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Shimizu Takayoshi,Fujibayashi Shunsuke,Masuda Soichiro,Kimura Hiroaki,Ishibe Tatsuya,Ota Masato,Tamaki Yasuyuki,Onishi Eijiro,Ito Hideo,Otsuki Bungo,Murata Koichi,Matsuda Shuichi 대한척추외과학회 2022 Asian Spine Journal Vol.16 No.6
Study Design: A retrospective multicenter case series was conducted.Purpose: This study was designed to investigate the clinical features and surgical outcomes of lower lumbar osteoporotic vertebral collapse (LL-OVC) with symptomatic stenosis based on various surgical procedures and classify them using the newly developed collapse severity criteria.Overview of Literature: The surgical outcomes of LL-OVC with symptomatic stenosis remain unclear.Methods: We investigated patients who underwent surgical intervention for LL-OVC (L3, L4, and/or L5) with symptomatic foraminal and/or central stenosis from eight spine centers. Only patients with a minimum follow-up duration of 1 year were included. We developed new criteria to grade vertebral collapse severity (grade 1, 0%–25%; grade 2, 25%–50%; grade 3, 50%–75%; and grade 4, 75%–100%). The clinical features and outcomes were compared based on the collapse grade and surgical procedures performed (i.e., decompression alone, posterior lateral fusion [PLF], lateral interbody fusion [LIF], posterior/transforaminal interbody fusion [PLIF/TLIF], or vertebral column resection [VCR]).Results: In this study, 59 patients (average age, 77.4 years) were included. The average follow-up period was 24.6 months. The clinical outcome score (Japanese Orthopaedic Association score) was more favorable in the LIF and PLIF/TLIF groups than in the decompression alone, PLF, and VCR groups. The use of VCR was associated with a high rate of revision surgery (57.1%). No significant difference in clinical outcomes was observed between the collapse grades; however, grade 4 collapse was associated with a high rate of revision surgery (40.0%).Conclusions: When treating LL-OVC, appropriate instrumented reconstruction with rigid intervertebral stability is necessary. According to our newly developed criteria, LIF may be a surgical option for any collapse grade. The use of VCR for grade 4 collapse is associated with a high rate of revision.
Management of Chronic Expanding Haematoma Using Triamcinolone after Latissimus Dorsi Flap Harvesting
Hamada, Mariko,Shimizu, Yusuke,Aramaki-Hattori, Noriko,Kato, Tatsuya,Takada, Keiko,Aoki, Marie,Kishi, Kazuo,Nagasao, Tomohisa Korean Society of Plastic and Reconstructive Surge 2015 Archives of Plastic Surgery Vol.42 No.2
Chronic expanding haematoma (CEH) is a rare type of haematoma that enlarges slowly and continuously without coagulation. It can occur following surgery because of shear stress-induced bleeding in the scar tissue between the subcutaneous fat and fascia. We present three cases of large chronic CEH that were successfully treated with triamcinolone injections. Three female patients developed large chronic CEH at 9 months, 5 years, and 6 years, respectively, after latissimus dorsi flap harvesting for breast reconstruction. Although the condition did not improve after multiple sessions of haematoma aspiration in the first two patients, it resolved following a single 40-mg triamcinolone injection along with appropriate compression dressing for several weeks. In the third patient, triamcinolone was injected immediately after the initial aspiration of the haematoma, and the condition improved considerably. There were no side effects in any of the patients. To the best of our knowledge, this is the first report of successful treatment of large CEH using triamcinolone. Therefore, we suggest that triamcinolone injections be considered for the treatment of CEH.
