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Jang, Yong Hyun,Hong, Nam-Soo,Moon, Sun Young,Eun, Dong Hyuk,Lee, Won Kee,Chi, Seong Geun,Kim, Jun Young,Lee, Weon Ju,Lee, Seok-Jong,Kim, Do Won S. Karger AG 2017 Dermatology Vol.233 No.2
<P>Background: In alopecia totalis (AT) and alopecia universalis (AU), the chance of full hair regrowth is known to be less than 10%. However, this information is based on a few older studies conducted in the 1950s and 1960s. Objective: We investigated the current long-term prognosis of individuals with AT/AU. Methods: A retrospective chart review was performed in patients with AT/AU between 1994 and 2005. Outcome data were collected by reviewing outpatient clinical files or by phone interviews. Finally, the long-term assessment of 70 patients with valid outcome data was performed. Results: Twelve out of 70 patients with AT/AU (17.1%) had complete hair regrowth. Five out of 24 patients with AT (20.8%) showed complete hair regrowth, and 7 of 46 patients with AU (15.2%) achieved complete regrowth. Seventeen out of 70 patients with AT/AU (24.2%) reported hair regrowth greater than or equal to 90%. Thirty patients with AU (65.2%) remained in an alopecic state without improvement, while 5 patients with AT (20.8%) showed no hair regrowth. Conclusion: Our results suggest that the long-term prognosis of AT/AU is more favorable than previously thought. However, the clinical burden of AT/AU is still substantial. (C) 2017 S. Karger AG, Basel</P>
Jang, Hye-Ock,Kim, Dong-Won,Kim, Byeong-Ill,Sim, Hong-Gu,Lee, Young-Ho,Lee, Jong-Hwa,Bae, Jung-Ha,Bae, Moon-Kyoung,Kwon, Tae-Hyuk,Yun, Il The Korean Society of Pharmacology 2004 The Korean Journal of Physiology & Pharmacology Vol.8 No.2
The purpose of this study was to provide a basis for studying the molecular mechanism of pharmacological action of chlorhexidine digluconate. Large unilamellar vesicles (OPGTL) were prepared with total lipids extracted from cultured Porphyromonas gingivalis outer membranes (OPG). The anthroyloxy probes were located at a graded series of depths inside a membrane, depending on its substitution position (n) in the aliphatic chain. Fluorescence polarization of n-(9-anthroyloxy)stearic acid was used to examine effects of chlorhexidine digluconate on differential rotational mobility, while changing the probes' substitution position (n) in the membrane phospholipids aliphatic chain. Magnitude of the rotational mobility of the intact six membrane components differed depending on the substitution position in the descending order of 16-(9-anthroyloxy)palmitic acid (16-AP), 12, 9, 6, 3 and 2-(9-anthroyloxy)stearic acid (12-AS, 9-AS, 6-AS, 3-AS and 2-AS). Chlorhexidine digluconate increased in a dose-dependent manner the rate of rotational mobility of hydrocarbon interior of the OPGTL prepared with total lipids extracted from cultured OPG, but decreased the mobility of membrane interface of the OPGTL. Disordering or ordering effects of chlorhexidine digluconate on membrane lipids may be responsible for some, but not all of its bacteriostatic and bactericidal actions.
( Won Gu Kim ),( Tae Yong Kim ),( Tae Hyuk Kim ),( Hye Won Jang ),( Young Suk Jo ),( Young Joo Park ),( Sun Wook Kim ),( Won Bae Kim ),( Min Ho Shong ),( Do Joon Park ),( Jae Hoon Chung ),( Young Kee 대한내과학회 2014 The Korean Journal of Internal Medicine Vol.29 No.3
Background/Aims: Follicular thyroid carcinoma (FTC) and Hurthle cell carcinoma(HCC) of the thyroid are relatively uncommon thyroid malignancies in iodine-sufficient areas. In this study we evaluated the clinical behavior, prognosticfactors and treatment outcomes of FTC and HCC in Korea. Methods: This multicenter study included 483 patients with FTC and 80 patientswith HCC who underwent an initial surgery between 1995 and 2006 in one of thefour tertiary referral hospitals in Korea. We evaluated clinicopathological factorsassociated with distant metastases and recurrence during a median of 6 years offollow-up. Results: HCC patients were significantly older (49 years vs. 43 years; p < 0.001) andhad more lymphovascular invasions (22% vs. 14%; p = 0.03) compared with FTCpatients. Distant metastases were confirmed in 40 patients (8%) in the FTC groupand in two patients (3%) in the HCC group (p = 0.07). Distant metastases weresignificantly associated with older age, widely invasive cancer and extrathyroidalinvasion. Only 14 patients (3%) had recurrent disease and there was no significantdifference between FTC and HCC groups (p = 0.38). Recurrence was associatedwith larger tumor size and cervical lymph node metastasis. Conclusions: HCC patients were older and had more lymphovascular invasionsthan FTC patients. However, FTC and HCC patients had similar initial clinicopathologicalfeatures. Older age, wide invasiveness and extrathyroidal invasionwere independent risk factors for predicting distant metastases in FTC and HCCpatients.