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First-principles molecular dynamics study of plasma-surface interactions
Tatsuya Koga,Motohiko Tanaka 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.III
Experiments show that the hydrocarbon molecules CH3 and CH4 in fusion devices are generated mainly by chemical sputtering. We numerically examine the chemical sputtering of graphite by hydrogen atoms by using the first-principles molecular dynamics simulation method based on quantum mechanics. We have shown that hydrogen atoms adsorbed on graphite break the carbon bonding of the graphite and hydrocarbon molecules are formed when they cover about half of the graphite surface. This occurs because an unstable configuration with a non-flat surface is formed due to adsorption of large numbers of hydrogen atoms. Moreover, we have shown that graphite is destroyed more actively in the high temperature region that models the actual fusion environment.
Isolation and characterization of acid-soluble bluefin tuna (Thunnus orientalis) skin collagen
Tanaka, Teruyoshi,Takahashi, Kenji,Tsubaki, Kazufumi,Hirata, Maika,Yamamoto, Keiko,Biswas, Amal,Moriyama, Tatsuya,Kawamura, Yukio The Korean Society of Fisheries and Aquatic Scienc 2018 Fisheries and Aquatic Sciences Vol.21 No.4
In this study, we isolated and characterized the acid-soluble skin collagen of Pacific bluefin tuna (PBT, Thunnus orientalis). The PBT skin collagen was composed of two ${\alpha}$ chains (${\alpha}1$ and ${\alpha}2$) and one ${\beta}$ chain. The denaturation temperature of PBT collagen was low although it was rich in proline and hydroxyproline. The primary structure of PBT skin collagen was almost identical to that of calf and salmon skin collagen; however, it differed with respect to the epitope recognition of the antibody against salmon type I collagen. These results suggest that the primary structure of skin collagen was highly conserved among animal species, although partial sequences that included the epitope structure differed among collagens.
Suction Performance and Cavitation Instabilities of Turbopumps with Three Different Inducer Design
Tatsuya Morii,Yohei Tanaka,Satoshi Watanabe,Satoru Ohashi,Yasushi Matsunaga 한국유체기계학회 2019 International journal of fluid machinery and syste Vol.12 No.2
In the present study, the suction performance and the cavitation instabilities in turbo-pumps with three different inducers designed with different design incidence angle are experimentally investigated in the wide range of operating flow rate. Three inducers L with the lowest design incidence angle, M with the moderate one and H with the largest one are used in combination with identical main impeller. As a result, the total head of pump with inducer H is confirmed to be the largest especially at large flow rates, while the shaft power is almost the same, resulting in the best efficiency with the inducer H. The suction performance is the best with inducer H at large flow rates and is the best with inducer L at low flow rates. Two kinds of instabilities, the cavitating whirling vortex and the surges are mainly observed for the all both inducers, but they are limited at low flow rates. The occurrence ranges of these instabilities in terms of the operating flow rate is the widest with inducer H. However, those in terms of the shockless flow rate ratio is similar for the all three inducers: This fact can contribute to establish some guideline to the pump operation avoiding serious flow instabilities.
Conformity in Heart Rate Variability under Online Game without Conversations
Hisaya Tanaka,Tatsuya Kawahara 제어로봇시스템학회 2009 제어로봇시스템학회 국제학술대회 논문집 Vol.2009 No.8
This paper describes the coaction-indexes based on physiological experiments in online-works such as tele-working or online-gaming in the Net. We think the important factor on online works is sharing strategies and situations. If the strategies are shared in the work, it is considered that self-regard operations decreases, and/or the conformities are seen in the physiological response by the situation acknowledgment. We experimented in the online action game. Two players had to be limited the conversation, and to acknowledge the strategy only by information onthe screen. We measured the frequency of player"s switch button as a behavioral indicator. Moreover, the heartbeatfluctuation was measured as a physiology index. The frequency of the button has decreased by the progress of the gamefrom the experiment. Moreover, it has been understood that consideration is shared from the conformity of the heartbeat fluctuation by the same scene.
