A self-powered β-Ga2O3/CsCu2I3 heterojunction photodiode responding to deep ultraviolet irradiation

Gao Ang,Jiang Weiyu,Ma Guoliang,Liu Zeng,Li Shan,Yan Zuyong,Sun Weiming,Zhang Shaohui,Tang Weihua 한국물리학회 2022 Current Applied Physics Vol.33 No.-

In this paper, a lead-free halide perovskite CsCu2I3 film with high stability was prepared by the anti-solvent assisted crystallization method. Then, we coupled it with Ga2O3 to prepare a corresponding heterojunction deep ultraviolet (UV) photodetector. After testing, we concluded that the photodetector is sensitive to 254 nm UV light. The photodetector has good reproducibility, and has an ultra-high photo-to-dark current ratio (PDCR) of more than 105. In addition, under a bias of 10 V and an illuminated intensity of 200 μW/cm2, the responsivity (R) and specific detectivity (D*) reached 20 mA/W and 107 cm Hz1/2 W 1 (Jones), and the external quantum efficiency (EQE) is 10%. Meanwhile, the prepared photodetector could operate at zero bias, i.e., self-powered operation, along with a photocurrent of about 1 nA under illumination with UV light intensity of 200 μW/cm2.

Knockdown of HMGN5 Expression by RNA Interference Induces Cell Cycle Arrest in Human Lung Cancer Cells

Chen, Peng,Wang, Xiu-Li,Ma, Zhong-Sen,Xu, Zhong,Jia, Bo,Ren, Jin,Hu, Yu-Xin,Zhang, Qing-Hua,Ma, Tian-Gang,Yan, Bing-Di,Yan, Qing-Zhu,Li, Yan-Lei,Li, Zhen,Yu, Jin-Yan,Gao, Rong,Fan, Na,Li, Bo,Yang, Jun Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.7

HMGN5 is a typical member of the HMGN (high mobility group nucleosome-binding protein) family which may function as a nucleosomal binding and transcriptional activating protein. Overexpression of HMGN5 has been observed in several human tumors but its role in tumorigenesis has not been fully clarified. To investigate its significance for human lung cancer progression, we successfully constructed a shRNA expression lentiviral vector in which sense and antisense sequences targeting the human HMGN5 were linked with a 9-nucleotide loop. Inhibitory effects of siRNA on endogenous HMGN5 gene expression and protein synthesis were demonstrated via real-time RT-PCR and western blotting. We found HMGN5 silencing to significantly inhibit A549 and H1299 cell proliferation assessed by MTT, BrdU incorporation and colony formation assays. Furthermore, flow cytometry analysis showed that specific knockdown of HMGN5 slowed down the cell cycle at the G0/G1 phase and decreased the populations of A549 and H1299 cells at the S and G2/M phases. Taken together, these results suggest that HMGN5 is directly involved in regulation cell proliferation in A549 and H1299 cells by influencing signaling pathways involved in cell cycle progression. Thus, our finding suggests that targeting HMGN5 may be an effective strategy for human lung cancer treatment.

Stochastic dynamic responses of a train-track-bridge system under spatially varying ground motions

Ma, Chun Yan(마춘연),Mu, Di(모디),Choi, Dong Ho(최동호) 한국강구조학회 2021 한국강구조학회 학술대회 발표집 Vol.32 No.1

Differential Roles of Glycogen Synthase Kinase 3 Subtypes Alpha and Beta in Cortical Development

Ma, Yan-xia,Wang, Xiu-li,Chen, Jian-quan,Li, Bin,Hur, Eun-Mi,Saijilafu Frontiers Media S.A. 2017 Frontiers in molecular neuroscience Vol.10 No.-

<P>Glycogen synthase kinases 3 (GSK3) α and β are expressed in the nervous system, and disruption of GSK3 signaling has been implicated in a wide range of neurodevelopmental and psychiatric disorders. Although several studies have established a role of GSK3 signaling in the nervous system, much less is known about isoform-specific functions. Here, we have examined the role of GSK3α and GSK3β in the developing neocortex by performing <I>in utero</I> electroporation with specific small interfering RNAs targeting each isoform. We found that depletion of either GSK3α or GSK3β commonly promoted the proliferation of neural progenitor cells in the ventricular zone, but at later stages, knocking down of each isoform resulted in distinct outcomes. In particular, the transformation of radial progenitors to intermediate progenitor cells was promoted in GSK3α-depleted cells, but markedly prevented in GSK3β-depleted cells. Moreover, knocking down of GSK3β but not GSK3α prevented the generation of upper-layer Cux1<SUP>+</SUP> neurons. Consistent with the distinct outcomes, protein levels of c-Myc and β-catenin, well-known substrates of GSK3, were differentially affected by depletion of GSK3α and GSK3β. Together, these results suggest that GSK3α and GSK3β might play distinct roles in the genesis and differentiation of neuronal lineage cells during neocortex development by differential regulation of downstream signaling pathways.</P>

Microstructure and Biocompatibility of Porous Ti-Nb-Zr-CPP Composite Fabricated by Spark Plasma Sintering and Leaching Process

