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Shifeng Wu,Tao Jiang,Xingang Wang,Weiwei Wu,Fan Zhang 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.4
Wound healing is a complex physiological process necessitating the coordinated action of various cell types, signals and microRNAs (miRNAs). However, little is known regarding the role of miRNAs in mediating this process. In the present study, we show that let-7c miRNA is decreased in heat-denatured fibroblasts and that inhibiting let-7c expression leads to the increased proliferation and migration of dermal fibroblasts, whereas the overexpression of let-7c exerts an opposite effect. Further investigation has identified heat shock protein 70 as a direct target of let-7c and has demonstrated that the expression of HSP70 in fibroblasts is negatively correlated with let-7c levels. Moreover, down-regulation of let-7c expression is accompanied by up-regulation of Bcl-2 expression and down-regulation of Bax expression, both of which are the downstream genes of HSP70. Notably, the knockdown of HSP70 by HSP70 siRNA apparently abrogates the stimulatory effect of let-7c inhibitor on heat-denatured fibroblasts proliferation and migration. Overall, we have identified let-7c as a key regulator that inhibits fibroblasts proliferation and migration during wound healing.
Shifeng Li,Yanming Shen,Min Xiao,Dongbin Liu,Lihui Fan,Keke Wu 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
Zn/Al-layered double hydroxides (LDHs) containing the organic anion of 2,4-dihydroxybenzophenone-5-sulfonate (DHBS) have been synthesized by co-precipitation method. Surface, structural, thermal and absorption properties of the ZnAl-DHBS-LDHs nanohybrids were characterized by BET analysis, scanning electron microscope, X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetry and differential thermal analysis and UV–visible spectroscopy. The results revealed that organic UV absorbent-DHBS has been intercalated into the interlayer spaces of ZnAl-LDHs and the intercalation of DHBS in LDHs interlayer galleries resulted to higher thermal stability and better UV absorption ability; these show that the hybrid ZnAl-DHBS-LDHs phase has potential applications as a UV absorber.
Shifeng Li,Yanming Shen,Dongbin Liu,Lihui Fan,Keke Wu 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.2
New organic-inorganic composite of 2,4-dihydroxybenzophenone (BP-1) encapsulation into dodecylbenzenesulfonate (DBS) modified layered double hydroxide (LDH) was successfully prepared. The surface, structural, thermal and absorption properties of the BP-1/DBS-LDH nanohybrid was characterized by BET analysis, scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), thermogravimetric analysis (TG) and diffuse reflectance UV-Vis absorbance spectra (DRUV-vis). The interlayer configuration of composite and the adsorption mechanism of BP-1 on MgAl-DBS-LDH were discussed. It was suspected that DBS anions located in the form of monolayer arrangement with a 75° anti parallel angle between dodecylbenzenesulfonate chain axis. The diffuse reflectance UV-Vis absorbance results revealed that the UV absorbing wavelength of BP-1/DBS-LDH evidently extends to about 400 nm, which shows that the BP-1/DBS-LDH has the potential application as a UV absorber.
Li, Shifeng,Shen, Yanming,Liu, Dongbin,Fan, Lihui,Wu, Keke Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.2
New organic-inorganic composite of 2,4-dihydroxybenzophenone (BP-1) encapsulation into dodecylbenzenesulfonate (DBS) modified layered double hydroxide (LDH) was successfully prepared. The surface, structural, thermal and absorption properties of the BP-1/DBS-LDH nanohybrid was characterized by BET analysis, scanning electron microscopy (SEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TG) and diffuse reflectance UV-Vis absorbance spectra (DRUV-vis). The interlayer configuration of composite and the adsorption mechanism of BP-1 on MgAl-DBS-LDH were discussed. It was suspected that DBS anions located in the form of monolayer arrangement with a $75^{\circ}$ anti parallel angle between dodecylbenzenesulfonate chain axis. The diffuse reflectance UV-Vis absorbance results revealed that the UV absorbing wavelength of BP-1/DBS-LDH evidently extends to about 400 nm, which shows that the BP-1/DBS-LDH has the potential application as a UV absorber.
Jiang, Tao,Wang, Xingang,Wu, Weiwei,Zhang, Fan,Wu, Shifeng Korean Society for Molecular and Cellular Biology 2016 Molecules and cells Vol.39 No.4
Wound healing is a complex physiological process necessitating the coordinated action of various cell types, signals and microRNAs (miRNAs). However, little is known regarding the role of miRNAs in mediating this process. In the present study, we show that let-7c miRNA is decreased in heat-denatured fibroblasts and that inhibiting let-7c expression leads to the increased proliferation and migration of dermal fibroblasts, whereas the overexpression of let-7c exerts an opposite effect. Further investigation has identified heat shock protein 70 as a direct target of let-7c and has demonstrated that the expression of HSP70 in fibroblasts is negatively correlated with let-7c levels. Moreover, down-regulation of let-7c expression is accompanied by up-regulation of Bcl-2 expression and down-regulation of Bax expression, both of which are the downstream genes of HSP70. Notably, the knockdown of HSP70 by HSP70 siRNA apparently abrogates the stimulatory effect of let-7c inhibitor on heat-denatured fibroblasts proliferation and migration. Overall, we have identified let-7c as a key regulator that inhibits fibroblasts proliferation and migration during wound healing.
C-Band Synthetic Aperture Microwave Radiometer and Its Imaging Experiments
Shengwei, Zhang,Xiaolong, Dong,Ji, Wu,Jingshan, Jiang,Shifeng, Zheng 대한원격탐사학회 2001 International Symposium on Remote Sensing Vol.17 No.1
The principles of the interferometric synthetic aperture was been briefly introduced, the system design of a C-band microwave interferometric synthetic aperture radiometer is presented. This systemhas a 6-element thinned array with 11 analog complex correlator to obtain the 11 visibility function spatial- frequency terns, which result in 22 digitally synthesizedspatial resolution cell. So the synthetic apertureradiometer have a spatial resolution as high as one 22nd of that corresponding to one antenna element. Thesynthetic radiometer has a real aperture resolution cell in the along-hack direction and has 22 synthetic apertureresolution cells in the cross-track direction. Finally, the results of imaging experiments are given.
Adaptive Variable Impulsive Synchronization of Multi‑agent Systems
Like Gao,Jing Xiao,Xiaoxuan Guo,Shifeng Ou,Yangjun Zhou,Ning Wu,Yubin Feng,Zhiyang Yao 대한전기학회 2020 Journal of Electrical Engineering & Technology Vol.15 No.1
This paper is concerned with the adaptive synchronization of multi-agent systems via variable impulsive control method. Based on the theory of impulsive diferential equations, adaptive control technique, Lyapunov stability theory and comparison system method, some novel adaptive synchronization conditions with impulsive time window are given to realize the synchronization of multi-agent nonlinear systems with uncertain parameters. Diferent from the existing investigations of impulsive synchronization of multi-agent systems, the proposed impulsive control protocol with impulsive time window is more efective in practical systems. Finally, two simulation results demonstrate the validity of the theoretical results.