Isolation and characterization of acid-soluble bluefin tuna (Thunnus orientalis) skin collagen
( Teruyoshi Tanaka ),( Kenji Takahashi ),( Kazufumi Tsubaki ),( Maika Hirata ),( Keiko Yamamoto ),( Amal Biswas ),( Tatsuya Moriyama ),( Yukio Kawamura ) 한국수산과학회(구 한국수산학회) 2018 Fisheries and Aquatic Sciences Vol.21 No.2
In this study, we isolated and characterized the acid-soluble skin collagen of Pacific bluefin tuna (PBT, Thunnus orientalis). The PBT skin collagen was composed of two α chains (α1 and α2) and one β chain. The denaturation temperature of PBT collagen was low although it was rich in proline and hydroxyproline. The primary structure of PBT skin collagen was almost identical to that of calf and salmon skin collagen; however, it differed with respect to the epitope recognition of the antibody against salmon type I collagen. These results suggest that the primary structure of skin collagen was highly conserved among animal species, although partial sequences that included the epitope structure differed among collagens.
RUNX1–Survivin Axis Is a Novel Therapeutic Target for Malignant Rhabdoid Tumors
Masamitsu Mikami,Tatsuya Masuda,Takuya Kanatani,Katsutsugu Umeda,Hidefumi Hiramatsu,Hirohito Kubota,Tomoo Daifu,Atsushi Iwai,Etsuko Yamamoto Hattori,Kana Furuichi,Saho Takasaki,Sunao Tanaka,Yasuzumi M 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.12
Malignant rhabdoid tumor (MRT) is a highly aggressive pediatric malignancy with no effective therapy. Therefore, it is necessary to identify a target for the development ofnovel molecule-targeting therapeutic agents. In this study, we report the importance of the runt-related transcription factor 1 (RUNX1) and RUNX1–Baculoviral IAP (inhibitor of apoptosis) Repeat-Containing 5 (BIRC5/survivin) axis in the proliferation of MRT cells, as it can be used as an ideal target for anti-tumor strategies. The mechanism of this reaction can be explained by the interaction of RUNX1 with the RUNX1-binding DNA sequence located in the survivin promoter and its positive regulation. Specific knockdown of RUNX1 led to decreased expression of survivin, which subsequently suppressed the proliferation of MRT cells in vitro and in vivo. We also found that our novel RUNX inhibitor, Chb-M, which switches off RUNX1 using alkylating agent-conjugated pyrrole-imidazole polyamides designed to specifically bind to consensus RUNX-binding sequences (5′-TGTGGT-3′), inhibited survivin expression in vivo. Taken together, we identified a novel interaction between RUNX1 and survivin in MRT. Therefore the negative regulation of RUNX1 activity may be a novel strategy for MRT treatment
Minamidani, Tetsuhiro,Tanaka, Takanori,Mizuno, Yoji,Mizuno, Norikazu,Kawamura, Akiko,Onishi, Toshikazu,Hasegawa, Tetsuo,Tatematsu, Ken'ichi,Takekoshi, Tatsuya,Sorai, Kazuo,Moribe, Nayuta,Torii, Kazufu American Institute of Physics 2011 The Astronomical journal Vol.141 No.3
<P>In order to precisely determine the temperature and density of molecular gas in the Large Magellanic Cloud, we made observations of the optically thin <SUP>13</SUP>CO(J = 3-2) transition using the ASTE 10 m telescope toward nine peaks where <SUP>12</SUP>CO(J = 3-2) clumps were previously detected with the same telescope. The molecular clumps include those in giant molecular cloud (GMC) Types I (with no signs of massive star formation), II (with H <SPAN CLASS='sml'>II</SPAN> regions only), and III (with H <SPAN CLASS='sml'>II</SPAN> regions and young star clusters). We detected <SUP>13</SUP>CO(J = 3-2) emission toward all the peaks and found that their intensities are 3-12 times lower than those of <SUP>12</SUP>CO(J = 3-2). We determined the intensity ratios of <SUP>12</SUP>CO(J = 3-2) to <SUP>13</SUP>CO(J = 3-2), R<SUP>12/13</SUP><SUB>3-2</SUB>, and <SUP>13</SUP>CO(J = 3-2) to <SUP>13</SUP>CO(J = 1-0), R<SUP>13</SUP><SUB>3-2/1-0</SUB>, at 45'' resolution. These ratios were used in radiative transfer calculations in order to estimate the temperature and density of the clumps. The clumps have a kinetic temperature range of T<SUB>kin</SUB> = 15-200 K and a molecular hydrogen gas density range of n(H<SUB>2</SUB>) = 8 × 10<SUP>2</SUP>-7 × 10<SUP>3</SUP> cm<SUP>–3</SUP>. We confirmed that the higher density clumps have higher kinetic temperature and that the lower density clumps have lower kinetic temperature to better accuracy than in previous work. The kinetic temperature and density increase generally from a Type I GMC to a Type III GMC. We interpret that this difference reflects an evolutionary trend of star formation in molecular clumps. The R<SUP>13</SUP><SUB>3-2/1-0</SUB> and kinetic temperature of the clumps are well correlated with the Hα flux, suggesting that the heating of molecular gas with density n(H<SUB>2</SUB>) = 10<SUP>3</SUP>-10<SUP>4</SUP> cm<SUP>–3</SUP> can be explained by stellar far-ultravoilet photons.</P>
