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- 저자 : Wang Liying (검색결과 35 건)
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Wang Fei,Luo Defan,Chen Jianxiang,Pan Cuiqing,Wang Zhongyao,Fu Housheng,Xu Jianbing,Yang Meng,Mo Shaowei,Zhuang Liying,Ye Liefu,Wang Weifu 대한남성과학회 2022 The World Journal of Men's Health Vol.40 No.2
Purpose: Genetic factors play an indispensable role in the pathogenesis of lifelong premature ejaculation (LPE). The suscep-tibility genes/SNPs that have been discovered are very limited and can only explain part of the genetic effects of LPE. There-fore, discovering more genetic polymorphisms associated with the occurrence and development of LPE will help reveal the pathogenesis of LPE. Materials Materials and and Methods:Methods: We conducted a genome-wide association study of LPE in 486 Chinese male Han people (cases and controls). We used Gene Titan multi-channel instrument and Axiom Analysis Suite 6.0 software for genotyping. Imputation was performed by IMPUTE2 software and the 1000 Genomes Project (Phase3) was used as reference for haplotype. Finally, logistic regression analysis was performed on all loci that passed the quality control. The odds ratio and 95% confidence in-terval were calculated to determine the association between each SNPs and Chinese male Han population LPE risk. Results:Results: The results showed that a total of 33 genetic variants in 13 genes (LACTBL1 , SSBP3 , ACOT11 , LINC02486 , TMEM154, LINC01098, NONE, HCG27, HLA-C, TNFSF8, TNC, FAM53B, SULF2) have a suggestively significant genome-wide association with LPE risk (p<5×10-6). Conclusions:Conclusions: This study is the first to conduct a GWAS on LPE in Chinese male Han population 33 genetic polymorphisms have a suggestive genome-wide association with LPE risk. This study have provided data supplement for the genetic loci of LPE risk, and laid a scientific foundation for the pathogenesis and the targeted therapy of LPE.
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Wang, Jianhong,Wang, Xiaoxiao,Li, Juntao,Chen, Yiqiang,Yang, Wenjun,Zhang, Liying Asian Australasian Association of Animal Productio 2015 Animal Bioscience Vol.28 No.2
This study was conducted to investigate the effects of dietary coconut oil as a medium-chain fatty acid (MCFA) source on performance, carcass composition and serum lipids in male broilers. A total of 540, one-day-old, male Arbor Acres broilers were randomly allotted to 1 of 5 treatments with each treatment being applied to 6 replicates of 18 chicks. The basal diet (i.e., R0) was based on corn and soybean meal and was supplemented with 1.5% soybean oil during the starter phase (d 0 to 21) and 3.0% soybean oil during the grower phase (d 22 to 42). Four experimental diets were formulated by replacing 25%, 50%, 75%, or 100% of the soybean oil with coconut oil (i.e., R25, R50, R75, and R100). Soybean oil and coconut oil were used as sources of long-chain fatty acid and MCFA, respectively. The feeding trial showed that dietary coconut oil had no effect on weight gain, feed intake or feed conversion. On d 42, serum levels of total cholesterol, low-density lipoprotein cholesterol, and low-density lipoprotein/high-density lipoprotein cholesterol were linearly decreased as the coconut oil level increased (p<0.01). Lipoprotein lipase, hepatic lipase, and total lipase activities were linearly increased as the coconut oil level increased (p<0.01). Abdominal fat weight/eviscerated weight (p = 0.05), intermuscular fat width (p<0.01) and subcutaneous fat thickness (p<0.01) showed a significant quadratic relationship, with the lowest value at R75. These results indicated that replacement of 75% of the soybean oil in diets with coconut oil is the optimum level to reduce fat deposition and favorably affect lipid profiles without impairing performance in broilers.
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A Bankruptcy Game for Optimize Caching Resource Allocation in Small Cell Networks
( Liying Zhang ),( Gang Wang ),( Fuxiang Wang ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.5
In this paper, we study the distributed cooperative caching for Internet content providers in a small cell of heterogeneous network (HetNet). A general framework based on bankruptcy game model is put forth for finding the optimal caching policy. In this framework, the small cell and different content providers are modeled as bankrupt company and players, respectively. By introducing strategic decisions into the bankruptcy game, we propose a caching value assessment algorithm based on analytic hierarchy process in the framework of bankruptcy game theory to optimize the caching strategy and increase cache hit ratio. Our analysis shows that resource utilization can be improved through cooperative sharing while considering content providers’ satisfaction. When the cache value is measured by multiple factors, not just popularity, the cache hit rate for user access is also increased. Simulation results show that our approach can improve the cache hit rate while ensuring the fairness of the distribution.
