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이응룡,강근호,강용진,김우열,최혜연,김봉우,정효순,조쌍구 충남대학교 형질전환복제돼지연구센터 2007 논문집 Vol. No.10
Many studies revealed the neuroprotective, cardioprotective, and chemopreventive actions of dietary flavonoids. The plausible mechanistic interpretation of the various effects of flavonoids was concentrated on the anti-oxidant or free radical-scavenging properties of these phytochernicals, both in model systems and under in vivo conditions. While there has been a major focus on the anti-oxidant properties. there is an emerging view that flavonoids and their in vivo metabolites. do not act as conventional hydrogen-donating anti-oxidants. but they may exert regulatory functions in cells through actions at protein kinase or lipid kinase signaling pathways. Flavonoids and more recently their metabolites. have been reported to act at phosphoinositide 3-kinase(PI 3-kinase). Akt/protein kinase B(Akt/PKB), protein kinase C (PKC), mitogen activated protein kinase(MAP kinase), and various tyrosine kinases signaling cascades. Inhibitory or stimulatory actions at these pathways are likely to affect cellular function profoundly by altering the phosphorylation state of target molecules and by modulating gene expression. A clear understanding of the mechanisms of action of flavonoids, either as anti-oxidants or modulators of cellular signaling pathways, and the influence of their metabolism on these properties are key to the evaluation of these potent biomolecules as anti-cancer agents, cardio-protectants, and inhibitors of neurodegeneration.
이우령 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1
Although advances in neonatal intensive care have led to improved survival, infection continues to be an important cause of death, especially among very low birth weight infants. Humans are constantly exposed to a wide variety of microorganism that can cause infection. In self-defense, the human host has evolved complex protective mechanisms. Immunity can be broadly classified as adaptive acquired immunity or innate immunity. Adaptive immunity is mediated by T and B lymphocytes that proliferate clonally in response to a specific pathogen or antigen. The generation of adaptive immune response requires a number of days. By contrast, the goals of innate immunity are to provide protection in the first minutes to hours after an infectious challenge. Innate immunity was once thought to be a nonspecific response. However, a sophisticated system of receptors, the Toll-like receptors(TRLs), provide considerable specificity for microbial pathogens. The activation of the innate immune system can be a prerequisite for the adaptive immune response. Defects in sensing of pathogens may predispose the host to significant infectious disease. Polymorphisms or mutations in TLRs are associated with increased predisposition to severe and recurrent infections. Recent advances in understanding the molecular basis of the innate immune system led to the identification of certain point mutations of genes involved in the early recognition of bacteria and associated with reduced host response. Much more remains to be learned about expression and function of innate immunity. The completion of the human genome project coupled with rapid advances in the manipulation and analysis of nucleic acids will likely result in an increasing array of techniques by which clinicians more accurately predict the risk of infectious disease and tailor prophylactic therapy accordingly as well as novel therapeutic agents.
이우령 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2
Neonatal lupus erythematosus is a rare passively acquired autoimmune disorder which is characterized by congenital heart block and/or cutaneous lupus lesions and less commonly hepatobiliary and hematologic abnormalities. Congenital heart block is believed to be caused by transplacental passage of anti-RO/SS-A antibodies from mother to neonate and potentially fatal. We experienced a case of neonatal lupus erythematosus with congenital heart block. The neonate was premature female baby born to a mother with systemic lupus erythematosus. Both the neonate and the mother were positive for anti RO/SS-A antibody.
( Ryoung-eun Ko ),( Kyung Hoon Min ),( Sang-bum Hong ),( Ae-rin Baek ),( Hyun-kyung Lee ),( Woo Hyun Cho ),( Changhwan Kim ),( Youjin Chang ),( Sung-soon Lee ),( Jee Youn Oh ),( Heung Bum Lee ),( Sooh 대한결핵 및 호흡기학회 2021 Tuberculosis and Respiratory Diseases Vol.84 No.4
Background: Hospital-acquired pneumonia (HAP) and ventilator-associated pneumonia (VAP) are significant public health issues in the world, but the epidemiological data pertaining to HAP/VAP is limited in Korea. The objective of this study was to investigate the characteristics, management, and clinical outcomes of HAP/VAP in Korea. Methods: This study is a multicenter retrospective cohort study. In total, 206,372 adult patients, who were hospitalized at one of the 13 participating tertiary hospitals in Korea, were screened for eligibility during the six-month study period. Among them, we included patients who were diagnosed with HAP/VAP based on the Infectious Diseases Society of America (IDSA)/American Thoracic Society (ATS) definition for HAP/VAP. Results: Using the IDSA/ATS diagnostic criteria, 526 patients were identified as HAP/VAP patients. Among them, 27.9% were diagnosed at the intensive care unit (ICU). The cohort of patients had a median age of 71.0 (range from 62.0 to 79.0) years. Most of the patients had a high risk of aspiration (63.3%). The pathogen involved was identified in 211 patients (40.1%). Furthermore, multidrug resistant (MDR) pathogens were isolated in 138 patients; the most common MDR pathogen was Acinetobacter baumannii . During hospitalization, 107 patients with HAP (28.2%) had to be admitted to the ICU for additional care. The hospital mortality rate was 28.1% in the cohort of this study. Among the 378 patients who survived, 54.2% were discharged and sent back home, while 45.8% were transferred to other hospitals or facilities. Conclusion: This study found that the prevalence of HAP/VAP in adult hospitalized patients in Korea was 2.54/1,000 patients. In tertiary hospitals in Korea, patients with HAP/VAP were elderly and had a risk of aspiration, so they were often referred to step-down centers.
