Teaching unawareness: the curriculum of desire and love in the risk society

Teng Huang 서울대학교 교육연구소 2010 Asia Pacific Education Review Vol.11 No.4

We are living in a world risk society where different forms of risk have become a part of daily life, such as energy crisis, financial crisis, global terrorism, and ecological crisis. Beck (World risk society, Polity Press, Cambridge, 1999) argues that knowing about 'unawareness' might provide another way for us to reconsider the problems of the risk society. This paper focuses on the discussions of the unawareness of the social practices of desire, because it may be the key point of the neoliberal world that has the strongest influence in this world. There are three main parts in this article. The first discusses the interlinked relationship between the risk society and desire, and the unawareness of the social practices of desire. Unawareness is identified according to three aspects: dualism, individualism, and rationalism. The second part focuses on the discussion of the possible ways to solve the three aspects of unawareness, for example, co-presence, holistic epistemology, and compassion. Finally, three suggestions are proposed for the future curriculum: reconstructing the subject-centered knowledge, the curriculum of desire, and the curriculum of love.

The association between acupuncture therapy and the risk of reduced pressure ulcers in dementia patients: a retrospective matched cohort study

Huang Chia-Yu,Wu Mei-Yao,Huang Ming-Cheng,Yu Teng-Shun,Yen Hung-Rong 한국한의학연구원 2023 Integrative Medicine Research Vol.12 No.3

Background: The pressure ulcer is a complication from dementia. The aim of this study is to study the association between the developing of pressure ulcers and the use of acupuncture therapy in patients with dementia. Methods: We performed a retrospective 1:1 propensity score-matched cohort study to investigate the association between acupuncture therapy and the risk of pressure ulcers in patients with dementia. Results: A total of 8,994 patients were identified, 237 patients in the acupuncture cohort and 362 patients in the no-acupuncture cohort developed pressure ulcers. A reduced cumulative incidence of pressure ulcers was observed in the acupuncture cohort (P < .001). The association between acupuncture and reducing the incidence of pressure ulcers was not affected by sex, age, residence, income, or comorbidities. The variables of etiologies to cause dementia did not change the final result. In the subgroups analyses, the patients without medication for dementia controlling had significant lower rate of pressure ulcers development when they had accepted acupuncture therapy (log-rank test, P <.001). Conclusion: Our results revealed the association between acupuncture therapy and a reduced incidence of pressure ulcer development in patients with dementia. This finding offers important ideas for further research.

SERVICE QUALITY EVALUATION OF INTERNATIONAL LOGISTICS COMPANY

Sheng Teng Huang,EmrahBulut,OkanDuru,ShigeruYoshida 인하대학교 정석물류통상연구원 2012 JOURNAL OF INTERNATIONAL LOGISTICS AND TRADE Vol.10 No.3

The national logistics policy report published by Ministry of Land, Infrastructure and Tourism in 2011 proposes to establish international logistics strategy teams in 10 different regions around Japan to satisfy the increasing demand for advance transportation infrastructure and stay competitive in Asia Pacific. The globalization of world economies creates many opportunities as well as challenges for international logistics companies to gain more business chances in this changing environment. The purpose of this paper is to improve service quality of international logistics companies and explores the quality function deployment in terms of quality evaluation method. The logistics service is particularly characterized by offering a series of transport solution and including other logistics activities. The major customers of the logistics services are the industrial clients. The customer satisfaction is key managerial mission since the competitiveness is a growing issue in this industry. The quality function deployment is one of the unique procedures to expose the requirements of customer and transform them into managerial tasks by cross correlation analysis between requirements and technical measures. The empirical study is performed to investigate service quality of the logistics industry by focusing on a group of leading logistics companies.

