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Thu Ha Nguyen,Thi Lan Pham,Anh Quan Cao,Tuan Anh Nguyen,Xuan Minh Vu,Thi My Hanh Le,Van Thuan Le,Seiichi Kawahara,Dai Lam Tran 한국고분자학회 2024 Macromolecular Research Vol.32 No.4
This study describes the preparation and characterization of a green and safe membrane based on a natural polymer for metal adsorption. Natural rubber-grafted-(2-hydroxyethyl methacrylate) with a special nanostructure was synthesized by graft copolymerization of 2-hydroxyethyl methacrylate (HEMA) onto the surface of natural rubber (NR) particles using tert-butylhydroperoxide/tetraethylenepentamine as initiators. Optimal conditions for achieving high conversion and grafting efficiency were identified. Characterization of the as-synthesized samples was performed using Fourier-transform infrared spectroscopy, transmission electron microscopy, thermogravimetric analysis, tensile measurement, swelling degree determination, and cytotoxicity testing. The results revealed that HEMA formed a nanoscale matrix surrounding NR particles, which improved the tensile strength, thermal resistance, and swelling degree of the as-prepared samples. Cytotoxicity testing demonstrated that the membrane was safe for human use, as it did not exhibit toxicity to Vero cells at concentrations up to 1024 μg/mL. Furthermore, the membrane displayed a high adsorption capacity toward Fe3+ and was well described by Koble-Corrigan isotherm model and the first–second-order kinetic equation. Moreover, the membrane demonstrated excellent recyclability maintaining its adsorption ability towards Fe3+ ions over five consecutive cycles. Overall, these findings may recommend the NR-HEMA membrane as a promising candidate for metal removal applications.
HER2 Status and Its Heterogeneity in Gastric Carcinoma of Vietnamese Patient
Dang Anh Thu Phan,Vu Thien Nguyen,Thi Ngoc Ha Hua,Quoc Dat Ngo,Thi Phuong Thao Doan,Sao Trung Nguyen,Anh Tu Thai,Van Thanh Nguyen 대한병리학회 2017 Journal of Pathology and Translational Medicine Vol.51 No.4
Background: Human epidermal growth factor receptor 2 (HER2) is related to the pathogenesis and poor outcome of numerous types of carcinomas, including gastric carcinoma. Gastric cancer patients with HER2 positivity have become potential candidates for targeted therapy with trastuzumab. Methods: We investigated 208 gastric cancer specimens using immunohistochemistry (IHC), fluorescence in situ hybridization and dual in situ hybridization (ISH). We also investigated the concordance between IHC and ISH. The correlation between HER2 status and various clinicopathological findings was also investigated. Results: In total, 15.9% (33/208) and 24.5% (51/208) of gastric cancers showed HER2 gene amplification and protein overexpression, respectively. A high level of concordance between ISH and IHC analyses (91.3%, κ = 0.76) was found. A significant correlation between HER2 status and intestinal-type (p < .05) and differentiated carcinomas (p < .05) was also noted. The HER2 heterogeneity was high in gastric cancers; we found 68.8% phenotypic heterogeneity and 57.6% genotypic heterogeneity. Heterogeneity in HER2 protein expression and gene amplification showed a close association with diffuse histologic type and IHC 2+. Conclusions: HER2 protein overexpression and gene amplification were detected in 24.5% and 15.9% of gastric cancer specimens, respectively. Intestinal-type showed a higher level of HER2 protein overexpression and gene amplification than diffuse type. HER2 status also showed a significant relationship with well- and moderately-differentiated carcinomas. The ratio of phenotypic and genotypic heterogeneity of HER2 was high in gastric carcinomas and was associated with HER2 IHC 2+ and diffuse histologic type.
Artocarpus nigrifolius: Cytotoxic and Antibacterial Constituents
Tran Minh Hoi,김영호,Ha Van Anh,Nguyen Thi Thanh Huong,Nguyen Van Tuyen,Le Thi Tu Anh,Nguyen Thanh Tra,Ba Thi Cham,Nguyen Thi Thu Ha,Pham Thuy Linh,Doan Duy Tien,Phan Van Kiem,Ninh Khac Ban,Lidziya Kukha 한국응용생명화학회 2013 Applied Biological Chemistry (Appl Biol Chem) Vol.56 No.6
Six known compounds including α-amyrin 3-acetate (1), β-sitosterol (2), betulinic acid (3), friedelan-3-one (4),artochamin B (5), and 2-C-methyl-D-erythritol 4-O-α-D-glucopyranoside (6) were isolated from the stem barks and leaves of Artocarpus nigrifolius (Moraceae) for the first time. Their structures were identified by spectroscopic methods as well as comparison with literatures. Cytotoxicity and antibacterial activity of 1-6 were evaluated. Results showed that artochamin B (5)possessed the highest cytotoxicity towards MCF7, Lu, HepG2,and KB cell lines with IC50 values of 4.59, 20.00, 3.60, and 1.18μg/mL, respectively. It also inhibited the growth of Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus), whereas inactive on the growth of both Gram-negative bacteria and yeast.
