White-Matter Hyperintensities and Lacunar Infarcts Are Associated with an Increased Risk of Alzheimer’s Disease in the Elderly in China

Shuai Ye,Shuyang Dong,Jun Tan,Le Chen,Hai Yang,Yang Chen,Zeyan Peng,Yingchao Huo,Juan Liu,Mingshan Tang,Yafei Li,Huadong Zhou,Yong Tao 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.1

Background and Purpose This study investigated the contribution of white-matter hyperintensities (WMH) and lacunar infarcts (LI) to the risk of Alzheimer’s disease (AD) in an elderly cohort in China. Methods Older adults who were initially cognitively normal were examined with MRI at baseline, and followed for 5 years. WMH were classified as mild, moderate, or severe, and LI were classified into a few LI (1 to 3) or many LI (≥4). Cognitive function was assessed using the Mini Mental State Examination and the Activities of Daily Living scale. Results Among the 2,626 subjects, 357 developed AD by the end of the 5-year follow-up period. After adjusting for age and other potential confounders, having only WMH, having only LI, and having both WMH and LI were associated with an increased risk of developing AD compared with having neither WMH nor LI. Moderate and severe WMH were associated with an increased risk of developing AD compared with no WMH. Furthermore, patients with many LI had an increased risk of developing AD compared with no LI. Conclusions Having moderate or severe WMH and many LI were associated with an increased risk of developing AD, with this being particularly striking when both WMH and LI were present.

Research on the reinforcement experiment of recycled aggregates based on particle shaping and vacuum cement coating

Shuai Wang,Aixun Wang,Xudong Fu,Keyang Wu,Xianwei Zhang,Yongpeng Tang 한양대학교 청정에너지연구소 2024 Journal of Ceramic Processing Research Vol.25 No.3

Reinforcement of recycled aggregates stands as a pivotal strategy to stimulate their resource utilization. This study proposesa strengthening method of recycled aggregate combined with particle molding and vacuum cement coating, and the keycontrol parameters in the reinforcement process, resultant reinforcement outcomes, failure modes, and water absorptionkinetics were discussed. Experimental findings suggest that diminutive surface particle sizes present amplified challenges forshaping. The particle strength within each size categories demonstrates an initial ascent followed by descent with prolongedshaping, underscoring an optimal reinforcement duration. Excessive shaping precipitates a decline in the property of recycledaggregates, manifested through fracture, crush, and local damage. The moisture content of recycled aggregates undergoesfluctuations throughout the shaping process. Notably, the application of vacuum cement coating markedly ameliorateswater absorption post-particle shaping, thereby augmenting failure mode resilience. Building upon these observations, theframework of “moderate shaping,” “moderate damage,” and “damage-repair integration” is introduced for both internaland external reinforcement. This paradigm aims to bolster the particle strength of recycled aggregates, thus facilitating waterconservation during the scale-up preparation phase. This study can guide the establishment of production facilities tailoredfor recycled concrete and furnish insights for the scaled-up preparation of recycled concrete materials.

Highly efficient and selective extraction of minor bioactive natural products using pure ionic liquids: Application to prenylated flavonoids in licorice

Shuai Ji,Yujie Wang,Shikai Gao,Xian Shao,Wei Cui,Yan Du,Mengzhe Guo,Daoquan Tang 한국공업화학회 2019 Journal of Industrial and Engineering Chemistry Vol.80 No.-

Lots of minor constituents in herbal medicines have shown great potential to devolve into leadcompounds, and their extraction is attracting more and more attention in pharmaceutical industry. Thisstudy provided an example that showed efficient and selective extraction of minor bioactive naturalproducts (prenylatedflavonoids with anti-cancer activities) from an herbal medicine (licorice) using pureionic liquids as green solvents. After investigation of a variety of hydrophobic ionic liquids withultrasonic-assisted extraction, we found that [C8MIM]BF4 (1-octyl-3-methylimidazolium tetrafluor-oborate) was the most effective one for extraction offive representative compounds (isoangustone A,glycycoumarin, licoisoflavanone, licoricidin and glabridin), and solvent to solid ratio, extraction time,extraction temperature and soaking time were then optimized through single-factor experiments andresponse surface methodology. As a result, the established method had significantly higher extractionselectivity than conventional organic solvents, which could be attributed to significant physical change oflicorice microstructures after extraction, as well as strong interactions (especially hydrogen bondinteractions) between [C8MIM]BF4 and prenylatedflavonoids by mechanism study. In addition, 78.92% ofthe extracted prenylatedflavonoids could be readily recovered from [C8MIM]BF4 by using reversed-phasesolid phase extraction, and the recyclability of [C8MIM]BF4 was also confirmed.

