Di-2-ethylhexyl phthalate induced oxidative damage involving FasL-associated apoptotic pathway in mouse spermatogenic GC-2spd cells

Xiao Tang,Kun Tong,Lishan Zhu,Guoqing Fu,Wei Chang,Ting Zhou,Zhibing Zhang,Ling Tong,Ling Zhang,Yuqin Shi,Ling Zhang,Yuqin Shi 대한독성 유전단백체 학회 2016 Molecular & cellular toxicology Vol.12 No.4

Di-2-ethylhexyl phthalate (DEHP) which belongs to phthalatic-acid esters, is a kind of harmful, global environmental pollutants. It is a known endocrine disrupting chemical and male reproductive toxicant. However, the mechanism by which DEHP exposure result in male reproductive toxicity is still unclear. To elucidate the productive toxicity mechanism of DEHP, we attemptted to investigate oxidative stress, apoptotic effects, mRNA and protein expression of apoptosis-associated genes including FasL, caspase-3, and caspase-8 in GC-2spd (mouse spermatogenic cells). The results showed that, with the increase of DEHP concentration, cell apoptosis rate increased; the activities of relation index of oxidative stress such as malondialdehyde (MDA), superoxide dismutase (SOD) and glutatione peroxidase (GSH-PX) changed significantly; the mRNA and protein expression levels of FasL, caspase-3, -8, altered obviously. These results suggested that DEHP could induce apoptosis of GC-2spd cells through oxidative stress and FasL-dependent pathway.

Pd Nanoparticles Self-Assembled on Fluorine-Modified MWCNTs as Electro-Catalysts for Methanol Electro-Oxidation

Xiao-Feng Zhang,Peng Dong,Ying-Jie Zhang,Xi-Kun Yang,Shu-Biao Xia,Zhen-Hua Jin,Ming-Li Xu 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.3

Multi-walled carbon nanotubes (MWCNTs) were modified by hydrogen fluoride (HF) in a simple method. With the help of fluorine, Pd nanoparticles (3.9 nm) synthesized by a one-step photochemical reduction were uniformly self-assembled on the active sites of functionalized MWCNTs and a new catalyst (Pd/HF-MWCNT) was obtained. UV–Vis absorption spectra, transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD) and X-ray photoelectron spectroscopy (XPS) were used. The results demonstrated that –F groups were introduced onto the surface of MWCNTs and C–F chemical bonds were formed. In addition, the electronic structure of Pd was changed. Pd–F coordination bond maybe formed between F atom and Pd atom. Cyclic voltammetry and chronoamperometry tests indicated that electrocatalytic activity of Pd/HF-MWCNTs catalyst for methanol in alkaline medium was about 1.6 times higher than that of the commercial Pd/C (JM) catalyst at the same condition. This new functionalized method has the advantages of simple step and safe operation. It is very significant to improve the wide application of MWCNTs and the commercial development of direct methanol fuel cells (DMFCs).

Electrical Conductivity Enhancement of Epoxy by Hybrid Carbon Nanotubes and Self-made Silver Nanoparticles

Xiao Min Zhang,Xiao-Li Yang,Kun-yan Wang 한국섬유공학회 2019 Fibers and polymers Vol.20 No.7

Flexibility electrode with high stretchability, electrical conductivity, and good mechanical properties are desirable,owing to their promising applications in electronic circuit and human motion monitoring systems. In this paper, a highperformance flexibility electrode was prepared based on printable and electrically conductive adhesive (ECA). Thisflexibility electrode is fabricated by mixing silver nanoparticles (AgNPs), carbon nanotube (CNT) and epoxy resin andscreen-printed to a required shape. The spherical AgNPs were prepared by DC arc plasma method. The Ag NPs present apolycrystalline crystal structure, the particle’s diameter range from 20 to 150 nm, with an average of 80 nm. Simultaneously,this flexibility electrode provides the advantages of simple, scalable fabrication, robust mechanical properties and versatilityin applications. Based on these performance characteristics, its applications in flexible printed electrodes are demonstrated,revealing its tremendous potential for applications in flexible and wearable electronics. The flexibility sensor prepared byECA exhibits fascinating comprehensive performances. The ECA filled with 65 % Ag NPs and 0.8 % CNT shows anexcellent electrical conductivity (9×10-4 Ω·cm) and bonding strength (9.2 MPa).