Artocarpus nigrifolius: Cytotoxic and Antibacterial Constituents
Hoi, Tran Minh,Anh, Ha Van,Huong, Nguyen Thi Thanh,Tuyen, Nguyen Van,Anh, Le Thi Tu,Tra, Nguyen Thanh,Cham, Ba Thi,Ha, Nguyen Thi Thu,Linh, Pham Thuy,Tien, Doan Duy,Kiem, Phan Van,Ban, Ninh Khac,Kukha The Korean Society for Applied Biological Chemistr 2013 Applied Biological Chemistry (Appl Biol Chem) Vol.56 No.6
Six known compounds including ${\alpha}$-amyrin 3-acetate (1), ${\beta}$-sitosterol (2), betulinic acid (3), friedelan-3-one (4), artochamin B (5), and 2-C-methyl-D-erythritol 4-O-${\alpha}$-D-glucopyranoside (6) were isolated from the stem barks and leaves of Artocarpus nigrifolius (Moraceae) for the first time. Their structures were identified by spectroscopic methods as well as comparison with literatures. Cytotoxicity and antibacterial activity of 1-6 were evaluated. Results showed that artochamin B (5) possessed the highest cytotoxicity towards MCF7, Lu, HepG2, and KB cell lines with $IC_{50}$ values of 4.59, 20.00, 3.60, and $1.18{\mu}g/mL$, respectively. It also inhibited the growth of Gram-positive bacteria (Bacillus subtilis, Staphylococcus aureus), whereas inactive on the growth of both Gram-negative bacteria and yeast.
Anh Thi Le,Manh Ha Hoang,Minh Hoa Nguyen,T. Anh Thu Do,Minh Tan Man 한국진공학회(ASCT) 2020 Applied Science and Convergence Technology Vol.29 No.5
We present an analytical method to model the influence of gold nanoparticle (Au NP) concentration on the energy transfer between Cy3 orange beads (OBs) and Au NPs. The OBs and Au NPs act as donor (D) and acceptor (A), respectively. In the D–A system, the energy transfer efficiency strongly depends on the spectral overlap and separation R between donor and acceptor. Theoretical calculations for a range of R values between 10 and 100 Å produce three parameters that each characterize one of three different resonant energy transfer mechanisms: fluorescence resonant energy transfer, surface resonant energy transfer and Coulomb energy transfer. The values of these parameters provide estimates of the degree of quenching or enhancement of the fluorescence of D–A complexes as a function of concentration. A comparison between experimental and theoretical data confirms the validity of the model.
Quang Anh Phan,Manh-Toan Ho,Quan-Hoang Vuong,Hiep-Hung Pham,Minh Huyen Vu,Thi Thu Ha Nguyen,Thanh Thao Thi Phan World Association for Triple Helix and Future Stra 2024 Journal of Contemporary Eastern Asia Vol.23 No.1
The overarching purpose of this study is to examine the current status of academic public engagement in Vietnam. Data were obtained from a survey with 245 university lecturers, and descriptive statistics were used jointly with Bayesian statistics as tools for analysis. This study reveals that a significant proportion of university lecturers are not involved in public engagement, neither through the public press (66.5%) nor social media (49%). Those who have been active in public engagement use the public press and social networks to communicate science, with the latter being more used than the former. In addition, this study also pointed out that experienced scientists tend to engage with the public press, while early-career researchers often choose social networks. The findings of this study provide implications for higher education policymakers and administrators.
Impact of Vocational Training on Wages of Ethnic Minority Labors in Vietnam
DO, Ha Thi Hai,MAI, Cuong Ngoc,MAI, Anh Ngoc,NGUYEN, Nui Dang,PHAM, Toan Ngoc,LE, Huong Thi Thu,TRAN, Manh Dung,VU, Tri Tuan Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.6
This research investigates the impact of vocational training on wages of ethnic minority labors in emerging countries; Vietnam is the case study. The study uses secondary data from 2014 to 2018 collected through Vietnam Household Living Standards Surveys (VHLSS) conducted by the General Statistics Office. In order to analyze the impact of vocational training on wages of ethnic minority areas in Vietnam, this research creates ethnic area variables. According to Vietnamese regulations, ethnic areas are communes of 51 different provinces, inhabited by ethnic minority people. The statistics from VHLSS in 2018, show that the proportion of labors of working age with a certificate was 22.5%. The research employs Heckman Sample Selection Model to estimate the impact of vocation training on wage of labors in ethnic minority areas. The results show that vocational training plays a crucial role in improving the wages of ethnic minorities and has a positive impact. However, apart from the achieved outcomes, vocational training and job creation for ethnic minorities are not without limitations and shortcomings. Based on the findings, some recommendations to ethnic minority labors, enterprises and the Government are proposed to encourage participation in vocational training for the purpose of promoting the efficiency of the labor market.