Discriminative self-representation sparse regression for neuroimaging-based alzheimer’s disease diagnosis

Zhu, Xiaofeng,Suk, Heung-Il,Lee, Seong-Whan,Shen, Dinggang SPRINGER SCIENCE AND BUSINESS MEDIA 2019 BRAIN IMAGING AND BEHAVIOR Vol.13 No.1

Subspace Regularized Sparse Multitask Learning for Multiclass Neurodegenerative Disease Identification

Zhu, Xiaofeng,Suk, Heung-Il,Lee, Seong-Whan,Shen, Dinggang IEEE 2016 IEEE Transactions on Biomedical Engineering Vol.63 No.3

<P>The high feature-dimension and low sample-size problem is one of the major challenges in the study of computer-aided Alzheimer's disease (AD) diagnosis. To circumvent this problem, feature selection and subspace learning have been playing core roles in the literature. Generally, feature selection methods are preferable in clinical applications due to their ease for interpretation, but subspace learning methods can usually achieve more promising results. In this paper, we combine two different methodological approaches to discriminative feature selection in a unified framework. Specifically, we utilize two subspace learning methods, namely, linear discriminant analysis and locality preserving projection, which have proven their effectiveness in a variety of fields, to select class-discriminative and noise-resistant features. Unlike previous methods in neuroimaging studies that mostly focused on a binary classification, the proposed feature selection method is further applicable for multiclass classification in AD diagnosis. Extensive experiments on the Alzheimer's disease neuroimaging initiative dataset showed the effectiveness of the proposed method over other state-of-the-art methods.</P>

A novel relational regularization feature selection method for joint regression and classification in AD diagnosis

Zhu, Xiaofeng,Suk, Heung-Il,Wang, Li,Lee, Seong-Whan,Shen, Dinggang Elsevier 2017 Medical image analysis Vol.38 No.-

<P><B>Abstract</B></P> <P>In this paper, we focus on joint regression and classification for Alzheimer’s disease diagnosis and propose a new feature selection method by embedding the relational information inherent in the observations into a sparse multi-task learning framework. Specifically, the relational information includes three kinds of relationships (such as feature-feature relation, response–response relation, and sample-sample relation), for preserving three kinds of the similarity, such as for the features, the response variables, and the samples, respectively. To conduct feature selection, we first formulate the objective function by imposing these three relational characteristics along with an ℓ<SUB>2,1</SUB>-norm regularization term, and further propose a computationally efficient algorithm to optimize the proposed objective function. With the dimension-reduced data, we train two support vector regression models to predict the clinical scores of ADAS-Cog and MMSE, respectively, and also a support vector classification model to determine the clinical label. We conducted extensive experiments on the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset to validate the effectiveness of the proposed method. Our experimental results showed the efficacy of the proposed method in enhancing the performances of both clinical scores prediction and disease status identification, compared to the state-of-the-art methods.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A novel graph feature selection method for the AD/MCI diagnosis. </LI> <LI> A novel regularization exploiting the relational information inherent in the observations. </LI> <LI> First work considering three relationships for joint classification and regression. </LI> <LI> High accuracy of 95.7% for AD classification and 79.9% for MCI classification. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Comparative Study of Field-Oriented Control in Different Coordinate Systems for DTP-PMSM

Zhang, Ping,Zhang, Wei,Shen, Xiaofeng Journal of International Conference on Electrical 2013 Journal of international Conference on Electrical Vol.2 No.3

This paper performs two kinds of Field-Oriented Control (FOC) for dual three phase permanent magnet synchronous motor (DTP-PMSM).The first is based on vector space decomposition to study the effect of current harmonics on electromechanical energy conversion. And the second presents the coupling relations between two sets of windings using two d-q transformation. And then this paper has deeply studied the differences between these two strategies, the different effect on the control of harmonic current and the reason for these differences. MATLAB-based Simulation studies of a 3KW DTP-PMSM are carried out to verify the analysis of differences between the two FOC strategies.

