Psychological Predictors of Satisfaction after Lumbar Surgery for Lumbar Spinal Stenosis

Yamamoto Yoshio,Kawakami Mamoru,Minetama Masakazu,Nakagawa Masafumi,Teraguchi Masatoshi,Kagotani Ryohei,Mera Yoshimasa,Sumiya Tadashi,Matsuo Sachika,Kitano Tomoko,Nakagawa Yukihiro 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.2

Study Design: A retrospective study of prospectively collected clinical data. Purpose: To identify preoperative psychological factors associated with patient satisfaction after surgery for lumbar spinal stenosis (LSS). Overview of Literature: Associations between depressive symptoms, anxiety, and worse surgical outcome or patient dissatisfaction have been reported in LSS patients. However, the influence of preoperative pain catastrophizing and fear-avoidance beliefs on postoperative satisfaction is not well understood. Methods: LSS patients who underwent decompression surgery with or without fusion were included. Clinical outcomes were measured before surgery and 6 months postoperatively using the Zurich Claudication Questionnaire (ZCQ); Visual Analog Scale (VAS) of low back pain, leg pain, and leg numbness; Japanese Orthopaedic Association Back Pain Evaluation Questionnaire; and the Medical Outcomes Study 36-item Short-Form General Health Survey (SF-36). The Hospital Anxiety and Depression Scale (HADS), Pain Catastrophizing Scale, and Pain Anxiety Symptoms Scale were used to evaluate psychological status before surgery. Patients were classified as satisfied or dissatisfied with surgery based on a ZCQ satisfaction subscale cutoff score of 2.5. Results: The satisfied and dissatisfied groups contained 128 and 29 patients, respectively. Six months postoperatively, outcome scores for the dissatisfied group were unchanged or worse than preoperative scores (p >0.05). Multivariate logistic regression analysis showed significant associations between dissatisfaction and preoperative low back pain VAS score ≥median (odds ratio [OR], 0.27; 95% confidence interval [CI], 0.10–0.74; p=0.01), preoperative mental health SF-36 score ≥median (OR, 0.26; 95% CI, 0.08–0.89; p=0.03), and preoperative anxiety HADS score ≥median (OR, 3.95; 95% CI, 1.16–13.46; p=0.03). Conclusions: Preoperative less severe low back pain, lower mental health, and higher anxiety are associated with patient dissatisfaction with lumbar surgery, not depression, pain catastrophizing, or fear-avoidance beliefs. Pre- and postoperative psychological status should be assessed carefully and managed appropriately.

Inhibitory Effect of Honeybee-Collected Pollen on Mast Cell Degranulation In Vivo and In Vitro

Yasuko Ishikawa,Tomoko Tokura,Nobuhiro Nakano,Mutsuko Hara,Fran?is Niyonsaba,Hiroko Ushio,Yuji Yamamoto,Tadahiro Tadokoro,Ko Okumura,Hideoki Ogawa 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.1

Bee-collected pollen (bee pollen [BP]) has been used as a folk medicine for centuries against various diseases,including allergy. There is no study elucidating how BP exerts such an anti-allergic effect. Since mast cells play a central rolein the pathogenesis of various allergic diseases, we investigated the effect of BP on mast cell activation elicited by the Fc im-munoglobulin E (IgE) receptor (Fc.RI)-mediated pathways. The in vivo effect of orally administered BP on cutaneous mastcell activation was examined by passive cutaneous anaphylaxis reaction. In vitromast cell degranulation and IgE binding tomast cells and the status of protein tyrosine phosphorylation were examined using bone marrow-derived mast cells. Daily oraladministration of BP to mice significantly reduced the cutaneous mast cell activation elicited by IgE and specific antigens.BP also reduced in vitromast cell degranulation and tumor necrosis factor-. production by inhibiting IgE binding to Fc.RIon mast cells. The inhibitory effect of BP on mast cell degranulation by preventing IgE binding was confirmed by the re-duced levels of protein tyrosine phosphorylation, which occurred as downstream events in activated mast cells via Fc.RI.These results first revealed that the anti-allergic action of BP was exerted by inhibiting the Fc.RI-mediated activation of mastcells, which plays important roles, not only in the early phase, but also in the late phase of allergic reactions.

