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Liang Zhang,Zhongyang Ding,Peng Xu,Yuhong Wang,Zhenghua Gu,Zhu Qian,Guiyang Shi,Kechang Zhang 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.3
Tyrosinase is a key enzyme in the biosynthesis of melanin, and the use of inhibitors against tyrosinase can prevent hyperpigmentation by inhibiting enzymatic oxidation. However, the current use of tyrosine inhibitors is limited by their low activities and high toxicities. The aim of the present research was to develop novel whitening agents, or tyrosinase-targeted medicine, from a submerged culture of the fungus Ganoderma lucidum. Methyl lucidenate F was isolated from the ethanol-soluble-acidic components (ESACs) of G. lucidum, with the structure of ESACs elucidated via UV, LC-MS, and ^(13)C-NMR spectral analysis. The tyrosinase inhibitory activity was measured using catechol as a substrate. Methyl lucidenate F displayed uncompetitive inhibition of the potato tyrosinase activity,for which Lineweaver-Burk plots revealed a maximum reaction rate (V_(max)) of 0.4367/min, Michaelis constant (K_m)of 6.765 mM and uncompetitive inhibition constant (K_i) of 19.22 μM. Meanwhile, methyl lucidenate F (tetra cyclic triterpenoid) exhibited high tyrosinase inhibitory activity,with an IC_(50) of 32.23 μM. These results suggest that methyl lucidenate F may serve as a potential candidate for skin-whitening agents.
Su, Yuhong,Xiong, Yuanzhu,Zhang, Qin,Liu, Weimin,Jiang, Siwen,Yu, Li,Xia, Xuanyan,Zeng, Rong,Deng, Changyan Asian Australasian Association of Animal Productio 2002 Animal Bioscience Vol.15 No.10
In aiming to identify the genes or genetic regions responsible for quantitative traits, a swine reference population had been constructed using three Large White boars and seven Meishan dams as parents. Five $F_1$ males and 23 $F_1$ females were intercrossed to generate 147 $F_2$ offspring. Thirty-one microsatellite markers covering Sus scrofa chromosomes (SSC) 2, 4, 6 and 7 were genotyped for all members. Construction of genetic microsatellite maps was performed using the CRIMAP software package. The lengths of these chromosomes were longer than MARC maps. They were 158.6cM, 180.3cM, 197.3cM and 171.4cM, respectively. A two modified orders of markers were observed for SSC6 and SSC7. The female map on SSC6 was shorter than male map, and the contrary was on SSC 2, 4 and 7.
Tian Guozhong,Zhang Li,Li Machao,Wang Xiaolei,Zheng Yuhong,Li Xiaojing,Huang Cheng,Li Xuechun,Xie Yongqiong,Xu Li,Ren Hongyu,Shao Zhujun 한국미생물학회 2009 The journal of microbiology Vol.47 No.4
Two hundred and seventy-three Haemophilus influenzae strains isolated from pediatric pneumonia patients in China were studied. We used Multilocus Sequence Typing (MLST) to analyze genotypic characteristics. All strains were biotyped and serotyped. Relatedness and patterns of genes among isolates were determined by the analysis of MLST and eBURST. H. influenzae primarily causes acute pneumonia in children under 1 year old. Nontypeable H. influenzae was responsible for most cases of pediatric pneumonia. All 273 strains were classified into eight biotypes. They mostly belonged to the I, II, and III biotypes (17.6%, 43.6%, and 22.7%, respectively). 62 strains (22.7%) produced β-lactamase. We found 28 novel alleles. Fifty different STs were found by MLST, of which 39 were novel. These were ST477 through ST508 and ST521 through ST527. Group 17 and predicted founders 503 were new groups in this study. No STs correlated with strains from Korea, which is adjacent to China. The H. influenzae strains from China appeared to have heterogeneous ST types patterns which may be the reason no outbreaks or epidemics of H. influenzae infections have occurred in Chengdu city, Sichuan, China.
Gradient Fusion Method for Night Video Enhancement
Yunbo Rao,Yuhong Zhang,Jianping Gou 한국전자통신연구원 2013 ETRI Journal Vol.35 No.5
To resolve video enhancement problems, a novel method of gradient domain fusion wherein gradient domain frames of the background in daytime video are fused with nighttime video frames is proposed. To verify the superiority of the proposed method, it is compared to conventional techniques. The implemented output of our method is shown to offer enhanced visual quality.