The novel herbal cocktail MA128 suppresses tumor growth and the metastatic potential of highly malignant tumor cells

KIM, AEYUNG,IM, MINJU,YIM, NAM-HIU,HWANG, YOUN-HWAN,YANG, HYE JIN,MA, JIN YEUL Spandidos Publications 2015 ONCOLOGY REPORTS Vol.34 No.2

<P>MA128, a novel herbal medicine, was previously identified and its effectiveness in the treatment of asthma and atopic dermatitis (AD) was demonstrated. In particular, post-inflammatory hyperpigmentation (PIH) in AD mice was improved by treatment with MA128. In addition, MA128 exhibited anti-melanogenic activity by inhibiting tyrosinase activity via the p38 MAPK and protein kinase A signaling pathways in B16F10 cells. In the present study, we examined whether oral administration of MA128 suppressed the in vivo tumor growth of HT1080 cells in athymic nude mice. The results showed that the daily oral administration of 75 and 150 mg/kg MA128 suppressed the tumorigenic growth of HT1080 cells efficiently. Since metastasis is a major cause of cancer-associated mortality and the greatest challenge during cancer treatment, we investigated the effect of non-toxic concentrations of MA128 on the metastatic potential of HT1080 cells. MA128 inhibited anchorage-independent colony formation, migration and invasion. Matrix metalloproteinase-9 (MMP-9) activity under resting and PMA-stimulated conditions was decreased in a dose-dependent manner by MA128 in HT1080 cells. In addition, the daily oral administration of MA128 at doses of 75 and 150 mg/kg efficiently blocked the lung metastasis of B16F10 cells that had been injected into the tail veins of C57BL/6 mice. In particular, none of the mice treated with MA128 exhibited systemic toxicity, such as body weight loss or liver and kidney dysfunction. MA128 also inhibited tumor-induced angiogenesis. Taken together, the results suggest that MA128 is a potential therapeutic agent and a safe herbal medicine for controlling malignant and metastatic cancer.</P>

Late Ordovician provenance and depositional setting in the southwestern Ordos Block, China: constraints from zircon U-Pb geochronology

Fu Yang,Gang Chen,Yu Kang,Dongmin Ma,Qilin Chen,Tian Tao,Fu Deliang 한국지질과학협의회 2020 Geosciences Journal Vol.24 No.2

The U-Pb ages of single zircon grains contained in the sandstone samples were analyzed by the LA-ICP-MS method, the sediment provenances and geological significance were discussed. The LA-ICP-MS zircon U-Pb dating from the sandstones, tuffaceous sandstones and volcanic tuffs of the Pingliang and Zhaolaoyu Formations along the southwestern Ordos Block are used to limit the maximum depositional age and material sources. The results show that: (1) The youngest ages of zircon dating in the three samples are 445 Ma, 444 Ma and 443 Ma, respectively, suggesting that the studied Formations were deposited in the Late Ordovician. (2) The detrital zircon U-Pb age analysis of the sandstones sample from the Pinliang Formation clustered in the 445–477 Ma, 588–1548 Ma and 1612–2496 Ma with the corresponding youngest peak age of 454.5 ± 3.3 Ma. (3) The distribution of zircon U-Pb age in sandstone samples showing that the sedimentary rocks detritus was mainly sourced from the North Qinling-Qilian terranes and the NCC, and has double provenance supply in the north and south. The material source of the tuffaceous sandstones and volcanic tuffs mainly comes from the volcanic and magmatic activity related to the North Qilian-North Qinling Island Arcs.

Design and research of high misalignment tolerant magnetic couplers for dynamic wireless charging systems

Zhenjie Li,Xuezhi Yang,Jun Ma,Mingfei Ban,Yiqi Liu 전력전자학회 2024 JOURNAL OF POWER ELECTRONICS Vol.24 No.3

This paper proposes a main-auxiliary cooperative receiving coil (MA-coil) with a lower space occupation rate and a simple control based on the time-sharing working principle, which can effectively improve the anti-misalignment capability of a dynamic wireless charging (DWC) system. First, the structure and circuit topology of the MA-coil are designed. The two auxiliary coils (A-coil) are connected in reverse series and symmetrically placed on both sides of the main coil (M-coil). Second, the output performance of the MA-coil in the y-direction is calculated based on the time-sharing working principle. The A-coil works by itself and enhances the output power when side shift occurs. Third, the most suitable ratio of coil width w M and w A is determined. The anti-misalignment performance and the effective side shift range are compared through simulation between the MA-coil in this case and the square coil. Finally, an experimental prototype is built to verify the feasibility of the proposed structure, and experimental results obtained from the prototype are basically consistent with the theoretical analysis. The anti-misalignment capability of the MA-coil is more than 20% higher than that of the square coil.