How syntactic processing training affects oral production of elementary level Japanese EFL learners

( Miwa Morishita ),( Tomoko Yamamoto ) 경희대학교 언어연구소 2013 언어연구 Vol.30 No.3

For EFL learners, especially elementary level learners, the initial step in language production is to combine several words into sentences. This study reports the results of classroom research aiming to facilitate oral production of elementary level Japanese EFL learners through syntactic processing training. University freshmen in five English classes which use CALL facilities engaged in a 15-minute training at the beginning of each lesson over a total of ten lessons. The training consisted of two types of tasks rearranging shuffled word groups, based on a hypothesis that such training might lead to better automatized language production. In the first half of the training, the written task, the students looked at four to five shuffled word groups and decided the correct order. In the second half of the training, the spoken task, they listened to three shuffled word groups and orally rearranged them into correct sentences. In working out such tasks, the test takers should access vocabulary in their mental lexicon, remember the shuffled word groups they listened to, and rearrange them into correct sentences, which might impose them a high cognitive load and can lead to automatized language production. The data of 88 students who engaged in such training were compared with those of 29 students who did not at both the pre-test and the post-test stages. It was found that although both the experimental and the control groups significantly increased their scores in the written task, only the experimental group significantly increased their scores in the spoken task. The results show that training as a whole seems to have had a positive effect on the students` oral production.

Combined Effects of Ionizing Radiation and Ultrasound on Malformation in ICR Mice at Organogenesis stage

GU,Yeunhwa,MORI,Takehiko,YAMAMOTO,Youichi,Hasegawa,Takeo,KUSAMA,Tomoko 대한방사선 방어학회 1999 방사선방어학회지 Vol.24 No.1

태생 8일째인 임신한 생쥐에 137-Cs 감마선과 초음파를 조사하였다. 복합조사의 경우 임신한 생쥐는 1.5 Gy 방사선과 1.0 W/㎠ 초음파로 -1, 0, 1, 3, 6 시간 간격으로 조사하였다. 사망과 외부 기형은 태생 18일에 검진하였다. 방사선에 의한 탠생 8일의 사망 임계값은 0.5에서 1.0 Gy 사이였으며, 초음파는 1.0에서 1.5 W/㎠ 사이였다. 태생 후반기의 사망은 방사선과 초음파의 복합 치료에 의해 상승적으로 증가되었다. 방사선에 의한 뇌탈출기형 및 무안구증의 임계값은 각각 0.5에서 1.0Gy사이와 1.0에서 1.5Gy 사이였다. 초음파에 의한 뇌탈출기형과 무안구증의 임계값은 각각 1.0에서 1.5W/㎠ 사이와 1.5 W/㎠ 이상이었다. 복합치료의 경우는 뇌탈출기형과 무안구증의 빈도가 상승적으로 증가하였다. 한 시간 간격으로 두 가지 치료를 받은 생쥐에서 뇌탈출기형과 무안구증의 빈도가 최고치에 도달하였다. Pregnant ICR mice were treated with 137Cs gamma-ray / ultrasound on day 8 of gestation. In combined treatments, pregnant mice were treated with both 1.5 Gy of radiation and 1.0 W/㎠ ultrasound at time intervals of -0, 1, 3 and 6 hours. The mortalities and external malformations were investigated on day 18 of gestation. The threshold dose of mortality induced by radiation on day 8 of gestation was between 0.5 and 1.0 Gy, and that which was induced by ultrasound was between 1.0 and 1.5 W/㎠. The mortalities in the late-stage of gestation induced by combined treatment with radiation and ultrasound increased synergistically. The threshold dose of exencephaly and anophthalmia induced by radiation were between 0.5 and 1.0 Gy and between 1.0 and 1.5 Gy, respectively. Those of exencephaly and anophthalmia induced by ultrasound were between 1.0 and 1.5 W/㎠ and more than 1.5 W/㎠, respectively. In combined treatments, the incidence of exencephaly and anophthalmia were found to increase synergistically. In the mice treated with both agents at a time interval of one hour, the incidence of exencephaly and anophthalmia reached maximum levels.