Atrial fibrillation risk in metabolically healthy obesity: A nationwide population-based study
Lee, HyunJung,Choi, Eue-Keun,Lee, Seung-Hwan,Han, Kyung-Do,Rhee, Tae-Min,Park, Chan-Soon,Lee, So-Ryoung,Choe, Won-Seok,Lim, Woo-Hyun,Kang, Si-Hyuck,Cha, Myung-Jin,Oh, Seil Elsevier/North-Holland Biomedical Press 2017 International journal of cardiology Vol.240 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Metabolically healthy obese (MHO) individuals are reported to have a marginal increase in cardiovascular risk; however, their atrial fibrillation (AF) risk is unclear. We aimed to assess AF risk in MHO individuals and identify whether AF development is associated with obesity or influenced by metabolic comorbidities.</P> <P><B>Methods</B></P> <P>A retrospective cohort of 389,321 individuals (age, 45.6±14.5years; male, 52.1%) was extracted from the Korean National Health Insurance sample database between 2004 and 2006 and followed-up for new-onset AF until 2013. Subjects with diabetes mellitus, hypertension, and/or dyslipidemia were classified as “metabolically unhealthy.” The cohort was stratified into four groups according to obesity and metabolic healthiness: metabolically healthy non-obese (MHNO), metabolically unhealthy non-obese (MUNO), MHO, and metabolically unhealthy obese (MUO).</P> <P><B>Results</B></P> <P>AF was newly diagnosed in 5106 (1.3%) individuals during a mean follow-up of 7.5±1.5years. The AF incidence rates for the MHNO, MUNO, MHO, and MUO groups were 0.76, 2.66, 1.10, and 2.88 per 1000 person-years, respectively. Compared with the MHNO group, the MHO group had increased AF risk (adjusted hazard ratio, 1.30; 95% CI, 1.14–1.48) on multivariate analysis. One fourth of the MHO cohort became metabolically unhealthy, contributing to increased AF risk. Obesity was an independent risk factor for AF, and increased AF risk by 20%. Metabolic unhealthiness increased AF risk by around 40%, and of its components, hypertension contributed the most.</P> <P><B>Conclusions</B></P> <P>MHO individuals are at increased risk for AF development, and obesity was independently associated with elevated AF risk.</P>
Lee, So-Ryoung,Choi, Eue-Keun,Rhee, Tae-Min,Lee, Hyun-Jung,Lim, Woo-Hyun,Kang, Si-Hyuck,Han, Kyung-Do,Cha, Myung-Jin,Cho, Youngjin,Oh, Il-Young,Oh, Seil Elsevier 2016 INTERNATIONAL JOURNAL OF CARDIOLOGY Vol.223 No.-
<P><B>Abstract</B></P> <P><B>Background</B></P> <P>Atrial fibrillation (AF) is prevalent among type 2 diabetic patients. However, the association between diabetic retinopathy (DR) and AF is controversial.</P> <P><B>Methods</B></P> <P>We included 40,500 patients with type 2 diabetes (≥40years, mean age 62±11years, 53% men) without AF from the Korean National Insurance Service-National Sample Cohort (2002–2007). Subjects were classified without DR (non-DR, n=30,178), with DR (DR, n=8920), and with proliferative DR (PDR, n=1402).</P> <P><B>Results</B></P> <P>During a mean 5.9-year follow-up, 1261 (3.1%) patients were newly diagnosed as having AF (4.9, 6.0, and 8.3 per 1000 person-years in the non-DR, DR, and PDR groups, respectively). In multivariate Cox proportional hazard models, patients in the DR and PDR groups had a significantly higher risk of AF than those in the non-DR group (DR group: hazard ratio [HR] 1.14, 95% confidence interval [CI] 1.00–1.30; PDR group: HR 1.46, 95% CI 1.13–1.87); p for trend <0.001). The risk of AF increased in patients with DR and end-stage renal disease (ESRD) (HR 2.39, 95% CI 1.31–3.96, p<0.001) and in those with PDR and ESRD (HR 3.59, 95% CI 1.96–5.97, p<0.001) compared to those without DR and ESRD.</P> <P><B>Conclusions</B></P> <P>The presence and severity of DR was significantly associated with the incidence of AF. Also, the presence of ESRD had an impact on the incidence of AF in patients with DR.</P>
TTAC-0001, a human monoclonal antibody targeting VEGFR-2/KDR, blocks tumor angiogenesis
Lee, Weon Sup,Pyun, Bo-Jeong,Kim, Sung-Woo,Shim, Sang Ryeol,Nam, Ju Ryoung,Yoo, Ji Young,Jin, Younggeon,Jin, Juyoun,Kwon, Young-Guen,Yun, Chae-Ok,Nam, Do-Hyun,Oh, Keunhee,Lee, Dong-Sup,Lee, Sang Hoon Taylor Francis 2015 mAbs Vol.7 No.5
( Woo Ryoung Lee ) 대한주산의학회 2017 大韓周産醫學會雜誌 Vol.28 No.4
Despite various national policies aimed at resolving the problems of low birth rates and aging society, the number of newborn babies in South Korea continues to decline. On the other hand, the birth rates of high-risk newborn babies are increasing. With the increase in survival rates, the burden of medical expenses is increasing in high-risk infants. Beginning in 2016, the 3rd national plan for aging society and population reinforces social responsibility for birth and nurture, focusing on easing the burden of intensive care on newborn babies. Thus, the Korean Society of Neonatology along with related organizations proposed and implemented policies to reduce the burden of medical expenses of high-risk infants. The Korean Society of Neonatology will continue the important role to analyze the burden of neonatal medical health care expenses and to establish the effective and efficient health care system for high-risk newborn babies.