안용찬,Shinichi Shimizu,Hiroki Shirato,Takayuki Hashimoto,Yasuhiro Osaka,Xiao-Qing Zhang,Tatsuya Abe,Masao Hosokawa,Kazuo Miyasaka 연세대학교의과대학 2004 Yonsei medical journal Vol.45 No.4
Herein is reported our experience of radiation therapy using a real-time tumor-tracking and gated radiotherapy (RTRT) system for inoperable pancreatic cancer. Three unresectable pancreatic cancer patients were treated with intraoperative electron beam radiation therapy, at the time of open biopsy, and postoperative external beam radiation therapy using an RTRT system with a 2.0mm diameter gold ball implanted into the pancreas. The total BED'sα/β=10 was intended to be equivalent to that of delivering 60 Gy by 2.0Gy/fraction, while the actual dose schedules were individualized. The movement of the pancreas was analyzed based on the 3-dimensional marker positions during the RTRT. The side effects and tumor responses were evaluated. During the RTRT course, the average movement of markers in the x (left to right), y (cranial to caudal) and z (dorsal to ventral) directions were 3.0mm (1.7-5.2mm), 5.2mm (3.5-6.8mm) and 3.5mm (2.7-5.1 mm), respectively. During and after the course of postoperative radiation therapy, no acute side effects of RTOG grade II or higher were detected. The objective tumor responses, as evaluated by CT scans 3 months after the treatment, were 2 partial responses and no response in one patient. Using the RTRT technique the margin of treatment planning and the possible errors in target localization were reduced, and the 3-dimensional movement of the internal marker implanted in the pancreas was able to be analyzed.
Mime Egami,Yuji Haraguchi,Tatsuya Shimizu,Masayuki Yamato,Teruo Okano 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.1
Cell sheet engineering, which allows tissueengineering to be realized without the use of biodegradablescaffolds as an original approach, using a temperatureresponsiveintelligent surface, has been applied in regenerativemedicine for various tissues, and a number ofclinical studies have been already performed for lifethreateningdiseases. By using the results and findingsobtained from the initial clinical studies, additional investigativeclinical studies in several tissues with cell sheetengineering are currently in preparation stage. For treatingmany patients effectively by cell sheet engineering, anautomated system integrating cell culture, cell-sheet fabrication,and layering is essential, and the system shouldinclude an advanced three-dimensional suspension cellculture system and an in vitro bioreactor system to scale upthe production of cultured cells and fabricate thicker vascularizedtissues. In this paper, cell sheet engineering, itsclinical application, and further the authors’ challenge todevelop innovative cell culture systems under newly legislatedregulatory platform in Japan are summarized anddiscussed.
Management of Chronic Expanding Haematoma Using Triamcinolone after Latissimus Dorsi Flap Harvesting
Mariko Hamada,Yusuke Shimizu,Noriko Aramaki-Hattori,Tatsuya Kato,Keiko Takada,Marie Aoki,Kazuo Kishi,Tomohisa Nagasao 대한성형외과학회 2015 Archives of Plastic Surgery Vol.42 No.2
Chronic expanding haematoma (CEH) is a rare type of haematoma that enlarges slowly andcontinuously without coagulation. It can occur following surgery because of shear stressinducedbleeding in the scar tissue between the subcutaneous fat and fascia. We present threecases of large chronic CEH that were successfully treated with triamcinolone injections. Threefemale patients developed large chronic CEH at 9 months, 5 years, and 6 years, respectively,after latissimus dorsi flap harvesting for breast reconstruction. Although the condition did notimprove after multiple sessions of haematoma aspiration in the first two patients, it resolvedfollowing a single 40-mg triamcinolone injection along with appropriate compression dressingfor several weeks. In the third patient, triamcinolone was injected immediately after the initialaspiration of the haematoma, and the condition improved considerably. There were no sideeffects in any of the patients. To the best of our knowledge, this is the first report of successfultreatment of large CEH using triamcinolone. Therefore, we suggest that triamcinolone injectionsbe considered for the treatment of CEH.