Intra-Articular Injection of miR-29a-3p of BMSCs Promotes Cartilage Self-Repairing and Alleviates Pain in the Rat Osteoarthritis

Wang Qing,Chen Yong,Shen Xiaofeng,Chen Ji,Li Yuwei 한국조직공학과 재생의학회 2021 조직공학과 재생의학 Vol.18 No.6

Background: Stem cells intra-articular injection stagey indicated a potential therapeutic effect on improving the pathological progress of osteoarthritis (OA). However, the long-term effect of stem cells intra-articular injection on the cartilage regeneration remains unclear. miR-29a-3p is predicted to be a critical target for inhibiting insulin-like growth factor-1 expression and may aggravate the progression of OA. Methods: In this study, we investigated the therapeutic efficacy of intra-articular injection of bone marrow mesenchymal stem cells (BMSCs) transfected with miR-29a-3p inhibitor in OA. Results: miR-29a-3p inhibitor transfection did not influence cell viability of BMSCs, while the chondrogenic differentiation potential of BMSCs was significantly improved. Interestingly, intra-articular injection of BMSCs with miR-29a-3p inhibition significantly prevented articular cartilage degeneration by up-regulating the expression of Sox 9, Col-2a1, aggrecan and down-regulating the expression of matrix metalloproteinase, as well as relieved pain in OA. Conclusion: The double effects on cartilage protection and pain relief indicated a great potential of intra-articular injection of miR-29a-3p inhibitor-transfected BMSCs for the treatment of OA. Background: Stem cells intra-articular injection stagey indicated a potential therapeutic effect on improving the pathological progress of osteoarthritis (OA). However, the long-term effect of stem cells intra-articular injection on the cartilage regeneration remains unclear. miR-29a-3p is predicted to be a critical target for inhibiting insulin-like growth factor-1 expression and may aggravate the progression of OA. Methods: In this study, we investigated the therapeutic efficacy of intra-articular injection of bone marrow mesenchymal stem cells (BMSCs) transfected with miR-29a-3p inhibitor in OA. Results: miR-29a-3p inhibitor transfection did not influence cell viability of BMSCs, while the chondrogenic differentiation potential of BMSCs was significantly improved. Interestingly, intra-articular injection of BMSCs with miR-29a-3p inhibition significantly prevented articular cartilage degeneration by up-regulating the expression of Sox 9, Col-2a1, aggrecan and down-regulating the expression of matrix metalloproteinase, as well as relieved pain in OA. Conclusion: The double effects on cartilage protection and pain relief indicated a great potential of intra-articular injection of miR-29a-3p inhibitor-transfected BMSCs for the treatment of OA.

Removal of aqueous Pb and Cr(VI) by magnetically modified biochars: Effects of feedstock properties and production conditions

Jun Dong,Wanpeng Liu,Xiaofeng Shen,Shengdao Shan 대한환경공학회 2019 대한환경공학회 학술발표논문집 Vol.2019 No.-

Effects of solvent extraction on the microstructure of bituminous coal-based graphite

Wang Lipeng,Yao Zongxu,Guo Zhimin,Shen Xiaofeng,Li Zhiang,Zhou Zhengqi,Wang Yuling,Yang Jian-Guo 한국탄소학회 2022 Carbon Letters Vol.32 No.3

Coal-based graphite has become the main material of emerging industries. The microstructure of coal-based graphite plays an important role in its applications in many fields. In this paper, the effect of carbon disulfide/N-methyl-2-pyrrolidone solvent mixture extraction on the microstructure of bituminous coal-based graphite was systematically studied through preliminary extraction coupled with high-temperature graphitization. The graphitization degree g (75.65%) of the coal residue-based graphite was significantly higher than that of the raw coal-based graphite. The crystallite size La of the coal residue-based graphite was reduced by 47.06% compared with the raw coal-based graphite. The ID/ IG value of the coal residue-based graphite is smaller than that of the raw coal-based graphite. The specific surface area (16.72 m2/g) and total pore volume (0.0567 m3/g) of the coal residue-based graphite are increased in varying degrees compared with the raw coal-based graphite. This study found a carbon source that can be used to prepare coal-based graphite with high graphitization degree. The results are expected to provide a theoretical basis for further clean and efficient utilization of the coal residue resources.

Ginsenoside Rb1 attenuates methamphetamine (METH)-induced neurotoxicity through the NR2B/ERK/CREB/BDNF signalings in vitro and in vivo models

Genmeng Yang,Juan Li,Yanxia Peng,Baoyu Shen,Yuanyuan Li,Liu Liu,Chan Wang,Yue Xu,Shucheng Lin,Shuwei Zhang,Yi Tan,Huijie Zhang,Xiaofeng Zeng,Qi Li,Gang Lu 고려인삼학회 2022 Journal of Ginseng Research Vol.46 No.3

