Protective Effect of Baicalin Against Carbon Tetrachloride–Induced Acute Hepatic Injury in Mice

Park, Sang-Won,Lee, Chan-Ho,Kim, Yeong Shik,Kang, Sam Sik,Jeon, Su Jin,Son, Kun Ho,Lee, Sun-Mee The Japanese Pharmacological Society 2008 JOURNAL OF PHARMACOLOGICAL SCIENCES Vol.106 No.1

<P>This study examined the effects of baicalin, a bioactive flavonoid isolated from <I>Scutellariae Radix</I>, on carbon tetrachloride (CCl<SUB>4</SUB>)-induced liver injury. Mice were treated intraperitoneally with 0.5 ml/kg CCl<SUB>4</SUB> and different groups of animals received 25, 50, 100, and 200 mg/kg baicalin. At 24 h after the CCl<SUB>4</SUB> treatment, the level of serum aminotransferases and lipid peroxidation was significantly elevated, whereas the hepatic glutathione content was decreased. These changes were attenuated by baicalin. The histological studies showed that baicalin inhibited the portal inflammation, centrizonal necrosis, and Kupffer cell hyperplasia, which are the three most common characteristics of CCl<SUB>4</SUB>-induced liver damage. The serum level and mRNA expression of tumor necrosis factor-α were markedly increased by the CCl<SUB>4</SUB> treatment but suppressed by baicalin. The mRNA and protein expression levels of inducible nitric oxide synthase and heme oxygenase-1 increased significantly at 24 h after the CCl<SUB>4</SUB> treatment. Baicalin attenuated the increase in the protein and gene expression of inducible nitric oxide synthase but augmented the increase in those of heme oxygenase-1. These findings suggest that baicalin protects hepatocytes from the oxidative damage caused by CCl<SUB>4</SUB>, and this protection is likely due to the induction of HO-1 expression and the inhibition of the proinflammatory mediators.</P>

Ho-166 부착풍선도자를 이용한 방사선 조사의 돼지 관상동맥 스텐트 재협착 예방 효과

김원 ( Kim Won ),정명호 ( Jeong Myeong Ho ),박옥영 ( Park Og Yeong ),정우곤 ( Jeong U Gon ),박우석 ( Park U Seog ),김주한 ( Kim Ju Han ),안영근 ( An Yeong Geun ),조정관 ( Jo Jeong Gwan ),박종춘 ( Park Jong Chun ),강정채 ( Kang Je 한국지질동맥경화학회 ( 구 한국지질학회 ) 2002 韓國脂質學會誌 Vol.12 No.1

배경 : 국내에서 개발된 방사선 동위원소 Holmium-166 (166Ho)은 주로 베타선을 방출하며, 166Ho을 부착한 풍선도자를 이용하여 돼지 관상동맥 재협착 모형에서 풍선확장술 후 신생내막 증식을 전신적 부작용 없이 안전하고 효과적으로 억제하였음을 보고한 바 있다. 본 연구에서는 돼지 관상동맥 스텐트 재협착 모형에서 스텐트 시술 후 신생내막 증식에 의한 재협착 병변을 166Ho 부착 풍선도자를 이용하여 치료하여 그 효과를 관찰하고자 하였다. 방법

국립공원 내 공중화장실에 대한 탐방객 인식에 관한 연구 : 지리산국립공원을 중심으로

이호(Ho Lee),이승록(Seung-Rok Lee),박기현(Ki-Hyun Park),박은희(Eun-Hee Park),차진열(Jin-Yeol Cha),심규원(Kyu-Won Sim),강동원(Dong-Won Gang) 국립공원연구원 2011 국립공원연구지 Vol.2 No.1