비가림 및 망사 시설재배가 참다래의 수체생육 및 과실품질에 미치는 영향

나양기,마경철,임동근,김병삼,임경호,김월수,이상현,박용서 全南大學校 農業科學技術硏究所 2001 農業科學技術硏究 Vol.36 No.-

This studies were conducted to investigate the effects of rain shelter and netting on the tree growth, fruit set fruit quality of kiwifruit (Actinidia deliciosa). In rain shelter and net house, shoot falling wasn't occurred by strong wind, and fruit set, fruit weight and also fruit malformation, side flowering increased at the same time. In rain shelter house the increment temperature forced blooming date and increased shoot length, leaf number and diameter but in net house these tendencies were not observed. Relative light intensity of rain shelter house was higher than that of net house with standard of field culture (relative light intensity: 100%). Soluble solid content was higher in rain shelter house, and acid content was higher in net house. With the effect of rain sheltering the occurrence of bacterial bloom rot and canker significantly decreased in both rain shelter and net house but insect injury increased. These data showed that rain shelter house is more suitable for kiwi fruit culture.

형상인식을 적용한 용접 결함의 특징변수 추출

김재열,마상동,오성민,송경석,김양중,김창현,곽이구 朝鮮大學校 機械技術硏究所 1999 機械技術硏究 Vol.2 No.2

In this study, the researches classifying the natural flaws in welding parts are performed using the signal pattern classification method. For this purpose 500MHz storage digital oscilloscope including FFT function and enveloped waveform generator are used and the signal pattern recognition procedure is made up the digital signal processing, feature extraction, feature selection and classifier design. Specially it is composed with and discussed using the distance classifier is based in euclidean distance the empirical Bayesian classifier. In feature extracting, it is performed using the class-mean scatter criteria. And the signal Pattern classification method is applied to the signal pattern recognition problems of natural flaw that is porosity inclusion, slag inclusion, lack of penetration, lack of fusion. center crack, side crack, toe crack. root crack as the planar and volumetric flaw classification problem. According to this results, if appropriately learned the neural network classifier is better acquire the recognition rate of 86.31% above through it is different a little according to domain extracting the feature and the classifier

세탁기용 자동변속기(Auto-Transmission)의 이상음 검사용 자동화 프로그램 개발

김재열,김양중,한재호,마상동,김창현 朝鮮大學校 機械技術硏究所 2000 機械技術硏究 Vol.3 No.1

This study includes automatic program for noise inspection of auto-transmission for washing machine one of modern home necessary. We effort to find and certificate sound noise source by sound power and sound intensity, and apply to frequency analysis in vibration related sound noise. Still more we have been studying to data acquisition and programming for MS VisualBasic version 5.0. System component is below. 1) Pentium PC for data acquisition. 2) DSO for noise acquisition. 3) S/W for comparison and decision. 4) I/F Board for data communication. Wave form data through the DSO are converting to ASCII code data. The ASCII code through binary converting S/W are to be decision fitness or the badness comparison S/W. Finally, we will making noise monitoring system and automatic program for inspection system

칼슘제 수관살포가 참다래의 과실 품질과 저장에 미치는 영향

임경호,나양기,임동근,마경철,조윤섭,김월수,이상현,박용서 全南大學校 農業科學技術硏究所 2001 農業科學技術硏究 Vol.36 No.-

This study were carried out to improve Kiwifruit quality and storage life. Three kinds of calcium compound were sprayed and calcium content of fruits, weight loss during fruit storage and fruit quality were investigated. Calcium contents within leaves and fruit were lower in Clef-non treatment than that of control. The calcium content in fruit pericarp of Kalk-H and CaCl2 was 0.04 to 0.05% higher than that of control. Fruit weight and soluble solids content at harvest was a little higher but acidity and fruit hardness was lowered. Fruit weight loss of Kalk-H and CaCl2 treatment was 1.39 to 1.53% lower than that of control during storage. The soluble solids of ripen fruit was 1.0 to 1.3% higher in all treatment and 0.8% higher in Kalk-H treatment in 120 of after storage. Fruit hardness of control fruit was higher at harvest but that of CaCl2 treatmented fruit was 0.39㎏/φ 5㎜ higher in 120 days of storage.