Impact of Caspase-8 (CASP8) -652 6N Del and D302H Polymorphisms on Prostate Cancer in Different Ethnic Groups

Zhang, Cheng-Dong,Li, Hong-Tao,Liu, Kun,Lin, Zhi-Di,Peng, Qi-Liu,Qin, Xue,He, Min,Wu, Hua,Mo, Zeng-Nan,Yang, Xiao-Li Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.18

Background: Despite evidence suggesting roles for caspase-8 (CASP8) -652 6N del and D302H polymorphisms in prostate cancer (PCa), the association of these polymorphisms with PCa risk remains inconclusive. Therefore, a meta-analysis was performed to more precisely estimate the association of CASP8 -652 6N del and D302H polymorphisms with PCa susceptibility. Materials and Methods: A comprehensive literature search was conducted to identify all case-control studies of CASP8 D302H and -652 6N del polymorphisms and PCa risk. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of the association and the precision of the estimate, respectively. Results: Nine -625 6N del studies and 4 D302H studies were included. CASP8 -652 6N del and D302H polymorphisms were not significantly associated with PCa risk in the overall analyses. However, in the subgroup analysis stratified by ethnicity, -625 6N del was significantly associated with PCa risk in the East Asian and Indian populations under the recessive model. Furthermore, the subgroup analysis strongly suggested that D302H was associated with lower PCa risk in the Non-Indian population under the dominant model. Conclusions: In our meta-analysis, ethnic-specific differences were evident in the association of CASP8-625 6N del and D302H polymorphisms with PCa risk.

Current Status of Indoor Positioning System Based on Visible Light

Kun Yan,Haiyan Zhou,Hailin Xiao,Xiangli Zhang 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10

With the flourishing of wireless information access, indoor positioning is becoming a topic of interest in both academic and industry community. Numerous techniques have been proposed to address this problem under diverse circumstances. Recently, the area of indoor positioning is dominated by three kinds of methodologies, such as rangebased positioning, fingerprint-based positioning and inertial positioning. This paper is presented to overview the indoor positioning techniques using visible light based on the range-based positioning. The state-of-the-art research results will be studied. The typical localization mechanisms used in visible light positioning systems are analyzed by evaluation metrics to provide an insight of the systems’ performances.

Microscopic Mechanisms and Acoustic Emission Characteristics of Sandy Mudstone under Different Water Saturations

Xiao-ming Sun,Fu-kun Shi,Ming-qun Zhu,Jia-xu Ding,Lin-sen He,Zhi-hu Li,Tong Zhang,Cheng-yu Miao 대한토목학회 2024 KSCE Journal of Civil Engineering Vol.28 No.1

In order to study the damage mechanism of surrounding rocks under water-rock coupling, an experimental study on the microscopic law of water absorption and mechanics of sandy mudstone was carried out in the sandy mudstone stratum of Wanfu coal mine in Shandong, China. The results indicate that the strength of sandy mudstone exhibits three stages of relative softening, rapid softening, and decelerated softening. The speed of water molecules entering the microscopic pore structure was analyzed based on the percentage of water molecules in the pore structure. The acoustic emission energy release process is divided into energy accumulation stage, stable release stage and intense release stage. With the increase of water content saturation,  (Spectral width of the multifractal spectrum) tends to decrease and the distribution of events is gradually uniform. The action of water gradually expands and penetrates the cracks and pores inside the sandy mudstone, which makes f (Frequency of occurrence of the signal) change from negative to positive values.

Three-dimensional Network Structure of Conductive Composites by Hybrid Conductive Fillers of Silver/graphene

Xiao Min Zhang,Kun-yan Wang,Guo Zhao,Qi Long Li,Bin Wang 한국섬유공학회 2019 Fibers and polymers Vol.20 No.6

In order to explore new generations of interconnecting materials in electronic packaging industries, silvernanoparticles (Ag NPS) and graphene nanosheets (GNS) were introduced into matrix resin to prepare conductive composites. The electrical and mechanical of above electrically conductive adhesives (ECAs) were investigated and characterized. It wasfound that the ECAs can be solidified through a chemical sintering in the air at 150 oC for 30 min. The results indicated thatthe percolation threshold of resistivity reaches 3.5×10-4 Ω·cm for ECAs filled with 65 wt.% Ag NPS, 0.5 wt.% GNS and theshear strength reaches 10.8 MPa, suggesting excellent electric conductivity and bonding strength.

