자외선 (UVB) 노출 증가에 대한 피부암 위해도 예측 모델의 적용

신동천,이종태,정용,강나경,양지연 한국환경독성학회 1996 환경독성보건학회지 Vol.11 No.1

A decrease in stratospheric ozone probably caused by chloroflurocarbons (CFCs) emissions, has been observed large parts of the globe. It is generally accepted that if ozone levels in the stratosphere are depleted, greater amounts of shortwave ultraviolet radiation-B (UVB) will reach the earth's surface, resulting in increased incidence of nonmelanoma skin cancer. In this study, we evaluated several mathematical models, such as a power and an exponential model, and a geometric model considering the surface area of a human body part and ages for the prediction of skin cancer incidence caused by exposure to the UVB radiation. These models basically estimated the risk of skin cancer based on those measurements of the local ozone in stratosphere and UVB. Both were measured at a part of Seoul with a Dobson ozone spectrometer and Robertson-Berger UV Biometer for 1995. As a result, we calculated the point estimation applying a biological amplification factor (BAF), UVB radiation and other factors. We used a Monte-Carlo simulation technique with assumption on the distribution of each considered factor. The sensitivity analysis of model by there components conducted using Gaussian sensitivity method. The annual integral of UVB radiation was 2275 MED (minimal erythema dose)/yr. Also, an estimate of the annual amount of UVB reaching the earth's surface at a korea's latitude and altitude was 3328 MED/yr. The values of the radiation amplification factor (RAF) were ranged from 0.9 to 1.5 in Seoul. To give the effective factors required to model the prediction of skin cancer incidence caused by exposure to the UVB radiation in Korea, we studied the pros and cons of above mentioned models with the application of those parameters measured in Seoul, Korea.

Differential Expression of PPARγ, FASN, and ACADM Genes in Various Adipose Tissues and Longissimus dorsi Muscle from Yanbian Yellow Cattle and Yan Yellow Cattle

Ji, Shuang,Yang, Runjun,Lu, Chunyan,Qiu, Zhengyan,Yan, Changguo,Zhao, Zhihui Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.1

The objective of this study was to investigate the correlation between cattle breeds and deposit of adipose tissues in different positions and the gene expressions of peroxisome proliferator-activated receptor gamma ($PPAR{\gamma}$), fatty acid synthase (FASN), and Acyl-CoA dehydrogenase (ACADM), which are associated with lipid metabolism and are valuable for understanding the physiology in fat depot and meat quality. Yanbian yellow cattle and Yan yellow cattle reared under the same conditions display different fat proportions in the carcass. To understand this difference, the expression of $PPAR{\gamma}$, FASN, and ACADM in different adipose tissues and longissimus dorsi muscle (LD) in these two breeds were analyzed using the Real-time quantitative polymerase chain reaction method (qRT-PCR). The result showed that $PPAR{\gamma}$ gene expression was significantly higher in adipose tissue than in LD in both breeds. $PPAR{\gamma}$ expression was also higher in abdominal fat, in perirenal fat than in the subcutaneous fat (p<0.05) in Yanbian yellow cattle, and was significantly higher in subcutaneous fat in Yan yellow cattle than that in Yanbian yellow cattle. On the other hand, FASN mRNA expression levels in subcutaneous fat and abdominal fat in Yan yellow cattle were significantly higher than that in Yanbian yellow cattle. Interestingly, ACADM gene shows greater fold changes in LD than in adipose tissues in Yan yellow cattle. Furthermore, the expressions of these three genes in lung, colon, kidney, liver and heart of Yanbian yellow cattle and Yan yellow cattle were also investigated. The results showed that the highest expression levels of $PPAR{\gamma}$ and FASN genes were detected in the lung in both breeds. The expression of ACADM gene in kidney and liver were higher than that in other organs in Yanbian yellow cattle, the comparison was not statistically significant in Yan yellow cattle.