Covalent Confinement of Sulfur Copolymers onto Graphene Sheets Affords Ultrastable Lithium-Sulfur Batteries with Fast Cathode Kinetics

Ma, Junpeng,Fan, Jingbiao,Chen, Shang,Yang, Xinyue,Hui, Kwun Nam,Zhang, Hongwen,Bielawski, Christopher W.,Geng, Jianxin American Chemical Society 2019 ACS APPLIED MATERIALS & INTERFACES Vol.11 No.14

<P>Lithium-sulfur (Li-S) batteries have received significant attention due to the high theoretical specific capacity of sulfur (1675 mA h g<SUP>-1</SUP>). However, the practical applications are often handicapped by sluggish electrochemical kinetics and the “shuttle effect” of electrochemical intermediate polysulfides. Herein, we propose an in-situ copolymerization strategy for covalently confining a sulfur-containing copolymer onto reduced graphene oxide (RGO) to overcome the aforementioned challenges. The copolymerization was performed by heating elemental sulfur and isopropenylphenyl-functionalized RGO to afford a sulfur-containing copolymer, that is, RGO-<I>g</I>-poly(S-<I>r</I>-IDBI), which is featured by a high sulfur content and uniform distribution of the poly(S-<I>r</I>-IDBI) on RGO sheets. The covalent confinement of poly(S-<I>r</I>-IDBI) onto RGO sheets not only enhances the Li<SUP>+</SUP> diffusion coefficients by nearly 1 order of magnitude, but also improves the mechanical properties of the cathodes and suppresses the shuttle effect of polysulfides. As a result, the RGO-<I>g</I>-poly(S-<I>r</I>-IDBI) cathode exhibits an enhanced sulfur utilization rate (10% higher than that of an elemental sulfur cathode at 0.1C), an improved rate capacity (688 mA h g<SUP>-1</SUP> for the RGO-<I>g</I>-poly(S-<I>r</I>-IDBI) cathode vs 400 mA h g<SUP>-1</SUP> for an elemental sulfur cathode at 1C), and a high cycling stability (a capacity decay of 0.021% per cycle, less than one-tenth of that measured for an elemental sulfur cathode).</P> [FIG OMISSION]</BR>

무-밸브 공기흡입 펄스데토네이션 엔진의 내부 유동과 성능

Fuhua Ma(F. Ma),최정열(J.-Y Choi),Vigor Yang(V. Yang) 한국추진공학회 2006 한국추진공학회 학술대회논문집 Vol.2006 No.5

Fenofibrate Increases Radiosensitivity in Head and Neck Squamous Cell Carcinoma via Inducing G2/M Arrest and Apoptosis

Liu, Jia,Ge, Yang-Yang,Zhu, Hong-Cheng,Yang, Xi,Cai, Jing,Zhang, Chi,Lu, Jing,Zhan, Liang-Liang,Qin, Qin,Yang, Yan,Yang, Yue-Hua,Zhang, Hao,Chen, Xiao-Chen,Liu, Zhe-Ming,Ma, Jian-Xin,Cheng, Hong-Yan,S Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.16

Radiation therapy is an important treatment for head and neck squamous cell carcinoma (HNSCC). However, how to promote radiation sensitivity in HNSCC remains a challenge. This study aimed to investigate the radiosensitizing effects of fenofibrate on HNSCC and explore the underlying mechanisms. HNSCC cell lines CNE-2 and KB were subjected to ionizing radiation (IR), in the presence or absence of fenofibrate treatment. Cell growth and survival, apoptosis and cell cycle were evaluated. In addition, CNE-2 cells were xenografted into nude mice and subjected to IR and/or fenofibrate treatment. The expression of cyclinB and CDK1 was detected by Western blotting. Our results showed that fenofibrate efficiently radiosensitized HNSCC cells and xenografts in mice, and induced apoptosis and G2/M arrest via reducing the activity of the CDK1/cyclinB1 kinase complex. These data suggest that fenofibrate could be a promising radiosensitizer for HNSCC radiotherapy.