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FK506이 T 림프구 사멸에서 활성산소 생성에 미치는 영향
이호균(Ho Kyun Lee),정상영(Sang Young Chung),최수진나(Soo Jin Na Choi) 대한외과학회 2009 Annals of Surgical Treatment and Research(ASRT) Vol.77 No.5
Purpose: Tacrolimus (FK506) has been widely used as an immunosuppressant in organ transplanted recipients to suppress organ rejection phenomenon. We investigated the role of oxidative stress and heme oxygense-1 by FK506 on human Jurkat T cells. Methods: The cells viability was examined by DAPI stain, enzyme activity of caspase family proteins, and western blotting for Baks, PUMA, iNOS, HO-1. Cells were cultured in the absence or presence of CoPPIX or ZnPPIX and the fluorescence intensity was analyzed using a flow cytometry. Results: Treatment with FK506 increased the generation of reactive oxygen species (ROS), including hydrogen peroxide and superoxide anion, and NO in Jurkat cells in a dose-dependent manner. Immunohistochemistry and Western blot analysis data revealed the hemoxygenase-1 (HO-1) was induced by the addition of FK506 in Jurkat cells. Induction of CoPP, HO-1 inducer, resulted in decreased intracellular H₂O₂ and NO concentrations. Instead ZnPP, an HO-1 competitive inhibitor did it reversely. In addition, ZnPP regulates iNOS protein synthesis by inhibition of HO-1. Conclusion: Increase of HO-1 expression would induce to decrease the intracellular H₂O₂ and NO concentrations. Also, HO-1 would regulate iNOS protein synthesis. Consequently, we can expect the regulation of HO-1 expression with concomitants use of FK506 to suppress organ rejection phenomenon by enhancing apoptosis.
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이호식 ( Ho Sik Lee ),안준호 ( Jun Ho Ahn ),이원재 ( Won Jae Lee ),장경욱 ( Kyung Uk Jang ),최명규 ( Myung Kyu Choi ),김태완 ( Tae Wan Kim ),이준웅 ( Joon Ung Lee ) 한국전기전자재료학회 2005 한국전기전자재료학회 하계학술대회 논문집 Vol.2005 No.0
We have fabricated solar cell devices based on zinc-phthalocyanine(ZnPc) as donor(D) and fullerene(C60) as electron acceptor(A) with doped charge transport layers, and BCP and Alq3 as an exciton blocking layer(EBL). We have measured the photovoltaic characteristics of the solar cell devices using the Xe lamp as a light source. We were use of Alq3 layer leads to external power conversion efficiency was 2.65% at illumination intensity 100mW/㎠. Also we confirmed the optimum thickness ratio of the DA hetero-junction is about 1:2.
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이호정 ( Ho Jung Lee ),홍정연 ( Jeong Yeon Hong ),박태흠 ( Tae Heum Park ),이성열 ( Sung Yul Lee ),이종석 ( Jong Suk Lee ),정의현 ( Euy Hyun Chung ),이상훈 ( Sang Hoon Lee ),김정은 ( Jung Eun Kim ) 대한피부과학회 2020 대한피부과학회지 Vol.58 No.6
Fixed drug eruption (FDE) is a drug-induced disorder that may appear as patches or bullae. It recurs at the same sites as those involved in exposure to the same drug (causative drug). We encountered two cases of generalized FDE, and both patients had a history of diclofenac exposure before the onset of skin lesions. In the first case, an 82-year-old female patient presented with multiple erythematous patches on the trunk and lower extremities. In the second case, a 71-year-old male patient developed multiple bullae on violaceous patches on the trunk and extremities. The findings of histopathologic examinations were indicative of the diagnosis of FDEs. Although diclofenac is commonly used as a non-steroidal inflammatory drug, diclofenac-induced generalized FDE occurs rarely and has not been reported in Korea. With reuse of causative drugs, the size and number of lesions tend to increase. Therefore, early diagnosis of FDE is important, and avoidance of repeated exposure to drugs should be educated
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이호형 ( Ho Hyung Lee ),김석영 ( Suk Young Kim ),변아롱 ( A Rong Byun ),오혜영 ( Hea Young Oh ),이현이 ( Hyun Lee Lee ),윤정혜 ( Jung Hye Yoon ),이상구 ( Sang Gu Lee ) 대한주산의학회 2006 Perinatology Vol.17 No.1
A herniated nucleus pulposus (HNP) during pregnancy has been a rare occurrence with a reported incidence of 1:10,000 case. It is hard to diagnose because of the potentially hazardous effect of ionizing radiation to the fetus when complaining back pain during pregnancy. In this case, magnetic resonance imaging (MRI) provide safe and useful modality and in general, back pain usually respond readily to conservative treatment. Cauda equina syndrome or severe and/or progressive neurologic deficit is a medical emergency that necessitates prompt surgery during pregnancy. She admitted at 31 weeks gestation for sudden development of right leg paresthesia and ankle motor weakness, an MRI showing compression on right nerve root at the level of L5~S1. After 4 weeks treated with bed rest and analgesics, we delivered by cesarean section and laminectomy at the same time. We have experienced a pregnancy with HNP, so report of this case with brief review of literature.
