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GOLPH3, a Good Prognostic Indicator in Early-stage NSCLC Related to Tumor Angiogenesis
Lu, Ming,Tian, Yu,Yue, Wei-Ming,Li, Lin,Li, Shu-Hai,Qi, Lei,Hu, Wen-Si,Gao, Cun,Si, Li-Bo,Tian, Hui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14
Background: Golgi phosphoprotein-3 (GOLPH3) is implicated in cancer development and progression. The aim of this study was to evaluate the prognostic significance of GOLPH3 protein and its association with tumor angiogenesis in patients with early-stage NSCLC. Materials and Methods: Immunohistochemistry was performed to determine GOLPH3 protein expression and allow assessment of intratumoral microvessel density (MVD) by counting CD-34 positive immunostained endothelial cells. Correlations of expression with MVD, clinicopathologic features and clinical prognosis were analyzed. Results: A notably higher level of GOLPH3 expression was found in early-stage NSCC tissues at the protein level. However, we do not find any correlation between GOLPH3 expression and clinicopathologic features (p>0.05), although higher MVD was positively associated with GOLPH3 overexpression (p<0.001). Expression of GOLPH3 was found to be an independent prognostic factor in early-stage NSCLC patients, those expressing high levels of GOLPH3 exhibiting a substantially lower 5-year overall survival than GOLPH3-negative patients (adjusted HR =1.899, 95% CI: 1.021-3.532, p=0.043). Conclusions: High expression of the GOLPH3 protein is common in early-stage NSCC, and is closely associated with tumor progression, increased tumor angiogenesis, and poor survival. We conclude a possibility of its use as a diagnostic and prognostic marker in early-stage NSCC patients.
Yan-Ming Mu,Xiang-ying Hou,Si-wei Yang,Xue-Ming He 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.24 No.5
For upgrading the transmission performance of spiral bevel gear and extending the time between overhauls of the helicopter reducer, an innovative multi-objective collaborative optimization strategy of shape and performance is put up for the super-high-contact-ratio spiral bevel gear transmission with the contact path along tooth width based on ease-off. Firstly, according to the preset contact path curve along tooth width and the symmetrical transmission error curve, the pinion optimal surface satisfying the preset functions is obtained based on ease-off. Secondly, based on the basic principles of simulated annealing and gravitational search, the simulated annealing-gravity search cooperative intelligent optimization algorithm is set up for the calculation of the multi-objective collaborative optimization model of the spiral bevel gear transmission, and the modified surface of pinion satisfying the function requirements is obtained based on the collaborative optimization of shape and performance. Finally, combined with the tooth contact analysis method, meshing impact analysis method and dynamic analysis method, the loaded transmission error, meshing impact and dynamic performance of the super-high-contact-ratio spiral bevel gear transmissions are discussed. The simulation result shows the contact path of the collaborative designed spiral bevel gear transmission is along the tooth width, and the contact ratio reaches the maximum. The loaded transmission error, meshing impact, dynamic load factor and root mean square of vibration acceleration of the collaborative design spiral bevel gear transmission are all smaller than the original design and optimized design spiral bevel gear transmissions. The feasibility of the innovative multi-objective collaborative optimization strategy of shape and performance for the spiral bevel gear is verified, and the super-high-contact-ratio design can greatly cut down the contact vibration of the spiral bevel gear transmissions and better the helicopter’s performance.
Ma Wei Qing,Zhao Dan Hua,Cheng Huang Zuo,Wang Si Bo,Yang Ji,Hong Xia Cui,Lu Ming Yuan,Wu Hong Zhi,Xu Li,Liu Guo Jun 아세아·태평양축산학회 2021 Animal Bioscience Vol.34 No.3
Objective: The aim of this study was to investigate the effects of Enteromorpha powder supplementation on reproduction-related hormones and genes in the late laying period of Zi geese. Methods: A total of 312 (1-year-old) Zi geese with similar laying rate were randomly divided into 2 groups with 6 replicates each, each with 21 female geese and 5 male geese. The control group was fed with a basal diet and the test group was fed with a diet containing 3% Enteromorpha powder. The trial period lasted for 7 weeks. Results: Our results showed that the laying rate was improved in the test group at each week of trial (p<0.01), and the levels of estradiol in serum and prolactin in ovary were increased compared with the control group (p<0.05). Conclusion: Based on above results, Enteromorpha powder supplementation at 3% could promote reproductive performance during the late laying period of Zi geese. Objective: The aim of this study was to investigate the effects of Enteromorpha powder supplementation on reproduction-related hormones and genes in the late laying period of Zi geese.Methods: A total of 312 (1-year-old) Zi geese with similar laying rate were randomly divided into 2 groups with 6 replicates each, each with 21 female geese and 5 male geese. The control group was fed with a basal diet and the test group was fed with a diet containing 3% <i>Enteromorpha</i> powder. The trial period lasted for 7 weeks.Results: Our results showed that the laying rate was improved in the test group at each week of trial (p<0.01), and the levels of estradiol in serum and prolactin in ovary were increased compared with the control group (p<0.05).Conclusion: Based on above results, <i>Enteromorpha</i> powder supplementation at 3% could promote reproductive performance during the late laying period of Zi geese.
