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[P210] Epidermal change due to chronic cold contact injury
( Jae Hwa Kim ),( Yu Jin Jeon ),( Dae Young Oh ),( Young Min Cho ),( Kyung Eun Jung ),( Dae Won Koo ),( Joong Sun Lee ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Chronic, irregular, and repeated exposure of the skin directly to the cold can result in varying degrees of damage to the skin. The cold injuries and resulting tissue damage in chronic cold contact injury are not fully understood. The level of cold injury may reversible or irreversible effects and depends on exposure time, temperature, medium and individual factors. A distinction is deducted between direct and indirect damage. Direct damage develops when there is a direct cold contact on the tissue and causes ice crystal formation, protein changes and plasma membrane impairment. In consequence, interstitial and intracellular liquids decrease. Indirect damage can be induced through reduced perfusion according to vasoconstriction, endothelial injury, vascular thrombosis or mediators. A 59-year-old male patient presented with eczema-like skin lesions of the groin, which had a history of intermittent itching for one year. He had ice massage from time to time until he was no longer itchy but his skin lesions did not improve. Histopathologic examination for the skin lesions revealed pale dyskeratotic keratinocytes and karyopyknosis. After treatment with oral and topical corticosteroids and antihistamines for 2 weeks under the suspicion of cold contact injury, his skin lesions and itchy improved. Herein, we report an interesting case of cold contact injury showing epidermal change histologically.
A case of long-pulse Nd:YAG laser for the treatment of onychodystrophy
( Jae Wook Jung ),( Ho Jung Jung ),( Yu Ri Kim ),( Yu Na Lee ),( Hyun Jung Park ),( Hyung Jin Hahn ),( Young Ji Hwang ),( Ji Young Kim ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2012 대한피부과학회 학술발표대회집 Vol.64 No.1
( Jae-hyeung Chu ),( Yun-jin Kim ),( Yu-min Ko ),( Ji Won Park ) 대한물리치료학회 2017 대한물리치료학회지 Vol.29 No.1
Purpose: This study was conducted to investigate the effects of variations in arm swing during gait on movement of the trunk and pelvis. During the gait task, the angle of the trunk and pelvic rotation were analyzed according to arm swing conditions. Methods: Seventeen healthy males participated in this study. All subjects were analyzed for gait on a treadmill three times each under three different types of arm swing conditions - natural arm swing, restricted arm swing using a phone, restricted swing in both arms. 3-D motion analysis systems were used to collect and analyze the kinematic data of trunk and pelvic movements, and repeated one-way ANOVA was used to compare the trunk and pelvic kinematic data and symmetry index. The level of significance was α=0.05. Results: The results showed kinematic differences in trunk and pelvic during gait based on the arm swing conditions. Specifically, there were significant differences in trunk rotation, left and right trunk rotation and symmetry index of trunk rotation during gait among the three arm swing conditions. ROM was used to calculate a symmetry index (SI) based on the average left and right trunk rotation in which a value closer to zero indicated better balance. The SI obtained for arm swing restricted with the phone was closer to -1 than the other conditions. Conclusion: Restricted arm swing due to use of a phone had the possibility to induce instability of postural control while walking, which could be seen to suggest a risk of falling during gait.
Cold atmospheric plasma (CAP): a novel therapeutic tool for cancer treatment
( Jae Won Choi ),( Yu Jin Lee ),( Young Jae Kim ),( Hak Tae Kim ),( Woo Jin Lee ),( Sung Eun Chang ),( Jee Ho Choi ),( Mi Woo Lee ),( Chong Hyun Won ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.2
Background: Cold atmospheric plasma (CAP), an ionized gas produced at room temperature, has become extremely attractive for biological applications, due to its potential in disinfection, wound healing and cancer treatment. CAP is gaining ground as a promising new oncological modality since it appears to be more potent against tumor cells rather than non-neoplastic cells. Namely, very low doses affect cellular motility, integrin expression and membrane lipid peroxidation; higher doses induce stress-related apoptosis; and very high doses cause necrosis Objectives: In this study, we investigated the effects of CAP in the in-vivo mouse model. Methods: Temperature of CAPJ-treated target was 23˚-36˚ C, and was dependent on the voltage applied. MC38 colon cancer cells of 2 x 10^6 were subcutaneously injected into the right flank of C57BL6 mice. MC38 tumors were treated with cold plasma once they were approximately 3mm in maximum diameter. Results: Tumor volume was significantly decreased in CAP treated tumors relatively to controls, and the longer exposure (5 min.) was more effective than the short exposure (2 min.). Importantly, pathologic examination revealed that normal skin was not harmed by CAP treatment. Conclusion: This preliminary study demonstrates the efficacy of room temperature CAP against melanoma progression in-vivo. Considering its biological mechanism, it is envisioned that adaptation of CAP technology may provide a new modality for the treatment of various solid tumors.
The Prognosis of Traumatic Small Bowel Injury Accompanied by Liver Injury
( Yu Seong Noh ),( Sung Won Jung ),( Tae Gil Heo ),( Pyong Wha Choi ),( Jae Il Kim ),( Heung Man Jun ),( Yong Chan Shin ),( Sung Min Jung ),( Eun Hae Um ) 대한외상학회 2021 大韓外傷學會誌 Vol.34 No.1
Purpose: The aim of this study was to elucidate the prognosis, and other clinical features, such as time to surgery and the amount of transfusion, of small bowel injury (SBI) accompanied by liver injury (LI). Methods: We investigated 221 patients with SBI who visited an emergency center from October 2000 to March 2019. We excluded patients with injuries that directly led to mortality, and the remaining 149 patients were divided into the SBI alone (SBI-A) group and the SBI accompanied by LI (SBI-LI) group. Data were collected for preoperative and surgical outcome variables, and the treatment results were compared between groups. Results: The SBI-LI group had a higher mortality rate than the SBI-A group (22.4% vs. 14.3%), but this difference was not statistically significant (p=0.061). There were no significant differences between the SBI-A and SBI-LI groups, except for the amount of red blood cell (RBC) transfusion (SBI-A: 3.53±0.1 vs. SBI-LI: 8.38±0.7 packs, p=0.035) and the length of intensive care unit (ICU) stay (SBI-A: 6.7±0.2 vs. SBI-LI: 11.1±0.5 days, p=0.047). Conclusions: The SBI-LI group required more RBC transfusions and longer ICU stays than the SBI-A group. SBI accompanied by LI may show higher mortality than SBI alone; however, since the difference was not statistically significant in the present study, larger-scale follow-up research is needed.