The tyrosine kinase inhibitor nintedanib activates SHP-1 and induces apoptosis in triple-negative breast cancer cells

Chun-Yu Liu,Tzu-Ting Huang,Pei-Yi Chu,Chun-Teng Huang,Chia-Han Lee,Wan-Lun Wang,Ka-Yi Lau,Wen-Chun Tsai,Tzu-I Chao,Jung-Chen Su,Ming-Huang Chen,Chung-Wai Shiau,Ling-Ming Tseng,Kuen-Feng Chen 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-

Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In this study, we examined a new molecular mechanism of nintedanib in TNBC. The results demonstrated that nintedanib enhanced TNBC cell apoptosis, which was accompanied by a reduction of p-STAT3 and its downstream proteins. STAT3 overexpression suppressed nintedanib-mediated apoptosis and further increased the activity of purified SHP-1 protein. Moreover, treatment with either a specific inhibitor of SHP-1 or SHP-1-targeted siRNA reduced the apoptotic effects of nintedanib, which validates the role of SHP-1 in nintedanib-mediated apoptosis. Furthermore, nintedanib-induced apoptosis was attenuated in TNBC cells expressing SHP-1 mutants with constantly open conformations, suggesting that the autoinhibitory mechanism of SHP-1 attenuated the effects of nintedanib. Importantly, nintedanib significantly inhibited tumor growth via the SHP-1/p-STAT3 pathway. Clinically, SHP-1 levels were downregulated, whereas p-STAT3 was upregulated in tumor tissues, and SHP-1 transcripts were associated with improved disease-free survival in TNBC patients. Our findings revealed that nintedanib induces TNBC apoptosis by acting as a SHP-1 agonist, suggesting that targeting STAT3 by enhancing SHP-1 expression could be a viable therapeutic strategy against TNBC.

Diabetes and Risk of Hepatocellular Carcinoma in Cirrhosis Patients with Nonalcoholic Fatty Liver Disease

Teng Pai-Chi,Huang Daniel Q.,Lin Ting-Yi,Noureddin Mazen,Yang Ju Dong 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.1

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the world. NAFLD is a hepatic manifestation of insulin resistance, the core pathophysiology of diabetes. Multiple clinical studies show that diabetes increases the risk of liver disease progression and cirrhosis development in patients with NAFLD. Diabetes has causal associations with many different cancers, including hepatocellular carcinoma (HCC). More recent studies demonstrate that diabetes increases the risk of HCC in patients with underlying NAFLD cirrhosis, confirming the direct hepatocarcinogenic effect of diabetes among cirrhosis patients. Diabetes promotes hepatocarcinogenesis via the activation of inflammatory cascades producing reactive oxygen species and proinflammatory cytokines, leading to genomic instability, cellular proliferation, and inhibition of apoptosis. Given the global increase in the burden of NAFLD and HCC, high-risk patients such as older diabetic individuals should be carefully monitored for HCC development. Future larger studies should explore whether the effect of diabetes on HCC risk in NAFLD cirrhosis is modifiable by the type of antidiabetic medication and the effectiveness of diabetes control.

The Application of Nursing Instructor in Teaching Knowledge of Advanced Cardiac Life Support (ACLS)

Huang Li-Hua,Teng Ying-Hock,Wu Chao-Hsin 한국간호과학회 2009 한국간호과학회 학술대회 Vol.2009 No.10

circSPG21 protects against intervertebral disc disease by targeting miR-1197/ATP1B3

Huang Yizhen,Zhang Zhenlei,Wang Jianle,Shen Shuying,Yao Teng,Xu Yining,Chen Zizheng,Fang Bin,Ma Jianjun 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

The abnormal expression of circular RNAs (circRNAs) is associated with numerous human diseases. This study investigated the mechanism by which circRNA acts as competitive endogenous RNA in the regulation of degenerative intervertebral disc disease (IVDD). Decreased expression of circSPG21 was detected in degenerated nucleus pulposus cells (NPCs), the function of circSPG21 in NPCs was explored and verified, and the downstream target of circSPG21 was investigated. The interaction between circSPG21 and miR-1197 and its target gene ( ATP1B3 ) was studied by online database prediction and molecular biological verification. Finally, the circSPG21/miR-1197/ATP1B3 axis was verified in the mouse tail-looping model. The expression of circSPG21 in the nucleus pulposus in IVDD was directly related to an imbalance of anabolic and catabolic factors, which affected cell senescence. circSPG21 was found to play a role in human NPCs by acting as a sponge of miR-1197 and thereby affecting ATP1B3 . The regulation of circSPG21 provides a potentially effective therapeutic strategy for IVDD.

