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CHISELED NICKEL HYDROXIDE NANOPLATES GROWTH ON GRAPHENE SHEETS FOR LITHIUM ION BATTERIES
LEI-LEI TIAN,XIAN-YONG WEI,QUAN-CHAO ZHUANG,CHAO WU,RUI-LUN XIE,ZHI-MIN ZONG,YONG-LI CUI,SHI-GANG SUN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2013 NANO Vol.8 No.6
The morphologies and structures of Ni(OH)2–graphene hybrid materials were tailored by using different mineralizers in this work. It was revealed that the synergic effects of the highly oxidized graphene sheets and the mineralizers played a crucial role in controlling the morphology and structure of the nanocomposites, and Na2CO3 is a very effective mineralizer for growing chiseled 2D nanoplates of Ni(OH)2 on graphene sheets. When produced with NaOH, fragmental Ni(OH)2 crystals with irregular shapes erratically decorated on graphene sheets. In contrast, chiseled Ni(OH)2 hexagonal nanoplates grown on graphene sheets were obtained when Na2CO3 was used as the mineralizer. These unique 2D–2D nanoarchitectures with higher contact area between the nanocrystals and graphene substrate can increase the interfacial interaction and then efficiently improve the structural stability of the composite material, thus exhibiting an enhanced Li storage capacity and excellent cycling performance of 562 mAh g-1 after the 36th cycle.
Wei Ma,Yun Ma,Dong Liu,Yuan Gao,Xiao-mei Sun,Ai-min Li,Chun-lei Zhang,Hong Chen 한국유전학회 2012 Genes & Genomics Vol.34 No.6
Transmembrane protein 18 (TMEM18) gene is expressed in the central nervous system that has recently been linked to human obesity and body mass index (BMI) in genome wide association studies (GWAS). In this study, two novel single nucleotide polymorphisms (SNPs), g.3835 G > A (aa. Gly >Ser) and g.3865 A > G were detected in cattle TMEM18 gene by DNA sequencing. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) and forced PCR-RFLP methods were used to genotype the two SNPs in 1218 Chinese native cattle individuals. The association between novel SNPs and growth traits (especially on body weight and body height) in Nanyang cattle showed that individuals with GG genotype was higher than those with AA genotype at g.3835G>A locus (P < 0.05) in Nanyang cattle. Significant association also revealed that individuals of AA genotype at g. 3865 A>G locus were higher in terms of body weight, average daily gain, chest circunmference, body length (P < 0.05), body height and hucklebone width (P < 0.01) than GG genotypes in Nanyang cattle. Moreover, the effect of XspI-MluI combinations with growth traits in Nanyang cattle revealed that AAGG type had higher body weight, body length, chest circumference and average daily gain (P < 0.05)than GGAG in Nanyang cattle aged at 6 months.
Dan-Min Xu,Yi-Lin Kong,Li Wang,Hua-Yuan Zhu,Jia-Zhu Wu,Yi Xia,Yue Li,Shu-Chao Qin,Lei Fan,Jian-Yong Li,Jin-Hua Liang,Wei Xu 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2
Purpose The purpose of this study was to investigate the prognostic impact of Epstein-Barr virus (EBV)–microRNA (miRNA, miR)-BHRF1-1 with chronic lymphocytic leukemia (CLL) as well as role of EBV-miR-BHRF1-1 in p53 gene. Materials and Methods Quantitative reverse transcription–polymerase chain reaction and western blotting were used to quantify EBV-miR-BHRF1-1 and p53 expression in cultured CLL. Results p53 aberration was associated with the higher expression level of EBV-miR-BHRF1-1 (p < 0.001) which was also an independent prognostic marker for overall survival (p=0.028; hazard ratio, 5.335; 95% confidence interval, 1.193 to 23.846) in 97 newly-diagnosed CLL patients after adjusted with International Prognostic Index for patients with CLL. We identified EBV-miR-BHRF1-1 as a viral miRNA regulator of p53. EBV-miR-BHRF1-1 repressed luciferase reporter activity by specific interaction with the seed region within the p53 3- untranslated region. Discordance of p53 messenger RNA and protein expression was associated with high EBV-miR-BHRF1-1 levels in CLL patients and cell lines. EBV-miR-BHRF1- 1 inhibition upregulated p53 protein expression, induced cell cycle arrest and apoptosis and decreased cell proliferation in cell lines. EBV-miR-BHRF1-1 mimics downregulated p53 protein expression, decreased cell cycle arrest and apoptosis, and induced cell proliferation in cell lines. Conclusion This study supported the role of EBV-miR-BHRF1-1 in p53 regulation in vitro. Our results support the potential of EBV-miR-BHRF1-1 as a therapeutic target in EBV-associated CLL with p53 gene aberration.
