A Phase 3 Evaluation of Daclatasvir plus Asunaprevir in Treatment-Naive Patients with Chronic HCV Genotype 1b Infection

( L. Wei ),( F. Wang ),( M. Zhang ),( J. Jia ),( A.A. Yakovlev ),( W. Xie ),( E.Z. Burnevich ),( J. Niu ),( Y.J. Jung ),( X. Jiang ),( M. Xu ),( X. Chen ),( Q. Xie ),( J. Li ),( J. Hou ),( H. Tang ),( 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Background/Aims: Treatment-naive GT 1b-infected patients from mainland China, South Korea and Russia were assessed for SVR at follow-up week 12 (SVR12) after receiving daclatasvir (60 mg, QD) and asunaprevir (100 mg, BID) (DCV+ASV). Methods: Patients were randomized 3:1 to receive DCV+ASV (24 weeks; immediate treatment [IM]) or 12 weeks of placebo followed by DCV+ASV (24 weeks; placebo-deferred treatment [PD]). The primary endpoint was to evaluate SVR12 in the IM arm to the historical rate for peginterferon/ribavirin (70%). Secondary endpoints included overall safety and safety comparisons between the treatment arms during the first 12 weeks. Results: 207 patients were randomized to IM (n=155) or PD (n=52); Asian (86%), female (59%), IL28B CC genotype (68%) and median age 49 (range 18-73) years; cirrhosis (13%), HCV RNA ≥6x106 IU/mL (53%). SVR12 in the IM arm was 92% and broadly unaffected by most baseline factors assessed (Figure); SVR12 was higher in patients without (96%) baseline NS5A-L31M/V or Y93H polymorphisms. There were 6 virologic breakthroughs, 6 relapses and 1 detectable HCV RNA at end-of-treatment in the IM arm. Safety was mostly comparable between the two arms during the first 12 weeks. The most frequent adverse events (AEs; ≥5%) during DCV+ASV (24 weeks) treatment in both arms were aminotransferase, bilirubin and INR elevations, hypertension, fatigue and respiratory tract infections; the most frequent treatment-emergent grade 3/4 laboratory abnormalities were aminotransferase (≤4.5%) and hematologic, lipase and total bilirubin abnormalities (≤2%); one patient (IM) discontinued DCV+ASV for aminotransferase elevations, nausea and jaundice (all reversible); one patient PD) discontinued DCV+ASV for a fatal AE unrelated to treatment. Conclusions: These data demonstrate that DCV+ASV is a highly efficacious and well tolerated treatment for treatment-naive HCV GT 1b-infected patients. Those treated immediately with DCV+ASV achieved a 92% SVR12 rate which was unaffected by factors known to attenuate response to interferon.

Very small “window of opportunity” for generating CO oxidation-active Au_<i>n</i> on TiO₂

Tang, X.,Schneider, J.,Dollinger, A.,Luo, Y.,Wö,rz, A. S.,Judai, K.,Abbet, S.,Kim, Y. D.,Gantefö,r, G. F.,Fairbrother, D. H.,Heiz, U.,Bowen, K. H.,Proch, S. The Royal Society of Chemistry 2014 Physical chemistry chemical physics Vol.16 No.14

<P>Recent research in heterogeneous catalysis, especially on size-selected model systems under UHV conditions and also in realistic catalytic environments, has proved that it is necessary to think in terms of the exact number of atoms when it comes to catalyst design. This is of utmost importance if the amount of noble metal, gold in particular, is to be reduced for practical reactions like CO oxidation. Here it is shown that on TiO<SUB>2</SUB> only Au<SUB>6</SUB> and Au<SUB>7</SUB> clusters are active for CO oxidation which holds for the single crystal, thin films, and titania clusters deposited on HOPG. Size-selected cluster deposition and TPD methods have been employed to investigate the CO oxidation activity of Au<SUB><I>n</I></SUB>/TiO<SUB>2</SUB> systems which are compared to recent results reported by Lee <I>et al.</I> to form a consistent picture in which only two species can be regarded as “active”. The efficiency of investigated Au<SUB><I>n</I></SUB>/(TiO<SUB>2</SUB>)<SUB>93</SUB>/HOPG composite materials is attributed to carbon-assisted oxygen spillover from gold to support particles and across grain boundaries.</P> <P>Graphic Abstract</P><P>The probability of creating CO oxidation-active species on TiO<SUB>2</SUB> is very small since only Au<SUB>6</SUB> and Au<SUB>7</SUB> are catalytically active. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c4cp00160e'> </P>

