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Stilbenes and Oligostilbenes from Leaf and Stem of Vitis amurensis and Their Cytotoxic Activity
Do Thi Ha,Quan Cheng Chen,Tran Manh Hung,Tran Minh Ngoc,Phuong Thien Thuong,김홍진,성연희,민병선,배기환,윤의중 대한약학회 2009 Archives of Pharmacal Research Vol.32 No.2
Chromatographic separation of the EtOAc fraction from the leaf and stem of Vitis amurensis led to the isolation of six oligostilbenoids (i.e., r-2-viniferin (1), trans-amurensin B (2), trans-ε -viniferin (3), gnetinH (4), amurensin G (5), (+)-ampelopsin A (8)) and four stilbenoids (i.e., trans-resveratrol (6), (+)- ampelopsin F (7), piceatannol (9), and trans-piceid (10)). The structures have been identified on the basis of spectroscopic evidence and physicochemical properties. The isolates were investigated for cytotoxic activity against three cancer cell lines in vitro using the MTT assay method. Amurensin G (5) and trans-resveratrol (6) showed significant cytotoxic activity against L1210, K562 and HTC116 cancer cell lines with IC50 values ranging from 15.7 ± 2.1 to 30.9 ± 1.8 μM. (+)-Ampelopsin A (8) and trans-piceid (10) exhibited considerable cytotoxic activity against L1210 (IC50 values of 30.6 ± 4.1 and 28.7 ± 2.81μM, respectively) and K562 (IC50 values of 38.6 ± 0.82 and 24.6 ± 0.76 μM, respectively). Gnetin H (4)showed only weak cytotoxic activity against L1210 with an IC50 value of 40.1 ± 4.23 μM. On the other hand, r-2-viniverin (1), trans-amurensin B (2), trans-ε -viniferin (3), (+)-ampelopsin F (7), and piceatannol(9) exhibited no activity on three cancer cell lines.
To Dao Cuong,Hoang Thi Ngoc Anh,Tran Thu Huong,Pham Ngoc Khanh,Vu Thi Ha,Tran Manh Hung,김영호,Nguyen Manh Cuong 한국생약학회 2019 Natural Product Sciences Vol.25 No.4
Soluble epoxide hydrolases (sEH) are enzymes present in all living organisms, metabolize epoxy fatty acids to 1,2-diols. sEH in the metabolism of polyunsaturated fatty acids plays a key role in inflammation. In addition, the endogenous lipid mediators in cardiovascular disease are also broken down to diols by the action of sEH that enhanced cardiovascular protection. In this study, sEH inhibitory guided fractionation led to the isolation of five phenolic compounds trans-resveratrol (1), trans-piceatannol (2), sulfuretin (3), (+)-balanophonin (4), and cassigarol E (5) from the ethanol extract of the seeds of Passiflora edulis Sims cultivated in Vietnam. The chemical structures of isolated compounds were determined by the interpretation of NMR spectral data, mass spectra, and comparison with data from the literature. The soluble epoxide hydrolase (sEH) inhibitory activity of isolated compounds was evaluated. Among them, trans-piceatannol (2) showed the most potent inhibitory activity on sEH with an IC50 value of 3.4 mM. This study marks the first time that sulfuretin (3) was isolated from Passiflora edulis as well as (+)-balanophonin (4), and cassigarol E (5) were isolated from Passiflora genus.
Hung, Tran Loc,Thanh, Tran Thien,Vu, Bui Quang Korean Mathematical Society 2008 대한수학회보 Vol.45 No.3
The main aim of this paper is to present some results related to asymptotic behavior of distribution functions of random variables of chi-square type $X^2_N={\Sigma}^N_{i=1}\;X^2_i$ with degrees of freedom N, where N is a positive integer-valued random variable independent on all standard normally distributed random variables $X_i$. Two ways for computing the distribution functions of chi-square type random variables with random degrees of freedom are considered. Moreover, some tables concerning considered distribution functions are demonstrated in Appendix.
Hung, Tran Loc,Thanh, Tran Thien Korean Mathematical Society 2010 대한수학회논문집 Vol.25 No.1
Let ${X_n,\;n\geq1}$ be a sequence of independent identically distributed (i.i.d.) random variables (r.vs.), defined on a probability space ($\Omega$,A,P), and let ${N_n,\;n\geq1}$ be a sequence of positive integer-valued r.vs., defined on the same probability space ($\Omega$,A,P). Furthermore, we assume that the r.vs. $N_n$, $n\geq1$ are independent of all r.vs. $X_n$, $n\geq1$. In present paper we are interested in asymptotic behaviors of the random sum $S_{N_n}=X_1+X_2+\cdots+X_{N_n}$, $S_0=0$, where the r.vs. $N_n$, $n\geq1$ obey some defined probability laws. Since the appearance of the Robbins's results in 1948 ([8]), the random sums $S_{N_n}$ have been investigated in the theory probability and stochastic processes for quite some time (see [1], [4], [2], [3], [5]). Recently, the random sum approach is used in some applied problems of stochastic processes, stochastic modeling, random walk, queue theory, theory of network or theory of estimation (see [10], [12]). The main aim of this paper is to establish some results related to the asymptotic behaviors of the random sum $S_{N_n}$, in cases when the $N_n$, $n\geq1$ are assumed to follow concrete probability laws as Poisson, Bernoulli, binomial or geometry.
