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Angel Chao,Yi-Hao Lin,Lan-Yan Yang,Ren-Chin Wu,Wei-Yang Chang,Pi-Yueh Chang,Shih-Cheng Chang,Chiao-Yun Lin,Huei-Jean Huang,Cheng-Tao Lin,Hung-Hsueh Chou,Kuan-Gen Huang,Wen-Ling Kuo,Ting-Chang Chang,Ch 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.3
Objective: The characteristics of patients with metachronous breast and ovarian malignancies and the pathogenic role of BRCA1/2 mutations remain poorly understood. We investigated these issues through a review of hospital records and nationwide Taiwanese registry data, followed by BRCA1/2 mutation analysis in hospital-based cases. Methods: We retrospectively retrieved consecutive clinical records of Taiwanese patients who presented with these malignancies to our hospital between 2001 and 2017. We also collected information from the Data Science Center of the Taiwan Cancer Registry (TCR) between 2007 and 2015. Next-generation sequencing and multiplex ligation-dependent probe amplification were used to identify BRCA1/2 mutations and large genomic rearrangements, respectively. When BRCA1/2 mutations were identified in index cases, pedigrees were reconstructed and genetic testing was offered to family members. Results: A total of 12,769 patients with breast cancer and 1,537 with ovarian cancer were retrieved from our hospital records. Of them, 28 had metachronous breast and ovarian malignancies. We also identified 113 cases from the TCR dataset. Eighteen hospital-based cases underwent BRCA1/2 sequencing and germline pathogenic mutations were detected in 7 patients (38.9%, 5 in BRCA1 and 2 in BRCA2). All BRCA1/2 mutation carriers had ovarian high-grade serous carcinomas. Of the 12 patients who were alive at the time of analysis, 5 were BRCA1/2 mutation carriers. All of them had family members with BRCA1/2-associated malignancies. Conclusions: Our results provide pilot evidence that BRCA1/2 mutations are common in Taiwanese patients with metachronous breast and ovarian malignancies, supporting the clinical utility of genetic counseling.
Chang Yan,Chuanhe Jing,Xuding Song 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.39 No.3
This work focused on aluminum foam sandwich (AFS) with different foam core densities and different face-sheet thicknesses subjected to constant amplitude three-point bending cyclic loading to study its fatigue performance. The experiments were conducted out by a high frequency fatigue test machine named GPS-100. The experimental results showed that the fatigue life of AFS decreased with the increasing loading level and the structure was sensitive to cyclic loading, especially when the loading level was under 20%. S-N curves of nine groups of AFS specimens were obtained and the fatigue life of AFS followed three-parameter lognormal distribution well. AFS under low cyclic loading showed pronounced cyclic hardening and the static strength after fatigue test increased. For the same loading level, effects of foam core density and face-sheet thickness on the fatigue life of AFS structure were trade-off and for the same loading value, the fatigue life of AFS increased with aluminum foam core density or face-sheet thickness monotonously. Core shear was the main failure mode in the present study.
Fatigue behavior and damage mechanism of aluminum foam sandwich with carbonfiber face-sheets
Chang Yan,Jian Wang,Xuding Song 대한기계학회 2020 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.34 No.3
Aluminum foam sandwich (AFS) has been used in engineering field, where cyclic loading is in most of the applications. However, limited research has been done on the fatigue behavior of AFS. In the present study, fatigue performance of AFS made of aluminum foam core and carbon-fiber face-sheet was studied experimentally by a high frequency fatigue test machine and the damage mechanisms of the structure were studied by SEM. Results indicated that the fatigue life of AFS decreased with the increasing loading level. The S-N curve of AFS obeys three-parameter lognormal distribution in most of the cases. AFS was sensitive to cyclic loading level and the load capacity after cyclic loading improved significantly when the cyclic loading level was lower. The main life of AFS was its crack initiation stage. Three categories of damage mechanisms were observed. This study is of great significance to the design and application of AFS.
AMORPHIZATION OF ZnO NANOWIRES BY PROTON BEAM IRRADIATION
CHANG FU DEE,ISHAQ AHMAD,LONG YAN,XINGTAI ZHOU,BURHANUDDIN YEOP MAJLIS 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2011 NANO Vol.6 No.3
We report the effects of 70 keV proton (H+) irradiation on the structure of zinc oxide nanowires (ZnO NWs) for a wide range of irradiation doses at room temperature. It was found that at low dose 5 × 1015 ions/cm2 of protons, few defects were created in ZnO NWs and the defects' density was increased with an increasing proton irradiation dose. After the irradiation dose was increased to 2 × 1017 ions/cm2, the crystal structure of the ZnO NWs was almost completely damaged and the crystalline wurtzite structure of the ZnO NWs could be transformed into a disordered amorphous structure. Structural changes in the ZnO NWs upon bombardment with 70 keV protons were characterized by high resolution transmission electron microscopy (HRTEM).
