Pressure and tilt

( Zhang Yanbo ) 한국기초조형학회 2019 한국기초조형학회 작품집 Vol.2019 No.2

Babeisa duncani infection alters gut microbiota profile in hamsters

Shangdi Zhang,Jinming Wang,Xiaoyun Li,Yanbo Wang,Yueli Nian,Chongge You,Dekui Zhang,Guiquan Guan 대한기생충학ㆍ열대의학회 2023 The Korean Journal of Parasitology Vol.61 No.1

The genus Babesia includes parasites that can induce human and animal babesiosis, which are common in tropical and subtropical regions of the world. The gut microbiota has not been examined in hamsters infected by Babesia duncani. Red blood cells infected with B. duncani were injected into hamsters through intraperitoneal route. To evaluate the changes in gut microbiota, DNAs were extracted from small intestinal contents, acquired from hamsters during disease development. Then, the V4 region of the 16S rRNA gene of bacteria was sequenced using the Illumina sequencing platform. Gut microbiota alternation and composition were assessed according to the sequencing data, which were clustered with >97.0% sequence similarity to create amplicon sequence variants (ASVs). Bacteroidetes and Firmicutes were made up of the major components of the gut microbiota in all samples. The abundance of Bacteroidetes elevated after B. duncani infection than the B. duncani-free group, while Firmicutes and Desulfobacterota declined. Alpha diversity analysis demonstrated that the shown ASVs were substantially decreased in the highest parasitemia group than B. duncani-free and lower parasitemia groups. Potential biomarkers were discovered by Linear discriminant analysis Effect Size (LEfSe) analysis, which demonstrated that several bacterial families (including Muribaculaceae, Desulfovibrionaceae, Oscillospiraceae, Helicobacteraceae, Clostridia UGG014, Desulfovibrionaceae, and Lachnospiraceae) were potential biomarkers in B. duncani-infected hamsters. This research demonstrated that B. duncani infectious can modify the gut microbiota of hamsters.

Simulation of Unsteady Incompressible 2D Cylinder Flow with Physics-Informed Neural Network

Hui Xiang,Yanbo Zhang,Yuanye Zhou,Tianyuan Liu,Xin Xie,Yunzhu Li,Qiao Zhao 한국전산유체공학회 2022 한국전산유체공학회 학술대회논문집 Vol.2022 No.10

A new device for restraining rail vibration of ballastless track and its effect study

Zhenxing He,Xu Zhang,Xiaotao Wang,Hualong Zhou,Quanbao Feng,Qingchao Chen,Junxia Chen,Yanbo Bai,Runxi Zhang,Nengneng Bao 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.8

A new type of rail vibration damping device (NTRVDV), which is arranged between the bottom of the rail and track bed, is proposed in this paper. The finite element model of the rail system with the NTRVDV and tuned rail damper (TRD) was established, respectively. The impact load was applied to the finite element model, and comparison of the set of existing TRD and NTRVDV on the dynamic response of rail and rail vibration decay rate. The effect of the stiffness change of the elastic layer of the NTRVDV on the rail vibration was studied, and a hammering test verified the theoretical research results. The research results show that compared with the traditional TRD, the NTRVDV has a more obvious suppression effect on rail vibration acceleration. The rail vibration decay rate is significantly improved, especially in the low-frequency stage. With the increase of the stiffness of the elastic layer of the vibration suppression device, the vibration suppression effect of the NTRVDV on the rail is improved. The change of the elastic layer stiffness significantly impacts the rail’s vibration suppression effect in the range of 0-7 kN/mm.