Density Functional Study of Deoxycytidine Radicals In Irradiated DNA

Yan-ju Ji,Feng-xiang Wang,Yang Jiao 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.52 No.-

Density functional theory is used to study the energetics and geometries of deoxycytidine radicals which are formed by removal of hydrogen from ve carbon atoms through irradiation. The C0 1 and C0 4 centered radicals (C0 1 and C0 4) are more energetically favored than the others. To investigate the cytosine release, a potential energy surface scan is performed to break the N1-glycosidic bond (N1-C0 1 bond). The result indicates that the activation energy needed for the N1-glycosidic bond breaking in every one of the deoxycytidine radicals is much lower than that in the parent deoxycytidine. The discussion shows that in irradiated molecular DNA, the C0 4 site is the most favored site for H abstraction; hence, there is C0 4-centered radical formation, subsequently leading to base release. This conclusion is in agreement with the experimental results. Density functional theory is used to study the energetics and geometries of deoxycytidine radicals which are formed by removal of hydrogen from ve carbon atoms through irradiation. The C0 1 and C0 4 centered radicals (C0 1 and C0 4) are more energetically favored than the others. To investigate the cytosine release, a potential energy surface scan is performed to break the N1-glycosidic bond (N1-C0 1 bond). The result indicates that the activation energy needed for the N1-glycosidic bond breaking in every one of the deoxycytidine radicals is much lower than that in the parent deoxycytidine. The discussion shows that in irradiated molecular DNA, the C0 4 site is the most favored site for H abstraction; hence, there is C0 4-centered radical formation, subsequently leading to base release. This conclusion is in agreement with the experimental results.

Fermentation Characteristics for Extruded Hair of Tissue Cultured Mountain Ginseng

Ji, Yan-Qing,Yang, Hye-Jin,Tie, Jin,Kim, Mi-Hwan,Yang, Jae-Ghan,Chung, Ki-Wha,Ryu, Gi-Hyung The Korean Society of Food Science and Nutrition 2009 Preventive Nutrition and Food Science Vol.14 No.2

Effects of extrusion conditions (barrel temperature and moisture content) and fermentation time on the antioxidant properties of root hair of tissue cultured raw mountain ginseng (MG) were investigated. The barrel temperature/ moisture combinations were: $110^{\circ}C$/25% (MG1), $140^{\circ}C$/25% (MG2), $110^{\circ}C$/35% (MG3) and $140^{\circ}C$/35% (MG4). Red ginseng (RG) was also investigated. The contents of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and polyphenolic increased after fermentation in RG and even more in MG, while extruded ginseng samples exhibited little change. The increases noted with MG and RG occurred during the first 4 days of fermentation. DPPH radical scavenging activity decreased after extrusion and was significantly higher in MG (20.93%) than RG (1.63%) on the first day of fermentation. DPPH radical scavenging activity in the barrel temperature/moisture combinations were 19.01% (MG1), 14.45% (MG2), 20.37% (MG3) and 15.78% (MG4). The content of polyphenolic compounds in ginseng samples displayed a similar trend. Acidic polysaccharide in RG and MG1${\sim}$MG4 were higher than MG, but decreased during fermentation. Crude saponin in RG and MG1${\sim}$MG4 decreased after 15 days of fermentation, while increasing in MG.

Structural, Half-metallic and Magnetic Properties of the Imperfect Pb₂FeReO<SUB>6</SUB> Containing Eight Different Inherent Defects

Yan Zhang,Hua-Xin Chen,Li Duan,Lei Ni,Ji-Bin Fan,Jie Wang,Guang-Teng Ci,Vincent Ji 한국자기학회 2019 Journal of Magnetics Vol.24 No.3

The structural, half-metallic (HM) and magnetic properties of the imperfect Pb₂FeReO6 containing eight different inherent defects of the FeRe or ReFe antisites, Fe1-Re1 or Fe1-Re4 interchanges, VFe, VRe, VO or VPb vacancies have been studied by first-principles calculations. No obvious structural changes are observed for FeRe or ReFe antisites, Fe1-Re1 or Fe1-Re4 interchanges and VPb vacancy defects, however, the six (two) nearest neighbors O (Fe or Re) of the vacancy move away from (close to) VFe or VRe (VO) vacancies. The HM character is maintained for FeRe or ReFe antisites, far Fe1-Re4 interchange, VFe, VO or VPb vacancies, while vanished for near Fe1-Re1 interchange or VRe vacancy. So the near Fe1-Re1 interchange or VRe vacancy defects should be avoided to preserve the HM character of the Pb₂FeReO6 and thus usable in spintronics devices. Except for the FeRe antisite case with a slightly higher total moment, the total moments μtot of the imperfect Pb₂FeReO6 with the other seven inherent defects are smaller than 3.96 μB/f.u. of the perfect Pb₂FeReO6.