This study investigates the effects of ginsenoside Rb1 (GsRb1) on methamphetamine (METH)-induced toxicity in SH-SY5Y neuroblastoma cells and METH-induced conditioned place preference (CPP)in adult Sprague-Dawley rats. It also examines whether GsRb1 can regulate these effects through theNR2B/ERK/CREB/BDNF signaling pathways. Methods: SH-SY5Y cells were pretreated with GsRb1 (20 mM and 40 mM) for 1 h, followed by METHtreatment (2 mM) for 24 h. Rats were treated with METH (2 mg/kg) or saline on alternating days for 10days to allow CPP to be examined. GsRb1 (5, 10, and 20 mg/kg) was injected intraperitoneally 1 h beforeMETH or saline. Western blot was used to examine the protein expression of NR2B, ERK, P-ERK, CREB, PCREB, and BDNF in the SH-SY5Y cells and the rats' hippocampus, nucleus accumbens (NAc), and prefrontal cortex (PFC). Results: METH dose-dependently reduced the viability of SH-SY5Y cells. Pretreatment of cells with 40mM of GsRb1 increased cell viability and reduced the expression of METH-induced NR2B, p-ERK, p-CREBand BDNF. GsRb1 also attenuated the expression of METH CPP in a dose-dependent manner in rats. Further, GsRb1 dose-dependently reduced the expression of METH-induced NR2B, p-ERK, p-CREB, andBDNF in the PFC, hippocampus, and NAc of rats. Conclusion: GsRb1 regulated METH-induced neurotoxicity in vitro and METH-induced CPP through theNR2B/ERK/CREB/BDNF regulatory pathway. GsRb1 could be a therapeutic target for treating METHinduced neurotoxicity or METH addiction.

Macrophage migration inhibitory factor mediates peripheral nerve injury-induced hypersensitivity by curbing dopaminergic descending inhibition

Xian Wang,Shaolei Ma,Haibo Wu,Xiaofeng Shen,Shiqin Xu,Xirong Guo,Maria L Bolick,Shizheng Wu,Fuzhou Wang 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-

Our previous works disclosed the contributing role of macrophage migration inhibitory factor (MIF) and dopaminergic inhibition by lysine dimethyltransferase G9a/Glp complex in peripheral nerve injury-induced hypersensitivity. We herein propose that the proinflammatory cytokine MIF participates in the regulation of neuropathic hypersensitivity by interacting with and suppressing the descending dopaminergic system. The lumbar spinal cord (L-SC) and ventral tegmental area (VTA) are two major locations with significant upregulation of MIF after chronic constriction injury (CCI) of the sciatic nerve, and they display time-dependent changes, along with a behavioral trajectory. Correspondingly, dopamine (DA) content shows the reverse characteristic change to MIF with a time-dependent curve in post-surgical behavior. The levels of both MIF and DA are reversed by the MIF tautomerase inhibitor ISO-1, and a negative relationship exists between MIF and DA. The reversed role of ISO-1 also affects tyrosine hydroxylase expression. Furthermore, CCI induces Th promoter CpG site methylation in the L-SC and VTA areas, and this effect could be abated by ISO-1 administration. G9a/SUV39H1 and H3K9me2/H3K9me3 enrichment within the Th promoter region following CCI in the L-SC and VTA was also decreased by ISO-1. In cultured dopaminergic neurons, rMIF enhanced the recruitment of G9a and SUV39H1, followed by an increase in H3K9me2/H3K9me3. These molecular changes correspondingly exhibited alterations in Th promoter CpG site methylation and pain behaviors. In summary, MIF functions as a braking factor in curbing dopaminergic descending inhibition in peripheral nerve injury-induced hypersensitivity by mediating Th gene methylation through G9a/SUV39H1-associated H3K9 methylation.

Optimization of impedance boundarycontrolled casing treatment on subsonic compressors

Dakun Sun,Yuqing Wang,Jia Li,Zihan Shen,ChunWang Geng,Xu Dong,Xiaoyu Wang,Xiaofeng Sun 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.5

Foam-metal casing treatment (FMCT) has the potential to enhance the stall margin while attenuating the broadband noise of compressors. An optimized structure of FMCT backed with an air gap was developed in this study with the basis of a prediction model. The eigenvalue theory with a linear perturbation assumption was employed to judge the stability of the compression system, where the casing treatment was considered as an impedance boundary condition. The effect of this kind of casing treatment on the compression system is introduced through the equivalent surface source method. The transfer element method was applied to match the relations between perturbation parameters on the surface of each section. Prediction results showed that the double-layer configuration has better stall margin improving ability, with experimental results on the steady characteristics confirming a 39.5 % stall margin improvement. The mechanism of exerting damping on the system and thus suppressing stall precursors was proved.