An Improved MITM Attack Against NTRU

Zhijian Xiong,Jinshuang Wang,Yanbo Wang,Tao Zhang,Liang Chen 보안공학연구지원센터 2012 International Journal of Security and Its Applicat Vol.6 No.2

The Analysis of Climate Change in Haiyan County

( Wenzheng Yu ),( Hanxiaoya Zhang ),( Tianliang Chen ),( Jing Liu ),( Yanbo Shen ) 한국인터넷정보학회 2020 KSII Transactions on Internet and Information Syst Vol.14 No.10

In this paper, the climate change in Haiyan County in recent decades was analyzed in detail with the methods of moving average, Mann-Kendall non-parametric mutation test and wavelet analysis. According to the variation trend of meteorological factors such as temperature, relative humidity, wind speed, pan evaporation and precipitation in recent decades, the climate of Haiyan County has a tendency of drought, which is becoming more and more serious. From the results of the analysis, the sunshine hours and the air temperature in Haiyan County have an obvious upward trend. The average surface temperature has increased by 2.75 ℃ from 1976, and its largest increase occurred in the late 1970s and 1980s. At this stage, the average surface temperature increased by 1.37 ℃. The relative humidity has a decreasing trend that has decreased by 2.75%. From 1976 to the present, there are two quasi-3a cycles and one quasi-6a cycle. The precipitation and evaporation showed the opposite change trend, in which the trend of precipitation fluctuated upward, while the trend of evaporation showed a fluctuating downward tendency, which led to the serious loss of water in the feeding area. The wind direction in Haiyan County are mainly from west to east, and its wind speed has a trend of slight increase.

ACT001 alleviates inflammation and pyroptosis through the PPAR-γ/NF-κB signaling pathway in LPS-induced alveolar macrophages

Fu Qiang,Shen Na,Fang Tao,Zhang Hewei,Di Yanbo,Liu Xuan,Du Chao,Guo Jianshuang 한국유전학회 2024 Genes & Genomics Vol.46 No.3

Background ACT001 is an anti-inflammatory agent that has been widely investigated for its role in tumors, intracranial diseases, and fibrotic diseases, but its effect on acute lung injury is less known. Objective The purpose of this study was to investigate the effect and mechanism of ACT001 on regulating inflammation and pyroptosis in lipopolysaccharide (LPS)-induced alveolar macrophages. Methods NR8383 alveolar macrophages treated with LPS were used to replicate the proinflammatory macrophage phenotype observed during acute lung injury. After ACT001 treatment, we measured the secretion and expression levels of critical inflammatory cytokines, the rate of pyroptosis, and the expression of NLRP3 inflammasome-associated proteins and pyroptosis-associated proteins. In addition, we assessed the role of the PPAR-γ/NF-κB signaling pathways and further validated the results with a PPAR-γ inhibitor. Results Our findings confirmed that ACT001 reduced the expression and release of inflammatory factors, attenuated cell pyroptosis, and downregulated the expression of NLRP3, ASC, caspase-1 p20, and GSDMD-N. These effects may be achieved by activating PPAR-γ expression and then inhibiting the NF-κB signaling pathway. When macrophages were treated with the PPAR-γ inhibitor, the protective effects of ACT001 were reversed. Conclusion ACT001 significantly ameliorated inflammation and pyroptosis via the PPAR-γ/NF-κB signaling pathways in LPS-induced NR8383 alveolar macrophages. Background ACT001 is an anti-inflammatory agent that has been widely investigated for its role in tumors, intracranial diseases, and fibrotic diseases, but its effect on acute lung injury is less known. Objective The purpose of this study was to investigate the effect and mechanism of ACT001 on regulating inflammation and pyroptosis in lipopolysaccharide (LPS)-induced alveolar macrophages. Methods NR8383 alveolar macrophages treated with LPS were used to replicate the proinflammatory macrophage phenotype observed during acute lung injury. After ACT001 treatment, we measured the secretion and expression levels of critical inflammatory cytokines, the rate of pyroptosis, and the expression of NLRP3 inflammasome-associated proteins and pyroptosis-associated proteins. In addition, we assessed the role of the PPAR-γ/NF-κB signaling pathways and further validated the results with a PPAR-γ inhibitor. Results Our findings confirmed that ACT001 reduced the expression and release of inflammatory factors, attenuated cell pyroptosis, and downregulated the expression of NLRP3, ASC, caspase-1 p20, and GSDMD-N. These effects may be achieved by activating PPAR-γ expression and then inhibiting the NF-κB signaling pathway. When macrophages were treated with the PPAR-γ inhibitor, the protective effects of ACT001 were reversed. Conclusion ACT001 significantly ameliorated inflammation and pyroptosis via the PPAR-γ/NF-κB signaling pathways in LPS-induced NR8383 alveolar macrophages.