Maximizing the Selection Response by Optimal Quantitative Trait Loci Selection and Control of Inbreeding in a Population with Different Lifetimes between Sires and Dams

Tang, G.Q.,Li, X.W.,Zhu, L.,Shuai, S.R.,Bai, L. Asian Australasian Association of Animal Productio 2008 Animal Bioscience Vol.21 No.11

A rule was developed to constrain the annual rate of inbreeding to a predefined value in a population with different lifetimes between sires and dams, and to maximize the selection response over generations. This rule considers that the animals in a population should be divided into sex-age classes based on the theory of gene flow, and restricts the increase of average inbreeding coefficient for new offspring by limiting the increase of the mean additive genetic relationship for parents selected. The optimization problem of this rule was formulated as a quadratic programming problem. Inputs for the rule were the BLUP estimated breeding values, the additive genetic relationship matrix of all animals, and the long-term contributions of sex-age classes. Outputs were optimal number and contributions of selected animals. In addition, this rule was combined with the optimization of emphasis given to QTL, and further increased the genetic gain over the planning horizon. Stochastic simulations of closed nucleus schemes for pigs were used to investigate the potential advantages obtained from this rule by combining the standard QTL selection, optimal QTL selection and conventional BLUP selection. Results showed that the predefined rates of inbreeding were actually achieved by this rule in three selection strategies. The rule obtained up to 9.23% extra genetic gain over truncation selection at the same rates of inbreeding. The combination of the extended rule and the optimization of emphasis given to QTL allowed substantial increases in selection response at a fixed annual rate of inbreeding, and solved substantially the conflict between short-term and long-term selection response in QTL-assisted selection schemes.

Rapid and Efficient Detection of 16SrI Group Areca Palm Yellow Leaf Phytoplasma in China by Loop-Mediated Isothermal Amplification

Shao-shuai Yu,Hai-yan Che,Sheng-jie Wang,Cai-li Lin,Ming-xing Lin,Wei-wei Song,Qing-hua Tang,Wei Yan,Wei-quan Qin 한국식물병리학회 2020 Plant Pathology Journal Vol.36 No.5

Areca palm yellow leaf (AYL) disease caused by the 16SrI group phytoplasma is a serious threat to the development of the Areca palm industry in China. The 16S rRNA gene sequence was utilized to establish a rapid and efficient detection system efficient for the 16SrI-B subgroup AYL phytoplasma in China by loopmediated isothermal amplification (LAMP). The results showed that two sets of LAMP detection primers, 16SrDNA-2 and 16SrDNA-3, were efficient for 16SrIB subgroup AYL phytoplasma in China, with positive results appearing under reaction conditions of 64oC for 40 min. The lowest detection limit for the two LAMP detection assays was the same at 200 ag/μl, namely approximately 53 copies/μl of the target fragments. Phytoplasma was detected in all AYL disease samples from Baoting, Tunchang, and Wanning counties in Hainan province using the two sets of LAMP primers 16SrDNA-2 and 16SrDNA-3, whereas no phytoplasma was detected in the negative control. The LAMP method established in this study with comparatively high sensitivity and stability, provides reliable results that could be visually detected, making it suitable for application and research in rapid diagnosis of AYL disease, detection of seedlings with the pathogen and breeding of diseaseresistant Areca palm varieties.

Research on the Application of Intelligent Technology Based on The Vector Controller and Wireless Module in Automotive Manufacturing

Wenna Li,Shuai Tang 대한전자공학회 2024 IEIE Transactions on Smart Processing & Computing Vol.13 No.3

The assembly of various components in automobiles is an essential component of manufactured products, and currently, most of the assembly is done manually, which has high labor intensity and specific human errors. An unmanned workshop and intelligent processing were achieved by improving the vector control of assembly motors operated by a microcontroller with embedded wireless modules in the background. This study also performed two-bit spatial modeling of the workshop and then combined sensor technology to build the environment and transport this motor to the operating table. Therefore, the ant colony algorithm is used for path planning to achieve obstacle avoidance and smooth transportation of automatic transportation in the workshop. The torque and current pulse output using the embedded vector controller were relatively smooth, with small fluctuations up and down and current fluctuations within 1A. Hence, the controller can achieve vector control while maintaining a stable torque output. The studied vector controller can achieve a given torque output at 0.1s, highlighting the high efficiency of the method. The path planning results of the three types of obstacle transportation robots can achieve path smoothness, with an error of only about 0.12, demonstrating the excellent performance of this method. Several vector controllers satisfied the frame and seat assembly when used with the transport robot.