( Yan Hua Ma ),( Kee Do Woo ),( Dong Soo Kang ),( Sang Mi Kim ) 대한금속재료학회(구 대한금속학회) 2013 대한금속·재료학회지 Vol.51 No.5

Metallic biomaterials such as titanium and its alloys have been widely used as permanent implant materials due to their excellent corrosion resistance, fatigue property, and strength. Calcium pyrophosphate (CPP) is an attractive bioceramic for human tissue implantation due to its good biocompatibility and similar composition to human bone. High energy mechanical milling and spark plasma sintering (SPS) can be used to fabricate a sound composite of the Ti-Nb-Zr-CPP. In a biomaterial such as the Ti-6Al-4V ELI alloy, the coating property between the bioceramic and Ti-based alloy is very important. By addition of CPP to the Ti-Nb-Zr alloy, the Ti-Nb-Zr alloy can improve the wetability between the Ti alloy and bioceramic as a coating material. Also the porous surface of the biomaterials can improve the symphyseal ability with osteoblast. In this study, a porous surface can be made by using several different leaching solutions such as aqueous diluted H3PO4. Ti-Nb-Zr-CPP composite was fabricated by spark plasma sintering (SPS) at 1000 ℃ under 70 MPa using high energy mechanical milled powder. A porous surface was successfully fabricated by using a 40 vol%H3PO4+ 60 vol.%H2O leaching solution at room temperature for 24 h.

Rice OsAS2 Gene, a Member of LOB Domain Family, Functions in the Regulation of Shoot Differentiation and Leaf Development

Yan Ma,Fang Wang,Jing Guo,Xian Sheng Zhang 한국식물학회 2009 Journal of Plant Biology Vol.52 No.5

LATERALORGAN BOUNDARIES DOMAIN (LBD) genes, a novel plant-specific family, play specific roles in plant development. Although function of ASYMMETRIC LEAVES2 (AS2), a LBD gene, was extensively studied in Arabidopsis of dicots, little is known on the role of its ortholog in rice of monocots. In this study, a LBD gene that shares higher homology with Arabidopsis AS2 gene was identified in rice and it was designated as OsAS2. Its transcripts were detected throughout predicted leaf primordia in shoot apical meristem (SAM), leaf primordia, and young leaves. Overexpression of the OsAS2 gene inhibited shoot differentiation, promoted cell division, and delayed cell differentiation in rice calli. Transgenic plants with OsAS2 gene showed the aberrant twisted leaves, which lack auricle, and leaf structure was abnormal. Furthermore, a few genes involved in shoot meristem development were upregulated in transgenic plants. Our results suggest that proper expression of the OsAS2 gene is required for shoot differentiation and leaf development in rice.

A Study on the Civil Liability of Freight Forwarders under Chinese Law - Focus on the Regulations on the Trial of Disputes over Ocean Freight Forwarding - 1

Yan-Qiu Ma,Yan-An Yu 한국해사법학회 2016 해사법연구 Vol.28 No.3

오늘날, 해상화물 운송주선인은 해상운송 시장 내 경쟁이 심화됨에 따라 그 의 업무 범위도 많이 변화되어, 화주와 운송업자 간의 연결 뿐만 아니라 많은 업무를 수행하고 있는데, mere agent, contracting carrier 및 performing carrier 등의 업무를 수행하면서 여러 가지 법적 문제가 발생 할 수 있다. 이러한 배경 을 바탕으로 중국최고법원은 해상화물 운송주선인의 분쟁의 재판에 관한 법규 를 제정하였다. 본 연구의 목적은 이 법규를 소개하고 해상화물 운송주선인의 정의 및 법적 책임, 운송 서류의 송달 지연, FOB 조건 하에서의 운송 서류의 송달, 화물의 멸실 및 훼손의 고지 및 해상화물 운송주선에 관한 분쟁의 시효 및 관할권에 대하여 논하고자 한다. With the highly competitive market, the functions of the freight forwarders have changed a lot. They are not only the link between the owner of the goods and the carrier, but also undertake many duties and can act as the mere agent, the contracting carrier or the performing carrier, while these may led to the arguments in judicial procedure with economic disputes. On such basis, the Supreme People’s Court of China had promulgated the Regulations concerning the trial of disputes over ocean freight forwarding. This article aims to outline the highlights of the Regulation on the identification of freight forwarders and their civil liability, and hope to answer and explain the detention of documents, the delivery of transport documents under FOB Terms, notice of loss or damage, time bar and jurisdiction over disputes of freight forwarding service.