Ship Twin-propeller Jet Model used to Predict the Initial Velocity and Velocity Distribution within Diffusing Jet

Jinxin Jiang,Wei-Haur Lam,Yonggang Cui,Tianming Zhang,Chong Sun,Jianhua Guo,Yanbo Ma,Shuguang Wang,Gerard Hamill 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.3

The current research proposed the theoretical model for ship twin-propeller jet based on the axial momentum theory and Gaussian normal distribution. The twin-propeller jet model is compared to the more matured single propeller jet model with good agreement. Computational Fluid Dynamics (CFD) method is used to acquire the velocity distribution within the twin-propeller jet for understanding of flow characteristics and validation purposes. Efflux velocity is the maximum velocity within the entire jet with strong influences by the geometrical profiles of the blades. Twin-propeller jet model showed four-peaked profile at the initial plane downstream to the propeller compared to the two-peaked profile from a single-propeller. The four-peaked profile merges to be twopeaked velocity profile and then one-peaked profile due to the fluid mixing. Entrainment occurs between the ambient still water outside and the rotating flow within jet due to the high velocity gradient. The research proposes a twin-propeller jet theory with a serial of equations enabling the predictions of velocity magnitude within the jet.

The Positive Association between Subclinical Hypothyroidism and Newly-Diagnosed Hypertension Is More Explicit in Female Individuals Younger than 65

Xichang Wang,Haoyu Wang,Li Yan,Lihui Yang,Yuanming Xue,Jing Yang,Yongli Yao,Xulei Tang,Nanwei Tong,Guixia Wang,Jinan Zhang,Youmin Wang,Jianming Ba,Bing Chen,Jianling Du,Lanjie He,Xiaoyang Lai,Yanbo Li 대한내분비학회 2021 Endocrinology and metabolism Vol.36 No.4

Background: Subclinical hypothyroidism (SCH) is the most common thyroid dysfunction, and its relationship with blood pressure(BP) has been controversial. The aim of the study was to analyze the association between SCH and newly-diagnosed hypertension. Methods: Based on data from the Thyroid disease, Iodine nutrition and Diabetes Epidemiology (TIDE) study, 49,433 euthyroid individuals and 7,719 SCH patients aged ≥18 years were enrolled. Patients with a history of hypertension or thyroid disease were excluded. SCH was determined by manufacturer reference range. Overall hypertension and stage 1 and 2 hypertension were diagnosedaccording to the guidelines issued by the American College of Cardiology/American Heart Association in 2017. Results: The prevalence of overall hypertension (48.7%), including stage 1 (28.9%) and 2 (19.8%) hypertension, increased significantly in SCH patients compared with euthyroid subjects. With elevated serum thyroid stimulating hormone (TSH) level, the hypertension prevalence also increased significantly from the euthyroid to different SCH subgroups, which was more profound in femalesor subjects aged <65 years. The age- and sex-specific regression analysis further demonstrated the same trends in the general population and in the 1:1 propensity matched population. Similarly, several BP components (i.e., systolic, diastolic, and mean arterial BP)were positively associated with TSH elevation, and regression analysis also confirmed that all BP components were closely relatedwith SCH in female subjects aged <65 years. Conclusion: The prevalence of hypertension increases for patients with SCH. SCH tends to be associated with hypertension and BPcomponents in females younger than 65 years.