본 연구는 공원 내 공중화장실에 대한 탐방객의 인식이 만족도에 미치는 영향을 규명하고자 수행하였다. 현지 설문조사는 지리산국립공원의 성삼재와 중산리 일원을 방문한 탐방객 292명을 대상으로 이루어졌다. 분석결과, 공중화장실의 관리상태, 외관, 디자인 요인 모두 탐방객의 공중화장실 이용 만족에 영향을 주는 것으로 분석되었으며, 그 중 관리상태가 가장 큰 영향을 주는 것으로 나타났다. 따라서 탐방객의 인식과 만족을 향상시키기 위해서는 공중화장실의 청결한 관리 및 유지, 악취 방지, 소모품의 원활한 공급 등에 우선순위를 두어 집중적으로 관리할 필요가 있는 것으로 나타났다. This study conducts to investigate the relationship between visitors’ perception and satisfaction. Data of 292 visitors were collected from Seongsamjae and Jungsanri in Jirisan National Park. The results showed that maintenance, outlook and design of public toilet are positively related to visitors’ satisfaction. One of the major research findings is that the maintenance of public toilet most affects visitors’ satisfaction. Therefore, the park managers need to put great emphasis on the cleanliness and maintenance, preventing stinks, consumable supplies of public toilet in order to enhance visitors’ perception and satisfaction.

3,4,5-Trihydroxycinnamic Acid Inhibits Lipopolysaccharide-Induced Inflammatory Response through the Activation of Nrf2 Pathway in BV2 Microglial Cells

( Jae Won Lee ),( Yong Jun Choi ),( Jun Ho Park ),( Jae Young Sim ),( Yong Soo Kwon ),( Hee Jae Lee ),( Sung Soo Kim ),( Wan Joo Chun ) 한국응용약물학회 2013 Biomolecules & Therapeutics(구 응용약물학회지) Vol.21 No.1

3,4,5-Trihydroxycinnamic acid (THC) is a derivative of hydroxycinnamic acids, which have been reported to possess a variety of biological properties such as anti-inflammatory, anti-tumor, and neuroprotective activities. However, biological activity of THC has not been extensively examined. Recently, we reported that THC possesses anti-inflammatory activity in LPS-stimulated BV2 microglial cells. However, its precise mechanism by which THC exerts anti-inflammatory action has not been clearly identified. Therefore, the present study was carried out to understand the anti-inflammatory mechanism of THC in BV2 microglial cells. THC effectively suppressed the LPS-induced induction of pro-inflammatory mediators such as NO, TNF-a, and IL-1b. THC also suppressed expression of MCP-1, which plays a key role in the migration of activated microglia. To understand the underlying mechanism by which THC exerts these anti-inflammatory properties, involvement of Nrf2, which is a cytoprotective transcription factor, was examined. THC resulted in increased phosphorylation of Nrf2 with consequent expression of HO-1 in a concentration-dependent manner. THC-induced phosphorylation of Nrf2 was blocked with SB203580, a p38 MAPK inhibitor, indicating that p38 MAPK is the responsible kinase for the phosphorylation of Nrf2. Taken together, the present study for the first time demonstrates that THC exerts anti-inflammatory properties through the activation of Nrf2 in BV2 microglial cells, suggesting that THC might be a valuable therapeutic adjuvant for the treatment of inflammation-related disorders in the CNS.

공급사슬에서 수량할인과 수익공유를 반영한 계약

박세호(Se Ho Park),이영해(Young Hae Lee),조동원(Dong Won Cho) 한국SCM학회 2012 한국SCM학회지 Vol.12 No.2

One of the most important reasons in pursuit of supply chain management is to prevent sub-optimization caused by decentralized decision making over the various entities. As supply chain coordination approach to overcome such a setting, contract mechanisms have frequently been used. However, a coordinated supply chain might fail to provide additional profit to one of the players. In result, it is necessary that a contract mechanism is designed to achieve the same profit in a centralized situation (coordination) and to improve the benefit of all the supply chain players (winwin). In this paper, we address supply chain contract based on revenue sharing and quantity discount considering price and service level. We show that the trade parameters among different entities in the supply chain contract can be chosen to achieve coordination and a win-win outcome.

