mice by increasing the expression of NOS3.

Outcomes of Anti-CD19 CAR-T Treatment of Pediatric B-ALL with Bone Marrow and Extramedullary Relapse

Xinyu Wan,Xiaomin Yang,Fan Yang,Tianyi Wang,Lixia Ding,Lili Song,Yan Miao,Xiang Wang,Yani Ma,Chengjuan Luo,Jingyan Tang,Longjun Gu,Jing Chen,Yanjing Tang,Jun Lu,Benshang Li 대한암학회 2022 Cancer Research and Treatment Vol.54 No.3

PurposeAnti-CD19 chimeric antigen receptor T-cell immunotherapy (19CAR-T) has achieved impressive clinical results in adult and pediatric relapsed/refractory (r/r) B-lineage acute lymphoblastic leukemia (B-ALL). However, the application and effect of CAR-T therapy in B-ALL patients with extramedullary relapse are rarely issued even disqualified in some clinical trials. Here, we examined the efficacy of 19CAR-T in patients with both bone marrow and extramedullary involvement.Materials and MethodsCAR-T cells were generated by transfection of primary human T lymphocytes with a lentiviral vector expressing anti-CD19 single chain antibody fragments (scFvs) with the cytoplasmic domains of 4-1BB and CD3ζ, and used to infuse patients diagnosed as having r/r B-ALL with extramedullary origination. Clinical responses were evaluated by the use of bone marrow aspiration, imaging, and flow cytometry. ResultsEight patients received 19CAR-T infusion and all attained complete remission (CR). Only one patient was bridged to hematopoietic stem cell transplantation (HSCT). Although three patients relapsed after infusion, they received 19/22CAR-T infusion sequentially and attained a second remission. To date, five patients are in continuous CR and all eight patients are still alive. The mean follow-up time was 21.9 months, while the 24-month estimated event-free survival is 51.4%. Conclusion19CAR-T therapy can lead to clinical remission for extramedullary relapsed pediatric B-ALL patients. However, the problem of CD19+ relapses after CAR-T remained to be solved. For patients relapsing after CAR-T, a second CAR-T therapy creates another opportunity for remission for subsequent HSCT.