Experimental Study of the Runaway Current in the J-TEXT Tokamak

Y. H. Luo,Z. Y. Chen,X. Q. Zhang,D. W. Huang,W. Jin,Y. H. Huang,Y. Tang,J. C. Li,R. H. Tong,W. Yan,G. Zhuang 한국물리학회 2014 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.64 No.3

Major plasma disruptions in tokamaks often generate runaway currents, which contain electronswith energies of several tens of megaelectron-volts (MeV). These currents can cause substantialdamage when control is lost and the current hits the limiters or the vessel wall. The interactionbetween the runaway electrons and the impurities inside the plasma results in soft X-ray emission,which can provide detailed information about the runaway generation process and the confinementof runaway electrons. A vertical soft X-ray array at the top of Joint Texas Experimental Tokamak(J-TEXT) was used to study the runaway beams resulting from major disruptions. Runawayelectron production and confinement of runaway current were observed by using soft X-ray images.

Use of negative capacitance to simulate the electrical characteristics in double-gate ferroelectric field-effect transistors

Y.G. Xiao,M.H. Tang,Y. Xiong,J. C. Lin,C.P. Cheng,B. Jiang,H.Q. Cai,Z.H. Tang,X.S. Lv,X.C. Gu,Y.C. Zhou 한국물리학회 2012 Current Applied Physics Vol.12 No.6

The surface potential and drain current of double-gate metal-ferroelectric-insulator-semiconductor (MFIS) field-effect transistor were investigated by using the ferroelectric negative capacitance. The derived results demonstrated that the up-converted semiconductor surface potential and low subthreshold swing S = 34 (<60 mV/dec) can be realized with appropriate thicknesses of ferroelectric thin film and insulator layer at room temperature. What’s more, a reduction gate voltage about 260 mV can be reached if the ON-state current is fixed to 600 mA/mm. It is expected that the derived results can offer useful guidelines for the application of low power dissipation in ongoing scaling of FETs.

Magnetic Annealing Effects on the Properties of Multilayer BaTiO3/CoFe2O4 Thin Films

Y. Q. Dai,J. M. Dai,X. W. Tang,X. B. Zhu,J. Yang,Q. C. Liu,Y. P. Sun 한국물리학회 2013 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.62 No.12

Multilayer BaTiO3/CoFe2O4 thin films are prepared via a chemical solution deposition methodwith and without magnetic annealing, respectively. The microstructural, magnetic, dielectric andferroelectric properties of the films’ are investigated. The dielectric constant, polarization andmagnetization of the multilayer thin films are improved with magnetic annealing. Moreover, forthe magnetic annealing films, the saturation magnetization measured with the measuring magneticfield vertical to the film surface is much higher than that measured with the field parallel to thefilm surface. These novel phenomena may be caused by the decrease in the clamping of the BaTiO3layer and the arrangement of the induced easy axis in the CoFe2O4 layer caused by the appliedannealing field.

Polymerdimethylsiloxane surface treatment with an atmospheric pressure helium plasma jet driven by unipolar nanosecond pulses

Tang T.Y.,Lee H.,Kim H.S.,Kim G.H.,Lee B.,Kim H.J.,Lee H.J. 한국물리학회 2021 Current Applied Physics Vol.29 No.-

A nanosecond-pulse power source transfers energy to electrons of atmospheric pressure discharges in a nanosecond-scale rising time and shows different plasma chemistry than a slowly varying sinusoidal discharge. We report how the operation parameters, such as applied voltage, pulse duration, and repetition frequency, affect the discharge characteristics and the surface property of polydimethylsiloxane (PDMS). The applied voltage controls the energy delivery per a pulse cycle, and the repetition frequency dominantly affects the plasma density in a long-term operation. The water contact angle, the optical emission spectroscopy, and the atomic force microscope diagnostics on the PDMS are presented. While the polarity of the nano pulse bias changes the emission length of the plasma jet, the hydrophilicity is not affected by it because the chemical reactions by radicals are more dominant than the physical reactions of charged particles on PDMS.