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이호형 ( Ho Hyung Lee ),이승철 ( Seung Chul Lee ),옥윤용 ( Yun Yong Ok ),이승호 ( Seung Ho Lee ) 한국설비안전학회 2014 대한설비관리학회지 Vol.19 No.4
Traditionally, the coefficients have been obtained using experimental measurements according to AHSRAE Standard 120, a process which is time consuming and expensive. An alternative is to use CFD, but this has uncertainty due to the approximations used in modeling turbulence. This study estimated that the pressure loss coefficients of duct fitting(elbow, tee) by turbulence model(Standard k-ε, Realizable k-ε, RSM, SST k-ω) using CFD techniques. The results show that Realizable k-ε model could accurately predict the pressure loss coefficients from all cases.
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도서산림 관리를 위한 관련 법제도 고찰과 개선방안에 관한 연구
이호상 ( Lee¸ Ho-sang ),현창석 ( Hyun¸ Chang-seok ),이보라 ( Lee¸ Bo-ra ),이광수 ( Lee¸ Kwang-soo ),신순호 ( Shin¸ Soon-ho ) 한국도서(섬)학회 2021 한국도서연구 Vol.33 No.2
This study was undertaken to suggest the direction of island forest management for the conservation of the forest ecosystem in the island region through the review of the current legal system for forest management in the island area. Recently, there has been an increasing discussion on the conservation of island biodiversity both domestically and internationally, and the island management policy in Korea has also been changed to consider the life, economy, and ecological sustainability of local residents. The total number of islands that are geographically cut off from land and surrounded by the sea was 3,383(465 inhabited islands and 2,918 uninhabited islands), 2,325 (55.9%) distributed forests and 220,819ha forest area, which is estimated to account for about 3.5% of the nation's forest area. In relation to the island area, the principal agents in island management are diversified by managing the populated islands via the Ministry of the Interior and Safety, the uninhabited islands with the Ministry of Oceans and Fisheries, the Ministry of Environment, the Ministry of Oceans and Fisheries, and the Ministry of the Interior and Safety. Mainly, inhabited islands are developed while uninhabited islands and special islands have conservation characteristics. In the forest sector, other than the Forest Protection Act, which is directly subject to forest protection, forests are indirectly protected in connection with environmental conservation or ecosystem conservation, including by the Natural Environmental Conservation Act. The legal system that approaches the concept of island forest as a different concept rather than that of a collective is needed, as most of the current forest-related laws are applied to develop, use, preserve, and manage forests and mountainous areas. As a measure to improve the legal system for the management of island forests, first, it is intended to suggest a plan to revise the current laws and regulations and to enact the Act on the Conservation and Management of Forests on Islands (tentative name). The revision (proposal) of the current law is the easiest improvement plan by revising only the regulations to create forest resources, protect forests, and strengthen budgets, mainly for forest management in the island areas. The plan to enact the Act on the Conservation and Management of Forests in Island Areas (tentative name) may make the authority of the management of island forests clearer, so that no conflict between ministries may occur. Through this, it will be possible to secure the effectiveness of island forest management and to secure the necessity of the Forest Service to take responsibility for the systematic management of forests in the island areas.
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