Dynamic performance of 6.5 kV SiC MOSFET body diodes and anti‑parallel Schottky barrier diodes

Yujie Du,Xinling Tang,Xiaoguang Wei,Shuai Sun,Fei Yang,Zhibin Zhao 전력전자학회 2023 JOURNAL OF POWER ELECTRONICS Vol.23 No.6

For a silicon carbide (SiC) metal–oxide–semiconductor fi eld-eff ect transistor (MOSFET), both the body diode of the MOSFET and an anti-parallel diode can function as a freewheeling diode that carries reverse current. Selecting a suitable freewheeling method is particularly important to fully exploit the performance of high-voltage SiC MOSFET devices. In this study, based on the 6.5 kV SiC MOSFET and the Schottky barrier diode (SBD) developed by our research group, the dynamic characteristics of the MOSFET body diode, the SBD, and the parallel connection of the two are investigated. In addition, the influence of capacitive current on the dynamic characteristics is analyzed by establishing an equivalent circuit model. Test results show that when compared with the body diode, the SBD has an extremely low reverse recovery current, a lower capacitive current, and better reverse recovery temperature stability. Thus, the SBD is regarded as the most suitable freewheeling diode for the 6.5 kV SiC MOSFET. Finally, a package solution for the 6.5 kV SiC MOSFET and SBD is proposed.

Syntheses, Structures and Luminescent Properties of Two Novel M(II)-Phen-SIP Supramolecular Compounds (M = Co, Ni)

Yu-Lan Zhu,Shuai Shao,Kui-Rong Ma,Xue-Ling Tang,Li Cao,Hui-Chao Zhao 대한화학회 2012 Bulletin of the Korean Chemical Society Vol.33 No.4

Two metal compounds, [Co(phen)2(H2O)2]·2H2SIP·2H2O 1 and [Ni(phen)3]·2H2SIP·3H2O 2, have been obtained by incorporating 1,10-phenanthroline (phen) and 5-sulfoisophthalic acid monosodium salt (NaH2SIP) ligands under hydrothermal conditions. Meanwhile, the two compounds were characterized by element analysis, IR, XRD, TG-DTA and single-crystal X-ray diffraction. Both 1 and 2 present 3D supramolecular structures via O–H···O hydrogen bond interactions. Luminescent properties for 1 and 2 were also studied. The compound 1 has two fluorescence emission peaks centered at 398 nm attributed to the intraligand emission from the SIP ligand and at 438 nm assigned to the combined interaction of intraligand π*-π transitions of the phen ligand and ligand-to-metal-charge-transfer (LMCT) transitions (λex = 233 nm). The compound 2 shows one emission band centered at 423 nm with a shoulder peak at 434 nm which may be originated from the intraligand π*-π transitions of the phen ligand (λex = 266 nm).

Microwave Absorption Enhancement of Fe/C Core–Shell Hybrid Derived from a Metal-Organic Framework

Liuyang Heng,Zilong Zhang,Shuai Wang,Xiqiao Chen,Xiubo Jia,Zhixiang Tang,Yanhong Zou 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.1

Core–shell structured Fe/C have been successfully derived from a metal-organic framework for microwave absorbing. Based on the measured electromagnetic parameters, it is found that the maximum reflection loss (RL) of Fe/C reaches 40 dB at 5.8 GHz with a thickness of 3.0 mm and the broadest absorption bandwidth (RL < -10 dB) is up to 6.0 GHz (from 11.2 to 17.2 GHz) with a thickness of 1.5 mm. The excellent microwave absorption is mainly ascribed to the multiple reflections, good impedance matching, dielectric loss and interface polarization originating from the core–shell structure. It is believed that Fe/C can be a promising microwave absorbing material.

Syntheses, Structures and Luminescent Properties of Two Novel M(II)-Phen-SIP Supramolecular Compounds (M = Co, Ni)

Zhu, Yu-Lan,Shao, Shuai,Ma, Kui-Rong,Tang, Xue-Ling,Cao, Li,Zhao, Hui-Chao Korean Chemical Society 2012 Bulletin of the Korean Chemical Society Vol.33 No.4

Two metal compounds, $[Co(phen)_2(H_2O)_2]{\cdot}2H_2SIP{\cdot}2H_2O$ 1 and $[Ni(phen)_3]{\cdot}2H_2SIP{\cdot}3H_2O$ 2, have been obtained by incorporating 1,10-phenanthroline (phen) and 5-sulfoisophthalic acid monosodium salt ($NaH_2SIP$) ligands under hydrothermal conditions. Meanwhile, the two compounds were characterized by element analysis, IR, XRD, TG-DTA and single-crystal X-ray diffraction. Both 1 and 2 present 3D supramolecular structures via O-H${\cdots}$O hydrogen bond interactions. Luminescent properties for 1 and 2 were also studied. The compound 1 has two fluorescence emission peaks centered at 398 nm attributed to the intraligand emission from the SIP ligand and at 438 nm assigned to the combined interaction of intraligand ${\pi}^*-{\pi}$ transitions of the phen ligand and ligand-to-metal-charge-transfer (LMCT) transitions (${\lambda}_{ex}$ = 233 nm). The compound 2 shows one emission band centered at 423 nm with a shoulder peak at 434 nm which may be originated from the intraligand ${\pi}^*-{\pi}$ transitions of the phen ligand (${\lambda}_{ex}$ = 266 nm).