Development of Population Pharmacokinetic Model for Ethambutol in Korean Patients with Tuberculosis
( Tran Minh Hung ),( Nguyen Phuoc Long ),( Pham Quang Hoa ),( Tae-won Jang ),( Jusang Kim ),( Jee Youn Oh ),( Hyun Kuk Kim ),( Ji Joung Kang ),( Yong-soon Cho ),( Jae-gook Shin ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.0
Background Ethambutol (EMB) is one of the four drugs to treat drug-susceptibility tuberculosis (TB). Therapeutic drug monitoring (TDM) is suggested to establish the safe and effective dosing of drugs in TB treatment. The population pharmacokinetic (PK) model provides a helpful tool for individualizing the treatment to minimize therapeutic failure and toxicity. This study was designed to evaluate the EMB PK parameters, characterize the interindividual variability of EMB PK parameters in Korean patients. Methods Data were collected from patients in the prospective cohort from the Center for Personalized Precision Medicine of Tuberculosis research center. The data were randomly divided into training and test sets with a ratio of 4:1. The model was developed using NONMEM version 4.7.1. Non-parametric bootstrapping and prediction-corrected visual predictive checks were used to validate the final model. Additionally, the model performance was evaluated on the test set. Results A model with two-compartment, one transit compartment prior to first-order absorption and elimination adequately described the PK profile of EMB. The estimates were 69.3 L/h for apparent clearance (CL/F), 154 L/h for apparent intercompartment clearance (Q/F), 98.8 L for apparent volume of central compartment (Vc/F), 849 L for apparent volume of peripheral compartment (Vp/F), 0.446 h-1 for rate constant of first-order absorption (Ka) and 0.719 h for mean transit time (MTT). Body weight significantly influenced CL/F and Q/F, and eGFR markedly affected CL/F. The internal and external validations indicated a satisfactory descriptive and predictive performance of the model, respectively. Conclusions We successfully established a population PK model to predict EMB concentrations for Korean TB patients. Internal and external validation confirmed that our model showed a good performance. Our model may be a valuable tool to support dose optimization according to individual patients' body weight and renal function in clinical management.
Tran Loc Hung,Tran Thien Thanh,Bui Quang Vu 대한수학회 2008 대한수학회보 Vol.45 No.3
The main aim of this paper is to present some results related to asymptotic behavior of distribution functions of random variables of chi-square type [수식] with degrees of freedom N, where N is a positive integer-valued random variable independent on all standard normally distributed random variables Xi. Two ways for computing the distribution functions of chi-square type random variables with random degrees of freedom are considered. Moreover, some tables concerning considered distribution functions are demonstrated in Appendix The main aim of this paper is to present some results related to asymptotic behavior of distribution functions of random variables of chi-square type [수식] with degrees of freedom N, where N is a positive integer-valued random variable independent on all standard normally distributed random variables Xi. Two ways for computing the distribution functions of chi-square type random variables with random degrees of freedom are considered. Moreover, some tables concerning considered distribution functions are demonstrated in Appendix
Tran, Ngoc Hung,Kim, Byung-Soo The Korean Society of Plant Pathology 2012 Plant Pathology Journal Vol.28 No.4
Eleven hot pepper accessions collected in Vietnam showed stable resistance to bacterial wilt as well-known resistance sources, MC4 and MC5, in repeated inoculation tests with different Ralstonia solanacearum isolates conducted from 2004 to 2010. Seven of these accessions (specifically KC981, KC1006, KC1021, KC1027, KC1045, KC1050, and KC1055) resulted in stable male sterile F1 plants in the crosses with a cytoplasmically male sterile (CMS) Chilseong (CMS-A, Srfrf ), and therefore, they were maintainers (CMS-B) with a genotype of Nrfrf. The rest (KC980, KC995, KC999, and KC1009) produced stable male fertile F1 plants in the crosses, and therefore, were restorers (CMS-C) with a genotype of N(S)RfRf. Therefore, the maintainer and restorer sources of resistance may be used in preference in breeding maternal (CMS and their maintainers) and paternal parents (restorers) for resistance to bacterial wilt, respectively, in the hybrid breeding system utilizing cytoplasmic male sterility.
Antioxidant Effect of Flavonoids Isolated from the Root of Clematis trichotoma Nakai
Hung, Tran Manh,Thuong, Phuong Thien,Bae, Ki-Hwan The Korean Society of Medicinal Crop Science 2005 한국약용작물학회지 Vol.13 No.5
The antioxidant effect of methanol extract (ME) and water extract (WE) from Clematis trichotoma was evaluated as primary study to scavenge stable 1,1-diphenyl-2-picrylhydrazyl radicals (DPPH), inhibited iron-induce lipid peroxidation in linoleic acid emulsion, peroxidation of liposome induced by $Fe^{3+}/H_2O_2/ascorbie$ acid, and on $Fe^{2+}/H_2O_2$ induced the mitochondrial lipid peroxidation. In secondary study, five flavonoids as luteolin (1), quercetin (2), apigenin (3), hirsutrin (4), kaempferol-3-O-glucoside were isolated (5). Among them, compounds 1 and 2 showed good activities in all the model systems. Compound 3 exhibited moderate antioxidant activities in both radical scavenging and these lipid peroxidation systems tested. Compound 4 showed significant inhibitions in liposome peroxidation and compound 5 displayed weak inhibition in all four tested systems. All the results presented herein indicate that products of C. trichotoma maybe useful in inhibiting membrane lipid peroxidation and preventing free radical-linked diseases.