Experimental investigation of vortex-induced aeroelastic effects on a square cylinder in uniform flow

Dongmei Huang,Teng Wu,Shiqing He 한국풍공학회 2020 Wind and Structures, An International Journal (WAS Vol.30 No.1

To investigate the motion-induced aeroelastic effects (or aerodynamic feedback effects) on a square cylinder in uniform flow, a series of wind tunnel tests involving the pressure measurement of a rigid model (RM) and simultaneous measurement of the pressure and vibration of an aeroelastic model (AM) have been systematically carried out. More specifically, the aerodynamic feedback effects on the structural responses, on the mean and root-mean-square wind pressures, on the power spectra and coherence functions of wind pressures at selected locations, and on the aerodynamic forces were investigated. The results indicated the vibration in the lock-in range made the shedding vortex more coherent and better organized, and hence presented unfavorable wind-induced effects on the structure. Whereas the vibration in the non-lock-in range generally showed insignificant effects on the flow structures surrounding the square cylinder.

Optimizing Preparation Conditions for Angiotensin-I-Converting Enzyme Inhibitory Peptides Derived from Enzymatic Hydrolysates of Ovalbumin

Qun Huang,Shu-gang Li,Hui Teng,Yong-guo Jin,Mei-hu Ma,Hong-bo Song 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.6

Angiotensin-I-converting enzyme (ACE) inhibitory peptides were prepared from ovalbumin using enzyme hydrolysis with pepsin as an enzyme source. Effects of pH, enzyme dosage, substrate concentration, hydrolysis temperature, and time on the degree of hydrolysis and the ACE inhibition rate were investigated using single factor experiments. Preparation conditions for ACE inhibitory peptides were optimized using a response surface design on the base of single factor experiments. Optimum preparation conditions were a substrate concentration of 5.2 g/100 mL of D.W with a pH value of 2.5, an enzyme dosage of 14,000 U/g, and a hydrolysis time of 250 min at 30℃. The ACE inhibition rate was up to 70.55±1.13% under these conditions.

Depression and APOEε4 Status in Individuals with Subjective Cognitive Decline: A Meta-Analysis

Yue-ping Huang,Ju-jun Xue,Chao Li,Xi Chen,Hong-juan Fu,Teng Fei,Peng-xiang Bi 대한신경정신의학회 2020 PSYCHIATRY INVESTIGATION Vol.17 No.9

Objective To evaluate the associative role of depression and apolipoprotein E epsilon 4 allele (APOEε4) in subjective cognitive decline(SCD) and its progression to objective cognitive decline. Methods After literature search in electronic databases, studies were selected by following precise eligibility criteria. Meta-analyses were performed to examine the role of APOEε4 and depression in SCD or its progression to mild cognitive impairment (MCI) or dementia. Results APOEε4 positivity was not different between SCD and normal individuals but was significantly higher in individuals with SCD plus than in normal individuals [odds ratio: 2.39 (95% CI: 1.87, 3.05); p<0.00001] and in SCD converters than in non-converters [odds ratio: 5.19 (95% CI: 2.36, 11.42); p<0.00001]. Depression was significantly higher in individuals with SCD [standardized mean difference: 0.63 (0.45, 0.82); p<0.00001] and SCD plus [standardized mean difference: 0.83 (0.43, 1.22); p<0.0001] than in normal individuals. However, depression was not different between SCD and MCI or between SCD converters and non-converters. Age of SCD converters was higher than non-converters [mean difference: 2.95 years (0.58, 5.31)]. Conclusion Whereas APOEε4 positivity was higher in SCD plus and SCD converters, depression was higher in SCD and SCD plus but was not different between SCD and MCI.