TEACHERS’ AND LEARNERS’ PERSPECTIVE ON USING ENGLISH LANGUAGE MOVIES IN THE LISTENING CLASS

JI YOUNG YAN 미래영어영문학회 2010 미래영어영문학회 학술대회 자료집 Vol.2010 No.12

[P8-188] Extruded Root Hair of Tissue Cultured Mountain Ginseng Extract and Their Functional Characterizations

Yan-Qing Ji,Jin Tie,Mi-Hwan Kim,Gi-Hyung Ryu 한국식품영양과학회 2008 한국식품영양과학회 학술대회발표집 Vol.2008 No.10

[P3-30] Comparison of Physical Properties for Extruded Ginseng Samples

Yan-Qing Ji,Krittika Norajit,Gi-Hyung Ryu 한국식품영양과학회 2009 한국식품영양과학회 학술대회발표집 Vol.2009 No.11

Fermentation Characteristics for Extruded Hair of Tissue Cultured Mountain Ginseng

Yan-Qing Ji,Hye-Jin Yang,Jin Tie,Mi-Hwan Kim,Jae-Ghan Yang,Ki-Wha Chung,Gi-Hyung Ryu 한국식품영양과학회 2009 Preventive Nutrition and Food Science Vol.14 No.2

Effects of extrusion conditions (barrel temperature and moisture content) and fermentation time on the antioxidant properties of root hair of tissue cultured raw mountain ginseng (MG) were investigated. The barrel temperature/moisture combinations were: 110oC/25% (MG1), 140oC/25% (MG2), 110oC/35% (MG3) and 140oC/35% (MG4). Red ginseng (RG) was also investigated. The contents of 2,2-diphenyl-1-picrylhydrazyl (DPPH) and polyphenolic increased after fermentation in RG and even more in MG, while extruded ginseng samples exhibited little change. The increases noted with MG and RG occurred during the first 4 days of fermentation. DPPH radical scavenging activity decreased after extrusion and was significantly higher in MG (20.93%) than RG (1.63%) on the first day of fermentation. DPPH radical scavenging activity in the barrel temperature/moisture combinations were 19.01% (MG1), 14.45% (MG2), 20.37% (MG3) and 15.78% (MG4). The content of polyphenolic compounds in ginseng samples displayed a similar trend. Acidic polysaccharide in RG and MG1~MG4 were higher than MG, but decreased during fermentation. Crude saponin in RG and MG1~MG4 decreased after 15 days of fermentation, while increasing in MG.

IL-2/anti-IL-2 complexes ameliorate lupus nephritis by expansion of CD4+CD25+Foxp3+ regulatory T cells

Yan, Ji-Jing,Lee, Jae-Ghi,Jang, Joon Young,Koo, Tai Yeon,Ahn, Curie,Yang, Jaeseok Springer-Verlag 2017 Kidney international Vol.91 No.3

<P>Adoptive transfer of regulatory T cells (Tregs) can delay disease progression and reduce mortality in lupus-prone mice. Here, we tested whether complex (IL-2C) consisting of IL-2 and anti -IL-2 monoclonal antibody (JES6-1) ameliorates lupus nephritis by expanding Tregs as an alternative to problematic Treg infusion therapy. IL-2C treatment of NZB/W Fl mice induced an effective and sustained expansion of CD4(+)CD25(+)Foxp3(+) Tregs in both the kidneys and spleen along with decreased renal infiltration of T cells, B cells, and innate immune cells. Compared with controls, mice treated with IL-2C showed reduced proteinuria and fewer acute and chronic renal pathological lesions with improved renal function and survival. IL-2C significantly attenuated glomerular and tubular injury, vasculitis scores, and renal deposition of IgG and C3. Disease activity markers, such as high levels of anti-dsDNA antibodies and immunoglobulin levels, and low levels of complement were improved in sera of IL-2C-treated mice. IL-2C treatment decreased renal expression of TNF-alpha and IL-6, and the frequencies of IFN-gamma(+)CD4(+) and IL-17A(+)CD4(+) T cells in both the kidneys and spleen. Depletion of Tregs by anti-CD25 antibodies abrogated the beneficial effects of IL-2C. When compared with combination therapy of steroid and mycophenolate mofetil, IL-2C treatment showed similar or better outcomes. Thus, IL-2C protected lupus-prone mice against lupus nephritis by expanding Tregs. Hence, IL-2C could have therapeutic potential in lupus nephritis.</P>