권역심뇌혈관질환센터 사업의 비용-편익 분석

김병호 ( Byung Ho Kim ),감신 ( Sin Kam ),배상근 ( Sang Geun Bae ),김건엽 ( Keon-yeop Kim ),이원기 ( Won Kee Lee ),홍남수 ( Nam-soo Hong ),박형근 ( Hyeung-keun Park ),이혜진 ( Heyjean Lee ),조은정 ( Eun-jung Cho ),채성철 ( Shung C 한국보건정보통계학회 2017 보건정보통계학회지 Vol.42 No.1

Objectives: This study was conducted to investigate economic feasibility of operating Regional Cardiocerebrovascular Centers using cost-benefit analysis. Methods: The current study assessed cost and benefit data collected from nine hospitals which were designated as Regional Cardiocerebrovascular Centers between 2008 and 2010. Results: The operation of Regional Cardiocerebrovascular Centers reduced mortality rate and length of stay due to acute myocardial infarction and stroke and also decreased disability occurred after stroke. The total calculated cost of operating nine Regional Cardiocerebrovascular Centers was 19.85-22.30 billion won and the minimum benefit calculated was 23.98 billion won. Applying the maximum cost and the minimum benefit, the net benefit was 1.68 billion won, which is estimated to 190 million won per Regional Cardiocerebrovascular Center. Conclusions: The present study revealed that the operation of Regional Cardiocerebrovascular Centers was economically beneficial. The benefit would be larger if intangible benefit such as the long-term effects to community hospitals and enhancement of quality of life of patients and their families are considered.

고차잉여류 문제에 기반을 둔 다중서명 방식

이보영(Lee Bo Young),박택진(Park Taek Jin),원동호(Won Dong Ho) 한국정보처리학회 1999 정보처리학회논문지 Vol.6 No.3

Itakura and Nakamura proposed the first multisignature scheme based on the RSA signature scheme. But if many users sign on one paper, then their scheme has a reblocking problem. In 1991, Ohta and Okamoto proposed a multisignature scheme by using Fiat-Shamir signature scheme. But in this scheme, the group of signers must generate common random number in the first round, and in the second round, they sign the message with common random number. Also L. Harn proposed a multisignature scheme which is based on the E1Gamal's. In korea, S.D.Kim et al. at ICEIC'95 conference, proposed an efficient sequential multisignature scheme by using the modified Park-Won scheme. This scheme is not require an additional round to generate common random number, and has fixed signature length. In this paper, we analyze problem of Kim's multisignature scheme, and propose a new multisignature scheme based on R(th-) residuosity problem.

완화환율의 장기구매력평가 : 정수차분과 분수차분

모수원(Soo Won Mo),박석호(Seok Ho Park) 한국국제경영학회 1999 國際經營硏究 Vol.10 No.1

구매력평가(PPP)는 국제금융이론에서 중요한 비중을 차지하고 있다. 초기 환율의 화폐적 모형인 신축물가모형은 지속적인 구매력평가의 성립을 전제로 하고 있으며, 경직물가모형은 환율의 구매력평가로부터의 단기적 괴리를 허용하나 장기에서는 균형이 이루어짐을 상정하고 있다. 이러한 PPP의 중요성에도 불구하고 단기에서 PPP가 성립하지 않는다는 데에는 일반적으로 견해가 일치하고 있으나, 장기에서의 PPP 타당성에 대해서는 많은 논란이 되고 있다. 이러한 결과는 저자에 따라 물가지수, 자료의 빈도 또는 이용하는 검정기법상의 차이가 있기 때문이다. 일반적으로 장기PPP검정에는 흔히 공적분기법이 주로 이용되고 있다. 그러나 많은 문헌들이 사용하는 정수차분에 근거를 두는 기존의 Dickey-Fuller류의 공적분기법은 충격효과가 즉시 소멸하는가 아니면 영구히 지속되는가 하는 양 극단의 경우만을 다룰 수 있을 뿐이다. 즉 시계열의 특성이 I(0)인가 흑은 I(1)인가를 식별하는 데 그치고 있다. 이에 따라 정상성과 추세회귀성향을 구분할 수 있는 장점을 지닌 분수차분에 의한 검정이 이루어져야 한다. 이러한 분수차분에 의한 GPH검정을 통해 한국의 원화환율은 장기에 있어서 PPP를 지지하지 않음을 밝힌다.