Glacier Change in the Yigong Zangbo Basin, Tibetan Plateau, China
Chang-Qing Ke,Hoonyol Lee,Yan-Fei Han 대한원격탐사학회 2019 大韓遠隔探査學會誌 Vol.35 No.4
Distinguishing debris-covered glaciers from debris-free glaciers is difficult when using only optical remote sensing images to extract glacier boundaries. According to the features that the surface temperature of debriscovered glacier is lower than surrounding objects, and higher than clean glaciers, glacial changes in the Yigong Zangbo basin was analyzed on the basis of visible, near-infrared and thermal-infrared band images of Landsat TM and OLI/TIRS in the support of ancillary digital elevation model (DEM). The results indicated that glacier area gradually declined from 928.76 km2 in 1990 to 918.46 km2 in 2000 and 901.51 km2 in 2015. However, debriscovered glacier area showed a slight increase from 63.39 km2 in 1990 to 66.24 km2 in 2000 and 71.16 km2 in 2015. During 25 years, the glacier length became shorter continuously with terminus elevation rising up. The area of moraine lakes in 1990 was 1.43 km2, which increased to 1.98 km2 in 2000 and 3.41 km2 in 2015. In other words, the total area of the moraine lakes in 2015 is 2.38 times of that in 1990. This increase in moraine lake area could be the result of accelerated glacier melt and retreat, which is consistent with the significant warming trend in recent decades in the basin.
Chang Yan,Xuding Song 국제구조공학회 2016 Steel and Composite Structures, An International J Vol.21 No.5
To study the effects of foam core density and face-sheet thickness on the mechanical properties and failure modes of aluminum foam sandwich (AFS) beam, especially when the aluminum foam core is made in aluminum alloy and the face sheet thickness is less than 1.5 mm, three-point bending tests were investigated experimentally by using WDW-50E electronic universal tensile testing machine. Load.displacement curves were recorded to understand the mechanical response and photographs were taken to capture the deformation process of the composite structures. Results demonstrated that when foam core was combined with face-sheet thickness of 0.8 mm, its carrying capacity improved with the increase of core density. But when the thickness of face-sheet increased from 0.8 mm to 1.2 mm, result was opposite. For AFS with the same core density, their carrying capacity increased with the face-sheet thickness, but failure modes of thin face-sheet AFS were completely different from the thick face-sheet AFS. There were three failure modes in the present research: yield damage of both core and bottom face-sheet (Failure mode I), yield damage of foam core (Failure mode II), debonding between the adhesive interface (Failure mode III).
Liu, Chang,Zhao, Guo Qiang,Wei, Sheng Nan,Kim, Hak Jin,Li, Yan Fen,Kim, Jong Geun Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.1
Objective: This study was conducted to investigate the effects of wilting and microbial inoculant treatment on the fermentation pattern and quality of Italian ryegrass silage. Methods: Italian ryegrass was harvested at heading stage and ensiled into vinyl bags (20 cm×30 cm) for 60d. Italian ryegrass was ensiled with 4 treatments (NWNA, no-wilting noadditive; NWA, no-wilting with additive; WNA, wilting no-additive; WA, wilting with additive) in 3 replications, wilting time was 5 hours and additives were treated with 106 cfu/g of Lactobacillus plantarum. The silages samples were collected at 1, 2, 3, 5, 10, 20, 30, 45, and 60 days after ensiling and analyzed for the ensiling quality and characteristics of fermentation patterns. Results: Wilting treatment resulted in lower crude protein and in vitro dry matter digestibility and there were no significant differences in acid detergent fiber (ADF), total digestible nutrient (TDN), water-soluble carbohydrate (WSC), ammonia content, and pH (p>0.05). However, wilting treatment resulted in higher ADF and neutral detergent fiber content of Italian ryegrass silage (p<0.05), and the WNA treatment showed the lowest TDN and in vitro dry matter digestibility. The pH of the silage was higher in the wilting group (WNA and WA) and lower in the additive treatment group. Meanwhile, the decrease in pH occurred sharply between the 3-5th day of storage. The ammonia nitrogen content was significantly lower in the additive treatment (p<0.05), and wilting had no effect. As fermentation progressed, the lactic and acetic acid contents were increased and showed the highest content at 30 days of storage. Conclusion: The wilting treatment did not significantly improve the silage fermentation, but the inoculant treatment improved the fermentation patterns and quality of the silage. So, inoculation before ensiling is recommended when preparing high quality of Italian ryegrass silage, and when wilting, it is recommended to combine inoculation for making high quality silage.