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Edwin David Morales-Álvarez,Claudia Marcela Rivera-Hoyos,Angélica María Baena-Moncada,Patricia Landázuri,Raúl A. Poutou-Piñales,Homero Sáenz-Suárez,Luis A. Barrera,Olga Y. Echeverri-Peña 한국미생물학회 2013 The journal of microbiology Vol.51 No.2
The sulfatase family involves a group of enzymes with a large degree of similarity. Until now, sixteen human sulfatases have been identified, most of them found in lysosomes. Human deficiency of sulfatases generates various genetic disorders characterized by abnormal accumulation of sulfated intermediate compounds. Mucopolysaccharidosis type II is characterized by the deficiency of iduronate 2-sulfate sulfatase (IDS), causing the lysosomal accumulation of heparan and dermatan sulfates. Currently, there are several cases of genetic diseases treated with enzyme replacement therapy, which have generated a great interest in the development of systems for recombinant protein expression. In this work we expressed the human recombinant IDS-Like enzyme (hrIDS-Like) in Escherichia coli DH5α. The enzyme concentration revealed by ELISA varied from 78.13 to 94.35 ng/ml and the specific activity varied from 34.20 to 25.97 nmol/h/mg. Western blotting done after affinity chromatography purification showed a single band of approximately 40 kDa, which was recognized by an IgY polyclonal antibody that was developed against the specific peptide of the native protein. Our 100 ml-shake-flask assays allowed us to improve the enzyme activity seven fold,compared to the E. coli JM109/pUC13-hrIDS-Like system. Additionally, the results obtained in the present study were equal to those obtained with the Pichia pastoris GS1115/pPIC-9-hrIDS-Like system (3 L bioreactor scale). The system used in this work (E. coli DH5α/pGEX-3X-hrIDS-Like)emerges as a strategy for improving protein expression and purification, aimed at recombinant protein chemical characterization,future laboratory assays for enzyme replacement therapy, and as new evidence of active putative sulfatase production in E. coli.
Yim, Su Y,Chae, Kab R,Shim, Sun B,Hong, Jin T,Park, Jung Y,Lee, Chung Y,Son, Hong J,Sheen, Yhun Y,Hwang, Dae Y D.A. Spandidos 2009 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.24 No.1
<P>Selenium reportedly contribute to the modulation process of protein phosphorylation to regulate various cellular functions including growth, differentiation, proliferation and development. The aim of this study was to investigate whether selenium and Selenoprotein M (SelM) affects the mechanism of Alzheimer's disease. To achieve this, we determined the change of the MAPK pathway, secretase activity, and Tau phosphorylation in the transgenic rat overexpressing human selenoprotein M. Based on these results, we concluded that, i) CMV/GFP-hSelM Tg rats showed a high activity level of antioxidant enzyme in the brain tissues, ii) in response to selenium treatment, the ERK signaling pathway was significantly increased in Tg rats, but did not change in wild-type rats, iii) the activation of the ERK pathway by selenium treatment and SelM overexpression induced the inhibition of the alpha/gamma-secretase activity related to the protection of Abeta-42 production, iv) the activation of the ERK pathway by selenium treatment and SelM overexpression inhibited the phosphorylation in several sites of Tau protein. Therefore, these results provide strong evidence that selenium treatment and SelM activate the ERK pathway to attenuate alpha/gamma-secretase-mediated proteolysis and Tau phosphorylation to protect brain function.</P>
Su, Y.,Liu, C.W.,Liu, L.,Ye, C.H.,Cao, W.Q.,Huang, Y.Q.,Zheng, J.,Cai, D.Y.,Olowofeso, O. Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.4
The genetic polymorphism and relationships of Muscovy, Cherry Valley Meat ducks, Partridge ducks and their crossbreds $F_1$ and $F_2$, respectively, were studied using a random amplified polymorphic DNA (RAPD) technique. The results showed that RAPD markers were effective for the analysis of genetic relationships among ducks. Amplification with 20-primers gave 760 reproducible amplified fragments. The percentage of polymorphic marker band was 74.70%, which indicates that the RAPD technique had higher efficiency of polymorphism detection and sensitivity in studying the genetic variations among ducks and showed that the genetic polymorphism was abundant between two species of duck populations. The average index of genetic distance in hybrid $F_2$ was 0.2341 and higher than that of its parents, which indicates that the genetic diversity was improved by crossbreeding with Muscovy.
