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Prognostic Factors of Patients With Thymoma
( Won Sup Lee ),( Dae Seog Heo ),( Yung Jue Bang ),( Keun Seok Lee ),( Jin Seok Ahn ),( Chul Won Jung ),( Sung Koo Han ),( Sook Whan Sung ),( Joo Hyun Kim ),( Young Soo Shim ),( Chan Il Park ),( Noe K 대한내과학회 1996 The Korean Journal of Internal Medicine Vol.11 No.1
Seok Won Kang,Eun Young Heo,전종갑,Sung Hoon Kim 대한화학회 2004 Bulletin of the Korean Chemical Society Vol.25 No.12
Allylations of N-benzyl and N-methyl cyclic imides were accomplished successfully under mild Barbier type conditions using zinc metal, allyl bromide and catalytic amount of PbBr2. Subsequent coupling reactions with some carbon nucleophiles afforded 1,2- and 1,4-addition products in moderate to high yields.
Seok Kim,Jaehoon Jung,Hwajin Kim,Rok Won Heo,Chin-ok Yi,Jung Eun Lee,Byeong Tak Jeon,Won-Ho Kim,Jong Ryeal Hahm,Gu Seob Roh 대한생리학회-대한약리학회 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.4
Exendin-4 (Ex-4), a glucagon-like peptide-1 receptor (GLP-1R) agonist, has been known to reverse hepatic steatosis in ob/ob mice. Although many studies have evaluated molecular targets of Ex-4, its mechanism of action on hepatic steatosis and fibrosis has not fully been determined. In the liver, glucose transporter 4 (GLUT4) is mainly expressed in hepatocytes, endothelial cells and hepatic stellate cells (HSCs). In the present study, the effects of Ex-4 on GLUT4 expression were determined in the liver of ob/ob mice. Ob/ob mice were treated with Ex-4 for 10 weeks. Serum metabolic parameters, hepatic triglyceride levels, and liver tissues were evaluated for hepatic steatosis. The weights of the whole body and liver in ob/ob mice were reduced by long-term Ex-4 treatment. Serum metabolic parameters, hepatic steatosis, and hepatic fibrosis in ob/ob mice were reduced by Ex-4. Particularly, Ex-4 improved hepatic steatosis by enhancing GLUT4 via GLP-1R activation in ob/ob mice. Ex-4 treatment also inhibited hepatic fibrosis by decreasing expression of connective tissue growth factor in HSCs of ob/ob mice. Our data suggest that GLP-1 agonists exert a protective effect on hepatic steatosis and fibrosis in obesity and type 2 diabetes.
Won, Ki-Bum,Kim, Yun Seok,Lee, Byoung Kwon,Heo, Ran,Han, Donghee,Lee, Ji Hyun,Lee, Sang-Eun,Sung, Ji Min,Cho, Iksung,Park, Hyung-Bok,Cho, In-Jeong,Chang, Hyuk-Jae Williams & Wilkins Co 2018 Medicine Vol.97 No.21
<P><B>Abstract</B></P><P>The triglyceride glucose (TyG) index is a useful surrogate marker for insulin resistance, which is an important risk factor for coronary artery disease (CAD). However, data on the relationship of the TyG index and coronary plaque characteristics are limited.</P><P>This study included 2840 participants with near-normal renal function who underwent coronary computed tomography angiography. CAD was defined as the presence of any plaques, and obstructive CAD was defined as the presence of plaques with ≥50% stenosis. The relationship between the TyG index and noncalcified plaque (NCP), calcified or mixed plaque (CMP), and coronary artery calcium score (CACS) was evaluated.</P><P>All participants were stratified into 4 groups based on the quartiles of the TyG index. The prevalence of CAD and obstructive CAD significantly increased with increasing quartiles. The risk for NCP and obstructive NCP was not different among all groups. However, compared with group I (lowest quartile), the risk for CMP was higher in groups III (odds ratio [OR]: 1.438) and IV (highest quartile) (OR: 1.895) (<I>P</I> < .05), and that for obstructive CMP was higher in groups II (OR: 1.469), III (OR: 1.595), and IV (OR: 2.168) (<I>P</I> < .05). Multivariate regression analysis showed that the TyG index was associated with an increased risk for CAD (OR: 1.700), obstructive CAD (OR: 1.692), and CACS >400 (OR: 1.448) (<I>P</I> < .05).</P><P>The TyG index was independently associated with the presence and severity of CAD due to an increased risk for CMP.</P>
Case Reports : Birt-Hogg-Dube Syndrome, a Rare Case in Korea Confirmed by Genetic Analysis
( Won Woong Shin ),( Yoo Sang Baek ),( Tae Seok Oh ),( Young Soo Heo ),( Soo Bin Son ),( Chil Hwan Oh ),( Hae Jun Song ) 대한피부과학회 2011 Annals of Dermatology Vol.23 No.2s
Simple benign tumors can present as part of a syndrome with substantial mortality. Fibrofolliculomas are benign skin tumors most often associated with the Birt-Hogg-Dube syndrome (BHDS). The most life-threatening complication of this syndrome is renal cancer and other major features include multiple lung cysts and spontaneous pneumothorax. We present the case of a 54 year-old man with multiple flesh-colored papules on his face confirmed histologically as fibrofolliculomas. He had a history of recurrent pneumothorax and chest computed tomography showed multiple lung cysts. To confirm the diagnosis of BHDS, we conducted gene analysis that revealed a single nucleotide duplication in the folliculin (FLCN) gene (Exon 11, C.1285dupC). BHDS confirmed by the FLCN gene mutation is rarely reported in Korea. Appropriate investigation is recommended whenever a patient with benign skin tumors is encountered. (Ann Dermatol 23(S2) S193~S196, 2011)