Xianjuan Pang,Lei Shi,Peng Wang,Yanqiu Xia,Wei-Min Liu 한국물리학회 2011 Current Applied Physics Vol.11 No.3
Ti-and TiAl-doped a-C:H films were deposited on silicon substrates by magnetron sputtering Ti and TiAl target in argon and methane gas mixture atmosphere. To better elucidate the structural evolution after Al adding, X-ray diffraction, Raman spectroscopy, and X-ray photoelectron spectroscopy were used to comparatively analyze the structural transformation in the as-deposited films. Compared with Ti-doped a-C:H films, the introduction of Al enhanced carbon films graphitization effectively lowered the residual stress from 1.35 GPa to 0.65 GPa. Furthermore, though the hardness of TiAl-doped a-C:H films was moderately lowered, TiAl-doped a-C:H films exhibited higher toughness, lower friction coefficient and lower wear rate. The better tribological performances of TiAl-doped a-C:H films may originate from the formation of graphitized transfer layer during the friction test.
Liu Xuemei,Min Jie,She Bin,Chen Yang,Li Jun,Huang Lei,Chen Ju,Luo Ai,Mei Yang,Li Ting,Wu Yanqing,Chen Daohong,Hongli Zhong,Liu Wei,Mao Bing,Jiang Hongli 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.3
Background: Binafuxi granules are a traditional Uighur medicine (TUM) for treating the common cold with fever. However, high-quality clinical studies supporting its efficacy and safety are lacking. Methods: In this multicenter, randomized, double-blind, placebo-controlled, phase II clinical trial, patients with common cold and fever were randomly assigned to a high-dose group, low-dose group, and placebo group in a 1:1:1 ratio. Outcomes were time to fever relief, time to fever clearance, proportion of afebrile patients, time to symptom disappearance, rate of symptom disappearance, effective rate, emergency drug usage and safety assessment. Results: A total of 235 patients were recruited. Of these, 234 were included in the full analysis set (FAS), and 217 were included in the per-protocol set (PPS). In the FAS analysis, the median time to fever relief was 6.00 h, 5.54 h and 10.65 h (P = 0.31) in the high-dose group, low-dose group and placebo group, respectively. The median time to fever clearance was 18.29 h, 20.08 h and 25.00 h (P = 0.0018), respectively, and the proportion of afebrile patients was 92.4%, 89.7% and 71.4% (P = 0.0002), respectively. There was a significant difference in the disappearance time and disappearance rate of all symptoms and of individual symptoms. No serious adverse events were found. Conclusions: Binafuxi granules can dose-dependently shorten the fever course and improve clinical symptoms in patients suffering from the common cold with fever.