Tomofumi Koyama,Tatsuo Katayama,Tatsuya Tanaka,Yuji Kuzuha,Yuzo Ohnishi,이상환 한국자원공학회 2013 Geosystem engineering Vol.16 No.1
Grouting is commonly used to decrease the hydraulic conductivity of fractured rock masses and control the groundwater inflow. Since underground facilities are constructed in various geological conditions, different types of grout material and mixing/injection methods have been developed for effective and economical grout injection. It is also important to evaluate the grout arrival distance and the range of the altered hydraulic conductivity field after grout injection. However, the mechanism of the grout injection process has not yet been clarified sufficiently due to complex chemical and physical processes during grout injection. In this study, to simulate the grout injection process, a three-dimensional numerical model based on an equivalent continuum approach was developed and applied to the in situ grout injection tests at the Grimsel test site, Switzerland. In the simulations, the injection pressure and/or the injection rate was given as a boundary condition and the total amount of injected grout (silica sol) was calculated. The breakthrough curves (grout arrival time and the time evolution of grout density) at the observation boreholes and the distribution of the altered hydraulic conductivity field were also investigated. The simulation results were also compared with the ones obtained from in situ measurements/monitoring, which showed qualitatively good agreement.
Hagihara Shusuke,Ohta Hideki,Tanaka Jun,Shiokawa Teruaki,Kida Yoshikuni,Iguchi Yohei,Tatsumi Masato,Shibata Ryo,Tahara Kenichi,Shibata Tatsuya,Sanada Kyoichi,Ymamoto Takuaki 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.5
Study Design: This study adopted a retrospective cohort study design.Purpose: This study aimed to clarify the influence of diffuse idiopathic skeletal hyperostosis (DISH) on bone fusion after transforaminal lumbar interbody fusion (TLIF).Overview of Literature: The negative effects of DISH on lumbar degenerative diseases have been reported, and DISH may be involved in the onset and severity of lumbar spinal canal stenosis. Patients with DISH have significantly more reoperations after posterior lumbar fusion, including TLIF. However, the effects of DISH on bone fusion after TLIF have not been reported.Methods: The medical records of patients with intervertebral TLIF from 2012 to 2018 were retrospectively examined. The patients were divided into those with fusion and those with pseudoarthrosis, and the following data were compared: age, sex, DISH, diabetes mellitus, smoking, drinking, albumin levels, body mass index ≥30 kg/m<sup>2</sup>, and L5/S fixation. Statistical analyses were performed using regression models.Results: In this study, 180 patients (78.6%) had fusion and 49 patients (21.4%) had pseudoarthrosis. The number of patients with DISH was significantly higher in the pseudoarthrosis group than in the fusion group (36.7% and 21.7%, respectively; univariate <i>p</i>=0.031, multivariate p =0.019). No significant differences in age, sex, diabetes mellitus, smoking, drinking, albumin levels, body mass index ≥30 kg/m<sup>2</sup>, and L5/S fixation were observed between the two groups. The risk factors for bone fusion were statistically analyzed in 57 patients with DISH. DISH with a caudal end below Th11 was an independent risk factor for pseudoarthrosis (univariate <i>p</i>=0.011, multivariate <i>p</i>=0.033).Conclusions: DISH is an independent risk factor for pseudoarthrosis after one intervertebral TLIF, and DISH with a caudal end below Th11 is associated with a higher risk of pseudoarthrosis than DISH without a caudal end below Th11.