Transformerless Photovoltaic Inverters with Leakage Current and Pulsating Power Elimination

Y. Tang,W. Yao,H. Wang,P. C. Loh,F. Blaabjerg 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6

This paper presents a transformerless inverter topology, which is capable of simultaneously solving leakage current and pulsating power issues in grid-connected photovoltaic (PV) systems. Without adding any additional components to the system, the leakage current caused by the PV-to-ground parasitic capacitance can be bypassed by introducing a common mode (CM) conducting path to the inverter. The resulting ground leakage current is therefore well controlled to be below the regulation limit. Moreover, the proposed inverter can also eliminate the well-known double line frequency pulsating power that is inherent in single-phase PV systems. By properly injecting CM voltages to the output filter capacitors, the pulsating power can be decoupled from the dc-link. Therefore, it is possible to use long lifetime film capacitors instead of electrolytic capacitors to improve the reliability of the PV system. The mechanism of leakage current suppression and the closedloop control of pulsating power decoupling are discussed in the paper in details. A 500 W prototype was also built and tested in the laboratory, and both simulation and experimental results are finally presented to show the excellent performance of the proposed PV inverter.

Pure gravitational dark matter, its mass and signatures

Tang, Y.,Wu, Y.L. North-Holland Pub. Co 2016 Physics letters. Section B Vol.758 No.-

In this study, we investigate a scenario that dark matter (DM) has only gravitational interaction. In the framework of effective field theory of gravity, we find that DM is still stable at tree level even if there is no symmetry to protect its longevity, but could decay into standard model particles due to gravitational loop corrections. The radiative corrections can lead to both higher- and lower-dimensional effective operators. We also first explore how DM can be produced in the early universe. Through gravitational interaction at high temperature, DM is then found to have mass around TeV@?m<SUB>X</SUB>@?10<SUP>11</SUP> GeV to get the right relic abundance. When DM decays, it mostly decays into gravitons, which could be tested by current and future CMB experiments. We also estimate the resulting fluxes for cosmic rays, gamma-ray and neutrino.

MEACHANISM AND METHOD OF DPF REGENERATION BY OXYGEN RADICAL GENERATED BY NTP TECHNOLOGY

Y. X. SHI,Y. X. CAI,X. H. LI,Y. Y. CHEN,D. W. DING,W. TANG 한국자동차공학회 2014 International journal of automotive technology Vol.15 No.6

By using a self-designed non-thermal plasma (NTP) injection system, an experimental study of theregeneration of DPF was conducted at different temperatures, where oxygen as the gas source. The results revealed that PMcan be decomposed to generate CO and CO2 by these active substances O3, O which was generated through the dischargereaction of NTP reactor. With the increasing of test temperature, the mass of C1 (C in CO) shows a overall downward trendwhile the mass of C2 (C in CO2) and C12 (C1 and C2) increase firstly and then decrease. When the test temperature is 80oC, thebackpressure of DPF decreases fastest and the regenerative effect is remarkable. DPF can be regenerated by NTP technologywithout any catalyst at a lower temperature. Compared with the traditional regeneration method, the NTP technology has itssuperiority.

Inductances of a Superconducting Magnet for Cyclotron K120

Tang, H.M.,Kim, D.L.,Choi, Y.S.,Lee, B.S.,Yang, H.S.,Kim, Y.S. The Korean Society of Superconductivity and Cryoge 2008 한국초전도저온공학회논문지 Vol.10 No.4

The design of a superconducting magnet system producing very high magnetic field is underway at Korea Basic Science Institute (KBSI) to accelerate three kinds of carbon irons (C+2, C+4, C+6) to 120 MeV. A quarter-scaled prototype will be manufactured in order to confirm the feasibility of our design. Magnet Inductances in the system have a great influence on the current ramping rates and contribute to the stored energy, which are usually considered to be unfavorable in magnet operation. The modeling and simulation scheme of a prototype superconducting magnet for the cyclotron K120 is described in this paper. The inductances are calculated by a numerical method with and without iron yokes, respectively. These calculation results will be used as engineering design details such as a current ramping rate and a quench protection design.