Y. Wang,S. Yang,F. Zhuang,H.Su,J.Gong,Y.Tang,P. Wang 전력전자학회 2023 ICPE(ISPE)논문집 Vol.2023 No.-
Modular multilevel converter (MMC) has been widely used in medium and high voltage fields. However, the low-frequency ripple power (fundamental and secondary) in the MMC submodule (SM) requires large capacity and volume capacitors to smooth the SM voltage, which limits its further application and the improvement of power density. In this paper, a split-capacitor decoupling SM topology is introduced, its working principle is explained and a set of selection flowchart is designed, so that the minimum device selection that meets the operation requirements can be obtained under given operating conditions, which effectively improves the converter power density. And the effectiveness of the selection is verified in the simulation.
Y. X. Peng,L. Wu,Y. Su,C. H. Chen 한국자원공학회 2016 Geosystem engineering Vol.19 No.4
Due to the presence of water medium, underwater drill and blasting vibration frequency are substantially increased, and the monitoring of underwater drill and blasting is increasingly difficult. Therefore, through the dimensional analysis and introducing the elevation difference factor β, the forecasting formula of vibration frequency which takes altitude effect into consideration was deduced. The software of ANSYS/LS-DYNA was employed to study the attenuation law of vibration frequency in underwater drill and blasting. Combining with the project of underwater drill and blasting for the anti-collision belts of Road Bridge over Yangtze River in Wanzhou, the correlation coefficients, K, α, and β, were solved, and which was contracted to the two commonly used prediction equations. It turned out that the forecasting formula of vibration frequency which takes altitude effect into consideration can properly reflect the attenuation law of vibration frequency, and which could also accurately predict the blasting vibration frequency in underwater drill and blasting.
Mechanics of stretchable electronics on balloon catheter under extreme deformation
Su, Y.,Liu, Z.,Wang, S.,Ghaffari, R.,Kim, D.H.,Hwang, K.C.,Rogers, J.A.,Huang, Y. Pergamon Press ; Elsevier Science Ltd 2014 International journal of solids and structures Vol.51 No.7
Stretchable electronics has been applied to balloon catheters for high-efficacy ablation, with tactile sensing integrated on the surface, to establish full and conformal contact with the endocardial surface for elimination of the heart sink caused by blood flow around their surfaces. The balloon of the catheter folds into uniform 'clover' patterns driven by the pressure mismatch inside (~vacuum) and outside of the balloon (pressure ~1atm). The balloon catheter, on which microelectrodes and interconnects are printed, undergoes extreme mechanical deformation during its inflation and deflation. An analytic solution is obtained for balloon catheter inflation and deflation, which gives analytically the distribution of curvatures and the maximum strain in the microelectrodes and interconnects. The analytic solution is validated by the finite element analysis. It also accounts for the effect of inflated radius, and is very useful to the optimal design of balloon catheter.
Effect of Austempering Treatment on Microstructure and Mechanical Properties of M50NiL Bearing Steel
Y. B. Li,W. Ren,X. F. Yu,Y. Su,S. J. Wang,Y. Liu,S. Yang,W. J. Liu 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.11
By means of microstructure observation, microhardness, tensile and rotating bending fatigue tests, the effects of austemperingtreatment on the formation of lower bainite, carbide precipitation and mechanical properties of M50NiL bearing steel werestudied. Results showed that multi-layer composite microstructure was formed in the steel after austempering treatment. Themicrostructure of the surface layer was mainly consisted of lower bainite, martensite and carbides, that of the sub-surfacelayer contained granular carbides, a little lower bainite, lath martensite, twin martensite and thin film retained austenite, andthat of the core region mostly contained lath martensite. In contrast with the traditional martensite quenching treatment,there was more lower bainite formed in the surface layer after austempering treatment. The appearance of acicular bainitedramatically decreased the effective grain size by refining the microstructure, and there were more finer carbides precipitatedin the lath martensite. After austempering treatment and tempering, the average hardness in surface layer of the steel increasedfrom 746.5 HV0.5to 786.4 HV0.5,and the rotating bending fatigue limit of the steel increased from 870.9 to 1170.0 MPa, butthe tensile strength of the steel decreased slightly. The effects of austempering treatment on the mechanical properties hada close relationship with the carbide precipitation behavior and the formation of lower bainite.