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Jianhong Wang,Xiaoxiao Wang,Juntao Li,Yiqiang Chen,Wenjun Yang,Liying Zhang 아세아·태평양축산학회 2015 Animal Bioscience Vol.28 No.2
This study was conducted to investigate the effects of dietary coconut oil as a medium-chain fatty acid (MCFA) source on performance, carcass composition and serum lipids in male broilers. A total of 540, one-day-old, male Arbor Acres broilers were randomly allotted to 1 of 5 treatments with each treatment being applied to 6 replicates of 18 chicks. The basal diet (i.e., R0) was based on corn and soybean meal and was supplemented with 1.5% soybean oil during the starter phase (d 0 to 21) and 3.0% soybean oil during the grower phase (d 22 to 42). Four experimental diets were formulated by replacing 25%, 50%, 75%, or 100% of the soybean oil with coconut oil (i.e., R25, R50, R75, and R100). Soybean oil and coconut oil were used as sources of long-chain fatty acid and MCFA, respectively. The feeding trial showed that dietary coconut oil had no effect on weight gain, feed intake or feed conversion. On d 42, serum levels of total cholesterol, low-density lipoprotein cholesterol, and low-density lipoprotein/high-density lipoprotein cholesterol were linearly decreased as the coconut oil level increased (p<0.01). Lipoprotein lipase, hepatic lipase, and total lipase activities were linearly increased as the coconut oil level increased (p<0.01). Abdominal fat weight/eviscerated weight (p = 0.05), intermuscular fat width (p<0.01) and subcutaneous fat thickness (p<0.01) showed a significant quadratic relationship, with the lowest value at R75. These results indicated that replacement of 75% of the soybean oil in diets with coconut oil is the optimum level to reduce fat deposition and favorably affect lipid profiles without impairing performance in broilers.
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Zhang, Liying,Li, Defa,Qiao, Shiyan,Wang, Jituan,Bai, Lu,Wang, Zongyi,Han, In K. Asian Australasian Association of Animal Productio 2001 Animal Bioscience Vol.14 No.11
Eight $12.4{\pm}0.6kg$ initial body weight crossbred barrows were used to determine the effect of soybean galactooligosaccharides on nutrient and energy digestibility, and digesta transit time. Four dietary treatments were utilized in this trial. Treatment one was a corn-soybean meal based diet (SBM) containing raffinose and stachyose at the levels of 0.16% and 0.75%, respectively. Treatment two (control) was a corn-HP300 (soybean concentrate protein) diet. In treatments three and four, 1.1% and 2.2% commercial stachyose was added to the control diet to provide total dietary stachyose at the levels of 1% and 2%, respectively. The soybean galactooligosaccharides (raffinose + stachyose) level in treatment one was slightly lower compared to that in treatment three. Three collection periods were run with two pigs for each treatment/period. There was a 4 d adjustment period followed by a 3 d collection period. The results showed that the nitrogen retention (86.79%) of pigs fed treatment two diet was higher than that of pigs fed treatment one by 5.2% (p<0.05). The nitrogen retention of treatment three was intermediate 83.09%. The apparent fecal digestibility of all amino acids in treatment two was numerically highest, followed by treatments three and four. However, there were no significant difference among groups (p>0.05). The dry matter (DM), organic matter (OM), crude protein (CP), and crude fiber (CF) digestibility numerically decreased as the soybean galactooligosaccharides level increased, but were not significantly different (p>0.05). Chromium content in feces (from the inclusion of 0.3% chromic oxide in the diets) differed among treatments (p<0.05) at 15 h, 18 h, and 21 h after eating. This showed that the digesta transit time was differed significantly among treatments. Treatment four was the shortest, followed by treatment three, SBM and control. The results demonstrated that in the absence of antinutritional factors and soybean antigen protein, inclusion of 1% and 2% stachyose in corn-HP300 diet has no significant effect on the digestibility of DM, OM, CP, CF and amino acids. When the soybean galactooligosaccharide level in diet one and diet three were adjusted to be almost the same, antinutritional factors such as trypsin inhibitor and soybean antigen protein could decrease the nutrient digestibility and nitrogen retention rate of diet. High levels of soybean galactooligosaccharides shortened the digesta transit time in the intestinal tract. This trial suggested that the total level of soybean galactooligosaccharides (stachyose+raffinose) in the weanling piglet diet is better not to exceed 1% when common soybean meal is used as main protein source.
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Huaxin Wang,Xuan Peng,Yayi Huang,Yeda Xiao,Zhuo Wang,Liying Zhan 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.12
Purpose: The aim of this study was to investigate whether propofol could attenuate hypoxia/reoxygenation-induced apoptosisand autophagy in human renal proximal tubular cells (HK-2) by inhibiting JNK activation. Materials and Methods: HK-2 cells were treated with or without propofol or JNK inhibitor SP600125 for 1 hour and then subjectedto 15 hours of hypoxia and 2 hours of reoxygenation (H/R). Cell viability and LDH release were measured with commercial kits. Cell apoptosis was evaluated by flow cytometry. The expressions of p-JNK, cleaved-caspase-3, Bcl-2, and autophagy markers LC3and p62 were measured by Western blot or immunofluorescence. Results: HK-2 cells exposed to H/R insult showed higher cell injury (detected by increased LDH release and decreased cell viability),increased cell apoptosis index and expression of cleaved-caspase-3, a decrease in the expression of Bcl-2 accompanied byincreased expression of p-JNK and LC3II, and a decrease in expression of p62. All of these alterations were attenuated by propofoltreatment. Similar effects were provoked upon treatment with the JNK inhibitor SP600125. Moreover, the protective effects weremore obvious with the combination of propofol and SP600125. Conclusion: These results suggest that propofol could attenuate hypoxia/reoxygenation induced apoptosis and autophagy inHK-2 cells, probably through inhibiting JNK activation.