도심지내 분수유형별 음이온 분포 및 상관성 분석

김정호 ( Jeong Ho Kim ),박승환 ( Seung Hwan Park1 ),김원태 ( Won Tae Kim ),윤용한 ( Yong Han Yoon ) 한국환경과학회 2013 한국환경과학회지 Vol.22 No.12

In order to verify the healing effect in the variety of effects according to fountain type, anion which is the representatives factor of healing, as the center of case studies which in Gwanghwamun(Ground fountain), Cheonggyecheon(Waterfall) and Myeongdong(Formative fountain). According to fountain type, the anion distribution as follow, figures typically 15,721 ± 419 ea/cm³, Formative fountain 40,190 ± 788 ea/cm³, Waterfall 4,480 ± 290 ea/cm³ and ground fountain 2,492 ± 180 ea/cm³. It is usually exceed to the distribution in natural green, which is 1070∼2100 ea/cm³. The interrelation between air temperature, relative humidity, wind speed and relative humidity, and wind speed is that, the relative humidity is directly proportional to wind speed and inversely proportional to temperature. As the temperature goes up, the distribution of anion goes down. And as the wind speed and relative humidity goes up, the distribution of anion decrease sharply. The result of interrelation between fountain type and the anion distribution is that, the distance of water falling is directly proportional to the anion distribution in the formative fountain and inversely proportional in the ground fountain. And the distribution of anion is largest in formative fountain. The distribution of anion in ground fountain is lower than in formative fountain, but it is far more than in natural greenery. And as the distance from fountain increase, the distribution of anion goes down.

Omeprazole 투여시 위산분비 억제능에 대한 CYP2C19 의 영향

박수헌(Soo Heon Park),김종원(Jong Won Kim),이수연(Soo Youn Lee),최명규(Myung Gyu Choi),김재광(Jae Kwang Kim),정인식(In Sik Chung),정규원(Gyu Won Chung),선희식(Hee Sik Sun),박두호(Doo Ho Park) 대한소화기학회 2001 대한소화기학회지 Vol.38 No.6

Background/Aims: CYP2C19 has an important role in the catabolism of several proton pump inhibitors. However, the relative contribution of CYP2C19-mediated metabolism varies among the different proton pump inhibitors. We investigate to determine the effect of CYP2C19 genotype status on intragastric pH during dosing with omeprazole. Methods: The subjects were 16 healthy volunteers. Their CYP2C19 genotype status was determined by a polymerase chain reaction-restriction fragment length polymorphism method. Twenty-four-hour monitoring of intragastric acidity were performed on the day without medication and day 4 after omeprazole administration. Results: A single dose of omeprazole significantly decreased 24 hour intragastric acidity (1.7±0.3 vs. 5.1±0.4). Subjects were divided into three groups on the basis of their CYP2C19 genotype status: homozygous extensive metabolizers (Ho-EMs, n=5), heterozygous extensive metabolizers (Ht-EMs, n=6), and poor metabolizers (PMs, n=5). Median 24 hour intragastric pH in the Ho-EM group was 3.1 compared with 5.5 in Ht-EM group and 5.9 in PM group(P<0.05). The median pH during omeprazole administration was influenced by CYP2C19 genotype. On the other hand, the Helicobacter pylori infection did not influence the median intragastric pH during omeprazole administration (p= NS). Conclusions: The effects of omeprazole on intragastric acidity is influenced by the CYP2C19 polymorphism. (Korean J Gastroenterol 2001;38:399-404)