Egami, Mime,Haraguchi, Yuji,Shimizu, Tatsuya,Yamato, Masayuki,Okano, Teruo 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.1
Cell sheet engineering, which allows tissue engineering to be realized without the use of biodegradable scaffolds as an original approach, using a temperature-responsive intelligent surface, has been applied in regenerative medicine for various tissues, and a number of clinical studies have been already performed for life-threatening diseases. By using the results and findings obtained from the initial clinical studies, additional investigative clinical studies in several tissues with cell sheet engineering are currently in preparation stage. For treating many patients effectively by cell sheet engineering, an automated system integrating cell culture, cell-sheet fabrication, and layering is essential, and the system should include an advanced three-dimensional suspension cell culture system and an in vitro bioreactor system to scale up the production of cultured cells and fabricate thicker vascularized tissues. In this paper, cell sheet engineering, its clinical application, and further the authors' challenge to develop innovative cell culture systems under newly legislated regulatory platform in Japan are summarized and discussed.
An Ultra-precision Electronic Clinometer for Measurement of Small Inclination Angles
Tan, Siew-Leng,Kataoka, Satoshi,Ishikawa, Tatsuya,Ito, So,Shimizu, Yuuki,Chen, Yuanliu,Gao, Wei,Nakagawa, Satoshi The Korean Society of Manufacturing Technology Eng 2014 한국생산제조학회지 Vol.23 No.6
This paper describes an ultra-precision electronic clinometer, which is based on the capacitive-based fluid type, for detection of small inclination angles. The main parts of the clinometer low-noise electronics are two capacitance measurement circuits for converting the capacitances of the capacitors of the clinometer into voltages, and a differential amplifier for obtaining the difference of the capacitances, which is proportional to the input inclination angle. A 16 bit analog to digital (AD) converter is also embedded into the same circuit board, whose output is sent to a PC via RS-232C, for achieving a small noise level down to tens of ${\mu}v$. A compensation method, which is referred to as the delay time method for shortening the stabilization time of the sensor was also discussed. Experimental results have shown the possibility of achieving a measurement resolution of $0.0001^{\circ}$ as well as the quick measurement with the delay time method.
Takumi Okamoto,Tetsushi Koide,Anh-Tuan Hoang,Tatsuya Shimizu,Koki Sugi,Toru Tamaki,Bisser Raytchev,Kazufumi Kaneda,Shigeto Yoshida,Hiroshi Mieno,Kazufumi Kaneda 대한전자공학회 2015 ITC-CSCC :International Technical Conference on Ci Vol.2015 No.6
Recently, with the increase in the number of colorectal cancer patients, the computer-aided diagnosis (CAD) systems which support a doctor"s diagnosis are essential for early stage treatment. In this paper, we introduce a SVM hardware architecture for CAD system for colorectal endoscopic images with NBI magnification findings. Additionally, we also propose a pyramid style structure with multi-SVMs for effective diagnosis image segmentation.
An Ultra-precision Electronic Clinometer for Measurement of Small Inclination Angles
Siew?Leng Tan,Satoshi Kataoka,Tatsuya Ishikawa,So Ito,Yuuki Shimizu,Yuanliu Chen,Wei Gao,Satoshi Nakagawa 한국생산제조학회 2014 한국생산제조학회지 Vol.23 No.6
This paper describes an ultra-precision electronic clinometer, which is based on the capacitive?based fluid type, for detection of small inclination angles. The main parts of the clinometer low?noise electronics are two capacitance measurement circuits for converting the capacitances of the capacitors of the clinometer into voltages, and a differential amplifier for obtaining the difference of the capacitances, which is proportional to the input inclination angle. A 16 bit analog to digital (AD) converter is also embedded into the same circuit board, whose output is sent to a PC via RS-232C, for achieving a small noise level down to tens of μv. A compensation method, which is referred to as the delay time method for shortening the stabilization time of the sensor was also discussed. Experimental results have shown the possibility of achieving a measurement resolution of 0.0001° as well as the quick measurement with the delay time method.