New Evidence for the Involvement of the EGF Receptor Pathway in Hair Follicle Morphogenesis in uncv Mice

Jing Zhang,Xiao Kun Teng,Li Zhen Si,Ping Tong Zhou,Xiang Yin Kong,Lan Dian Hu 한국유전학회 2008 Genes & Genomics Vol.30 No.4

Hair follicle (HF) morphogenesis depends upon a delicate balance between cell proliferation and apoptosis, both of which are known to be controlled by a number of signal pathways. In this study, we utilize the uncv homozygous mouse to investigate the underlying mechanisms giving rise to the relevant phenotypes. In so doing, we have detected changes in the EGFR, Akt and MAPK signaling pathways. Our results show that the expression patterns of active Akt, MAPK and EGFR are altered with regard to localization in the outer root sheath (ORS) of the wild type mouse and in the follicular bulbs of the uncv homozygous mouse. These data suggest that EGFR signaling may play different roles in different cellular locations. Further, ectopic EGFR signaling in the follicular bulbs of the uncv homozygous mouse may lead to catagen (entrance into the apoptosis phase). Moreover, when the EGFR ligand was overexpressed in the uncv heterozygous mouse, aggravation of HF disordered development ensued. Together, these results demonstrate that EGFR participates in a functionally compartmentalized signaling network that controls follicular development homeostasis.

국제경영 : 중국소비자의 한국드라마 시청이 한국제품 이미지에 미치는 경로에 대한 연구

전종근 ( Jong Kun Jun ),장소우 ( Xiao Yu Zhang ) 국제지역학회 2012 국제지역연구 Vol.16 No.2

본 연구는 중국 시청자들을 대상으로 한국TV드라마 시청이 휴대폰, 냉장고, 에어컨, 자동차 등 네 가지 한국 제품에 대한 이미지에 어떤 영향을 미치는지 경로를 분석하였다. 구체적으로 한국TV 드라마 시청에 따른 노출정도와 드라마 만족도가 국가이미지상승을 통한 한국제품이미지 상승이라는 후광효과경로 그리고 드라마 노출에 따른 제품친숙도 상승을 통한 한국제품이미지 상승이라는 단순노출효과 경로 등 이원화된 경로를 설정하고 설문조사를 통해 분석하였다. 분석 결과 노출효과는 유의하지 않았고 후광효과는 유의한 것으로 나타났으며 한국 드라마만족도는 국가이미지 상승을 통해 제품이미지에 간접적인 영향을 미칠 뿐만 아니라 직접적으로도 제품이미지에 긍정적인 영향을 미치는 것으로 나타났다. 또한 드라마 만족도는 제품 친숙도에도 긍정적인 영향을 미쳐서 결과적으로 제품이미지를 강화하였다. 한국드라마 시청에 따른 후광효과와 노출효과는 제품별로도 차이가 있는 것으로 나타났다. 휴대폰과 자동차 등 드라마에서 노출빈도와 연기 관련성이 높은 제품에서 냉장고, 에어컨 등 그렇지 않은 제품보다 후광효과가 더 크게 나타났고 노출효과는 더 낮게 나타났다. 이러한 결과를 바탕으로 시사점을 도출 및 제시하였다. This study examines the impact processes of watching Korean TV dramas on the images of four Korean products including cell phones, refrigerators, air-conditioners, and automobiles among Chinese consumers. The research model describes one impact process as halo effects, in which consumer satisfactions on the drama improves the country image of Korea and then the good product image follows. Anther impact process is described as mere exposure effects, in which the exposure to the drama itself increases the familiarity on Korean products featured in the dramas as product placement and in turn, the familarity improves the product image. The results report that only halo effects were significant and the satisfactions on the TV dramas have both direct and indirect positive impact on the product images. The halo effects and the mere exposure effects varied among the four products.

New triterpenoids from Staphylea bumalda flower buds and their neuroprotective activity against H2O2-induced injury in vitro

Zheng-Xi Zhang,Kun Feng,Xian-Jin Sui,Wen-Shu Wang,Lin Wang,Dong-Hong Wang,Xiao-Min Luo,Xiao-Fei Chen 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.12

Four new acylated triterpene glycosides with aliphatic chains (4–7) as well as five known triterpenoids were isolated from the flower buds of Staphylea bumalda with bioassay guidance. Their structures were determined on the basis of spectral techniques, including IR, 1D and 2D NMR, and HR-APCI-MS. Most compounds (except 8) were isolated from S. bumalda for the first time. Additionally, the neuroprotective effects of 1 and 4–9 on suckling rat primary cultured hippocampal neurons against H2O2-induced injury were evaluated in vitro. The four new triterpenoids (4–7) showed neuroprotective effects, which increased the cell viability to over 74% at different concentrations, which was higher than the negative control (59%), while compounds 1 and 8–9 exhibited cytotoxic activity.