Selective Inhibition of β-Catenin/Co-Activator Cyclic AMP Response Element-Binding Protein-Dependent Signaling Prevents the Emergence of Hapten-Induced Atopic Dermatitis-Like Dermatitis

( Haruna Matsuda-hirose ),( Tomoko Yamate ),( Mizuki Goto ),( Akira Katoh ),( Hiroyuki Kouji ),( Yuya Yamamoto ),( Takashi Sakai ),( Naoto Uemura ),( Takashi Kobayashi ),( Yutaka Hatano ) 대한피부과학회 2019 Annals of Dermatology Vol.31 No.6

Background: The canonical Wnt/β-catenin signaling pathway is a fundamental regulatory system involved in various biological events. ICG-001 selectively blocks the interaction of β-catenin with its transcriptional co-activator cyclic AMP response element-binding protein (CBP). Recent studies have provided convincing evidence of the inhibitory effects of ICG-001 on Wnt-driven disease models, such as organ fibrosis, cancer, acute lymphoblastic leukemia, and asthma. However, the effects of ICG-001 in atopic dermatitis (AD) have not been investigated. Objective: To investigate whether β-catenin/CBP-dependent signaling was contributed in the pathogenesis of AD and ICG-001 could be a therapeutic agent for AD. Methods: We examined the effects of ICG-001 in an AD-like murine model generated by repeated topical application of the hapten, oxazolone (Ox). ICG-001 or vehicle alone was injected intraperitoneally every day during the development of AD-like dermatitis arising from once-daily Ox treatment. Results: Ox-induced AD-like dermatitis characterized by increases in transepidermal water loss, epidermal thickness, dermal thickness accompanied by increased myofibroblast and mast cell counts, and serum levels of thymic stromal lymphopoietin and thymus and activation- regulated chemokine, and decreases in stratum corneum hydration, were virtually normalized by the treatment with ICG-001. Elevated serum levels of periostin tended to be downregulated, without statistical significance. Conclusion: These results suggest that β-catenin/CBP-dependent signaling might be involved in the pathogenesis of AD and could be a therapeutic target. (Ann Dermatol 31(6) 631∼639, 2019)

テレビドラマを用いたシナリオ · ドラマ活動について

津崎浩一(Tsuzaki Koichi),山本智子(Yamamoto Tomoko) 중앙대학교 일본연구소 2010 日本 硏究 Vol.0 No.28

Clostridioides difficile Infection in a Japanese Tertiary Children’s Hospital

Mariko Meguro,Ryusuke Nambu,Tomoko Hara,Ryo Ebana,Masashi Yoshida,Saki Yamamoto,Koki Mori,Itaru Iwama 대한소아소화기영양학회 2022 Pediatric gastroenterology, hepatology & nutrition Vol.25 No.5

Purpose: Toxins produced by Clostridioides difficile infection (CDI) can cause enteritis and diarrhea. Although the number of pediatric CDI cases is increasing, the clinical management of pediatric CDI, including patient characteristics and prognosis, remains unclear. This study aimed to elucidate the background and clinical course of patients with CDI and evaluate the reliability of diagnostic tests in a tertiary pediatric hospital in Japan. Methods: We retrospectively analyzed the clinical data of children diagnosed with CDI between 2011 and 2021 at the Saitama Children’s Medical Center in Saitama, Japan. Results: During the study period, 1,252 C. difficile antigen/toxin tests were performed, and 37 patients were diagnosed with CDI. The main underlying diseases among the patients were hematological and malignant disorders and gastrointestinal diseases, including inflammatory bowel disease (IBD) (59.4%). Two patients (5.4%) had an unremarkable medical history. Among the 37 patients, 27 (73.0%) were immunocompromised, 25 (67.6%) had a history of antibiotic use within the past two months, and 6 (16.2%) were negative on the initial test but were positive on the second test. Finally, 28 patients (75.7%) required primary antibiotic therapy only, and two patients with IBD required additional antibiotic therapy as secondary treatment. Conclusion: The number of pediatric patients with CDI is increasing. Both a comprehensive interview, including underlying diseases and history of antibiotic use, and an understanding of the features of clinical examinations should be emphasized to appropriately diagnose and treat CDI.

Analytical Approach for Design of the MEMS-Viscosity Sensor with a Tapered Shape Spiral Beam

Seung Chol Choi,Yasuyuki Yamamoto,Sohei Matsumoto,Tomoko Yamamoto 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.5

テレビドラマを用いた授業の可能性と授業デザインの提言

津崎浩一(Tsuzaki Koichi),山本智子(Yamamoto Tomoko) 중앙대학교 일본연구소 2009 日本 硏究 Vol.0 No.26

テレビドラマを用いた授業のための予備的調査とその考察

진기호일 ( Tsuzaki Koichi ),산본지자 ( Yamamoto Tomoko ) 한국일어일문학회 2009 日語日文學硏究 Vol.68 No.1