( Xiaoning Li ),( Si-xiang Ling ),( Chun-wei Sun ),( Bao-long Zhu ),( Ming-uuan Sun ) 대한지질공학회 2019 대한지질공학회 학술발표회논문집 Vol.2019 No.2
This work addresses the freeze-thaw cycles of subgrade in seasonal permafrost region western Sichuan plateau. The mechanism of freeze-thaw cycle effect of seasonal frozen subgrade under freeze-thaw cycle is explained. The analysis results show that the variation tendency of the simulated results are in good agreement with that of the field measured results. The freezing depth of the slope foot is smaller than that of the natural ground and is larger than that of the roadbed, which is affected by the freeze-thaw cycle effect, the freezing depth of the roadbed is more easily and the freezing depth is further increased. During the freezing period, a freezing front quickly forms at the natural ground surface with the water below migrates to it. The variation of the saturation at the maximum freezing depth is affected not only by the ambient temperature of the surface boundary during the melting period, but also by the continuous downward flow of cold energy, which makes the ambient temperature down to the freezing temperature, resulting in a short period of freezing, and in consequence, the saturation decreases briefly. Under the same circumstances, the closer the freezing front is to the underground water level, the smaller the frost heave and thawing settlement rate are. The water-thermal coupling effect has a further affect on the frost heaving rate.
Zhao, Cheng-Xiao,Liu, Ming,Xu, Yong,Yang, Kuo,Wei, Dong,Shi, Xiao-Hong,Yang, Fan,Zhang, Yao-Guang,Wang, Xin,Liang, Si-Ying,Zhao, Fan,Zhang, Yu-Rong,Wang, Na-Na,Chen, Xin,Sun, Liang,Zhu, Xiao-Quan,Yuan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19
Background: Evidence supporting an association between the 8q24 rs4242382-A polymorphism and prostate cancer (PCa) risk has been reported in North American and Europe populations, though data from Asian populations remain limited. We therefore investigated this association by clinical detection in China, and meta-analysis in Asian, Caucasian and African-American populations. Materials and Methods: Blood samples and clinical information were collected from ethnically Chinese men from Northern China with histologically-confirmed PCa (n=335) and from age-matched normal controls (n=347). The 8q24 (rs4242382) gene polymorphism was genotyped by polymerase chain reaction-high-resolution melting analysis. We initially analyzed the associations between the risk allele and PCa and clinical covariates. A meta-analysis was then performed using genotyping data from a total of 1,793 PCa cases and 1,864 controls from our study and previously published studies in American and European populations, to determine the association between PCa and risk genotype. Results: The incidence of the risk allele was higher in PCa cases than controls (0.222 vs 0.140, $P=7.3{\times}10^{-5}$), suggesting that the 8q24 rs4242382-A polymorphism was associated with PCa risk in Chinese men. The genotypes in subjects were in accordance with a dominant genetic model (ORadj=2.03, 95%CI: 1.42-2.91, $Padj=1.1{\times}10^{-4}$). Presence of the risk allele rs4242382-A at 8q24 was also associated with clinical covariates including age at diagnosis ${\geq}65$ years, prostate specific antigen >10 ng/ml, Gleason score <8, tumor stage and aggressive PCa, compared with the non-risk genotype ($P=4.6{\times}10^{-5}-3.0{\times}10^{-2}$). Meta-analysis confirmed the association between 8q24 rs4242382-A polymorphism and PCa risk (OR=1.62, 95%CI: 1.39-1.88, $P=1.0{\times}10^{-5}$) across Asian, Caucasian and African American populations. Conclusions: The replicated data suggest that the 8q24 rs4242382-A variation might be associated with increased PCa susceptibility in Asian, Caucasian and African American populations. These results imply that this polymorphism may be a useful risk biomarker for PCa in multi-ethnic populations.
DE-GUO WANG,SI-WEI ZHANG,REN-YANG HE,MING-YUAN LI 한국트라이볼로지학회 2002 한국트라이볼로지학회 학술대회 Vol.2002 No.10
The mechanisms of formation of transfer film under the condition of wear of Steel AISI1020 by natural rubber were investigated. The transfer film was observed and the formation mechanisms were clarified. The formation process of transfer film on the worn surface of the steel could be divided into two stages. Firstly, the adhesive layer emerged on the worn surface of the steel by adhesion of natural rubber, in which the macromolecular chains of natural rubber joined to the surface of the steel by Van der Waals' force. And then, the iron atom and metal oxide reacted with the macroradicals of natural rubber in the adhesive layer and produced Fe-polymer compound. As a result, the transfer film was formed on the worn surface of the steel. The transfer film was joined to the worn surface of the steel by the chemical bonds and electrostatic force.