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Trapidil determines the fate of RHF rats through inhibition of ER stress
Yilin Wang,Yu Wang,Chengxi Wei,Quan Wan,Zhifei Fan,Liying Xuan,Wanru Geng,Liqun Shao,Jie Long,Junyi Gu,Ming Zhao 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.4
Pulmonary arterial hypertension is a fatal disease,especially when it causes right heart failure (RHF). However, it is difficult to treat. It has been reported thattrapidil (Tra) can improve the redox balance and cardiacconditions. In this study, we investigated the effect of Tra onRHF induced by monocrotaline (MCT) in rats. Male Wistarrats were treated with MCT or Tra. Treatment lasted 28 days,then rats were euthanized after echocardiography and catheterization. Subsequently, lungs and right ventricular myocardiawere evaluated by hematoxylin and eosin, Masson,and TUNEL staining. Protein expression was detected bywestern blotting. We found remarkably expanded rightventricle end-diastolic volume, decreased partial pressureof oxygen (PaO2), increased partial pressure of carbondioxide (PaCO2), right ventricular systolic pressure, meanpulmonary arterial pressure, lung/body weight, and liver/body weight in the RHF rat group, as well as increases inthe apoptosis rate and the expression of endoplasmic reticulumstress (ERS)-related proteins. However, these changes were significantly inhibited by Tra. Our data suggested thatinhibition of ERS is essential for improving RHF, and thattherapeutic intervention of Tra in RHF rats works by reducingERS.
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Application of amine-loaded activated carbon fiber in CO2 capture and separation
Haoran Liu,Xinmei Lu,Liying Liu,Jian Wang,Pengyu Wang,Peng Gao,Tingsheng Ren,Guo Tian,Di Wang 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.9
The CO2 emitted by coal-fired power plants is the main factor leading to global warming, and the captureof CO2 in the flue gas of power plants is still the main task at this stage. Many adsorbents have been developed to captureCO2 in high-temperature flue gas, but some materials are complicated to synthesize or the cost is too high. Here,we used low-cost raw materials activated carbon fiber and PEI, and used green synthesis to synthesize new adsorbentsin order to capture CO2 in high-temperature flue gas of a power plant. To improve the performance of highly porousactivated carbon fiber (ACF) in CO2 capture and separation, an organic polymer polyethylenimine (PEI) was loadedsuccessfully into the oxidized ACF. The modified adsorbent was tested by FT-IR, XRD and SEM, and the CO2 adsorptioncapacity and CO2/N2 selectivity were analyzed. The results showed that the as-synthesized PEI-modified adsorbenthas a CO2 adsorption capacity of 2.5mmol/g, which is 1.7 times better than that of the pristine ACF adsorbent(1.5mmol/g), at 1 bar and 333 K, and it has excellent CO2/N2 selectivity, as calculated by ideal adsorption solution theory(IAST). These data indicate that PEI was loaded successfully into the oxidized ACF. In addition, the dual site Langmuirisotherm equation and Langmuir isotherm equation can be in good agreement with the adsorption curves ofCO2 and N2. In comparison with other composite adsorbents, the preparation process of the present new adsorbent ishighly environmentally friendly, the synthesis method is simple and the cost is low, which demonstrates potential applicationsin the separation of CO2 from the flue gas of power plants.
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Synthesis of fly ash-based microporous copper silicate for CO2 capture from humid flue gases
Liying Liu,Xudong Chen,Yushun Wang,Tao Du,Gang Li 한국화학공학회 2019 Korean Journal of Chemical Engineering Vol.36 No.3
Conventional microporous adsorbents suffer from CO2 adsorption capacity reduction due to the presence of water vapor in real flue gases. Therefore, development of low-cost moisture-insensitive adsorbents is of great significance. In the present work, microporous copper silicate was synthesized from waste fly ash for the first time. The synthesis conditions were further optimized to obtain copper silicates with high purities. The as-synthesized product was characterized in terms of structural morphology, chemical composition, and surface properties. The CO2 and H2O adsorption properties of the prepared copper silicate were also investigated by single-component isotherm measurements and dynamic CO2/H2O binary breakthrough experiments. The results show that the as-synthesized fly ash-based copper silicate exhibited excellent CO2 adsorption properties even in the presence of water vapor, thus demonstrating promising potential as a moisture-insensitive adsorbent for directly capturing CO2 from humid flue gases.
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