( Gangping Li ),( Min Yang ),( Kan Zhou ),( Lei Zhang ),( Lugao Tian ),( Shangze Lv ),( Yu Jin ),( Wei Qian ),( Hanhua Xiong ),( Rong Lin ),( Yu Fu ),( Xiaohua Hou ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.7
The diverse microbial communities that colonize distinct segments of the gastrointestinal tract are intimately related to aspects of physiology and the pathology of human health. However, most recent studies have focused on the rectal or fecal microbiota, and the microbial signature of the duodenum is poorly studied. In this study, we compared the microbiota in duodenal and rectal samples to illustrate the characteristic microbial signatures of the duodenum in healthy adults. Nine healthy volunteers donated biopsies and luminal contents from the duodenum and rectum. To determine the composition and diversity of the microbiota, 454- pyrosequencing of bacterial 16S rRNA was performed and multiple bioinformatics analyses were applied. The α-diversity and phylogenetic diversity of the microbiota in the duodenal samples were higher than those of the rectal samples. There was higher biodiversity among the microbiota isolated from rectal biopsies than feces. Proteobacteria were more highly represented in the duodenum than in the rectum, both in the biopsies and in the luminal contents from the healthy volunteers (38.7% versus 12.5%, 33.2% versus 5.0%, respectively). Acinetobacter and Prevotella were dominant in the duodenum, whereas Bacteroides and Prevotella were dominant in the rectum. Additionally, the percentage of OTUs shared in biopsy groups was far higher than in the luminal group (43.0% versus 26.8%) and a greater number of genera was shared among the biopsies than the luminal contents. Duodenal samples demonstrated greater biological diversity and possessed a unique microbial signature compared with the rectum. The mucosa-associated microbiota was more relatively conserved than luminal samples.
A Deep Reinforcement Learning-Based Energy Management Strategy for Fuel Cell Hybrid Buses
Chunhua Zheng,Wei Li,Wei-Min Liu,Kun Xu,Lei Peng,차석원 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.3
An energy management strategy (EMS) plays an important role for hybrid vehicles, as it is directly related to the power distribution between power sources and further the energy saving of the vehicles. Currently, rule-based EMSs and optimizationbased EMSs are faced with the challenge when considering the optimality and the real-time performance of the control at the same time. Along with the rapid development of the artificial intelligence, learning-based EMSs have gained more and more attention recently, which are able to overcome the above challenge. A deep reinforcement learning (DRL)-based EMS is proposed for fuel cell hybrid buses (FCHBs) in this research, in which the fuel cell durability is considered and evaluated based on a fuel cell degradation model. The action space of the DRL algorithm is limited according to the efficiency characteristic of the fuel cell in order to improve the fuel economy and the Prioritized Experience Replay (PER) is adopted for improving the convergence performance of the DRL algorithm. Simulation results of the proposed DRL-based EMS for an FCHB are compared to those of a dynamic programming (DP)-based EMS and a reinforcement learning (RL)-based EMS. Comparison results show that the fuel economy of the proposed DRL-based EMS is improved by an average of 3.63% compared to the RL-based EMS, while the difference to the DP-based EMS is within an average of 5.69%. In addition, the fuel cell degradation rate is decreased by an average of 63.49% using the proposed DRL-based EMS compared to the one without considering the fuel cell durability. Furthermore, the convergence rate of the proposed DRL-based EMS is improved by an average of 30.54% compared to the one without using the PER. Finally, the adaptability of the proposed DRL-based EMS is validated on a new driving cycle, whereas the training of the DRL algorithm is completed on the other three driving cycles.
A QoE Evaluation Method for RT-HDMV Based on Multipath Relay Service
Yu-Zhuo Zhan,Wei-Min Lei,Yun-Chong Guan 한국통신학회 2019 한국통신학회 학술대회논문집 Vol.2019 No.1
In the paper, a multipath relay service based on QoE (Quality of Experience) evaluation method is proposed for RT-HDMV (Real-Time High Definition Medical Video). The method eliminates several of the limitations in the existing methods for the conventional single-path transmission. It can fully utilize the finite network resources and transmission bandwidth to meet the users’ demands of RT-HDMV to get the better score of QoE. We use a three-stage framework to evaluate the QoE: construct the multipath relay transmission for RT-HDMV, design the load distribution strategy by the mapping between QoS (Quality of Service) and QoE and coupling the multipath scene, and redefine the rule of QoE evaluation. The experiments show that our framework can provide better QoE guarantees for RT-HDMV than existing methods in traditional single-channel transmission scenarios.