Effect of Dietary Concentrate:forage Ratios and Undegraded Dietary Protein on Nitrogen Balance and Urinary Excretion of Purine Derivatives in Dorper×thin-tailed Han Crossbred Lambs

Ma, Tao,Deng, Kai-Dong,Tu, Yan,Jiang, Cheng-Gang,Zhang, Nai-Feng,Li, Yan-Ling,Si, Bing-Wen,Lou, Can,Diao, Qi-Yu Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.2

This study aimed to investigate dietary concentrate:forage ratios (C:F) and undegraded dietary protein (UDP) on nitrogen balance and urinary excretion of purine derivatives (PD) in lambs. Four Dorper${\times}$thin-tailed Han crossbred castrated lambs with $62.3{\pm}1.9$ kg body weight at 10 months of age were randomly assigned to four dietary treatments in a $2{\times}2$ factorial arrangement of two levels of C:F (40:60 and 60:40) and two levels of UDP (35% and 50% of CP), according to a complete $4{\times}4$ Latin-square design. Each experimental period lasted for 19 d. After a 7-d adaptation period, lambs were moved into individual metabolism crates for 12 d including 7 d of adaption and 5 d of metabolism trial. During the metabolism trial, total urine was collected for 24 h and spot urine samples were also collected at different times. Urinary PD was measured using a colorimetric method and creatinine was measured using an automated analyzer. Intake of dry matter (DM) (p<0.01) and organic matter (OM) (p<0.01) increased as the level of UDP decreased. Fecal N was not affected by dietary treatment (p>0.05) while urinary N increased as the level of UDP decreased (p<0.05), but decreased as dietary C:F increased (p<0.05). Nitrogen retention increased as dietary C:F increased (p<0.05). As dietary C:F increased, urinary excretion of PD increased (p<0.05), but was not affected by dietary UDP (p>0.05) or interaction between dietary treatments (p>0.05). Daily excretion of creatinine was not affected by dietary treatments (p<0.05), with an average value of $0.334{\times}0.005$ mmol/kg $BW^{0.75}$. A linear correlation was found between total PD excretion and PDC index ($R^2$ = 0.93). Concentrations of creatinine and PDC index in spot urine were unaffected by sampling time (p>0.05) and a good correlation was found between the PDC index (average value of three times) of spot urine and daily excretion of PD ($R^2$ = 0.88). These results suggest that for animals fed ad libitum, the PDC index in spot urine is effective to predict daily excretion of PD. In order to improve the accuracy of the spot sampling technique, an appropriate lag phase between the time of feeding and sampling should be determined so that the sampling time can coincide with the peak concentration of PD in the urine.

High-j Proton h11/2 and g7/2 Intruder Bands in 113In

Ma Ke Yan,Lu Jing Bin,Ma Ying Jun,Li Jian,Yang Dong,Sun Wu Ji,Wang Hao,Pan Hao Nan,Wang Jia Qi,Yang Qing Yu,Zhang Da Ming,Zhu Li Hua,Wu Xiao Guang,Zheng Yun,Li Cong Bo 한국물리학회 2020 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.76 No.12

Excited states of 113In have been populated through the heavy-ion fusion evaporation reaction 110Pd(7Li, 4n)113In. A new band with the configuration of a proton d5/2 orbital is identified. Two ΔI = 2 intruder bands, built on the πh11/2 and the πg7/2 orbitals, have been extended to spins (63/2-)ħ and (55/2+)ħ, respectively. The negative-parity πh11/2 intruder band shows a smooth increase in aligned spin, which is attributed to a strong proton-neutron interaction. The properties of the positive-parity πg7/2 band are discussed based on tilted axis cranking model calculations, and the features of the antimagnetic rotation for this band are shown after backbend. Furthermore, the contributions of the two-shears-like mechanism, the neutron (gd)ν shell and the core rotation are investigated for the positive-parity πg7/2 band.

Clinical Evaluation of Tumor Markers for Diagnosis in Patients with Non-small Cell Lung Cancer in China

Ma, Li,Xie, Xiao-Wei,Wang, Hai-Yan,Ma, Ling-Yun,Wen, Zhong-Guang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12

Background: To evaluate the value of combined detection of serum carcinoembryonic antigen (CEA), cytokeratin 19 fragment (CYFRA21-1), and carbohydrateantigen 125 (CA125) for the clinical diagnosis of nonsmall cell lung cancer (NSCLC). Materials and Methods: Serum CEA, CYFRA21-1 and CA125 were assessed in 140 patients with NSCLC, 90 patients with benign lung disease and 90 normal control subjects, and differences of expression were compared in each group, and joint effects of these tumor markers in the diagnosis of NSCLC were analyzed. Results: Serum CEA, CYFRA21-1 and CA125 in patients with NSCLC were significantly higher than those with benign lung disease and normal controls (P<0.05). The sensitivity of CEA, CYFRA21-1 and CA125 were 49.45%, 59.67%, and 44.87% respectively. As expected, combinations of these tumor markers improved their sensitivity for NSCLC. The combined detection of CEA + CYFRA21-1 was the most cost-effective combination which had higher sensitivity and specificity in NSCLC. Elevation of serum CEA and CYFRA21-1 was significantly associated with pathological types (P<0.05) and elevation of serum CEA, CYFRA21-1 and CA125 was significantly associated with TNM staging (P<0.05). Conclusions: Single measurement of CEA, CYFRA21-1 and CA125 is of diagnostic value in the diagnosis of lung cancer, and a joint detection of these three tumor markers, could greatly improve the sensitivity of diagnosis on NSCLC. Combined detection of CEA + CYFRA21-1 proved to be the most economic and practical strategy in diagnosis of NSCLC, which can be used to screen the high-risk group.