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( Le Kim Huyen Trang ),남윤성 한국공업화학회 2015 한국공업화학회 연구논문 초록집 Vol.2015 No.0
Polyglycerol-based amphiphilic copolymers have gained much attention as a novel biomaterial in the biomedical field because of the biocompatibility and facile chemical modification capability of polyglycerol.Here, we fabricate cancer-targeted theranostic polymeric nanoemulsions composed of linear polyglycerol-poly(ε-caprolactone) (PG-PCL) diblock copolymer as a polymeric shell and CT contrast agent lipiodol as a core oil. PG-PCLs are synthesized through ring-opening polymerization,and folates are conjugated to the hydroxyl moieties of polyglycerol block with 19.2% degree of substitution. The incorporated lipiodol facilitates to encapsulate water-insoluble anticancer drug paclitaxel in the nanoemulsion due to its high solubility of paclitaxel. In vitro studies with HeLa ovarian cancer cells demonstrate excellent anti-cancer activities (LD50 < 3 ng mL-1) and the applicability as a contrast agent for CT imaging. We anticipate our PG-PCL amphiphilic polymer can be widely applied to drug delivery nanocarriers for cancer-targeting of therapeutic and imaging agents.
Trang Huyen Le Kim,전휘석,김진호,박근칠,김지선,남윤성 한국생체재료학회 2017 생체재료학회지 Vol.21 No.4
Background: Polyglycerol is an attractive hydrophilic building block of amphiphilic copolymers for biomedical and pharmaceutical applications due to its biocompatibility, facile chemical modification, and anti-fouling activity. Herein we introduce theranostic nanoemulsions incorporating anti-cancer therapeutic and contrast agents using linear polyglycerol-poly(ε-caprolactone) diblock copolymers (PG-b-PCL). Lipiodol is used as a core oil that dissolves paclitaxel and serves as a contrast agent for computer tomography (CT). Methods: PG-b-PCL is synthesized by three-step processes: polymerization of ethoxyethyl glycerol ether; ringopening polymerization of ε-caprolactone; and deprotection of the PEEGE block. In vitro cytotoxicity of the polyglycerolated lipiodol nanoemulsions is demonstrated using HeLa ovarian cancer cells. The applicability of the prepared nanoemulsions as a contrast agent for CT imaging is also evaluated using micro-CT. Results: Three compositions of PG-b-PCL with different block lengths are synthesized to prepare nanoemulsions. The polyglycerolated lipiodol nanoemulsions exhibit excellent anti-cancer activities, while placebo nanoemulsions have no significant cytotoxicity under the same condition. Micro-CT imaging of the nanoemulsions confirms the ability of nanoemulsions as a contrast agent. Conclusions: This study suggests that PG-b-PCL is a promising polymeric emulsifier for effective stabilization and surface functionalization of drug delivery nanocarriers for therapeutic and imaging agents.
Le Kim, Trang Huyen,Yu, Jeong Heon,Jun, Hwiseok,Yang, Moon Young,Yang, Mi-Jin,Cho, Jae-Woo,Kim, Jin Woong,Kim, Jee Seon,Nam, Yoon Sung Elsevier 2017 Biomaterials Vol.145 No.-
<P><B>Abstract</B></P> <P>Despite the excellent biocompatibility and antifouling effect of poly(ethylene glycol) (PEG), the high steric hindrance, limited chemical functionality, and low ligand multivalency of PEGylated nanocarriers often lead to inefficient cell targeting and intracellular trafficking. Hence, a new structure of hydrophilic corona allowing a higher ligand density without loss of excellent biocompatibility is highly desirable. Here we introduce tumor-targeted polyglycerolated (PGylated) nanocarriers that dramatically enhance the <I>in vivo</I> therapeutic efficacy of incorporated paclitaxel simply by increasing the surface density of hydrophobic tumor-targeting ligands. Linear polyglycerol-poly (ε-caprolactone) block copolymer (PG-<I>b</I>-PCL) is used to prepare PGylated lipiodol nanoemulsions, where PG serves as a corona conjugated with a large number of folic acid (FA) for efficient tumor targeting. Unlike FA-PEGylated nanoemulsions, FA-PGylated nanoemulsions can display a larger number of FA without structural destabilization. This property enables excellent anti-cancer activities and effective tumor regression in a cervical cancer xenograft murine model at a cumulative drug dose of ∼5 mg kg<SUP>−1</SUP>, which is about four fold smaller than that of commercial Taxol formulation. This study highlights the importance of surface chemistry of nanocarriers that enable multivalent ligand functionalization and high tolerance to the conjugation of hydrophobic ligands, which make PG as a very effective hydrophilic corona for <I>in vivo</I> drug delivery.</P>
이영선(Lee, Youngsun),김금희(Kim, GumHee),민기연(Min, Ki-Yeon),박미숙(Park, MiSuk),박순덕(Park, Soonduk),방현희(Bang, Hyunhee),선곡유화(Seongok, Yuhoa),이석란(Lee, Sokran),전경미(Chun, Kyungmi),팜티휀짱(Pham, Thi Huyen Trang),이설희(Le 이화여자대학교 특수교육연구소 2015 특수교육 Vol.14 No.1
본 연구에서는 낯선 환경과 문화권에서 장애자녀를 양육하며 이중적 소외를 경험하고 있는 다문화가정 부모, 특히 여성결혼이민자의 한국사회 적응을 시작으로 장애 자녀의 양육, 특수교육 및 지원프로그램 참여 등 장애가정으로서의 경험에 대해 알아보고자 한다. 이를 위해 본 연구는 장애자녀를 둔 다문화가정의 부모를 대상으로 이루어졌으며, 서울, 경기, 인천, 경북에 거주하는 다문화가정의 부모 2쌍(필리핀, 베트남 출신의 여성 및 그들의 한국인 남편)과 여성결혼이민자 9명(필리핀인 2명, 중국인 3명, 베트남인 2명, 일본인 2명)을 포함한 총 13명을 연구 참여자로 선정하였다. 심층인터뷰는 개별로 이루어졌고 면대면 또는 전화인터뷰로 진행되었다. 분석 자료는 전사 작업을 통해 요인별, 영역별로 정리하여 범주화 되었으며, 이 결과는 “다문화가정 그리고 장애자녀의 부모”, “학교라는 높은 벽 그리고 작은 나”라고 하는 2개의 대주제와 5개의 하위 주제로 정리되었다. 연구결과를 바탕으로 장애자녀를 둔 여성결혼이민자 및 다문화가정이 직면한 어려움에 대한 이해와 특수교육 현장에서 이를 지원하기 위한 방안 등이 논의되었다. This study describes the experiences of multicultural families, especially female marriage immigrants having a child with disability in Korea. Using purposive sampling, semi-structured interviews were conducted with 2 sets of parents and nine mothers of children with disabilities. The interviews were transcribed and translated verbatim and analyzed using content analysis. Two main themes regarding multicultural families’ experiences were derived from the data: female marriage immigrants and their families; multicultural family and a parent of a child with disability; and their experiences and needs as working with professionals. Based on the results, implications for further studies and practice regarding serving multicultural families in special education system were discussed. It is also suggested that more cultural studies focusing on diverse population with specific needs should be conducted in further studies.